H Raff

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. pmc Circadian rhythm of salivary cortisol, plasma cortisol, and plasma ACTH in end-stage renal disease
    Hershel Raff
    Division of Endocrinology, Department of Medicine Medical College of Wisconsin Milwaukee, Wisconsin, 53226 USA Department of Surgery Medical College of Wisconsin Milwaukee, Wisconsin, 53226 USA Department of Physiology Medical College of Wisconsin Milwaukee, Wisconsin, 53226 USA Endocrine Research Laboratory Aurora St Luke s Medical Center 2801 W Kinnickinnic Parkway, Suite 245, Milwaukee, Wisconsin, 53215 USA
    Endocr Connect 2:23-31. 2013
  2. ncbi request reprint Update on late-night salivary cortisol for the diagnosis of Cushing's syndrome: methodological considerations
    Hershel Raff
    Endocrine Research Laboratory, Department of Endocrinology, Aurora St Luke s Medical Center, Aurora Research Foundation, 2801 W KK River Pky Suite 245, Milwaukee, WI, 53215, USA
    Endocrine 44:346-9. 2013
  3. doi request reprint Cushing's syndrome: diagnosis and surveillance using salivary cortisol
    Hershel Raff
    Endocrine Research Laboratory, Endocrine Diabetes Center, Aurora St Luke s Medical Center, Milwaukee, WI 53215, USA
    Pituitary 15:64-70. 2012
  4. doi request reprint Effects of body temperature maintenance on glucose, insulin, and corticosterone responses to acute hypoxia in the neonatal rat
    Mitchell A Guenther
    Endocrine Research Laboratory, Aurora St Luke s Medical Center, Milwaukee WI 53215, USA
    Am J Physiol Regul Integr Comp Physiol 302:R627-33. 2012
  5. pmc Cardiac and plasma lipid profiles in response to acute hypoxia in neonatal and young adult rats
    Eric D Bruder
    Endocrine Research Laboratory, Aurora St, Luke s Medical Center, Milwaukee, WI 53215, USA
    Lipids Health Dis 9:3. 2010
  6. ncbi request reprint Adrenocortical responses to ACTH in neonatal rats: effect of hypoxia from birth on corticosterone, StAR, and PBR
    Hershel Raff
    Endocrine and Transplant Research Laboratories, St Luke s Medical Center, and Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53215, USA
    Am J Physiol Regul Integr Comp Physiol 284:R78-85. 2003
  7. doi request reprint Pre-analytical issues for testosterone and estradiol assays
    Hershel Raff
    Endocrine Research Laboratory, Aurora St Luke s Medical Center, Milwaukee, WI 53215, United States
    Steroids 73:1297-304. 2008
  8. pmc Augmented hypothalamic corticotrophin-releasing hormone mRNA and corticosterone responses to stress in adult rats exposed to perinatal hypoxia
    H Raff
    Endocrine Research Laboratory, Aurora St Luke s Medical Center, Medical College of Wisconsin, Milwaukee, WI, USA
    J Neuroendocrinol 19:907-12. 2007
  9. ncbi request reprint A physiologic approach to diagnosis of the Cushing syndrome
    Hershel Raff
    Endocrinology, St Luke s Medical Center, Medical College of Wisconsin, 2801 W KK River Parkway, Suite 245, Milwaukee, Wisconsin 53215, USA
    Ann Intern Med 138:980-91. 2003
  10. ncbi request reprint The effect of fetal hypoxia on adrenocortical function in the 7-day-old rat
    H Raff
    Endocrine Research Laboratory, St Luke s Medical Center, Medical College of Wisconsin, Milwaukee, USA
    Endocrine 13:111-6. 2000

Detail Information

Publications70

  1. pmc Circadian rhythm of salivary cortisol, plasma cortisol, and plasma ACTH in end-stage renal disease
    Hershel Raff
    Division of Endocrinology, Department of Medicine Medical College of Wisconsin Milwaukee, Wisconsin, 53226 USA Department of Surgery Medical College of Wisconsin Milwaukee, Wisconsin, 53226 USA Department of Physiology Medical College of Wisconsin Milwaukee, Wisconsin, 53226 USA Endocrine Research Laboratory Aurora St Luke s Medical Center 2801 W Kinnickinnic Parkway, Suite 245, Milwaukee, Wisconsin, 53215 USA
    Endocr Connect 2:23-31. 2013
    ..We evaluated the circadian rhythm of plasma compared with salivary cortisol in subjects with ESRD...
  2. ncbi request reprint Update on late-night salivary cortisol for the diagnosis of Cushing's syndrome: methodological considerations
    Hershel Raff
    Endocrine Research Laboratory, Department of Endocrinology, Aurora St Luke s Medical Center, Aurora Research Foundation, 2801 W KK River Pky Suite 245, Milwaukee, WI, 53215, USA
    Endocrine 44:346-9. 2013
    ..With the large increase in the number LNSCs being ordered around the world, it is likely that more preanalytic and analytic issues will arise, which laboratorians and clinical chemists will need to resolve. ..
  3. doi request reprint Cushing's syndrome: diagnosis and surveillance using salivary cortisol
    Hershel Raff
    Endocrine Research Laboratory, Endocrine Diabetes Center, Aurora St Luke s Medical Center, Milwaukee, WI 53215, USA
    Pituitary 15:64-70. 2012
    ..Salivary cortisol is most useful as the initial test when Cushing's syndrome is suspected and for periodic patient monitoring after pituitary surgery for Cushing's disease...
  4. doi request reprint Effects of body temperature maintenance on glucose, insulin, and corticosterone responses to acute hypoxia in the neonatal rat
    Mitchell A Guenther
    Endocrine Research Laboratory, Aurora St Luke s Medical Center, Milwaukee WI 53215, USA
    Am J Physiol Regul Integr Comp Physiol 302:R627-33. 2012
    ..Prevention of hypothermia during hypoxia further disrupts glucose homeostasis and increases metabolic challenges...
  5. pmc Cardiac and plasma lipid profiles in response to acute hypoxia in neonatal and young adult rats
    Eric D Bruder
    Endocrine Research Laboratory, Aurora St, Luke s Medical Center, Milwaukee, WI 53215, USA
    Lipids Health Dis 9:3. 2010
    ..The physiological and biochemical responses to acute hypoxia have not been fully characterized in neonates. Fatty acids and lipids play an important role in most aspects of cardiac function...
  6. ncbi request reprint Adrenocortical responses to ACTH in neonatal rats: effect of hypoxia from birth on corticosterone, StAR, and PBR
    Hershel Raff
    Endocrine and Transplant Research Laboratories, St Luke s Medical Center, and Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53215, USA
    Am J Physiol Regul Integr Comp Physiol 284:R78-85. 2003
    ..The augmentation of the corticosterone response to acute increases in ACTH in hypoxic pups is likely to be an important component of the overall physiological adaptation to hypoxia in the neonate...
  7. doi request reprint Pre-analytical issues for testosterone and estradiol assays
    Hershel Raff
    Endocrine Research Laboratory, Aurora St Luke s Medical Center, Milwaukee, WI 53215, United States
    Steroids 73:1297-304. 2008
    ..We recommend that great attention be paid to these pre-analytical issues before the assay methodologies are harmonized...
  8. pmc Augmented hypothalamic corticotrophin-releasing hormone mRNA and corticosterone responses to stress in adult rats exposed to perinatal hypoxia
    H Raff
    Endocrine Research Laboratory, Aurora St Luke s Medical Center, Medical College of Wisconsin, Milwaukee, WI, USA
    J Neuroendocrinol 19:907-12. 2007
    ....
  9. ncbi request reprint A physiologic approach to diagnosis of the Cushing syndrome
    Hershel Raff
    Endocrinology, St Luke s Medical Center, Medical College of Wisconsin, 2801 W KK River Parkway, Suite 245, Milwaukee, Wisconsin 53215, USA
    Ann Intern Med 138:980-91. 2003
  10. ncbi request reprint The effect of fetal hypoxia on adrenocortical function in the 7-day-old rat
    H Raff
    Endocrine Research Laboratory, St Luke s Medical Center, Medical College of Wisconsin, Milwaukee, USA
    Endocrine 13:111-6. 2000
    ..We conclude that fetal hypoxia in late gestation results in a subtle decrease in cAMP-stimulated steroidogenesis. Fetal hypoxia appears to have minimal effects on subsequent adrenal function in the neonatal rat...
  11. ncbi request reprint Elevated corticosterone and inhibition of ACTH responses to CRH and ether in the neonatal rat: effect of hypoxia from birth
    Hershel Raff
    Endocrinology and Diabetes, St Luke s Physician s Office Bldg, 2801 W KK River Pkwy, Suite 245, Milwaukee, WI 53215, USA
    Am J Physiol Regul Integr Comp Physiol 285:R1224-30. 2003
    ..The neural and biochemical mechanism of this effect has yet to be elucidated...
  12. ncbi request reprint Total and active ghrelin in developing rats during hypoxia
    Hershel Raff
    Endocrine Research Laboratory, St Luke s Medical Center, Medical College of Wisconsin, Milwaukee, WI 53215, USA
    Endocrine 21:159-61. 2003
    ..We conclude that the anorexia and weight loss associated with hypoxia is probably not mediated by ghrelin. There appear to be changes in active ghrelin levels in plasma during early development in the rat...
  13. ncbi request reprint Basal and adrenocorticotropin-stimulated corticosterone in the neonatal rat exposed to hypoxia from birth: modulation by chemical sympathectomy
    Hershel Raff
    Endocrine and Transplant Research Laboratories, St Luke s Medical Center, Milwaukee, Wisconsin 53215, USA
    Endocrinology 145:79-86. 2004
    ....
  14. pmc Glucocorticoid feedback control of corticotropin in the hypoxic neonatal rat
    Hershel Raff
    Endocrine Research Laboratory, Aurora St Luke s Medical Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53215, USA
    J Endocrinol 192:453-8. 2007
    ..We conclude that ACTH responses to acute stimuli in hypoxic neonatal rats are prevented by ACTH-independent increases in corticosterone, rather than by intrinsic hypothalamic-pituitary hypoactivity...
  15. pmc Adiponectin and resistin in the neonatal rat: effects of dexamethasone and hypoxia
    Hershel Raff
    Endocrine Research Laboratory, St Luke s Medical Center, Milwaukee, WI 53215, USA
    Endocrine 29:341-4. 2006
    ..We also conclude that adiponectin is increased during hypoxia in response to a decrease in the sensitivity to insulin...
  16. ncbi request reprint Neonatal dexamethasone therapy: short- and long-term consequences
    Hershel Raff
    Endocrine Research Laboratory, St Luke s Medical Center, Milwaukee, WI 53215, USA
    Trends Endocrinol Metab 15:351-2. 2004
    ..Significant attention is now being paid to the long-term consequences of glucocorticoid therapy in premature and full-term neonates...
  17. ncbi request reprint Teaching glucocorticoid negative feedback and adrenocortical regulation using a classic paper by Dr. Dwight Ingle
    Hershel Raff
    Department of Medicine, Medical College of Wisconsin, Endocrine Research Laboratory, St Luke s Medical Center, Milwaukee, WI 53215, USA
    Adv Physiol Educ 29:141-3. 2005
    ..Furthermore, the brilliance and imagination of the physiologists of the last century are highlighted, which allows an appreciation of the seminal work of our predecessors...
  18. ncbi request reprint Effect of hypoxia on parathyroid hormone in lactating and neonatal rats: interaction with halothane
    Hershel Raff
    Endocrine Research Laboratory, St Luke s Medical Center, Medical College of Wisconsin, Milwaukee, USA
    Endocrine 17:157-60. 2002
    ..We hypothesize that halothane and hypoxia alter parathyroid gland function by a direct effect on cellular calcium dynamics. This interaction may have clinical significance in hypoxic patients requiring general anesthesia...
  19. ncbi request reprint Steroidogenesis in human aldosterone-secreting adenomas and adrenal hyperplasias: effects of hypoxia in vitro
    Hershel Raff
    Endocrine Research Laboratory, St Luke s Medical Center, Medical College of Wisconsin, Milwaukee, WI 53215, USA
    Am J Physiol Endocrinol Metab 290:E199-E203. 2006
    ..These studies may have implications for oxygen therapy in critically ill patients with functional adrenal insufficiency, as well as for therapeutic options in patients with adrenal neoplasms...
  20. ncbi request reprint Neonatal hypoxic hyperlipidemia in the rat: effects on aldosterone and corticosterone synthesis in vitro
    H Raff
    Endocrine Research Laboratory, St Luke s Medical Center, Milwaukee, Wisconsin 53215, USA
    Am J Physiol Regul Integr Comp Physiol 278:R663-8. 2000
    ..We conclude that hypoxia induces hyperlipidemia in the suckling neonate and that elevated nonesterified fatty acids inhibit aldosteronogenesis...
  21. ncbi request reprint Elevated salivary cortisol in the evening in healthy elderly men and women: correlation with bone mineral density
    H Raff
    Department of Medicine, Medical College of Wisconsin, Milwaukee, USA
    J Gerontol A Biol Sci Med Sci 54:M479-83. 1999
    ..Salivary cortisol results were correlated with BMD. We hypothesized that salivary cortisol is elevated at 2300 h in elderly people, and that salivary cortisol will correlate negatively with BMD...
  22. ncbi request reprint Utility of salivary cortisol measurements in Cushing's syndrome and adrenal insufficiency
    Hershel Raff
    Endocrine Research Laboratory, Aurora St Luke s Medical Center, Milwaukee, Wisconsin 53215, USA
    J Clin Endocrinol Metab 94:3647-55. 2009
    ..There are a variety of simple methods to obtain saliva samples without stress, making this a robust test applicable to many different experimental and clinical situations...
  23. ncbi request reprint The effect of hypoxia from birth on the regulation of aldosterone in the 7-day-old rat: plasma hormones, steroidogenesis in vitro, and steroidogenic enzyme messenger ribonucleic acid
    H Raff
    Endocrine Research Laboratory St Luke s Medical Center, Medical College of Wisconsin, Milwaukee 53215, USA
    Endocrinology 140:3147-53. 1999
    ..This functional augmentation of aldosteronogenesis may be due to a change in mitochondrial permeability to steroid substrates and/or the effect of cytosolic factors that control mitochondrial steroidogenesis...
  24. ncbi request reprint Effect of neonatal hypoxia on leptin, insulin, growth hormone and body composition in the rat
    H Raff
    St Luke s Medical Center, and Department of Medicine, Medical College of Wisconsin, Milwaukee, USA
    Horm Metab Res 33:151-5. 2001
    ..We conclude that leptin is decreased during neonatal hypoxia despite no change in adiposity. Furthermore, insulin is increased probably to overcome the effects of increased counterregulatory hormones (such as corticosterone)...
  25. pmc Effect of animal facility construction on basal hypothalamic-pituitary-adrenal and renin-aldosterone activity in the rat
    Hershel Raff
    Endocrine Research Laboratory, Aurora St Luke s Medical Center, Milwaukee, Wisconsin 53215, USA
    Endocrinology 152:1218-21. 2011
    ..We conclude that nearby construction can cause a stress response without long-term effects on hypothalamic-pituitary-adrenal axis gene expression and body weight...
  26. ncbi request reprint Growth hormone therapy during neonatal hypoxia in rats: body composition, bone mineral density, and insulin-like growth factor-1 expression
    H Raff
    Endocrine Research Laboratories, St Luke s Medical Center, Milwaukee, WI 53215, USA
    Endocrine 16:139-43. 2001
    ..GH therapy for more than 14 days may be necessary to appreciate fully its potential in the treatment of the sequelae of neonatal hypoxia...
  27. doi request reprint Cosyntropin-stimulated salivary cortisol in hospitalized patients with hypoproteinemia
    Hershel Raff
    Endocrine Research Laboratory, Endocrine Diabetes Center, Aurora St Luke s Medical Center, 2801W KK River Pky Suite 245, Milwaukee, WI 53215, USA
    Endocrine 34:68-74. 2008
    ..Salivary cortisol is a clinically useful surrogate for serum free cortisol in dynamic testing of adrenocortical function...
  28. ncbi request reprint The effect of hypoxia on plasma leptin and insulin in newborn and juvenile rats
    H Raff
    Endocrine Research Laboratory, St Luke s Medical Center, Milwaukee, WI 53215, USA
    Endocrine 11:37-9. 1999
    ..We conclude that exposure to hypoxia for 7 d leads to a decrease in body weight and plasma leptin in infant and juvenile rats. The decrease in leptin may be an attempt to reverse hypoxia-induced anorexia...
  29. doi request reprint Adrenocorticotropic hormone and corticosterone responses to acute hypoxia in the neonatal rat: effects of body temperature maintenance
    Eric D Bruder
    Endocrine Research Laboratory, Aurora St Luke s Medical Center, Medical College of Wisconsin, Milwaukee, USA
    Am J Physiol Regul Integr Comp Physiol 300:R708-15. 2011
    ..Prevention of hypothermia may increase the stress response during neonatal hypoxia, becoming more pronounced with increased age...
  30. pmc Development of the ACTH and corticosterone response to acute hypoxia in the neonatal rat
    Eric D Bruder
    Endocrinology, St Luke s Physician s Office Bldg, 2801 W KK River Pky, Suite 245, Milwaukee, WI 53215, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1195-203. 2008
    ..The present data describe a developmentally regulated, differential corticosterone response to acute hypoxia, shifting from ACTH independence in early life (PD2) to ACTH dependence less than 1 wk later (PD8)...
  31. ncbi request reprint Late-night salivary cortisol as a screening test for Cushing's syndrome
    H Raff
    Endocrine Diabetes Center, St Luke s Medical Center, Medical College of Wisconsin, Milwaukee 53215, USA
    J Clin Endocrinol Metab 83:2681-6. 1998
    ..In addition, late-night salivary cortisol measurements may simplify the evaluation of suspected intermittent hypercortisolism, and they may facilitate the screening of large high-risk populations (e.g. patients with diabetes mellitus)...
  32. ncbi request reprint Effect of neonatal hypoxia on the development of hepatic lipase in the rat
    P C Lee
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Physiol Regul Integr Comp Physiol 279:R1341-7. 2000
    ..Hypoxia delays the maturation of hepatic lipases. We suggest that the decrease in hepatic lipase activity contributes to hyperlipemia in the hypoxic newborn rats...
  33. ncbi request reprint Comparison of adrenal vein sampling and computed tomography in the differentiation of primary aldosteronism
    S B Magill
    Endocrine Diabetes Center, Department of Medicine, St Luke s Medical Center, Milwaukee, Wisconsin 53215, USA
    J Clin Endocrinol Metab 86:1066-71. 2001
    ..We conclude that adrenal CT imaging is not a reliable method to differentiate primary aldosteronism. Adrenal vein sampling is essential to establish the correct diagnosis of primary aldosteronism...
  34. pmc Adrenal lipid profiles of chemically sympathectomized normoxic and hypoxic neonatal rats
    E D Bruder
    Endocrine Research Laboratory, St Luke s Medical Center, Milwaukee, WI 53215, USA
    Horm Metab Res 38:807-11. 2006
    ..The results support the idea that the ACTH-independent corticosterone response to hypoxia in the neonatal rat is mediated by specific, sympathetically driven alterations in the adrenal lipid profile...
  35. ncbi request reprint Oxygen-dependence of ACTH-stimulated aldosterone and corticosterone synthesis in the rat adrenal cortex: developmental aspects
    E D Bruder
    Endocrine Research Laboratory, St Luke s Medical Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53215, USA
    J Endocrinol 172:595-604. 2002
    ..These findings illustrate a novel developmental alteration in O(2)-regulated steroid production, and may have implications for neonatal health and disease...
  36. ncbi request reprint Mandibular and palatal tori, bone mineral density, and salivary cortisol in community-dwelling elderly men and women
    J Hjertstedt
    Division of Oral Medicine and Diagnostic Sciences, Marquette University School of Dentistry, Milwaukee, Wisconsin 53201 1881, USA
    J Gerontol A Biol Sci Med Sci 56:M731-5. 2001
    ..This investigation evaluated the relationship between the presence of tori and bone mineral density (BMD) and salivary cortisol levels...
  37. pmc Plasma leptin and ghrelin in the neonatal rat: interaction of dexamethasone and hypoxia
    Eric D Bruder
    Endocrine Research Laboratory, St Luke s Medical Center, Milwaukee, Wisconsin 53215, USA
    J Endocrinol 185:477-84. 2005
    ..The changes in ghrelin, leptin, and corticosterone may be beneficial to the hypoxic neonate through the maintenance of appetite and shifts in intermediary metabolism...
  38. ncbi request reprint Hypoxia in vivo inhibits aldosterone synthesis and aldosterone synthase mRNA in rats
    H Raff
    Endocrine Laboratories, St Luke s Medical Center, Medical College of Wisconsin, Milwaukee 53215, USA
    J Appl Physiol (1985) 81:604-10. 1996
    ..We conclude that relatively short-term chronic hypoxia in rats leads to a decrease in aldosteronogenesis by decreasing the expression of the gene for the late-pathway enzyme unique to the aldosterone pathway (P-450c11AS)...
  39. ncbi request reprint An oxidized derivative of linoleic acid stimulates dehydroepiandrosterone production by human adrenal cells
    E D Bruder
    Endocrine Research Laboratory, Aurora St Luke s Medical Center, Milwaukee, WI 53215, USA
    Horm Metab Res 38:803-6. 2006
    ..This may be an important phenomenon in the genesis of changes in adrenal function associated with syndromes of obesity, especially those that include androgen excess...
  40. pmc Epidermal growth factor and parathyroid hormone-related peptide mRNA in the mammary gland and their concentrations in milk: effects of postpartum hypoxia in lactating rats
    E D Bruder
    Endocrine Research Laboratory, Aurora St Luke s Medical Center, Milwaukee, Wisconsin, USA
    Horm Metab Res 40:446-53. 2008
    ..Decreased EGF and increased adiponectin concentrations in milk from hypoxic dams likely affect the development of neonatal intestinal function...
  41. doi request reprint Late-night salivary cortisol measurement in the diagnosis of Cushing's syndrome
    Ty Carroll
    Division of Endocrinology, Metabolism, and Clinical Nutrition, Medical College of Wisconsin, Milwaukee, WI, USA
    Nat Clin Pract Endocrinol Metab 4:344-50. 2008
    ..In this Review, we discuss the methods and value of measuring salivary cortisol for the diagnosis of Cushing's syndrome, and put forward some recommendations to maximize accuracy of results...
  42. pmc Microarray and real-time PCR analysis of adrenal gland gene expression in the 7-day-old rat: effects of hypoxia from birth
    Eric D Bruder
    Endocrine Research Laboratory, Aurora St Luke s Medical Center, Milwaukee, Wisconsin, USA
    Physiol Genomics 29:193-200. 2007
    ..Furthermore, hypoxia induced changes in gene expression that account for more productive and efficient steroidogenesis...
  43. ncbi request reprint Effects of hypoxia on the development of intestinal enzymes in neonatal and juvenile rats
    Ping C Lee
    Departments of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Exp Biol Med (Maywood) 228:717-23. 2003
    ..Increases in serum glucocorticoids after hypoxic exposure probably do not play a major role in the delayed maturation of the disaccharidase activity in the small intestine...
  44. ncbi request reprint Metabolomic analysis of adrenal lipids during hypoxia in the neonatal rat: implications in steroidogenesis
    Eric D Bruder
    Endocrine Research Laboratory, St Luke s Medical Center, Milwaukee, WI 53215, USA
    Am J Physiol Endocrinol Metab 286:E697-703. 2004
    ..These cellular changes may be a mechanism by which the neonate can increase circulating adrenal steroids necessary for survival, therefore bypassing a relative insensitivity to normal stimuli...
  45. ncbi request reprint Metabolic consequences of hypoxia from birth and dexamethasone treatment in the neonatal rat: comprehensive hepatic lipid and fatty acid profiling
    Eric D Bruder
    Endocrinology, St Luke s Physician s Office Building, 2801 West Kinnickinnic River Parkway, Suite 245, Milwaukee, Wisconsin 53215, USA
    Endocrinology 145:5364-72. 2004
    ..The effects of dexamethasone on hepatic function in the hypoxic neonate are dramatic and have significant implications in the assessment and treatment of metabolic dysfunction in the newborn...
  46. ncbi request reprint Neonatal hypoxia in the rat: effects on exocrine pancreatic development
    Ping C Lee
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226, USA
    J Pediatr Gastroenterol Nutr 34:542-7. 2002
    ..Glucocorticoids profoundly affect pancreatic development during the suckling period. Increases in circulating glucocorticoids during exposure to hypoxia may alter the normal pattern of pancreatic enzyme development...
  47. doi request reprint Late-night salivary cortisol for the diagnosis of Cushing syndrome: a meta-analysis
    Ty Carroll
    Endocrinology Center, Medical College of Wisconsin, Menomonee Falls, WI 53051, USA
    Endocr Pract 15:335-42. 2009
    ..To report a meta-analysis of late-night salivary cortisol testing for the diagnosis of Cushing syndrome...
  48. ncbi request reprint Interactions between neurohypophysial hormones and the ACTH-adrenocortical axis
    H Raff
    Department of Medicine, Medical College of Wisconsin, St Luke s Medical Center, Milwaukee 53215
    Ann N Y Acad Sci 689:411-25. 1993
    ..The converse is also true in that patients with adrenal insufficiency may have an SIAD-like scenario. CRH may be synthesized in, and secreted from, magnocellular OT neurons and may be involved in the control of neurohypophysial function...
  49. ncbi request reprint Diagnosis and differential diagnosis of Cushing's syndrome
    J W Findling
    Endocrine-Diabetes Center, St. Luke's Medical Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Endocrinol Metab Clin North Am 30:729-47. 2001
    ..2). Clinicians who have never missed the diagnosis of Cushing's syndrome or have never been fooled by attempting to establish its cause should refer their patients with suspected hypercortisolism to someone who has...
  50. ncbi request reprint Limitations of nocturnal salivary cortisol and urine free cortisol in the diagnosis of mild Cushing's syndrome
    Srividya Kidambi
    Endocrine Research Laboratory, Endocrine Diabetes Center, Aurora St Luke s Medical Center, Milwaukee, Wisconsin 53215, USA
    Eur J Endocrinol 157:725-31. 2007
    ..However, its performance in mild CS has not been reported. We present 11 cases of CS with normal or mildly elevated UFC in whom NSC was helpful in making a diagnosis...
  51. ncbi request reprint Dexamethasone treatment in the newborn rat: fatty acid profiling of lung, brain, and serum lipids
    Eric D Bruder
    Endocrinology Research Laboratory, St Luke s Medical Center, Milwaukee, WI 53215, USA
    J Appl Physiol 98:981-90. 2005
    ..These findings illustrate the benefits of dexamethasone on lung function but also raise the potential for negative effects due to hyperlipidemia and subtle changes in brain lipid metabolism...
  52. ncbi request reprint The low-dose dexamethasone suppression test: a reevaluation in patients with Cushing's syndrome
    James W Findling
    The Endocrine Diabetes Center, St Luke s Medical Center and Medical College of Wisconsin, Milwaukee, Wisconsin 53215, USA
    J Clin Endocrinol Metab 89:1222-6. 2004
    ....
  53. ncbi request reprint Randomized trial of oral hydrocortisone and its effect on emergency physicians during night duty
    J E Whitcomb
    Department of Emergency Medicine, St Luke s Medical Center, Milwaukee, WI 53215, USA
    WMJ 99:37-41, 46. 2000
    ..To analyze the effects of hydrocortisone (40 mg. p.o.) administered to emergency physicians on their first night shift following a series of day shifts...
  54. ncbi request reprint Renal interstitial corticosterone and 11-dehydrocorticosterone in conscious rats
    Kristie Usa
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 293:F186-92. 2007
    ..8-fold. These results demonstrated that corticosterone excess in the renal medulla might be sufficient to cause hypertension and provided the first characterization of renal interstitial glucocorticoids...
  55. ncbi request reprint Identification of patients with Cushing's disease with negative pituitary adrenocorticotropin gradients during inferior petrosal sinus sampling: prolactin as an index of pituitary venous effluent
    James W Findling
    Endocrine Diabetes Center, St Luke s Medical Center, Milwaukee, Wisconsin 53215, USA
    J Clin Endocrinol Metab 89:6005-9. 2004
    ..PRL is an index of pituitary venous effluent during inferior petrosal sinus sampling in patients with CD who fail to have a peak IPS:P ACTH ratio greater than 3.0 after CRH. IPS:P PRL should be measured when results indicate EAS...
  56. ncbi request reprint Association of adrenal steroids with hypertension and the metabolic syndrome in blacks
    Srividya Kidambi
    Medical College of Wisconsin, Milwaukee, USA
    Hypertension 49:704-11. 2007
    ..In addition, we speculate that relatively high aldosterone and low PRA in these hypertensive individuals may reflect a mild variant of primary aldosteronism...
  57. ncbi request reprint Cushing's Syndrome: important issues in diagnosis and management
    James W Findling
    Endocrime Diabetes Center, St Luke s Physician s Office Building, 2801 West KK River Parkway, Suite 245, Milwaukee, WI 53215, USA
    J Clin Endocrinol Metab 91:3746-53. 2006
    ..We focus on critical questions addressing screening for Cushing's syndrome, differentiation of Cushing's subtypes, and treatment options...
  58. ncbi request reprint A comparison of methods for assessing hypothalamic-pituitary-adrenal (HPA) axis activity in asthma patients treated with inhaled corticosteroids
    Harold S Nelson
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Clin Pharmacol 42:319-26. 2002
    ..Because it is noninvasive, salivary cortisol measurement offers distinct advantages as a screening method for detecting pronounced HPA axis suppression in asthma patients receiving corticosteroid therapy...
  59. ncbi request reprint An oxidized metabolite of linoleic acid stimulates corticosterone production by rat adrenal cells
    Eric D Bruder
    Endocrine Research Laboratory, St Luke s Medical Center, Milwaukee, Wisconsin 53215, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1631-5. 2003
    ..We conclude that EKODE stimulates corticosterone biosynthesis and amplifies the effect of ACTH. Increased levels of fatty acid metabolites may be involved in the increased glucocorticoid production observed in obese humans...
  60. ncbi request reprint Lipid and fatty acid profiles in the brain, liver, and stomach contents of neonatal rats: effects of hypoxia
    Eric D Bruder
    Endocrine Research Laboratory, St Luke s Medical Center, 2801 W KK River Parkway, Suite 245, Milwaukee, WI 53215, USA
    Am J Physiol Endocrinol Metab 288:E314-20. 2005
    ..Hypoxia also exhibits some direct affects through modulation of metabolic pathways in situ, mostly in the liver. In this respect, the neonatal brain exhibits tighter control on lipid homeostasis than the liver during neonatal hypoxia...
  61. ncbi request reprint Screening and diagnosis of Cushing's syndrome
    James W Findling
    Endocrine Diabetes Center, St Luke s Medical Center, 2801 West KK River Parkway, Suite 245, Milwaukee, WI 53215, USA
    Endocrinol Metab Clin North Am 34:385-402, ix-x. 2005
    ..of late-night salivary cortisol provides the most sensitive method for screening, and urine-free cortisol and low-dose dexamethasone suppression testing may be used for confirmation of the diagnosis of endogenous hypercortisolism..
  62. ncbi request reprint Elevated late-night salivary cortisol levels in elderly male type 2 diabetic veterans
    Hau Liu
    Division of Endocrinology and Metabolism, Stanford University, Stanford, CA 94305, USA
    Clin Endocrinol (Oxf) 63:642-9. 2005
    ..The purpose of this study was to evaluate LNSC levels in elderly male veterans with and without diabetes...
  63. doi request reprint Using saliva to measure endogenous cortisol in nursing home residents with advanced dementia
    Diana Lynn Woods
    School of Nursing, University of California, Los Angeles, 700 Tiverton Avenue, Box 956919, Los Angeles, CA 90095 6919, USA
    Res Nurs Health 31:283-94. 2008
    ..A third of the participants demonstrated an increase in the evening cortisol levels, while the remaining profiles were flat, suggesting hypothalamic-pituitary-adrenal (HPA) dysregulation in this population...
  64. ncbi request reprint Characterization of pituitary-adrenocortical activity in the Malayan flying fox (Pteropus vampyrus)
    Deeann M Reeder
    Department of Biology, Boston University, Boston, MA 02215, USA
    J Comp Physiol B 176:513-9. 2006
    ....
  65. ncbi request reprint Comparison of two methods for measuring salivary cortisol
    Hershel Raff
    Clin Chem 48:207-8. 2002
  66. ncbi request reprint The significance of the blood gas analyzer
    Hershel Raff
    J Appl Physiol 97:1597-8. 2004
  67. ncbi request reprint New enzyme immunoassay for salivary cortisol
    Hershel Raff
    Clin Chem 49:203-4. 2003
  68. ncbi request reprint PTHrP during petrosal sinus sampling
    Hershel Raff
    Clin Endocrinol (Oxf) 56:419. 2002
  69. ncbi request reprint Introduction to the classic papers commemorating the APS Legacy Project
    Hershel Raff
    Am J Physiol Renal Physiol 287:F859-60. 2004

Research Grants8

  1. PERINATAL HYPOXIA--ADRENOCORTICAL/METABOLIC ADAPTATIONS
    Hershel Raff; Fiscal Year: 1999
    ..Specific aim 5 will determine if the dramatic changes in plasma lipids which occur in the hypoxic, suckling rat, are a major influence on aldosteroidogenesis. ..
  2. PERINATAL HYPOXIA--ADRENOCORTICAL/METABOLIC ADAPTATIONS
    Hershel Raff; Fiscal Year: 2000
    ..Specific aim 5 will determine if the dramatic changes in plasma lipids which occur in the hypoxic, suckling rat, are a major influence on aldosteroidogenesis. ..
  3. PERINATAL HYPOXIA--ADRENOCORTICAL/METABOLIC ADAPTATIONS
    Hershel Raff; Fiscal Year: 2001
    ..Specific aim 5 will determine if the dramatic changes in plasma lipids which occur in the hypoxic, suckling rat, are a major influence on aldosteroidogenesis. ..
  4. PERINATAL HYPOXIA--ADRENOCORTICAL/METABOLIC ADAPTATIONS
    Hershel Raff; Fiscal Year: 2002
    ..Specific aim 5 will determine if the dramatic changes in plasma lipids which occur in the hypoxic, suckling rat, are a major influence on aldosteroidogenesis. ..
  5. PERINATAL HYPOXIA: ADRENOCORTICAL-METABOLIC ADAPTATIONS
    Hershel Raff; Fiscal Year: 2003
    ..Characterization of the hypothalamic-pituitary-adrenal and metabolic adaptations to perinatal hypoxia can lead to new diagnostic approaches and therapies to minimize morbidity and mortality. ..
  6. PERINATAL HYPOXIA: ADRENOCORTICAL-METABOLIC ADAPTATIONS
    Hershel Raff; Fiscal Year: 2006
    ..Characterization of the hypothalamic-pituitary-adrenal and metabolic adaptations to perinatal hypoxia can lead to new diagnostic approaches and therapies to minimize morbidity and mortality. ..