Shane A Phillips

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi request reprint The mechanism of flow-induced dilation in human adipose arterioles involves hydrogen peroxide during CAD
    Shane A Phillips
    Cardiovascular Center, Dept of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 292:H93-100. 2007
  2. pmc Measuring FMD in the brachial artery: how important is QRS gating?
    Tinoy J Kizhakekuttu
    Cardiovascular Medicine Division, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Appl Physiol (1985) 109:959-65. 2010
  3. ncbi request reprint High-salt diet impairs vascular relaxation mechanisms in rat middle cerebral arteries
    Julian H Lombard
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 284:H1124-33. 2003
  4. pmc Thrombin increases inflammatory cytokine and angiogenic growth factor secretion in human adipose cells in vitro
    Jennifer L Strande
    Division of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    J Inflamm (Lond) 6:4. 2009
  5. pmc Acute exertion elicits a H2O2-dependent vasodilator mechanism in the microvasculature of exercise-trained but not sedentary adults
    Matthew J Durand
    From the Department of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee M J D, K D, E D, D D G and Department of Physical Therapy J T B, S A P and Department of Medicine, Cardiology M V, S A P, University of Illinois at Chicago
    Hypertension 65:140-5. 2015
  6. ncbi request reprint Chronic At1 receptor blockade alters the mechanisms mediating hypoxic dilation in middle cerebral arteries
    Shane A Phillips
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Cardiovasc Pharmacol 46:706-12. 2005
  7. ncbi request reprint Restoration of normal vascular relaxation mechanisms in cerebral arteries by chromosomal substitution in consomic SS.13BN rats
    Ines Drenjancevic-Peric
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 289:H188-95. 2005
  8. ncbi request reprint Chronic AT(1) receptor blockade alters mechanisms mediating responses to hypoxia in rat skeletal muscle resistance arteries
    Shane A Phillips
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 287:H545-52. 2004
  9. pmc An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles
    Andreas M Beyer
    Department of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin
    Am J Physiol Heart Circ Physiol 307:H1587-93. 2014
  10. pmc Benefit of low-fat over low-carbohydrate diet on endothelial health in obesity
    Shane A Phillips
    Department of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Hypertension 51:376-82. 2008

Collaborators

Detail Information

Publications15

  1. ncbi request reprint The mechanism of flow-induced dilation in human adipose arterioles involves hydrogen peroxide during CAD
    Shane A Phillips
    Cardiovascular Center, Dept of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 292:H93-100. 2007
    ..This study provides evidence that adverse microvascular changes during CAD are evident in human visceral adipose, a tissue associated with CAD...
  2. pmc Measuring FMD in the brachial artery: how important is QRS gating?
    Tinoy J Kizhakekuttu
    Cardiovascular Medicine Division, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Appl Physiol (1985) 109:959-65. 2010
    ..This finding may allow for simplification of FMD measurement and aid in the development of FMD as a potentially useful clinical tool...
  3. ncbi request reprint High-salt diet impairs vascular relaxation mechanisms in rat middle cerebral arteries
    Julian H Lombard
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 284:H1124-33. 2003
    ..These observations suggest that angiotensin II suppression with a HS diet leads to impaired relaxation of cerebral arteries in response to vasodilator stimuli acting at the cell membrane...
  4. pmc Thrombin increases inflammatory cytokine and angiogenic growth factor secretion in human adipose cells in vitro
    Jennifer L Strande
    Division of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    J Inflamm (Lond) 6:4. 2009
    ..Therefore, the purpose of this study was to examine the expression of thrombin receptors (PAR1 and PAR4) human adipose tissue and whether thrombin stimulates an inflammatory cytokine and growth factor profile in human adipose tissue...
  5. pmc Acute exertion elicits a H2O2-dependent vasodilator mechanism in the microvasculature of exercise-trained but not sedentary adults
    Matthew J Durand
    From the Department of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee M J D, K D, E D, D D G and Department of Physical Therapy J T B, S A P and Department of Medicine, Cardiology M V, S A P, University of Illinois at Chicago
    Hypertension 65:140-5. 2015
    ....
  6. ncbi request reprint Chronic At1 receptor blockade alters the mechanisms mediating hypoxic dilation in middle cerebral arteries
    Shane A Phillips
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Cardiovasc Pharmacol 46:706-12. 2005
    ....
  7. ncbi request reprint Restoration of normal vascular relaxation mechanisms in cerebral arteries by chromosomal substitution in consomic SS.13BN rats
    Ines Drenjancevic-Peric
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 289:H188-95. 2005
    ..13(BN) rats...
  8. ncbi request reprint Chronic AT(1) receptor blockade alters mechanisms mediating responses to hypoxia in rat skeletal muscle resistance arteries
    Shane A Phillips
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 287:H545-52. 2004
    ..These data suggest that AT(1) receptor activation has an important role in maintaining the vascular release of prostaglandins responsible for mediating hypoxic dilation in skeletal muscle microvessels...
  9. pmc An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles
    Andreas M Beyer
    Department of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin
    Am J Physiol Heart Circ Physiol 307:H1587-93. 2014
    ..3 ± 14.5 vs. 127.9 ± 57.7). These results demonstrate a novel compensatory dilator mechanism in humans that is triggered by IILP, inducing a change in the mediator of FMD from NO to mitochondria-derived H2O2. ..
  10. pmc Benefit of low-fat over low-carbohydrate diet on endothelial health in obesity
    Shane A Phillips
    Department of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Hypertension 51:376-82. 2008
    ..Despite similar degrees of weight loss and changes blood pressure, LF diets improved brachial artery flow-mediated dilation over LC diets. LF diets may confer greater cardiovascular protection than LC diets...
  11. ncbi request reprint Oxidant stress and constrictor reactivity impair cerebral artery dilation in obese Zucker rats
    Shane A Phillips
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Physiol Regul Integr Comp Physiol 288:R522-30. 2005
    ..However, oxidative stress-independent increases in myogenic tone and constrictor reactivity may contribute to blunted dilator responses of cerebral microvessels...
  12. ncbi request reprint Chronic intermittent hypoxia impairs endothelium-dependent dilation in rat cerebral and skeletal muscle resistance arteries
    Shane A Phillips
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 286:H388-93. 2004
    ..These findings suggest that exposure to CIH reduces the bioavailability of nitric oxide in the cerebral and skeletal muscle circulations and severely blunts vasodilator responsiveness to acute hypoxia...
  13. ncbi request reprint Chronic intermittent hypoxia alters NE reactivity and mechanics of skeletal muscle resistance arteries
    Shane A Phillips
    Department of Physiology, Medical College of Wisconsin, Milwaukee, USA
    J Appl Physiol 100:1117-23. 2006
    ..CIH also leads to an increased stiffness and reduced vessel wall distensibility that were not correctable with oral tempol treatment...
  14. ncbi request reprint The effect of exertional hypertension evoked by weight lifting on vascular endothelial function
    Jason W Jurva
    J Am Coll Cardiol 48:588-9. 2006
  15. ncbi request reprint Enhanced skeletal muscle arteriolar reactivity to ANG II after recovery from ischemic acute renal failure
    David P Basile
    Dept of Cellular and Integrative Physiology, Indiana Univ School of Medicine, 635 Barnhill Drive MS 334, Indianapolis, IN 46202, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1770-6. 2005
    ..Although the mechanisms of this altered responsiveness are unclear, such changes may relate, in part, to cardiovascular complications in patients with ARF and/or after renal transplant...