Sandra L Pfister

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Glibenclamide inhibits thromboxane-mediated vasoconstriction by thromboxane receptor blockade
    Sandra L Pfister
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Vascul Pharmacol 40:285-92. 2004
  2. pmc Characterization of endothelial thromboxane receptors in rabbit aorta
    Sandra L Pfister
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Prostaglandins Other Lipid Mediat 87:54-61. 2008
  3. ncbi request reprint Role of platelet microparticles in the production of thromboxane by rabbit pulmonary artery
    Sandra L Pfister
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 43:428-33. 2004
  4. ncbi request reprint Aortic thromboxane receptor deficiency alters vascular reactivity in cholesterol-fed rabbits
    Sandra L Pfister
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Atherosclerosis 189:358-63. 2006
  5. ncbi request reprint Role of contaminating platelets in thromboxane synthesis in primary cultures of human umbilical vein endothelial cells
    Sandra L Pfister
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226, USA
    Prostaglandins Other Lipid Mediat 70:39-49. 2002
  6. pmc Role of lipoxygenase metabolites of arachidonic acid in enhanced pulmonary artery contractions of female rabbits
    Sandra L Pfister
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 57:825-32. 2011
  7. pmc Role of superoxide and thromboxane receptors in acute angiotensin II-induced vasoconstriction of rabbit vessels
    Sandra L Pfister
    Dept of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 300:H2064-71. 2011
  8. pmc Chronic hypoxia enhances 15-lipoxygenase-mediated vasorelaxation in rabbit arteries
    Nitin T Aggarwal
    Dept of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 296:H678-88. 2009
  9. doi request reprint Hypercholesterolemia enhances 15-lipoxygenase-mediated vasorelaxation and acetylcholine-induced hypotension
    Nitin T Aggarwal
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Arterioscler Thromb Vasc Biol 28:2209-15. 2008
  10. ncbi request reprint 11,12,15-Trihydroxyeicosatrienoic acid mediates ACh-induced relaxations in rabbit aorta
    William B Campbell
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 285:H2648-56. 2003

Research Grants

  1. EICOSANOIDS AND PULMONARY VASCULAR TONE
    SANDRA PFISTER; Fiscal Year: 2002

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Glibenclamide inhibits thromboxane-mediated vasoconstriction by thromboxane receptor blockade
    Sandra L Pfister
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Vascul Pharmacol 40:285-92. 2004
    ..These studies provide the first evidence that the ability of glibenclamide to inhibit TX-mediated contractions occurs independent of the vascular K(ATP) channel and is, instead, mediated by the blockade of the vascular TX receptor...
  2. pmc Characterization of endothelial thromboxane receptors in rabbit aorta
    Sandra L Pfister
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Prostaglandins Other Lipid Mediat 87:54-61. 2008
    ..The results of this study suggest an important role for endothelial TP receptors in modulating vascular function...
  3. ncbi request reprint Role of platelet microparticles in the production of thromboxane by rabbit pulmonary artery
    Sandra L Pfister
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 43:428-33. 2004
    ....
  4. ncbi request reprint Aortic thromboxane receptor deficiency alters vascular reactivity in cholesterol-fed rabbits
    Sandra L Pfister
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Atherosclerosis 189:358-63. 2006
    ..In summary, these studies are the first to show that if rabbits lack only vascular TP receptors, impaired vascular reactivity responses normally associated with hypercholesterolemia are diminished...
  5. ncbi request reprint Role of contaminating platelets in thromboxane synthesis in primary cultures of human umbilical vein endothelial cells
    Sandra L Pfister
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226, USA
    Prostaglandins Other Lipid Mediat 70:39-49. 2002
    ..These studies suggest that primary cultures of human umbilical vein endothelial cells contain adherent platelets that contribute to thromboxane synthesis...
  6. pmc Role of lipoxygenase metabolites of arachidonic acid in enhanced pulmonary artery contractions of female rabbits
    Sandra L Pfister
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 57:825-32. 2011
    ..Understanding this novel sex-specific mechanism may provide insight into the increased incidence of pulmonary hypertension in females...
  7. pmc Role of superoxide and thromboxane receptors in acute angiotensin II-induced vasoconstriction of rabbit vessels
    Sandra L Pfister
    Dept of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 300:H2064-71. 2011
    ..Results suggest the factor activating thromboxane receptors and contributing to angiotensin II vasoconstriction involves the superoxide-mediated generation of a 15-series isoprostane...
  8. pmc Chronic hypoxia enhances 15-lipoxygenase-mediated vasorelaxation in rabbit arteries
    Nitin T Aggarwal
    Dept of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 296:H678-88. 2009
    ..Therefore, hypoxia increased the relaxations to agonists in the rabbit mesenteric arteries by enhancing endothelial 15-LO-1 expression and synthesis of the hyperpolarizing factors THETA and HEETA...
  9. doi request reprint Hypercholesterolemia enhances 15-lipoxygenase-mediated vasorelaxation and acetylcholine-induced hypotension
    Nitin T Aggarwal
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Arterioscler Thromb Vasc Biol 28:2209-15. 2008
    ..We studied 15-LO-1 expression, THETA and HEETA synthesis, and their effect on arterial relaxations and blood pressure in hypercholesterolemic nonatherosclerotic rabbits...
  10. ncbi request reprint 11,12,15-Trihydroxyeicosatrienoic acid mediates ACh-induced relaxations in rabbit aorta
    William B Campbell
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 285:H2648-56. 2003
    ..Additionally, this lipoxygenase pathway mediates the nonnitric oxide, nonprostaglandin relaxations to ACh in the rabbit aorta by acting as a source of an endothelium-derived hyperpolarizing factor...
  11. ncbi request reprint Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism
    Erica J Carrier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226 0509, USA
    Mol Pharmacol 65:999-1007. 2004
    ..These data suggest that 2-AG activation of CB(2) receptors may contribute to the proliferative response of microglial cells, as occurs in neurodegenerative disorders...
  12. pmc Endothelial 12(S)-HETE vasorelaxation is mediated by thromboxane receptor inhibition in mouse mesenteric arteries
    Lawan Siangjong
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 304:H382-92. 2013
    ..These 12(S)-HETE relaxations are mediated by TP receptor competitive inhibition and inhibition of TP agonist-induced increases in intracellular calcium...
  13. ncbi request reprint Production of hydroxyeicosatetraenoic acids and prostaglandins by a novel rat microglial cell line
    David J Rademacher
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Neuroimmunol 149:130-41. 2004
    ..RTMGL1 synthesize 5-HETE from arachidonic acid (AA) likely via a 5-lipoxygenase (LO). Thus, RTMGL1 have morphological and histological characteristics of primary microglia and metabolize AA via both COX and LO pathways...
  14. ncbi request reprint Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450
    Sandra L Pfister
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Arch Biochem Biophys 420:142-52. 2003
    ..Further hydrolysis of the epoxy group of the HEETAs results in the formation of 11,12,15- and 11,14,15-THETAs. The HEETAs and THETAs are both vasodilators and may function as important regulators of vascular tone...
  15. ncbi request reprint Metabolism of 12-hydroperoxyeicosatetraenoic acid to vasodilatory trioxilin C3 by rabbit aorta
    Sandra L Pfister
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Biochim Biophys Acta 1622:6-13. 2003
    ..6+/-1.3%). In conclusion, trioxilin C(3) acid was isolated and identified as a novel biologically active arachidonic acid metabolite formed by rabbit aorta when 12-lipoxygenase is supplied exogenously...
  16. ncbi request reprint Arachidonic acid metabolites and an early stage of pulmonary hypertension in chronically hypoxic newborn pigs
    Candice D Fike
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Lung Cell Mol Physiol 284:L316-23. 2003
    ....
  17. pmc Vascular pharmacology of epoxyeicosatrienoic acids
    Sandra L Pfister
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Adv Pharmacol 60:27-59. 2010
    ..Furthermore, the therapeutic potential of targeting the EET pathway in vascular disease will be highlighted...
  18. ncbi request reprint Estrogen acutely activates prostacyclin synthesis in ovine fetal pulmonary artery endothelium
    Todd S Sherman
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Am J Respir Cell Mol Biol 26:610-6. 2002
    ..These mechanisms may play a role in pulmonary vasodilation in the perinatal period...
  19. ncbi request reprint Cyclooxygenase contracting factors and altered pulmonary vascular responses in chronically hypoxic newborn pigs
    Candice D Fike
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Appl Physiol 92:67-74. 2002
    ..The early development of thromboxane-mediated constriction may contribute to the pathogenesis of chronic hypoxia-induced pulmonary hypertension in newborns...
  20. ncbi request reprint Cyclooxygenase-2 and an early stage of chronic hypoxia-induced pulmonary hypertension in newborn pigs
    Candice D Fike
    Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    J Appl Physiol 98:1111-8; discussion 1091. 2005
    ..COX-2-dependent contracting factors, such as thromboxane, contribute to aberrant pulmonary arterial responses in piglets exposed to 3 days of hypoxia...

Research Grants1

  1. EICOSANOIDS AND PULMONARY VASCULAR TONE
    SANDRA PFISTER; Fiscal Year: 2002
    ....