KIRKWOOD A contact PRITCHARD

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. pmc Anion exchange HPLC isolation of high-density lipoprotein (HDL) and on-line estimation of proinflammatory HDL
    Xiang Ji
    Department of Geriatrics, Qilu Hospital, Shandong University, Key Laboratory of Cardiovascular Proteomics of Shandong Province, Jinan, Shandong, China Department of Surgery, Division of Pediatric Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 9:e91089. 2014
  2. pmc Effects of experimental asthma on inflammation and lung mechanics in sickle cell mice
    Kirkwood A Pritchard
    Department of Surgery, Division of Pediatric Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Respir Cell Mol Biol 46:389-96. 2012
  3. doi request reprint Surfactant protein D: not just for the lung anymore
    Kirkwood A Pritchard
    Children s Research Institute, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 294:H1994. 2008
  4. ncbi request reprint Hypoxia-induced acute lung injury in murine models of sickle cell disease
    Kirkwood A Pritchard
    Medical College of Wisconsin, Div of Pediatric Surgery, Cardiovascula Center M4060, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Lung Cell Mol Physiol 286:L705-14. 2004
  5. ncbi request reprint Chromium (VI) increases endothelial cell expression of ICAM-1 and decreases nitric oxide activity
    K A Pritchard
    Department of Pathology, Pharmacology and Toxicology, Medical College of Wisconsin, The Cardiovascular Research Center, Milwaukee 53226, USA
    J Environ Pathol Toxicol Oncol 19:251-60. 2000
  6. ncbi request reprint Native low-density lipoprotein induces endothelial nitric oxide synthase dysfunction: role of heat shock protein 90 and caveolin-1
    Kirkwood A Pritchard
    Department of Surgery, Division of Pediatric Surgery, Pharmacology and Toxicology, and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Free Radic Biol Med 33:52-62. 2002
  7. ncbi request reprint Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase
    K A Pritchard
    Division of Pediatric Surgery, Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 276:17621-4. 2001
  8. ncbi request reprint [A comparison between L-4F and SC-4F in preventing low density lipoprotein induced endothelial cell dysfunction in cell culture]
    Zhi Jun Ou
    Department of Cardiology, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China
    Zhonghua Xin Xue Guan Bing Za Zhi 33:411-4. 2005
  9. ncbi request reprint Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90
    Yang Shi
    Division of Pediatric Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Mol Cell Cardiol 38:625-35. 2005
  10. ncbi request reprint Endothelium-derived microparticles inhibit human cardiac valve endothelial cell function
    Denise B Klinkner
    Department of Surgery, Division of Pediatric Surgery, Medical College of Wisconsin and Children s Research Institute, Milwaukee, WI 53226, USA
    Shock 25:575-80. 2006

Research Grants

  1. NATIVE LDL, CHOLESTEROL AND IMPAIRED VASORELAXATION
    Kirkwood Pritchard; Fiscal Year: 1999
  2. HDL Dysfunction and Vascular Inflammation
    Kirkwood A Pritchard; Fiscal Year: 2010
  3. HDL Dysfunction and Vascular Inflammation
    Kirkwood Pritchard; Fiscal Year: 2009
  4. HDL Dysfunction and Vascular Inflammation
    Kirkwood Pritchard; Fiscal Year: 2007
  5. HDL Dysfunction and Vascular Inflammation
    Kirkwood Pritchard; Fiscal Year: 2006
  6. Native LDL, Cholesterol and Impaired Vasodilation
    Kirkwood Pritchard; Fiscal Year: 2006
  7. Hsp90 Mediates eNOS and Vascular Function
    Kirkwood Pritchard; Fiscal Year: 2005
  8. Native LDL, Cholesterol and Impaired Vasodilation
    Kirkwood Pritchard; Fiscal Year: 2005
  9. Native LDL, Cholesterol and Impaired Vasodilation
    Kirkwood Pritchard; Fiscal Year: 2004
  10. Hsp90 Mediates eNOS and Vascular Function
    Kirkwood Pritchard; Fiscal Year: 2004

Collaborators

Detail Information

Publications42

  1. pmc Anion exchange HPLC isolation of high-density lipoprotein (HDL) and on-line estimation of proinflammatory HDL
    Xiang Ji
    Department of Geriatrics, Qilu Hospital, Shandong University, Key Laboratory of Cardiovascular Proteomics of Shandong Province, Jinan, Shandong, China Department of Surgery, Division of Pediatric Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 9:e91089. 2014
    ..The AE-HPLC p-HDL assay reduces the influence of the supernatants and shows that SCD increases p-HDL. ..
  2. pmc Effects of experimental asthma on inflammation and lung mechanics in sickle cell mice
    Kirkwood A Pritchard
    Department of Surgery, Division of Pediatric Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Respir Cell Mol Biol 46:389-96. 2012
    ..SCD alone induces a baseline lung pathology that increases large and small airway resistance and primes the lungs to increased inflammation and airway hyperresponsiveness after OVA sensitization...
  3. doi request reprint Surfactant protein D: not just for the lung anymore
    Kirkwood A Pritchard
    Children s Research Institute, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 294:H1994. 2008
  4. ncbi request reprint Hypoxia-induced acute lung injury in murine models of sickle cell disease
    Kirkwood A Pritchard
    Medical College of Wisconsin, Div of Pediatric Surgery, Cardiovascula Center M4060, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Lung Cell Mol Physiol 286:L705-14. 2004
    ....
  5. ncbi request reprint Chromium (VI) increases endothelial cell expression of ICAM-1 and decreases nitric oxide activity
    K A Pritchard
    Department of Pathology, Pharmacology and Toxicology, Medical College of Wisconsin, The Cardiovascular Research Center, Milwaukee 53226, USA
    J Environ Pathol Toxicol Oncol 19:251-60. 2000
    ..Cr(VI)-induced increases in the adhesive properties of the endothelium may play a critical role in the initiation and progression of tissue injury through increased recruitment of proinflammatory white blood cells...
  6. ncbi request reprint Native low-density lipoprotein induces endothelial nitric oxide synthase dysfunction: role of heat shock protein 90 and caveolin-1
    Kirkwood A Pritchard
    Department of Surgery, Division of Pediatric Surgery, Pharmacology and Toxicology, and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Free Radic Biol Med 33:52-62. 2002
    ..These data support the hypothesis that n-LDL increases O(2)(*-), which scavenges *NO, and suggest that n-LDL uncouples eNOS activity by decreasing the association of hsp90 as an initial step in signaling eNOS to generate O(2)(*-)...
  7. ncbi request reprint Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase
    K A Pritchard
    Division of Pediatric Surgery, Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 276:17621-4. 2001
    ..These data show that Hsp90 is essential for eNOS-dependent.NO production and that inhibition of ATP-dependent conformational changes in Hsp90 uncouples eNOS activity and increases eNOS-dependent O(2) production...
  8. ncbi request reprint [A comparison between L-4F and SC-4F in preventing low density lipoprotein induced endothelial cell dysfunction in cell culture]
    Zhi Jun Ou
    Department of Cardiology, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China
    Zhonghua Xin Xue Guan Bing Za Zhi 33:411-4. 2005
    ..The study was designed to compare the effect of L-4F and scramble-4F (SC-4F) in preventing low density lipoprotein (LDL) induced endothelial cell dysfunction. L-4F and SC-4F has the same amino acids but different nucleotide sequence...
  9. ncbi request reprint Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90
    Yang Shi
    Division of Pediatric Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Mol Cell Cardiol 38:625-35. 2005
    ..NO production and decreases uncoupled NOS3 activity. We conclude increased association of hsp90 with NOS3 is a major mechanism by which BN/Mcw hearts are more resistant to ischemia than SS/Mcw hearts...
  10. ncbi request reprint Endothelium-derived microparticles inhibit human cardiac valve endothelial cell function
    Denise B Klinkner
    Department of Surgery, Division of Pediatric Surgery, Medical College of Wisconsin and Children s Research Institute, Milwaukee, WI 53226, USA
    Shock 25:575-80. 2006
    ..These results implicate EMPs as a possible source of downstream EC dysfunction in disease states. EMPs may play a role in valvular leaflet injury in human disease by inhibiting normal growth and repair of endothelium...
  11. ncbi request reprint Rosiglitazone antagonizes vascular endothelial growth factor signaling and nuclear factor of activated T cells activation in cardiac valve endothelium
    Tara L Sander
    Department of Surgery, Medical College of Wisconsin and Children s Research Institute, Milwaukee, Wisconsin 53226, USA
    Endothelium 13:181-90. 2006
    ..These data provide the first demonstration that ROSI negatively regulates VEGF signaling in the valve endothelium by a mechanism involving NFATc1 activation and nuclear translocation...
  12. ncbi request reprint Endothelium-derived microparticles induce endothelial dysfunction and acute lung injury
    John C Densmore
    Department of Surgery, Medical College of Wisconsin and Children s Hospital of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Shock 26:464-71. 2006
    ..Endothelium-derived microparticles inhibit endothelium-mediated vasodilation and *NO generation from eNOS. Once elucidated, EMP mechanisms of inducing ALI and endothelial dysfunction may present new therapeutic targets...
  13. ncbi request reprint Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells
    Yuenmu Chen
    Pulmonary and Critical Care Division, Department of Medicine, Division of Pediatric Surgery and Childrens Research Institute, Cardiovascular Center Medical College of Wisconsin, 53226, USA
    Am J Physiol Lung Cell Mol Physiol 291:L378-85. 2006
    ..Unlike aortic endothelial cells, eNOS activation in BPAECs by either VEGF or 20-HETE does not appear to require increased association of Hsp90...
  14. ncbi request reprint A heat shock protein 90 binding domain in endothelial nitric-oxide synthase influences enzyme function
    Hao Xu
    Department of Surgery, Division of Pediatric Surgery, Medical College of Wisconsin, Children s Research Institute, Cardiovascular Research Center, Milwaukee, WI 53226, USA
    J Biol Chem 282:37567-74. 2007
    ..Such chaperone-dependent signaling may play an important role in modulating the balance of *NO and O(2)(*) generation from eNOS and, therefore, vascular function...
  15. ncbi request reprint 20-hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling
    Jennifer Cheng
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 294:H1018-26. 2008
    ....
  16. pmc Vascular dysfunction in a murine model of severe hemolysis
    Anne C Frei
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin, USA
    Blood 112:398-405. 2008
    ..Together, these data indicate that sph/sph mice with severe HS have increased plasma hemoglobin and NO scavenging capacity, likely contributing to aberrant vasoregulation and initiating oxidative damage...
  17. ncbi request reprint Comparative proteomic analysis of PAI-1 and TNF-alpha-derived endothelial microparticles
    Danielle B Peterson
    Department of Surgery, Medical College of Wisconsin and Children s Research Institute, Milwaukee, WI 53226, USA
    Proteomics 8:2430-46. 2008
    ..These observations provide fundamental insight into the mechanisms regulating the production of these particles and their physiological role in numerous diseases...
  18. pmc Histopathology of experimentally induced asthma in a murine model of sickle cell disease
    Sandhya D Nandedkar
    Department of Surgery, Division of Pediatric Surgery, Medical College of Wisconsin, Blood Research Institute, Children s Research Institute, Cardiovascular Center, Milwaukee, WI 53226, USA
    Blood 112:2529-38. 2008
    ..Our findings indicate SCD mice with experimentally induced asthma are more susceptible to death and pulmonary inflammation compared with control mice, suggesting that asthma contributes significantly to morbidity and mortality in SCD...
  19. doi request reprint Targeted increases in endothelial cell superoxide anion production stimulate eNOS-dependent nitric oxide production, not uncoupled eNOS activity
    Hao Xu
    Arterioscler Thromb Vasc Biol 28:1580-1. 2008
  20. ncbi request reprint Effects of D-4F on vasodilation, oxidative stress, angiostatin, myocardial inflammation, and angiogenic potential in tight-skin mice
    Dorothee Weihrauch
    Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, CVC M 4060, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 293:H1432-41. 2007
    ..As SSc patients have increased plasma p-HDL and angiostatin levels similar to the Tsk(-/+) mice, D-4F may be effective at treating vascular complications in patients with SSc...
  21. ncbi request reprint BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat
    Anne E Kwitek
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 25:303-13. 2006
    ..These data provide a baseline for physiological comparison of traits related to cardiovascular, lung, blood, and renal function in the sequenced BN rats relative to the major strains of rats studied in biomedical research...
  22. ncbi request reprint Activation of protein kinases in chronically hypoxic infant human and rabbit hearts: role in cardioprotection
    Parvaneh Rafiee
    Division of Pediatric Surgery, Medical College of Wisconsin, Milwaukee 53226, USA
    Circulation 106:239-45. 2002
    ..However, the signaling pathways by which infant hearts adapt to chronic hypoxia and resist subsequent surgical ischemia is unknown...
  23. ncbi request reprint Trichloroethylene decreases heat shock protein 90 interactions with endothelial nitric oxide synthase: implications for endothelial cell proliferation
    Jingsong Ou
    Department of Surgery, Division of Pediatric Surgery, Cardiovascular Center, Milwaukee, Wisconsin 53226, USA
    Toxicol Sci 73:90-7. 2003
    ..Such changes in endothelial function may play an important role in the development of congenital heart defects...
  24. ncbi request reprint Decreased association of HSP90 impairs endothelial nitric oxide synthase in fetal lambs with persistent pulmonary hypertension
    Girija G Konduri
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 285:H204-11. 2003
    ..Decreased HSP90-eNOS interactions may contribute to the impaired NO release and vasodilation observed in the ductal ligation model of PPHN...
  25. ncbi request reprint L-4F, an apolipoprotein A-1 mimetic, dramatically improves vasodilation in hypercholesterolemia and sickle cell disease
    Jingsong Ou
    Division of Pediatric Surgery, Department of Surgery, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Circulation 107:2337-41. 2003
    ..Here we hypothesize that L-4F, an apoA-1 mimetic, preserves vasodilation in hypercholesterolemia and SCD by decreasing mechanisms that increase O2*- generation...
  26. ncbi request reprint Angiostatin: a negative regulator of endothelial-dependent vasodilation
    Ryoji Koshida
    Department of Physiology, and Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226, USA
    Circulation 107:803-6. 2003
    ..This avenue of investigation was based on recent reports suggesting that hsp90 modulates NOS production of *NO and O2-...
  27. ncbi request reprint Mechanisms of endotoxin tolerance in human intestinal microvascular endothelial cells
    Hitoshi Ogawa
    Division of Gastroenterology and Hepatology, Department of Surgery, Milwaukee Veterans Administration Medical Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 170:5956-64. 2003
    ..HIMEC possess specific mechanisms of immunoregulatory hyporesponsiveness to repeated LPS exposure...
  28. ncbi request reprint Cellular redistribution of inducible Hsp70 protein in the human and rabbit heart in response to the stress of chronic hypoxia: role of protein kinases,
    Parvaneh Rafiee
    Division of Pediatric Surgery, Medical College of Wisconsin and Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 278:43636-44. 2003
    ..We conclude the Hsp70 signal transduction pathway plays an important role in adaptation of infant human and rabbit hearts to chronic hypoxemia...
  29. ncbi request reprint Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production
    Michelle I Lin
    Department of Pharmacology and Program in Vascular Cell Signaling and Therapeutics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Biol Chem 278:44719-26. 2003
    ..Thus, the phosphorylation/dephosphorylation of Thr497 may be an intrinsic switch mechanism that determines whether eNOS generates NO versus superoxide in cells...
  30. ncbi request reprint Heat shock protein 90 and tyrosine kinase regulate eNOS NO* generation but not NO* bioactivity
    Jingsong Ou
    Division of Pediatric Surgery, Department of Surgery, Cardiovascular Center, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Physiol Heart Circ Physiol 286:H561-9. 2004
    ..These data suggest that the tyrosine kinases, either directly or indirectly, and HSP90-dependent signaling pathways act in concert to suppress uncoupled eNOS activity...
  31. ncbi request reprint Inhibition of heat shock protein 90 (hsp90) in proliferating endothelial cells uncouples endothelial nitric oxide synthase activity
    Jingsong Ou
    Department of Surgery, Division of Pediatric Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Free Radic Biol Med 34:269-76. 2003
    ..This study provides new understanding of the mechanisms by which ansamycin antibiotics inhibit endothelial cell proliferation. Such information may be useful in the development and design of new antineoplastic agents in the future...
  32. ncbi request reprint Acute cardioprotective effects of erythropoietin in infant rabbits are mediated by activation of protein kinases and potassium channels
    Yang Shi
    Pediatric Surgery, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Basic Res Cardiol 99:173-82. 2004
    ..We conclude the rapid activation of potassium channels and protein kinases by erythropoietin represents an important new mechanism for increasing cardioprotection...
  33. ncbi request reprint Chronic hypoxia increases endothelial nitric oxide synthase generation of nitric oxide by increasing heat shock protein 90 association and serine phosphorylation
    Yang Shi
    Division of Pediatric Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Circ Res 91:300-6. 2002
    ..Such changes in eNOS function appear to play a critical role in protecting the myocardium against ischemic injury...
  34. ncbi request reprint Native LDL and minimally oxidized LDL differentially regulate superoxide anion in vascular endothelium in situ
    David W Stepp
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 283:H750-9. 2002
    ..As HSP90 mediates the balance of.NO and O. generation by eNOS, these data provide new insight into the mechanisms by which oxidative stress, induced by nLDL and mmLDL, uncouple eNOS activity to increase endothelial O. generation...
  35. ncbi request reprint L-4F, an apolipoprotein A-1 mimetic, restores nitric oxide and superoxide anion balance in low-density lipoprotein-treated endothelial cells
    Zhijun Ou
    Department of Surgery, Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee 53226, USA
    Circulation 107:1520-4. 2003
    ..Here we hypothesize that L-4F, an apoA-1 mimetic that inhibits atherosclerosis induced by hypercholesterolemia, protects endothelial cell function by preventing LDL from uncoupling eNOS activity...
  36. ncbi request reprint Protein composition of plasminogen activator inhibitor type 1-derived endothelial microparticles
    Tara L Sander
    Department of Surgery, Medical College of Wisconsin and Children s Research Institute, Milwaukee, Wisconsin 53226, USA
    Shock 29:504-11. 2008
    ..Important insight is provided into the generation and protein composition of PAI-1-derived EMPs...
  37. ncbi request reprint AP-4F, antennapedia peptide linked to an amphipathic alpha helical peptide, increases the efficiency of Lipofectamine-mediated gene transfection in endothelial cells
    Jingsong Ou
    Division of Pediatric Surgery, Department of Surgery, Medical College of Wisconsin, Cardiovascular Center M4060, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Biochem Biophys Res Commun 305:605-10. 2003
    ..These observations demonstrate that AP-4F may be useful for increasing the transfection efficiency of endothelial cell cultures with standard commercially available reagents...
  38. ncbi request reprint Erythropoietin protects the infant heart against ischemia-reperfusion injury by triggering multiple signaling pathways
    Parvaneh Rafiee
    Medical College of Wisconsin, Division of Pediatric Surgery, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Basic Res Cardiol 100:187-97. 2005
    ..SB203580 inhibited only p38 MAPK activation by EPO. We can conclude EPO increases immediate cardioprotection through the activation of multiple signal transduction pathways...
  39. pmc Effects of D-4F on vasodilation and vessel wall thickness in hypercholesterolemic LDL receptor-null and LDL receptor/apolipoprotein A-I double-knockout mice on Western diet
    Jingsong Ou
    Division of Pediatric Surgery, Department of Surgery, Children s Research Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Circ Res 97:1190-7. 2005
    ....
  40. ncbi request reprint Tetrahydrobiopterin in pulmonary hypertension: pulmonary hypertension in guanosine triphosphate-cyclohydrolase-deficient mice
    Kirkwood A Pritchard
    Circulation 111:2022-4. 2005
  41. ncbi request reprint Alpha phenyl-tert-butyl nitrone (PBN) protects syngeneic marrow transplant recipients from the lethal cytokine syndrome occurring after agonistic CD40 antibody administration
    Maria Gendelman
    Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Blood 105:428-31. 2005
    ....
  42. ncbi request reprint Delayed cardioprotection with isoflurane: role of reactive oxygen and nitrogen
    Yang Shi
    Division of Pediatric Surgery, Free Radical Research Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 288:H175-84. 2005
    ..8% but not in 1.0% isoflurane-treated hearts. We conclude that isoflurane confers delayed cardioprotection in the adult rat, triggered by ROS and RNS...

Research Grants18

  1. NATIVE LDL, CHOLESTEROL AND IMPAIRED VASORELAXATION
    Kirkwood Pritchard; Fiscal Year: 1999
    ..The research combines the use of cell biology and vascular physiology to understand the biophysical and biochemical mechanisms by which cholesterol enrichment of the endothelium impairs vasorelaxation. ..
  2. HDL Dysfunction and Vascular Inflammation
    Kirkwood A Pritchard; Fiscal Year: 2010
    ..Through these studies, new treatment modalities may be realized for preventing vascular dysfunction in a variety of diseases characterized by increases in oxidative stress and inflammation. ..
  3. HDL Dysfunction and Vascular Inflammation
    Kirkwood Pritchard; Fiscal Year: 2009
    ..Through these studies, new treatment modalities may be realized for preventing vascular dysfunction in a variety of diseases characterized by increases in oxidative stress and inflammation. ..
  4. HDL Dysfunction and Vascular Inflammation
    Kirkwood Pritchard; Fiscal Year: 2007
    ..Through these studies, new treatment modalities may be realized for preventing vascular dysfunction in a variety of diseases characterized by increases in oxidative stress and inflammation. ..
  5. HDL Dysfunction and Vascular Inflammation
    Kirkwood Pritchard; Fiscal Year: 2006
    ..Through these studies, new treatment modalities may be realized for preventing vascular dysfunction in a variety of diseases characterized by increases in oxidative stress and inflammation. ..
  6. Native LDL, Cholesterol and Impaired Vasodilation
    Kirkwood Pritchard; Fiscal Year: 2006
    ..Investigations in to how 4F protects vascular function will provide new understanding of the mechanisms by which LDL impairs vasodilation and HDL protects vascular function. ..
  7. Hsp90 Mediates eNOS and Vascular Function
    Kirkwood Pritchard; Fiscal Year: 2005
    ..Findings from these studies will probably be relevant to and provide new understanding of mechanisms mediating vascular disease related to atherogenesis, hypertension and diabetes ..
  8. Native LDL, Cholesterol and Impaired Vasodilation
    Kirkwood Pritchard; Fiscal Year: 2005
    ..Investigations in to how 4F protects vascular function will provide new understanding of the mechanisms by which LDL impairs vasodilation and HDL protects vascular function. ..
  9. Native LDL, Cholesterol and Impaired Vasodilation
    Kirkwood Pritchard; Fiscal Year: 2004
    ..Investigations in to how 4F protects vascular function will provide new understanding of the mechanisms by which LDL impairs vasodilation and HDL protects vascular function. ..
  10. Hsp90 Mediates eNOS and Vascular Function
    Kirkwood Pritchard; Fiscal Year: 2004
    ..Findings from these studies will probably be relevant to and provide new understanding of mechanisms mediating vascular disease related to atherogenesis, hypertension and diabetes ..
  11. Native LDL, Cholesterol and Impaired Vasodilation
    Kirkwood Pritchard; Fiscal Year: 2003
    ..Investigations in to how 4F protects vascular function will provide new understanding of the mechanisms by which LDL impairs vasodilation and HDL protects vascular function. ..
  12. Hsp90 Mediates eNOS and Vascular Function
    Kirkwood Pritchard; Fiscal Year: 2003
    ..Findings from these studies will probably be relevant to and provide new understanding of mechanisms mediating vascular disease related to atherogenesis, hypertension and diabetes ..
  13. NATIVE LDL, CHOLESTEROL AND IMPAIRED VASORELAXATION
    Kirkwood Pritchard; Fiscal Year: 2002
    ..The research combines the use of cell biology and vascular physiology to understand the biophysical and biochemical mechanisms by which cholesterol enrichment of the endothelium impairs vasorelaxation. ..
  14. Hsp90 Mediates eNOS and Vascular Function
    Kirkwood Pritchard; Fiscal Year: 2002
    ..Findings from these studies will probably be relevant to and provide new understanding of mechanisms mediating vascular disease related to atherogenesis, hypertension and diabetes ..
  15. NATIVE LDL, CHOLESTEROL AND IMPAIRED VASORELAXATION
    Kirkwood Pritchard; Fiscal Year: 2001
    ..The research combines the use of cell biology and vascular physiology to understand the biophysical and biochemical mechanisms by which cholesterol enrichment of the endothelium impairs vasorelaxation. ..
  16. NATIVE LDL, CHOLESTEROL AND IMPAIRED VASORELAXATION
    Kirkwood Pritchard; Fiscal Year: 2000
    ..The research combines the use of cell biology and vascular physiology to understand the biophysical and biochemical mechanisms by which cholesterol enrichment of the endothelium impairs vasorelaxation. ..
  17. Asthma Increases Vaso-occlusion in Sickle Cell Disease
    KIRKWOOD A contact PRITCHARD; Fiscal Year: 2010
    ..If we are correct, then our drug therapies should improve blood vessel function and decrease airway resistance in SCD mice with experimental asthma. ..