Jong In Park

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. pmc Autophagy sensitivity of neuroendocrine lung tumor cells
    Seung Keun Hong
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Oncol 43:2031-8. 2013
  2. pmc Recombinant leukemia inhibitory factor suppresses human medullary thyroid carcinoma cell line xenografts in mice
    Dmytro Starenki
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Cancer Lett 339:144-51. 2013
  3. pmc AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion
    Seung Keun Hong
    Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Exp Cell Res 319:1732-43. 2013
  4. pmc A mortalin/HSPA9-mediated switch in tumor-suppressive signaling of Raf/MEK/extracellular signal-regulated kinase
    Pui Kei Wu
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Mol Cell Biol 33:4051-67. 2013
  5. pmc The Raf/MEK/extracellular signal-regulated kinase 1/2 pathway can mediate growth inhibitory and differentiation signaling via androgen receptor downregulation in prostate cancer cells
    Seung Keun Hong
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Exp Cell Res 317:2671-82. 2011
  6. pmc Mitochondria-targeted nitroxide, Mito-CP, suppresses medullary thyroid carcinoma cell survival in vitro and in vivo
    Dmytro Starenki
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Clin Endocrinol Metab 98:1529-40. 2013

Research Grants

  1. Mechanisms of MEK/ERK growth arrest signaling
    Jong In Park; Fiscal Year: 2010

Collaborators

  • Ming Fong Lin
  • Seung Keun Hong
  • Dmytro Starenki
  • Pui Kei Wu
  • Jin Hwan Kim
  • Sudhakar Veeranki
  • Joseph H Jeong
  • Andrew M Chan
  • Francis C Peterson
  • Mansi Karkhanis
  • Nishant K Singh
  • Jose A Plaza
  • Davin R Jensen

Detail Information

Publications6

  1. pmc Autophagy sensitivity of neuroendocrine lung tumor cells
    Seung Keun Hong
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Oncol 43:2031-8. 2013
    ..These results suggest that NE lung tumor cells share a common feature of autophagy and are more sensitive to autophagy inhibition than non-NE lung tumor cells...
  2. pmc Recombinant leukemia inhibitory factor suppresses human medullary thyroid carcinoma cell line xenografts in mice
    Dmytro Starenki
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Cancer Lett 339:144-51. 2013
    ..These results suggest that LIF is a potent cytostatic agent for MTC cells, which regulates unique mechanisms that are not targeted by currently available therapeutic agents...
  3. pmc AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion
    Seung Keun Hong
    Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Exp Cell Res 319:1732-43. 2013
    ..Our results also demonstrate that AKT regulates androgen receptor levels partly via the Raf/MEK/ERK pathway. This study reveals a novel crosstalk between ERK1/2 and AKT in PCa cells. ..
  4. pmc A mortalin/HSPA9-mediated switch in tumor-suppressive signaling of Raf/MEK/extracellular signal-regulated kinase
    Pui Kei Wu
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Mol Cell Biol 33:4051-67. 2013
    ..Our study also demonstrates that p21(CIP1) has dual effects under mortalin-depleted conditions, i.e., mediating cell cycle arrest while limiting cell death. ..
  5. pmc The Raf/MEK/extracellular signal-regulated kinase 1/2 pathway can mediate growth inhibitory and differentiation signaling via androgen receptor downregulation in prostate cancer cells
    Seung Keun Hong
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Exp Cell Res 317:2671-82. 2011
    ..Our study demonstrates a novel role of the Raf/MEK/ERK pathway in regulating AR expression in certain PCa types and provides an insight into PCa responses to its aberrant activation...
  6. pmc Mitochondria-targeted nitroxide, Mito-CP, suppresses medullary thyroid carcinoma cell survival in vitro and in vivo
    Dmytro Starenki
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Clin Endocrinol Metab 98:1529-40. 2013
    ..Nevertheless, not all patients with the progressive MTC respond to these drugs, requiring the development of additional therapeutic modalities that have distinct activity...

Research Grants1

  1. Mechanisms of MEK/ERK growth arrest signaling
    Jong In Park; Fiscal Year: 2010
    ..Exploration of the possibility that these cancer types can be effectively suppressed by modulating the pathway via mortalin into the direction of growth arrest may allow development of new therapeutic strategies to control them. ..