Margie M Peden-Adams

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. ncbi request reprint Alterations in immune function and CYP450 activity in adult male deer mice (Peromyscus maniculatus) following exposure to benzo[a]pyrene, pyrene, or chrysene
    M M Peden-Adams
    Department of Pediatrics and the Marine Biomedicine and Environmental Science Center, Medical University of South Carolina, Charleston, South Carolina 29412, USA
    J Toxicol Environ Health A 70:1783-91. 2007
  2. doi request reprint Suppression of humoral immunity in mice following exposure to perfluorooctane sulfonate
    Margie M Peden-Adams
    Department of Pediatrics, Medical, University of South Carolina, Charleston, South Carolina 29412, USA
    Toxicol Sci 104:144-54. 2008
  3. ncbi request reprint Suppression of humoral immunity following exposure to the perfluorinated insecticide sulfluramid
    Margie M Peden-Adams
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29412, USA
    J Toxicol Environ Health A 70:1130-41. 2007
  4. ncbi request reprint Developmental immunotoxicity of trichloroethylene (TCE): studies in B6C3F1 mice
    Margie M Peden-Adams
    Department of Pediatrics, Medical University of South Carolina MUSC, Charleston, South Carolina 29412, USA
    J Environ Sci Health A Tox Hazard Subst Environ Eng 41:249-71. 2006
  5. ncbi request reprint Pyridostigmine bromide (PYR) alters immune function in B6C3F1 mice
    M M Peden-Adams
    Department of Rheumatology and Immunology, Medical University of South Carolina, Charleston, South Carolina 29412, USA
    Immunopharmacol Immunotoxicol 26:1-15. 2004
  6. doi request reprint Lifetime exposure to trichloroethylene (TCE) does not accelerate autoimmune disease in MRL +/+ mice
    Margie M Peden-Adams
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29412, USA
    J Environ Sci Health A Tox Hazard Subst Environ Eng 43:1402-9. 2008
  7. doi request reprint Immune function in female B(6)C(3)F(1) mice is modulated by DE-71, a commercial polybrominated diphenyl ether mixture
    Patricia A Fair
    National Oceanic and Atmospheric Administration, National Ocean Services, Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC 29412, USA
    J Immunotoxicol 9:96-107. 2012
  8. pmc Effects of environmentally-relevant levels of perfluorooctane sulfonate on clinical parameters and immunological functions in B6C3F1 mice
    Patricia A Fair
    National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC, USA
    J Immunotoxicol 8:17-29. 2011
  9. doi request reprint Effects of perfluorooctane sulfonate (PFOS) exposure on markers of inflammation in female B6C3F1 mice
    Meagan A M Mollenhauer
    Molecular and Cellular Biology and Pathobiology, Medical University of South Carolina, Charleston, South Carolina, USA
    J Environ Sci Health A Tox Hazard Subst Environ Eng 46:97-108. 2011
  10. pmc Relationship of blood mercury levels to health parameters in the loggerhead sea turtle (Caretta caretta)
    Rusty D Day
    National Institute of Standards and Technology, Hollings Marine Laboratory, Charleston, South Carolina 29412, USA
    Environ Health Perspect 115:1421-8. 2007

Research Grants

Detail Information

Publications19

  1. ncbi request reprint Alterations in immune function and CYP450 activity in adult male deer mice (Peromyscus maniculatus) following exposure to benzo[a]pyrene, pyrene, or chrysene
    M M Peden-Adams
    Department of Pediatrics and the Marine Biomedicine and Environmental Science Center, Medical University of South Carolina, Charleston, South Carolina 29412, USA
    J Toxicol Environ Health A 70:1783-91. 2007
    ..These results indicate that immune function endpoints appear to be more sensitive to these PAHs than measured hepatic CYP450 activity...
  2. doi request reprint Suppression of humoral immunity in mice following exposure to perfluorooctane sulfonate
    Margie M Peden-Adams
    Department of Pediatrics, Medical, University of South Carolina, Charleston, South Carolina 29412, USA
    Toxicol Sci 104:144-54. 2008
    ..Overall, this study provides a profile of PFOS immunotoxicity showing effects at levels reported in humans and identifies the B-cells as a potential target...
  3. ncbi request reprint Suppression of humoral immunity following exposure to the perfluorinated insecticide sulfluramid
    Margie M Peden-Adams
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29412, USA
    J Toxicol Environ Health A 70:1130-41. 2007
    ..Additional immunotoxicity studies are required to understand potential mechanisms of suppression and determine potential health risks associated with exposure to perfluorinated hydrocarbons...
  4. ncbi request reprint Developmental immunotoxicity of trichloroethylene (TCE): studies in B6C3F1 mice
    Margie M Peden-Adams
    Department of Pediatrics, Medical University of South Carolina MUSC, Charleston, South Carolina 29412, USA
    J Environ Sci Health A Tox Hazard Subst Environ Eng 41:249-71. 2006
    ..These results indicate that TCE may be an effective developmental immunotoxicant and suggests that additional studies are required to determine the health risks associated with developmental exposure to TCE...
  5. ncbi request reprint Pyridostigmine bromide (PYR) alters immune function in B6C3F1 mice
    M M Peden-Adams
    Department of Rheumatology and Immunology, Medical University of South Carolina, Charleston, South Carolina 29412, USA
    Immunopharmacol Immunotoxicol 26:1-15. 2004
    ..This is the first study to examine the immunotoxicological effects of PYR and demonstrate that this compound selectively suppresses humoral antibody responses...
  6. doi request reprint Lifetime exposure to trichloroethylene (TCE) does not accelerate autoimmune disease in MRL +/+ mice
    Margie M Peden-Adams
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29412, USA
    J Environ Sci Health A Tox Hazard Subst Environ Eng 43:1402-9. 2008
    ....
  7. doi request reprint Immune function in female B(6)C(3)F(1) mice is modulated by DE-71, a commercial polybrominated diphenyl ether mixture
    Patricia A Fair
    National Oceanic and Atmospheric Administration, National Ocean Services, Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC 29412, USA
    J Immunotoxicol 9:96-107. 2012
    ..5, 5, and 100 mg/kg TAD. This study provides an assessment of the systemic toxicity and immunotoxicity of DE-71, and indicates that immune parameters are modulated at exposure concentrations lower than previously reported...
  8. pmc Effects of environmentally-relevant levels of perfluorooctane sulfonate on clinical parameters and immunological functions in B6C3F1 mice
    Patricia A Fair
    National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC, USA
    J Immunotoxicol 8:17-29. 2011
    ....
  9. doi request reprint Effects of perfluorooctane sulfonate (PFOS) exposure on markers of inflammation in female B6C3F1 mice
    Meagan A M Mollenhauer
    Molecular and Cellular Biology and Pathobiology, Medical University of South Carolina, Charleston, South Carolina, USA
    J Environ Sci Health A Tox Hazard Subst Environ Eng 46:97-108. 2011
    ..Overall, these data suggest that PFOS exposure can alter some inflammatory processes, which could potentially lead to misdirected inflammatory responses...
  10. pmc Relationship of blood mercury levels to health parameters in the loggerhead sea turtle (Caretta caretta)
    Rusty D Day
    National Institute of Standards and Technology, Hollings Marine Laboratory, Charleston, South Carolina 29412, USA
    Environ Health Perspect 115:1421-8. 2007
    ..Mercury is a pervasive environmental pollutant whose toxic effects have not been studied in sea turtles in spite of their threatened status and evidence of immunosuppression in diseased populations...
  11. doi request reprint Developmental toxicity in white leghorn chickens following in ovo exposure to perfluorooctane sulfonate (PFOS)
    Margie M Peden-Adams
    Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29412, USA
    Reprod Toxicol 27:307-18. 2009
    ....
  12. ncbi request reprint A dolphin peripheral blood leukocyte cDNA microarray for studies of immune function and stress reactions
    Annalaura Mancia
    Marine Biomedicine and Environmental Science Center, Medical University of South Carolina, Hollings Marine Laboratory, 331 Ft Johnson Road, Charleston, SC 29412, USA
    Dev Comp Immunol 31:520-9. 2007
    ..The results demonstrate that the array is a reproducible and informative tool for assessing differential gene expression in dolphin PBL and in other tissues...
  13. ncbi request reprint In vitro PFOS exposure on immune endpoints in bottlenose dolphins (Tursiops truncatus) and mice
    Jena R Wirth
    Graduate Program in Marine Biology, College of Charleston, 205 Fort Johnson Road, Charleston, SC, 29412, USA
    J Appl Toxicol 34:658-66. 2014
    ....
  14. doi request reprint Gene expression changes in bottlenose dolphin, Tursiops truncatus, skin cells following exposure to methylmercury (MeHg) or perfluorooctane sulfonate (PFOS)
    Meagan A M Mollenhauer
    Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA
    Aquat Toxicol 91:10-8. 2009
    ..Alterations in normal cellular biology, like those observed, may lead to changes in health in marine mammals exposed to contaminants; however, this warrants further investigation...
  15. doi request reprint Complex contaminant exposure in cetaceans: a comparative E-Screen analysis of bottlenose dolphin blubber and mixtures of four persistent organic pollutants
    Jennifer E Yordy
    Marine Biomedicine and Environmental Sciences Center, Medical University of South Carolina, Charleston, South Carolina 29412, USA
    Environ Toxicol Chem 29:2143-53. 2010
    ..These observations do not necessarily provide direct evidence of endocrine disruption; however, they may indicate an environmental source of xenoestrogenic exposure warranting future research...
  16. doi request reprint Gestational exposure to perfluorooctane sulfonate suppresses immune function in B6C3F1 mice
    Deborah E Keil
    National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Toxicol Sci 103:77-85. 2008
    ..This study establishes that the developing immune system is sensitive to the effects of PFOS and results in functional deficits in innate and humoral immunity detectable at adulthood...
  17. pmc Effects of organochlorine contaminants on loggerhead sea turtle immunity: comparison of a correlative field study and in vitro exposure experiments
    Jennifer M Keller
    Nicholas School of the Environment and Earth Sciences, Coastal Systems Science and Policy, and Integrated Toxicology Program, Duke University, Beaufort, North Carolina, USA
    Environ Health Perspect 114:70-76. 2006
    ..The similarities between the in vitro experiments and the correlative field study suggest that OC exposure modulates immunity in loggerhead turtles...
  18. ncbi request reprint Mitogen-induced lymphocyte proliferation in loggerhead sea turtles: comparison of methods and effects of gender, plasma testosterone concentration, and body condition on immunity
    Jennifer M Keller
    Coastal Systems Science and Policy, and Integrated Toxicology Program, Nicholas School of the Environment and Earth Sciences, Duke University, 135 Duke Marine Lab Road, Beaufort, NC 28516, USA
    Vet Immunol Immunopathol 103:269-81. 2005
    ..Lastly, using these optimized methods, we investigated the effect of gender, plasma testosterone concentration, and body condition on LP in loggerhead turtles and found that none of the parameters largely influenced LP...
  19. ncbi request reprint Immunological function in mice exposed to JP-8 jet fuel in utero
    Deborah E Keil
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
    Toxicol Sci 76:347-56. 2003
    ..This study demonstrates that prenatal exposure to JP-8 can target the developing murine fetus and result in impaired immune function and altered T4 levels in adulthood...

Research Grants1

  1. Perfluorooctane sulfonate (PFOS) Affects Immunity through PPAR-alpha.
    Margie Peden Adams; Fiscal Year: 2007
    ..In Experiment B mice will not be immunized. The unimmunized and immunized experiments will be conducted to control for possible differences in response related to lymphocyte activation from the immunization. ..