P S Pagel

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. doi request reprint Chronic pressure-overload hypertrophy attenuates vortex formation time in patients with severe aortic stenosis and preserved left ventricular systolic function undergoing aortic valve replacement
    Paul S Pagel
    Anesthesia Service, Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, WI 53295, USA
    J Cardiothorac Vasc Anesth 27:660-4. 2013
  2. doi request reprint A bibliometric analysis of geographic publication variations in the Journal of Cardiothoracic and Vascular Anesthesia from 1990 to 2011
    Paul S Pagel
    Anesthesia Service, Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, WI 53295, USA
    J Cardiothorac Vasc Anesth 27:208-12. 2013
  3. doi request reprint H-index is a sensitive indicator of academic activity in highly productive anaesthesiologists: results of a bibliometric analysis
    P S Pagel
    Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, WI, USA
    Acta Anaesthesiol Scand 55:1085-9. 2011
  4. doi request reprint Cardiopulmonary bypass transiently inhibits intraventricular vortex ring formation in patients undergoing coronary artery bypass graft surgery
    Paul S Pagel
    Anesthesia Service, Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, WI 53295, USA
    J Cardiothorac Vasc Anesth 26:376-80. 2012
  5. pmc Recent trends in publication of basic science and clinical research by United States investigators in anesthesia journals
    Paul S Pagel
    Professor of Anesthesiology, the Clement J, Zablocki Veterans Affairs Medical Center, 5000 West National Avenue, Milwaukee, WI 53295, USA
    BMC Anesthesiol 12:5. 2012
  6. pmc Axial stent strut angle influences wall shear stress after stent implantation: analysis using 3D computational fluid dynamics models of stent foreshortening
    John F LaDisa
    Division of Cardiology, Department of Pediatrics, Stanford University, Palo Alto, California, USA
    Biomed Eng Online 4:59. 2005
  7. pmc Alterations in regional vascular geometry produced by theoretical stent implantation influence distributions of wall shear stress: analysis of a curved coronary artery using 3D computational fluid dynamics modeling
    John F LaDisa
    Department of Pediatrics Division of Cardiology, Stanford University, Stanford, California, USA
    Biomed Eng Online 5:40. 2006
  8. pmc Ischemia reperfusion dysfunction changes model-estimated kinetics of myofilament interaction due to inotropic drugs in isolated hearts
    Samhita S Rhodes
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Biomed Eng Online 5:16. 2006
  9. ncbi request reprint Surgical repair of long-standing mitral valve prolapse: a case report and brief review of the literature
    Paul S Pagel
    Clement J Zablocki Veterans Affairs Medical Center, Anesthesia Service, 5000 W National Ave, Milwaukee, WI 53295, USA
    WMJ 108:44-7. 2009
  10. pmc Inhibition of glycogen synthase kinase or the apoptotic protein p53 lowers the threshold of helium cardioprotection in vivo: the role of mitochondrial permeability transition
    Paul S Pagel
    Clement J Zablocki Veterans Affairs Medical Center, Anesthesia Service, 5000 W National Ave, Milwaukee, WI 53295, USA
    Anesth Analg 107:769-75. 2008

Collaborators

Detail Information

Publications100

  1. doi request reprint Chronic pressure-overload hypertrophy attenuates vortex formation time in patients with severe aortic stenosis and preserved left ventricular systolic function undergoing aortic valve replacement
    Paul S Pagel
    Anesthesia Service, Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, WI 53295, USA
    J Cardiothorac Vasc Anesth 27:660-4. 2013
    ..The current investigation tested the hypothesis that chronic LV pressure-overload hypertrophy produced by severe aortic stenosis (AS) reduces VFT in patients with preserved LV systolic function undergoing aortic valve replacement...
  2. doi request reprint A bibliometric analysis of geographic publication variations in the Journal of Cardiothoracic and Vascular Anesthesia from 1990 to 2011
    Paul S Pagel
    Anesthesia Service, Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, WI 53295, USA
    J Cardiothorac Vasc Anesth 27:208-12. 2013
    ..The authors also determined whether previously described reductions in North American research productivity were accompanied by similar decreases in the number of other forms of publication in JCVA...
  3. doi request reprint H-index is a sensitive indicator of academic activity in highly productive anaesthesiologists: results of a bibliometric analysis
    P S Pagel
    Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, WI, USA
    Acta Anaesthesiol Scand 55:1085-9. 2011
    ..We tested the hypothesis that h-index is an indicator of not only publication record, but also grant funding and mentoring in highly productive US academic anaesthesiologists...
  4. doi request reprint Cardiopulmonary bypass transiently inhibits intraventricular vortex ring formation in patients undergoing coronary artery bypass graft surgery
    Paul S Pagel
    Anesthesia Service, Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, WI 53295, USA
    J Cardiothorac Vasc Anesth 26:376-80. 2012
    ....
  5. pmc Recent trends in publication of basic science and clinical research by United States investigators in anesthesia journals
    Paul S Pagel
    Professor of Anesthesiology, the Clement J, Zablocki Veterans Affairs Medical Center, 5000 West National Avenue, Milwaukee, WI 53295, USA
    BMC Anesthesiol 12:5. 2012
    ..abstract:..
  6. pmc Axial stent strut angle influences wall shear stress after stent implantation: analysis using 3D computational fluid dynamics models of stent foreshortening
    John F LaDisa
    Division of Cardiology, Department of Pediatrics, Stanford University, Palo Alto, California, USA
    Biomed Eng Online 4:59. 2005
    ..The angle created between axially aligned stent struts and the principal direction of blood flow varies with the degree to which the stent foreshortens after implantation...
  7. pmc Alterations in regional vascular geometry produced by theoretical stent implantation influence distributions of wall shear stress: analysis of a curved coronary artery using 3D computational fluid dynamics modeling
    John F LaDisa
    Department of Pediatrics Division of Cardiology, Stanford University, Stanford, California, USA
    Biomed Eng Online 5:40. 2006
    ..It appears highly probable that restenosis occurring after stent implantation in curved arteries also occurs as a consequence of changes in fluid dynamics that are established immediately after stent implantation...
  8. pmc Ischemia reperfusion dysfunction changes model-estimated kinetics of myofilament interaction due to inotropic drugs in isolated hearts
    Samhita S Rhodes
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Biomed Eng Online 5:16. 2006
    ....
  9. ncbi request reprint Surgical repair of long-standing mitral valve prolapse: a case report and brief review of the literature
    Paul S Pagel
    Clement J Zablocki Veterans Affairs Medical Center, Anesthesia Service, 5000 W National Ave, Milwaukee, WI 53295, USA
    WMJ 108:44-7. 2009
    ....
  10. pmc Inhibition of glycogen synthase kinase or the apoptotic protein p53 lowers the threshold of helium cardioprotection in vivo: the role of mitochondrial permeability transition
    Paul S Pagel
    Clement J Zablocki Veterans Affairs Medical Center, Anesthesia Service, 5000 W National Ave, Milwaukee, WI 53295, USA
    Anesth Analg 107:769-75. 2008
    ..We tested the hypothesis that inhibition of GSK or p53 lowers the threshold of helium cardioprotection via a mitochondrial permeability transition pore (mPTP)-dependent mechanism...
  11. ncbi request reprint Mechanical function of the left atrium: new insights based on analysis of pressure-volume relations and Doppler echocardiography
    Paul S Pagel
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Anesthesiology 98:975-94. 2003
  12. doi request reprint An analysis of scholarly productivity in United States academic anaesthesiologists by citation bibliometrics
    P S Pagel
    Anesthesia Service, the Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin, USA
    Anaesthesia 66:873-8. 2011
    ..You can respond to this article at http://www.anaesthesiacorrespondence.com...
  13. doi request reprint Transient metabolic alkalosis during early reperfusion abolishes helium preconditioning against myocardial infarction: restoration of cardioprotection by cyclosporin A in rabbits
    Paul S Pagel
    Department of Anesthesiology, The Medical Collegeof Wisconsin, Milwaukee, Wisconsin, USA
    Anesth Analg 108:1076-82. 2009
    ....
  14. doi request reprint Bibliometric analysis of anaesthesia journal editorial board members: correlation between journal impact factor and the median h-index of its board members
    P S Pagel
    Anesthesia Service, Clement J Zablocki Veterans Affairs Medical Center, Anesthesia Service, 5000 W National Avenue, Milwaukee, WI 53295, USA
    Br J Anaesth 107:357-61. 2011
    ..We conducted a bibliometric analysis of h-index in editorial board members and tested the hypothesis that editorial board members of anaesthesia journals with higher impact factors (IFs) have higher h-indices...
  15. ncbi request reprint A triple-lumen aorta: an unusual manifestation of complex aortic pathology associated with crack cocaine abuse
    Moshe Feldhendler
    Department of Anesthesiology, Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, WI 53295, USA
    J Cardiothorac Vasc Anesth 21:462-4. 2007
  16. doi request reprint Scholarly productivity of united states academic cardiothoracic anesthesiologists: influence of fellowship accreditation and transesophageal echocardiographic credentials on h-index and other citation bibliometrics
    Paul S Pagel
    Anesthesia Service, Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, WI 53295, USA
    J Cardiothorac Vasc Anesth 25:761-5. 2011
    ....
  17. doi request reprint Morphine reduces the threshold of helium preconditioning against myocardial infarction: the role of opioid receptors in rabbits
    Paul S Pagel
    Department of Anesthesiology, Medical College of Wisconsin and Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, WI, USA
    J Cardiothorac Vasc Anesth 23:619-24. 2009
    ....
  18. pmc The mechanism of helium-induced preconditioning: a direct role for nitric oxide in rabbits
    Paul S Pagel
    Department of Anesthesiology, Medical College of Wisconsin, Clement J Zablocki Veterans Affairs Medical Center, Anesthesia Service, 5000 W National Ave, Milwaukee, WI 53295, USA
    Anesth Analg 107:762-8. 2008
    ..We tested the hypothesis that NO mediates helium-induced cardioprotection in vivo...
  19. ncbi request reprint K(ATP) channels mediate the beneficial effects of chronic ethanol ingestion
    P S Pagel
    Departments of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Physiol Heart Circ Physiol 279:H2574-9. 2000
    ..No differences in hemodynamics or coronary collateral blood flow (through radioactive microspheres) were observed among groups. The results indicate that K(ATP) channels mediate the protective effects of chronic consumption of ethanol...
  20. ncbi request reprint Noble gases without anesthetic properties protect myocardium against infarction by activating prosurvival signaling kinases and inhibiting mitochondrial permeability transition in vivo
    Paul S Pagel
    Department of Anesthesiology, The Medical College of Wisconsin and the Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295, USA
    Anesth Analg 105:562-9. 2007
    ....
  21. ncbi request reprint Inhibition of glycogen synthase kinase enhances isoflurane-induced protection against myocardial infarction during early reperfusion in vivo
    Paul S Pagel
    Department of Anesthesiology, Medical College of Wisconsin and the Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226, USA
    Anesth Analg 102:1348-54. 2006
    ..6 mg/kg SB21 and 0.5 MAC isoflurane plus 0.2 mg/kg SB21. Thus, GSK inhibition enhances isoflurane-induced protection against infarction during early reperfusion via a mPTP-dependent mechanism...
  22. doi request reprint Use of ECMO to temporize circulatory instability during severe Brugada electrical storm
    Paul S Pagel
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Ann Thorac Surg 88:982-3. 2009
    ..Oral anti-arrhythmic therapy was subsequently reinstituted, and the remainder of the patient's hospital course was uneventful...
  23. pmc Reactive oxygen species and mitochondrial adenosine triphosphate-regulated potassium channels mediate helium-induced preconditioning against myocardial infarction in vivo
    Paul S Pagel
    Department of Anesthesiology, Medical College of Wisconsin and Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, WI 53295, USA
    J Cardiothorac Vasc Anesth 22:554-9. 2008
    ..The authors tested the hypothesis that ROS and mitochondrial K(ATP) channels mediate helium-induced preconditioning in vivo...
  24. ncbi request reprint Diabetes and hyperglycemia impair activation of mitochondrial K(ATP) channels
    J R Kersten
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 280:H1744-50. 2001
    ..The results indicate that diabetes or hyperglycemia impairs activation of mitochondrial K(ATP) channels...
  25. ncbi request reprint Diabetes abolishes ischemic preconditioning: role of glucose, insulin, and osmolality
    J R Kersten
    Division of Cardiovascular Diseases, Department of Anesthesiology, Medical College of Wisconsin and Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 278:H1218-24. 2000
    ..The results indicate that hyperglycemia is a major determinant of the extent of myocardial infarction in the dog...
  26. ncbi request reprint Isoflurane mimics ischemic preconditioning via activation of K(ATP) channels: reduction of myocardial infarct size with an acute memory phase
    J R Kersten
    Department of Anesthesiology, Medical College of Wisconsin and the Zablocki Veterans Administration Medical Center, Milwaukee 53226, USA
    Anesthesiology 87:361-70. 1997
    ....
  27. ncbi request reprint Propofol, but not thiopentone or etomidate, enhances isoflurane-induced coronary vasodilatation in dogs
    P S Pagel
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Can J Anaesth 45:809-17. 1998
    ..To test the hypothesis that thiopentone, propofol, and etomidate alter the coronary vascular effects of abruptly administered isoflurane...
  28. ncbi request reprint Sevoflurane selectively increases coronary collateral blood flow independent of KATP channels in vivo
    J R Kersten
    Department of Anesthesiology, Pharmacology and Toxicology, Medical College of Wisconsin, Marquette University, Milwaukee 53226, USA
    Anesthesiology 90:246-56. 1999
    ..The authors tested the hypothesis that sevoflurane selectively increases coronary collateral blood flow and assessed the role of KATP channel activation in this process...
  29. ncbi request reprint Perfusion of ischemic myocardium during anesthesia with sevoflurane
    J R Kersten
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226
    Anesthesiology 81:995-1004. 1994
    ....
  30. ncbi request reprint Hyperglycemia reduces coronary collateral blood flow through a nitric oxide-mediated mechanism
    J R Kersten
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Physiol Heart Circ Physiol 281:H2097-104. 2001
    ..The results suggest that hyperglycemia decreases retrograde coronary collateral blood flow by adversely affecting nitric oxide availability...
  31. ncbi request reprint Mitochondrial adenosine triphosphate-regulated potassium channel opening acts as a trigger for isoflurane-induced preconditioning by generating reactive oxygen species
    Katsuya Tanaka
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 98:935-43. 2003
    ..We tested the hypothesis that the opening of mitochondrial K(ATP) channels triggers isoflurane-induced preconditioning by generating reactive oxygen species (ROS) in vivo...
  32. ncbi request reprint Preconditioning by isoflurane is mediated by reactive oxygen species generated from mitochondrial electron transport chain complex III
    Lynda M Ludwig
    Medical College of Wisconsin, MEB M4280, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Anesth Analg 99:1308-15; table of contents. 2004
    ..DPI and MYX selectively reduced complex I- and complex III-mediated ATP synthesis, respectively. ROS generated from electron transport chain complex III mediate ISO-induced cardioprotection...
  33. ncbi request reprint Role of Erk1/2, p70s6K, and eNOS in isoflurane-induced cardioprotection during early reperfusion in vivo
    John G Krolikowski
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Can J Anaesth 53:174-82. 2006
    ..We tested the hypothesis Erk1/2, p70s6K, and eNOS mediate isoflurane-induced postconditioning in rabbit myocardium in vivo...
  34. pmc Xenon preconditioning: the role of prosurvival signaling, mitochondrial permeability transition and bioenergetics in rats
    Yasushi Mio
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Anesth Analg 108:858-66. 2009
    ..We tested the hypothesis that xenon-induced cardioprotection is mediated by prosurvival signaling kinases that target mitochondria...
  35. ncbi request reprint Isoflurane protects against myocardial infarction during early reperfusion by activation of phosphatidylinositol-3-kinase signal transduction: evidence for anesthetic-induced postconditioning in rabbits
    Pascal C Chiari
    Departments of Anesthesiology, Division of Cardiovascular Diseases, The Medical College of Wisconsin, the Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin, USA
    Anesthesiology 102:102-9. 2005
    ..The authors tested the hypothesis that isoflurane produces cardioprotection during early reperfusion after myocardial ischemia by a PI3K-dependent mechanism...
  36. ncbi request reprint Isoflurane produces delayed preconditioning against myocardial ischemia and reperfusion injury: role of cyclooxygenase-2
    Katsuya Tanaka
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Anesthesiology 100:525-31. 2004
    ..The authors tested the hypothesis that isoflurane causes delayed preconditioning against infarction and, further, that cyclooxygenase (COX)-2 mediates this beneficial effect...
  37. ncbi request reprint Morphine enhances pharmacological preconditioning by isoflurane: role of mitochondrial K(ATP) channels and opioid receptors
    Lynda M Ludwig
    Department of Anesthesiology, The Medical College of Wisconsin, Milwaukee 53226, USA
    Anesthesiology 98:705-11. 2003
    ..We tested the hypothesis that morphine enhances the protective effect of isoflurane by activating mitochondrial adenosine triphosphate-regulated potassium channels and opioid receptors...
  38. ncbi request reprint Isoflurane does not produce a second window of preconditioning against myocardial infarction in vivo
    Franz Kehl
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Anesth Analg 95:1162-8, table of contents. 2002
    ..The results indicate that isoflurane does not produce a SWOP when administered 24 h before prolonged myocardial ischemia in vivo...
  39. ncbi request reprint Correlation of esophageal conductance measurements with aortic and left ventricular diameters and stroke volume
    D A Hettrick
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
    IEEE Trans Biomed Eng 47:559-64. 2000
    ..Esophageal conductance measurements are directly influenced by local hemodynamic events adjacent to the site of measurement...
  40. ncbi request reprint Cardiovascular effects of propofol in dogs with dilated cardiomyopathy
    P S Pagel
    Department of Anesthesiology, Medical College of Wisconsin and the Clement J Zablocki Veterans Affairs Medical Center, Milwaukee 53226, USA
    Anesthesiology 88:180-9. 1998
    ..The authors tested the hypothesis that propofol improves left ventricular diastolic function in dogs with dilated cardiomyopathy by reducing left ventricular preload and afterload...
  41. ncbi request reprint Cardiovascular effects of xenon in isoflurane-anesthetized dogs with dilated cardiomyopathy
    D A Hettrick
    Department of Anesthesiology, Medical College of Wisconsin, and the Zablocki VA Medical Center, Milwaukee 53226, USA
    Anesthesiology 89:1166-73. 1998
    ..The cardiovascular effects of xenon were examined in isoflurane-anesthetized dogs before and after the development of rapid left ventricular (LV) pacing-induced cardiomyopathy...
  42. ncbi request reprint Desflurane, sevoflurane, and isoflurane affect left atrial active and passive mechanical properties and impair left atrial-left ventricular coupling in vivo: analysis using pressure-volume relations
    M Gare
    Department of Medicine, Medical College of Wisconsin and the Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee 53226, USA
    Anesthesiology 95:689-98. 2001
    ....
  43. ncbi request reprint Is isoflurane-induced preconditioning dose related?
    Franz Kehl
    Department of Anesthesiology, Medical College of Wisconsin and the Zablocki VA Medical Center, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 96:675-80. 2002
    ..The authors tested the hypothesis that isoflurane decreases myocardial infarct size in a dose-dependent fashion in vivo...
  44. ncbi request reprint N-acetylcysteine restores isoflurane-induced preconditioning against myocardial infarction during hyperglycemia
    Franz Kehl
    Department of Anesthesiology, Medical College of Wisconsin and the Zablocki VA Medical Center, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 98:1384-90. 2003
    ..The authors tested the hypothesis that scavenging reactive oxygen species with N-acetylcysteine will restore protection against myocardial infarction produced by isoflurane in vivo...
  45. ncbi request reprint Protein kinase C translocation and Src protein tyrosine kinase activation mediate isoflurane-induced preconditioning in vivo: potential downstream targets of mitochondrial adenosine triphosphate-sensitive potassium channels and reactive oxygen species
    Lynda M Ludwig
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Anesthesiology 100:532-9. 2004
    ..The authors tested the hypotheses that protein kinase C (PKC)-specific isoform translocation and Src protein tyrosine kinase (PTK) activation play important roles in isoflurane-induced preconditioning in vivo...
  46. ncbi request reprint Adenosine type 1 (A1) receptors mediate protection against myocardial infarction produced by chronic, intermittent ingestion of ethanol in dogs
    Franz Kehl
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Cardiol 88:175-82. 2003
    ..Chronic consumption of small amounts of ethanol protects myocardium from ischemic injury. We tested the hypothesis that adenosine type 1 (A(1)) receptors mediate these beneficial effects...
  47. ncbi request reprint Cyclooxygenase-2 mediates ischemic, anesthetic, and pharmacologic preconditioning in vivo
    Dunbar Alcindor
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 100:547-54. 2004
    ..The authors tested the hypothesis that COX-2 is an essential mediator of IPC, APC, and PPC in vivo...
  48. ncbi request reprint Dexmedetomidine produces similar alterations in the determinants of left ventricular afterload in conscious dogs before and after the development of pacing-induced cardiomyopathy
    P S Pagel
    Department of Anesthesiology, Medical College of Wisconsin, Clement J Zablocki Veterans Affairs Medical Center, Milwaukee 53226, USA
    Anesthesiology 89:741-8. 1998
    ..The authors tested the hypothesis that intravenous dexmedetomidine produces alterations in left ventricular (LV) afterload that are deleterious to cardiac performance in conscious dogs with pacing-induced cardiomyopathy...
  49. ncbi request reprint Morphine enhances isoflurane-induced postconditioning against myocardial infarction: the role of phosphatidylinositol-3-kinase and opioid receptors in rabbits
    Dorothee Weihrauch
    Department of Anesthesiology, Medical College of Wisconsin and Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226, USA
    Anesth Analg 101:942-9, table of contents. 2005
    ..A reduction in apoptotic cell death contributes to preservation of myocardial integrity during postconditioning by isoflurane...
  50. ncbi request reprint Cardioprotection by glucose-insulin-potassium: dependence on KATP channel opening and blood glucose concentration before ischemia
    John F LaDisa
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 287:H601-7. 2004
    ..The insulin component of GIK promotes cardioprotection by K(ATP) channel activation. However, glucose decreases K(ATP) channel activity, and this effect predominates when hyperglycemia is present before ischemia...
  51. ncbi request reprint Intravenous emulsified halogenated anesthetics produce acute and delayed preconditioning against myocardial infarction in rabbits
    Pascal C Chiari
    Department of Anesthesiology and Pharmacology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Anesthesiology 101:1160-6. 2004
    ..The authors tested the hypothesis that new emulsified formulations of halogenated anesthetics administered intravenously reduce myocardial infarct size when administered either 1 or 24 h before prolonged ischemia and reperfusion...
  52. ncbi request reprint Gender-specificity of delayed preconditioning by isoflurane in rabbits: potential role of endothelial nitric oxide synthase
    Chen Wang
    Department of Anesthesiology, Medical College of Wisconsin and Clement J Zablocki Veterans Affairs Medical Center, MEB M4280, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Anesth Analg 103:274-80, table of contents. 2006
    ..We tested the hypothesis that gender-specific reductions in myocardial infarct size occur in female rabbits, but that this inherent cardioprotection abrogates further beneficial effects of isoflurane-induced delayed preconditioning...
  53. ncbi request reprint Inhibition of mitochondrial permeability transition enhances isoflurane-induced cardioprotection during early reperfusion: the role of mitochondrial KATP channels
    John G Krolikowski
    Departments of Anesthesiology, Pharmacology and Toxicology, and Medicine Division of Cardiovascular Diseases, The Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Anesth Analg 101:1590-6. 2005
    ..This isoflurane-induced inhibition of mitochondrial permeability transition is dependent on activation of mitochondrial KATP channels in vivo...
  54. ncbi request reprint Multifactorial basis for coronary collateralization: a complex adaptive response to ischemia
    J R Kersten
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Cardiovasc Res 43:44-57. 1999
    ..Impairment of angiogenic adaptive responses to ischemia during disease states is an important subject for future investigation...
  55. ncbi request reprint The influence of B-cell lymphoma 2 protein, an antiapoptotic regulator of mitochondrial permeability transition, on isoflurane-induced and ischemic postconditioning in rabbits
    Chen Wang
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesth Analg 102:1355-60. 2006
    ..5 MAC isoflurane plus 10 s postconditioning ischemia. The results suggest that Bcl-2 mediates isoflurane-induced and ischemic postconditioning by indirectly modulating mPTP activity in vivo...
  56. ncbi request reprint Influence of isoflurane on left atrial function in dogs with pacing-induced cardiomyopathy: evaluation with pressure-volume relationships
    Franz Kehl
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Cardiothorac Vasc Anesth 17:709-14. 2003
    ..The hypothesis was tested that isoflurane alters LA mechanics evaluated with pressure-volume relations...
  57. ncbi request reprint Cardioprotection by volatile anesthetics: new applications for old drugs?
    Phillip F Pratt
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Curr Opin Anaesthesiol 19:397-403. 2006
    ..This review will update and integrate these recent data into the current mechanistic model of anesthetic-induced preconditioning...
  58. ncbi request reprint Mechanisms of cardioprotection by volatile anesthetics
    Katsuya Tanaka
    Department of Anesthesiology, Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226, USA
    Anesthesiology 100:707-21. 2004
  59. ncbi request reprint Isoflurane-induced preconditioning is attenuated by diabetes
    Katsuya Tanaka
    Department of Anesthesiology, Milwaukee, Wisconsin 53226
    Am J Physiol Heart Circ Physiol 282:H2018-23. 2002
    ..The results indicate that blood glucose and end-tidal isoflurane concentrations are important determinants of infarct size during anesthetic-induced preconditioning...
  60. ncbi request reprint Mechanism of preconditioning by isoflurane in rabbits: a direct role for reactive oxygen species
    Katsuya Tanaka
    Department of Anesthesiology, Pharmacology and Toxicology, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Anesthesiology 97:1485-90. 2002
    ..We tested the hypothesis that ROS mediate isoflurane-induced preconditioning in vivo...
  61. ncbi request reprint Reactive oxygen species contribute to contractile dysfunction following rapid ventricular pacing in dogs
    Meir Gare
    Department of Medicine Division of Cardiovascular Diseases, The Medical College of Wisconsin and the Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, WI 53226, USA
    Int J Cardiol 83:125-31. 2002
    ..We tested the hypothesis that the antioxidant N-acetylcysteine enhances recovery of contractile function after rapid ventricular pacing...
  62. ncbi request reprint Conscious sedation with midazolam or propofol does not alter left ventricular diastolic performance in patients with preexisting diastolic dysfunction: a transmitral and tissue Doppler transthoracic echocardiography study
    M Gare
    Department of Anesthesiology, The Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesth Analg 93:865-71. 2001
    ....
  63. ncbi request reprint Desflurane and isoflurane produce similar alterations in systemic and pulmonary hemodynamics and arterial oxygenation in patients undergoing one-lung ventilation during thoracotomy
    P S Pagel
    Department of Anesthesiology, Medical College of Wisconsin and the Clement J Zablocki Veterans Affairs Medical Center, Milwaukee 53226, USA
    Anesth Analg 87:800-7. 1998
    ..We conclude that DES and ISO produce very similar alterations in systemic and pulmonary hemodynamics and arterial oxygenation in patients undergoing OLV during thoracotomy...
  64. doi request reprint Successful use of spinal anesthesia in a patient with severe Klippel-Trénaunay syndrome associated with upper airway abnormalities and chronic Kasabach-Merritt coagulopathy
    Elena J Holak
    Clement J Zablocki Veterans Affairs Medical Center, Anesthesia Service, 5000 W National Avenue, Milwaukee, WI 53295, USA
    J Anesth 24:134-8. 2010
    ....
  65. pmc Abnormal fibrillin-1 expression and chronic oxidative stress mediate endothelial mesenchymal transition in a murine model of systemic sclerosis
    Hao Xu
    Dept of Anesthesiology, Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Cell Physiol 300:C550-6. 2011
    ..This mesenchymal transition may contribute to the reduction in angiogenesis that is known to occur in this model of SSc...
  66. doi request reprint Elevated postoperative inflammatory biomarkers are associated with short- and medium-term cognitive dysfunction after coronary artery surgery
    Judith A Hudetz
    Department of Anesthesiology, Clement J Zablocki Veterans Administration Medical Center, 5000 W National Avenue, Milwaukee, WI 53295, USA
    J Anesth 25:1-9. 2011
    ....
  67. ncbi request reprint Cardioprotection by volatile anesthetics
    Martin W Bienengraeber
    Department of Anesthesiology, Pharmacology and Toxicology, Division of Cardiovascular Diseases, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Vascul Pharmacol 42:243-52. 2005
    ..This review summarizes some of the recent major developments in the understanding of cardioprotection by volatile anesthetics...
  68. ncbi request reprint Ischemia-reperfusion injury changes the dynamics of Ca2+-contraction coupling due to inotropic drugs in isolated hearts
    Samhita S Rhodes
    Department of Anesthesiology, M4280, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Appl Physiol (1985) 100:940-50. 2006
    ....
  69. ncbi request reprint Increases in coronary collateral blood flow produced by sevoflurane are mediated by calcium-activated potassium (BKCa) channels in vivo
    Franz Kehl
    Department of Anesthesiology, the Medical College of Wisconsin and the Zablocki VA Medical Center, Milwaukee 53226, USA
    Anesthesiology 97:725-31. 2002
    ....
  70. ncbi request reprint Perioperative considerations in the patient with a left ventricular assist device
    Alfred C Nicolosi
    Department of Surgery Division of Cardiothoracic Surgery, The Medical College of Wisconsin and the Clement J Zablocki Veterans Affairs Medical Center, Milwaukee 53226, USA
    Anesthesiology 98:565-70. 2003
  71. ncbi request reprint Role of endothelial nitric oxide synthase as a trigger and mediator of isoflurane-induced delayed preconditioning in rabbit myocardium
    Pascal C Chiari
    Division of Cardiovascular Diseases, Department of Anesthesiology, The Medical College of Wisconsin, Milwaukee 53226, USA
    Anesthesiology 103:74-83. 2005
    ..Isoflurane produces delayed preconditioning in vivo. The authors tested the hypothesis that endothelial, inducible, or neuronal nitric oxide synthase (NOS) is a trigger or mediator of this protective effect...
  72. ncbi request reprint The role of mitochondrial and sarcolemmal K(ATP) channels in canine ethanol-induced preconditioning in vivo
    Paul S Pagel
    Department of Anesthesiology, Medical College of Wisconsin and Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226, USA
    Anesth Analg 94:841-8, table of contents. 2002
    ..The results indicate that mitochondrial and sarcolemmal K(ATP) channels mediate ethanol-induced preconditioning in dogs independent of alterations in systemic hemodynamics or coronary collateral blood flow...
  73. ncbi request reprint Hyperglycemia prevents isoflurane-induced preconditioning against myocardial infarction
    Franz Kehl
    Department of Anesthesiology, Medical College of Wisconsin and Zablocki VA Medical Center, Milwaukee, 53226, USA
    Anesthesiology 96:183-8. 2002
    ..The authors tested the hypothesis that acute hyperglycemia interferes with isoflurane-induced preconditioning in vivo...
  74. ncbi request reprint Chronic hyperglycemia attenuates coronary collateral development and impairs proliferative properties of myocardial interstitial fluid by production of angiostatin
    Dorothee Weihrauch
    Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Circulation 109:2343-8. 2004
    ..We tested the hypothesis that hyperglycemia alone attenuates collateral development and abolishes proliferative properties of myocardial interstitial fluid (MIF) by enhancing expression of matrix metalloproteinases (MMP) and angiostatin...
  75. ncbi request reprint Approaches to the prevention of perioperative myocardial ischemia
    D C Warltier
    Department of Anesthesiology, Pharmacology and Toxicology, Medical College of Wisconsin and the Zablocki Veterans Affairs Medical Center, Milwaukee 53226, USA
    Anesthesiology 92:253-9. 2000
    ....
  76. ncbi request reprint Diabetes abolishes sildenafil-induced cGMP-dependent protein kinase-I expression and cardioprotection
    Marina Jamnicki-Abegg
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Cardiovasc Pharmacol 50:670-6. 2007
    ..The results indicate that diabetes abolishes cardioprotection by sildenafil and implicates PKG-I in the signal transduction pathway activated by this drug...
  77. ncbi request reprint Reactive oxygen species are critical mediators of coronary collateral development in a canine model
    Weidong Gu
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Water town Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 285:H1582-9. 2003
    ..The results indicate that ROS are critical for the development of the coronary collateral circulation...
  78. ncbi request reprint Isoflurane inhibits cardiac myocyte apoptosis during oxidative and inflammatory stress by activating Akt and enhancing Bcl-2 expression
    Marina Jamnicki-Abegg
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 103:1006-14. 2005
    ..The underlying mechanisms remain undefined. The authors tested whether isoflurane reduces apoptosis in cardiomyocytes subjected to oxidative or inflammatory stress by enhancing Akt and B-cell lymphoma-2 (Bcl-2)...
  79. doi request reprint Simvastatin restores ischemic preconditioning in the presence of hyperglycemia through a nitric oxide-mediated mechanism
    Weidong Gu
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Anesthesiology 108:634-42. 2008
    ..The authors tested the hypothesis that simvastatin restores the beneficial effects of IPC during hyperglycemia through a nitric oxide-mediated mechanism...
  80. ncbi request reprint An intramyocardial catheter for repeated in vivo sampling of interstitial fluid
    John P Tessmer
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Pharmacol Toxicol Methods 47:73-8. 2002
    ..We report the implantation of an exchange catheter capable of in vivo sampling of myocardial interstitial fluid in chronically instrumented dogs...
  81. ncbi request reprint An automated coronary artery occlusion device for stimulating collateral development in vivo
    Richard Rys
    Department of Anesthesiology, Medical College of Wisconsin, MEB M4280, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Pharmacol Toxicol Methods 48:111-8. 2002
    ..We report the design and use of a fully automated hydraulic coronary occlusion device capable of producing repetitive coronary occlusions and enhancement of coronary collateral development in dogs...
  82. ncbi request reprint Extracellular signal-regulated kinases trigger isoflurane preconditioning concomitant with upregulation of hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression in rats
    Chen Wang
    Department of Anesthesiology, Medical College of Wisconsin and Clement J Zablocki Veterans Affairs Medical Center, MEB M4280, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Anesth Analg 103:281-8, table of contents. 2006
    ....
  83. ncbi request reprint Propofol alters left atrial function evaluated with pressure-volume relations in vivo
    Franz Kehl
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Anesth Analg 94:1421-6, table of contents. 2002
    ..Relaxation was unchanged. The results indicate that propofol depresses LA myocardial contractility, reduces dynamic chamber stiffness, maintains reservoir function, and impairs LA-LV coupling but does not alter LA relaxation in vivo...
  84. ncbi request reprint An unusual right atrial structure in a patient with a new diastolic murmur
    Zafar Iqbal
    Department of Anesthesiology, The Medical College of Wisconsin and the Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, WI 53226, USA
    J Cardiothorac Vasc Anesth 21:152-4. 2007
  85. ncbi request reprint Circumferential vascular deformation after stent implantation alters wall shear stress evaluated with time-dependent 3D computational fluid dynamics models
    John F LaDisa
    Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin, USA
    J Appl Physiol 98:947-57. 2005
    ..The results obtained using three-dimensional CFD models suggest that changes in vascular geometry after stent implantation are important determinants of WSS distributions that may be associated with subsequent neointimal hyperplasia...
  86. doi request reprint Ketamine attenuates post-operative cognitive dysfunction after cardiac surgery
    J A Hudetz
    Department of Anesthesiology, Clement J Zablocki Veterans Administration Medical Center, Milwaukee, WI
    Acta Anaesthesiol Scand 53:864-72. 2009
    ..We hypothesized that ketamine attenuates POCD in patients undergoing cardiac surgery concomitant with an anti-inflammatory effect...
  87. ncbi request reprint Perioperative implications of charcot-marie-tooth disease during coronary artery bypass graft surgery
    Vijayashree Shankar
    Department of Anesthesiology, Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, WI 53295, USA
    J Cardiothorac Vasc Anesth 21:567-9. 2007
  88. ncbi request reprint A circular structure in the aortic outflow tract during diastole: an unusual complication of cocaine abuse
    Ala Alosman
    Department of Anesthesiology, Medical College of Wisconsin and the Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, 53226, USA
    J Cardiothorac Vasc Anesth 20:458-60. 2006
  89. doi request reprint A large, spherical echogenic object appearing in the left atrium during early left ventricular ejection
    Kishan Patel
    Anesthesia, Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, WI, USA
    J Cardiothorac Vasc Anesth 22:321-3. 2008
  90. ncbi request reprint Three-dimensional computational fluid dynamics modeling of alterations in coronary wall shear stress produced by stent implantation
    John F LaDisa
    Department of Anesthesiology, The Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Ann Biomed Eng 31:972-80. 2003
    ..The present results depict alterations in wall shear stress caused by a slotted-tube stent and support the hypothesis that stent geometry may be a risk factor for restenosis by affecting local wall shear stress distributions...
  91. ncbi request reprint Suxamethonium-induced hyperkalaemia 6 weeks after chemoradiotherapy in a patient with rectal carcinoma
    E J Holak
    Clement J Zablocki Veterans Affairs Medical Center, Anesthesia Service, Milwaukee, Wisconsin, USA
    Br J Anaesth 98:766-8. 2007
    ..In the current report, we describe a patient with rectal cancer initially treated with chemoradiotherapy who developed hyperkalaemia after suxamethonium and further discuss the potential factors that contributed to this response...
  92. ncbi request reprint Atrial pacing lead location alters the hemodynamic effects of atrial-ventricular delay in dogs with pacing induced cardiomyopathy
    Douglas A Hettrick
    Medtronic, Inc, Minneapolis, Minnesota 55432, USA
    Pacing Clin Electrophysiol 26:853-61. 2003
    ..Atrial lead location affects indices of LV performance independent of AV delay during dual chamber pacing in dogs with cardiomyopathy...
  93. ncbi request reprint Inhibition of apoptotic protein p53 lowers the threshold of isoflurane-induced cardioprotection during early reperfusion in rabbits
    Suneetha Venkatapuram
    Anesth Analg 103:1400-5. 2006
    ..The apoptotic protein, p53, is regulated by PI3K, and inhibition of p53 protects against ischemic injury. We tested the hypothesis that p53 inhibition lowers the threshold of isoflurane-induced postconditioning in vivo...
  94. ncbi request reprint Levosimendan in cardiac surgery: a unique drug for the treatment of perioperative left ventricular dysfunction or just another inodilator searching for a clinical application?
    Paul S Pagel
    Anesth Analg 104:759-61. 2007
  95. ncbi request reprint Anesthetics and echocardiographic assessment of left ventricular function: lessons learned from invasive analysis of cardiovascular mechanics
    Paul S Pagel
    J Am Soc Echocardiogr 20:440-1. 2007
  96. ncbi request reprint Atrial pacing lead location alters the effects of atrioventricular delay on atrial and ventricular hemodynamics
    Douglas A Hettrick
    Medtronic, Incorporated, Minneapolis, Minnesota 55432, USA
    Pacing Clin Electrophysiol 25:888-96. 2002
    ..The results indicate that the atrial contribution to cardiac output depends on AV timing and atrial lead location in isoflurane-anesthetized dogs with AV nodal conduction block...
  97. doi request reprint Induction of heat shock protein 70 and preconditioning by sevoflurane: a potent protective interaction against myocardial ischemia-reperfusion injury
    Paul S Pagel
    Anesth Analg 107:742-5. 2008
  98. ncbi request reprint Cross-bridge kinetics modeled from myoplasmic [Ca2+] and LV pressure at 17 degrees C and after 37 degrees C and 17 degrees C ischemia
    Samhita S Rhodes
    Department of Biomedical Engineering, Marquette University, Milwaukee 53233, USA
    Am J Physiol Heart Circ Physiol 284:H1217-29. 2003
    ..This cardiac muscle kinetic model predicted a better-restored relationship between Ca(2+) and cross-bridge function on RP after an eightfold longer period of 17 degrees C than 37 degrees C ischemia...
  99. ncbi request reprint Additive cardioprotection by ethanol and sevoflurane: are sarcolemmal K ATP channels also involved?
    Paul S Pagel
    Anesth Analg 106:1926; author reply 1926-7. 2008
  100. ncbi request reprint Nitrous oxide and preconditioning
    Paul S Pagel
    Anesthesiology 105:630; author reply 631. 2006