Research Topics
Genomes and Genes | Anilkumar PillaiSummaryAffiliation: Medical College of Georgia Country: USA Publications
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Publications
Prevention of oxidative stress-mediated neuropathology and improved clinical outcome by adjunctive use of a combination of antioxidants and omega-3 fatty acids in schizophreniaSahebarao P Mahadik
Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, 30904, USA
Int Rev Psychiatry 18:119-31. 2006....- Erythropoietin prevents haloperidol treatment-induced neuronal apoptosis through regulation of BDNFAnilkumar Pillai
Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, GA 30904, USA
Neuropsychopharmacology 33:1942-51. 2008..01). These findings may have significant implications for the development of neuroprotective strategies to improve clinical outcomes when antipsychotic drugs are used chronically... 
Increased truncated TrkB receptor expression and decreased BDNF/TrkB signaling in the frontal cortex of reeler mouse model of schizophreniaAnilkumar Pillai
Department of Psychiatry and Health Behavior, Medical College of Georgia and Medical Research Service, Veterans Affairs Medical Center, Augusta, GA 30907, USA
Schizophr Res 100:325-33. 2008..In summary, molecular processes associated with defective BDNF signaling in reeler mice provide new therapeutic targets for neuroprotective pharmacotherapy for schizophrenia...
Age-dependent alterations in nerve growth factor (NGF)-related proteins, sortilin, and learning and memory in ratsAlvin V Terry
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia 30912, United States
Physiol Behav 102:149-57. 2011..These results may also help to identify specific components of the NGF-signaling pathway that could serve as targets for novel drug discovery and development for age-related disorders of cognition (e.g., Alzheimer's disease)...- Cysteamine attenuates the decreases in TrkB protein levels and the anxiety/depression-like behaviors in mice induced by corticosterone treatmentAmmar Kutiyanawalla
Department of Psychiatry and Health Behavior, Georgia Health Sciences University, Augusta, Georgia, United States of America
PLoS ONE 6:e26153. 2011..Studies designed to elucidate the mechanisms whereby TrkB signaling is regulated in chronic stress might provide valuable information for the development of new therapeutic strategies for several stress-related psychiatric disorders... - Brain-derived neurotropic factor/TrkB signaling in the pathogenesis and novel pharmacotherapy of schizophreniaAnilkumar Pillai
Department of Psychiatry and Health Behavior, Medical College of Georgia, Medical Research Service Line, Veterans Affairs Medical Center, Augusta, GA 30904, USA
Neurosignals 16:183-93. 2008..More importantly, this review will provide future perspective on BDNF/TrkB signaling as a novel molecular target to correct the pathogenesis and improve the long-term clinical outcome by treatments with conventional and adjunctive drugs... - Cystamine prevents haloperidol-induced decrease of BDNF/TrkB signaling in mouse frontal cortexAnilkumar Pillai
Department of Psychiatry and Health Behavior, Medical College of Georgia, Medical Research Service, Augusta, Georgia 30904, USA
J Neurochem 107:941-51. 2008..The findings from the present study may be helpful for the development of novel neuroprotective strategies to improve the treatment outcome of schizophrenia... - Decreased BDNF levels in CSF of drug-naive first-episode psychotic subjects: correlation with plasma BDNF and psychopathologyAnilkumar Pillai
Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, GA 30912, USA
Int J Neuropsychopharmacol 13:535-9. 2010..The parallel changes in BDNF levels in plasma and CSF indicate that plasma BDNF levels reflect the brain changes in BDNF levels in schizophrenia... - Differential effects of haloperidol and olanzapine on the expression of erythropoietin and its receptor in rat hippocampus and striatumAnilkumar Pillai
Department of Psychiatry and Health Behavior, Medical College of Georgia, USA
J Neurochem 98:1411-22. 2006..These data suggest that SGAs such as OLZ may have neuroprotective effects through expression of EPO that may be clinically relevant for long-term safe and beneficial management of psychotic patients... - Differential effects of haloperidol and olanzapine on levels of vascular endothelial growth factor and angiogenesis in rat hippocampusAnilkumar Pillai
Department of Psychiatry and Health Behavior, Medical College of Georgia, and Medical Research Service Line, Veterans Affairs Medical Center, Augusta, GA 30904, United States
Schizophr Res 87:48-59. 2006..These changes probably provide a new molecular mechanism to better explain their differential effects on the patterns of regional blood flow and associated changes in regional volume/neuroplasticity and psychopathology... - Long-term antipsychotic treatments and crossover studies in rats: differential effects of typical and atypical agents on the expression of antioxidant enzymes and membrane lipid peroxidation in rat brainAnilkumar Pillai
Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, GA, United States
J Psychiatr Res 41:372-86. 2007..These data may be very helpful in planning long-term use as well as switch over of these antipsychotics for the management of schizophrenia... - Differential effects of long-term treatment with typical and atypical antipsychotics on NGF and BDNF levels in rat striatum and hippocampusAnilkumar Pillai
Psychiatry and Health Behavior, Medical College of Georgia, Augusta, GA, USA
Schizophr Res 82:95-106. 2006..These data may have significant clinical implications for long-term antipsychotic selection as well as the common practice of antipsychotic switchover... - Antioxidant enzyme activity and lipid peroxidation in liver of female rats co-exposed to lead and cadmium: effects of vitamin E and Mn2+Anilkumar Pillai
Faculty of Science, Department of Biochemistry, M S University of Baroda, Vadodara, Gujarat, India
Free Radic Res 39:707-12. 2005..These results suggest that when lead and cadmium are present together in similar concentrations, cadmium mediates major effects due to its more reactive nature... - Decreased expression of Sprouty2 in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder: a correlation with BDNF expressionAnilkumar Pillai
Department of Psychiatry and Health Behavior, Medical College of Georgia, Medical Research Service Line, Veterans Affairs Medical Center, Augusta, Georgia, United States of America
PLoS ONE 3:e1784. 2008..The potential effect of antipsychotic drugs on Sprouty2 expression was tested in adult rats... - Cysteamine treatment ameliorates alterations in GAD67 expression and spatial memory in heterozygous reeler miceAmmar Kutiyanawalla
Department of Psychiatry and Health Behavior, Georgia Health Sciences University, Augusta, GA, USA
Int J Neuropsychopharmacol 15:1073-86. 2012..Finally, mice deficient in TrkB, showed a reduced response to cysteamine in GAD67 expression suggesting that TrkB signalling plays an important role in GAD67 regulation by cysteamine... - Time-dependent effects of haloperidol and ziprasidone on nerve growth factor, cholinergic neurons, and spatial learning in ratsAlvin V Terry
Department of Pharmacology and Toxicology, CB 3618, Medical College of Georgia, 1120 Fifteenth St, Augusta, GA 30912 2450, USA
J Pharmacol Exp Ther 318:709-24. 2006..e., important neurobiological substrates of memory), and cognitive function... - Chronic antipsychotic treatment: protracted decreases in phospho-TrkA levels in the rat hippocampusAlvin V Terry
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912 2300, USA
Int J Neuropsychopharmacol 13:799-805. 2010..These data indicate that chronic antipsychotic treatment may result in deleterious effects on neurotrophin signalling in an important brain region for information processing and cognition... - Long-term continuous corticosterone treatment decreases VEGF receptor-2 expression in frontal cortexKristy R Howell
Department of Psychiatry and Health Behavior, Georgia Health Sciences University, Augusta, Georgia, United States of America
PLoS ONE 6:e20198. 2011..However, the mechanism of regulation of VEGF/Flk1 signaling under long-term continuous glucocorticoid exposure has not been elucidated... - Neurotrophins and schizophreniaPeter F Buckley
Department of Psychiatry and Health Behavior, Medical College of Georgia, 1515 Pope Avenue, Augusta, Georgia 30912, United States
Schizophr Res 94:1-11. 2007..This article reviews the literature on neurotrophins and schizophrenia. A schema for understanding the neurobiology of relapse in schizophrenia is offered... - An inverse relationship between cortisol and BDNF levels in schizophrenia: data from human postmortem and animal studiesGeorge Issa
Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, GA 30912, USA
Neurobiol Dis 39:327-33. 2010..The above data from human and animal studies suggest that a negative association between stress hormone, cortisol and neuroprotective molecule, BDNF plays an important role in the pathophysiology of schizophrenia... - Brain derived neurotropic factor in first-episode psychosisPeter F Buckley
Department of Psychiatry and Health Behavior, School of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
Schizophr Res 91:1-5. 2007..Low BDNF levels at the onset of psychosis suggest that it may contribute to the pathogenesis of schizophrenia and/or perhaps could be a helpful neurobiological marker for possible early treatment intervention... - Reliable biomarkers and predictors of schizophrenia and its treatmentAnilkumar Pillai
Department of Psychiatry and Health Behavior, Medical College of Georgia, Georgia Health Sciences University, 997 Saint Sebastian Way, Augusta, GA 30912, USA
Psychiatr Clin North Am 35:645-59. 2012..This article reviews early progress and strategies for evaluating biomarkers, as well as how this approach can advance the treatment of schizophrenia toward personalized medicine... - Effect of gestational and lactational exposure to lead and/or cadmium on reproductive performance and hepatic oestradiol metabolising enzymesAnilkumar Pillai
Department of Biochemistry, Faculty of Science, M.S. University of Baroda, Vadodara, Gujarat 390002, India
Toxicol Lett 155:179-86. 2005..However, these results suggest that when lead and cadmium are administered together in similar concentrations, the major effects are mediated by cadmium... - Plasma BDNF levels vary in relation to body weight in femalesAnilkumar Pillai
Department of Psychiatry and Health Behavior, Medical College of Georgia, Georgia Health Sciences University, Augusta, Georgia, USA
PLoS ONE 7:e39358. 2012..In conclusion, the lower BDNF levels observed in females suggest that changes in peripheral BDNF levels are likely secondary to an altered energy balance. However, further studies using larger sample size are warranted... - Brain-derived neurotrophic factor: findings in schizophreniaPeter F Buckley
Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, Georgia, USA
Curr Opin Psychiatry 24:122-7. 2011.... - BDNF-TrkB signaling and neuroprotection in schizophreniaChirayu D Pandya
Department of Psychiatry and Health Behavior, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA, USA
Asian J Psychiatr 6:22-8. 2013..This article will present an overview of recent findings on the role of BDNF signaling in the pathophysiology and treatment of schizophrenia, with a special focus on its neuroprotective effects... - Opposite changes in predominantly docosahexaenoic acid (DHA) in cerebrospinal fluid and red blood cells from never-medicated first-episode psychotic patientsAnvita Kale
Interactive Research School for Health Affairs, Bharati Vidyapeeth, Pune 411043, India
Schizophr Res 98:295-301. 2008..01) whereas higher in CSF (p=<0.01) in male>female patients. This altered DHA metabolism may provide clues for neuropathology and treatment of schizophrenia...