Danijel Pravdic

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. pmc Anesthetic-induced preconditioning delays opening of mitochondrial permeability transition pore via protein Kinase C-epsilon-mediated pathway
    Danijel Pravdic
    Department of Anesthesiology, Medical College of Wisconsin, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 111:267-74. 2009
  2. pmc Cardiac-specific overexpression of GTP cyclohydrolase 1 restores ischaemic preconditioning during hyperglycaemia
    Zhi Dong Ge
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Cardiovasc Res 91:340-9. 2011
  3. pmc Monitoring mitochondrial electron fluxes using NAD(P)H-flavoprotein fluorometry reveals complex action of isoflurane on cardiomyocytes
    Filip Sedlic
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Biochim Biophys Acta 1797:1749-58. 2010
  4. pmc Isoflurane differentially modulates mitochondrial reactive oxygen species production via forward versus reverse electron transport flow: implications for preconditioning
    Naoyuki Hirata
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Anesthesiology 115:531-40. 2011
  5. pmc Mitochondrial depolarization underlies delay in permeability transition by preconditioning with isoflurane: roles of ROS and Ca2+
    Filip Sedlic
    Department of Anesthesiology and Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin53226, USA
    Am J Physiol Cell Physiol 299:C506-15. 2010
  6. pmc Complex I and ATP synthase mediate membrane depolarization and matrix acidification by isoflurane in mitochondria
    Danijel Pravdic
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Eur J Pharmacol 690:149-57. 2012
  7. doi request reprint Isoflurane postconditioning protects against reperfusion injury by preventing mitochondrial permeability transition by an endothelial nitric oxide synthase-dependent mechanism
    Zhi Dong Ge
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 112:73-85. 2010
  8. pmc Differences in production of reactive oxygen species and mitochondrial uncoupling as events in the preconditioning signaling cascade between desflurane and sevoflurane
    Filip Sedlic
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesth Analg 109:405-11. 2009
  9. pmc Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel
    Qunli Cheng
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    FEBS Lett 585:328-34. 2011
  10. pmc Effect of nitric oxide donors S-nitroso-N-acetyl-DL-penicillamine, spermine NONOate and propylamine propylamine NONOate on intracellular pH in cardiomyocytes
    Danijel Pravdic
    Department of Anaesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA
    Clin Exp Pharmacol Physiol 39:772-8. 2012

Detail Information

Publications11

  1. pmc Anesthetic-induced preconditioning delays opening of mitochondrial permeability transition pore via protein Kinase C-epsilon-mediated pathway
    Danijel Pravdic
    Department of Anesthesiology, Medical College of Wisconsin, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 111:267-74. 2009
    ..This study investigated the importance of APC-activated PKC in delaying mitochondrial permeability transition pore (mPTP) opening...
  2. pmc Cardiac-specific overexpression of GTP cyclohydrolase 1 restores ischaemic preconditioning during hyperglycaemia
    Zhi Dong Ge
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Cardiovasc Res 91:340-9. 2011
    ....
  3. pmc Monitoring mitochondrial electron fluxes using NAD(P)H-flavoprotein fluorometry reveals complex action of isoflurane on cardiomyocytes
    Filip Sedlic
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Biochim Biophys Acta 1797:1749-58. 2010
    ..The NAD(P)H-FP fluorometry is a useful method for exploring the effect of drugs on mitochondria and identifying their specific sites of action within the ETC of intact cardiomyocytes...
  4. pmc Isoflurane differentially modulates mitochondrial reactive oxygen species production via forward versus reverse electron transport flow: implications for preconditioning
    Naoyuki Hirata
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Anesthesiology 115:531-40. 2011
    ..Further, the authors investigated the mechanism by which isoflurane alters ROS generation in isolated mitochondria and submitochondrial particles...
  5. pmc Mitochondrial depolarization underlies delay in permeability transition by preconditioning with isoflurane: roles of ROS and Ca2+
    Filip Sedlic
    Department of Anesthesiology and Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin53226, USA
    Am J Physiol Cell Physiol 299:C506-15. 2010
    ..Such decrease in DeltaPsi(m) primarily attenuates mitochondrial ROS production, with consequential decrease in mitochondrial Ca(2+) uptake...
  6. pmc Complex I and ATP synthase mediate membrane depolarization and matrix acidification by isoflurane in mitochondria
    Danijel Pravdic
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Eur J Pharmacol 690:149-57. 2012
    ..K(+) channels and uncoupling proteins appear not to be involved in the direct effects of isoflurane on mitochondria...
  7. doi request reprint Isoflurane postconditioning protects against reperfusion injury by preventing mitochondrial permeability transition by an endothelial nitric oxide synthase-dependent mechanism
    Zhi Dong Ge
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 112:73-85. 2010
    ..The role of endothelial nitric oxide synthase (eNOS) in isoflurane postconditioning (IsoPC)-elicited cardioprotection is poorly understood. The authors addressed this issue using eNOS mice...
  8. pmc Differences in production of reactive oxygen species and mitochondrial uncoupling as events in the preconditioning signaling cascade between desflurane and sevoflurane
    Filip Sedlic
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesth Analg 109:405-11. 2009
    ..Here, we investigated the roles of reactive oxygen species (ROS) and mitochondrial uncoupling in cardiomyocyte preconditioning by two modern volatile anesthetics: desflurane and sevoflurane...
  9. pmc Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel
    Qunli Cheng
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    FEBS Lett 585:328-34. 2011
    ..These biphasic effects on the cardiac VDAC and the mitochondrial PT pore reveal a tandem impact of NO() on the two mitochondrial entities...
  10. pmc Effect of nitric oxide donors S-nitroso-N-acetyl-DL-penicillamine, spermine NONOate and propylamine propylamine NONOate on intracellular pH in cardiomyocytes
    Danijel Pravdic
    Department of Anaesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA
    Clin Exp Pharmacol Physiol 39:772-8. 2012
    ..Carbonic anhydrase and chloride-dependent sarcolemmal HCO₃⁻ and OH⁻ transporters are not involved in the NO-induced decrease in pH(i) in rat isolated ventricular myocytes...
  11. doi request reprint Survival of neurally induced mesenchymal cells may determine degree of motor recovery in injured spinal cord rats
    Arshak R Alexanian
    Neuroscience Research Labs, Deptpartment of Neurosurgery, Medical College of Wisconsin, VAMC, Milwaukee, WI 53295, USA
    Restor Neurol Neurosci 28:761-7. 2010
    ..The aim of this study was to determine whether transplanted NI-MSCs survive, differentiate, and integrate in injured spinal cord (ISC) rats and promote functional recovery...