Dennis R Ownby

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. ncbi request reprint Asthma in rural America
    Dennis R Ownby
    Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912, USA
    Ann Allergy Asthma Immunol 95:S17-22. 2005
  2. doi request reprint Influence of dose and frequency of antigen injection on IgE development in young children: a comparison of fire ant stings and tetanus immunizations
    Dennis R Ownby
    Medical College of Georgia, Department of Allergy and Immunology, Augusta, GA 30912 3790, USA
    Ann Allergy Asthma Immunol 103:337-41. 2009
  3. doi request reprint Variation of dust endotoxin concentrations by location and time within homes of young children
    Dennis R Ownby
    Department of Allergy and Immunology, Medical College of Georgia, Augusta, GA, USA
    Pediatr Allergy Immunol 21:533-40. 2010
  4. ncbi request reprint The relationship of physical activity and percentage of body fat to the risk of asthma in 8- to 10-year-old children
    Dennis R Ownby
    Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912 3790, USA
    J Asthma 44:885-9. 2007
  5. ncbi request reprint The relationship between seroatopy and symptoms of either allergic rhinitis or asthma
    Christina M Abraham
    Section of Allergy and Immunology, Medical College of Georgia, Augusta, GA 30912, USA
    J Allergy Clin Immunol 119:1099-104. 2007
  6. doi request reprint Prevalence of allergic sensitization to imported fire ants in children living in an endemic region of the southeastern United States
    Megan E Partridge
    Department of Allergy Immunology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Ann Allergy Asthma Immunol 100:54-8. 2008
  7. ncbi request reprint Does exposure to dogs and cats in the first year of life influence the development of allergic sensitization?
    Dennis R Ownby
    Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912, USA
    Curr Opin Allergy Clin Immunol 3:517-22. 2003
  8. doi request reprint Differences in total and allergen specific IgE during pregnancy compared with 1 month and 1 year post partum
    Lee M Perry
    Section of Allergy and Immunology, Medical College of Georgia, Augusta, 30912 3790, USA
    Ann Allergy Asthma Immunol 103:342-7. 2009
  9. ncbi request reprint Exposure to dogs and cats in the first year of life and risk of allergic sensitization at 6 to 7 years of age
    Dennis R Ownby
    Section of Allergy and Immunology, Department of Pediatrics, BG 1019, Medical College of Georgia, Augusta, GA 30912 3790, USA
    JAMA 288:963-72. 2002
  10. doi request reprint Pet dander and difficult-to-control asthma: The burden of illness
    Dennis R Ownby
    Department of Pediatrics, Medical College of Georgia, Augusta, 30912 3790, USA
    Allergy Asthma Proc 31:381-4. 2010

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Asthma in rural America
    Dennis R Ownby
    Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912, USA
    Ann Allergy Asthma Immunol 95:S17-22. 2005
    ..To examine current trends of asthma prevalence, diagnosis, and utilization of care in rural areas, increase awareness about asthma disease burden, and provide general recommendations for improving care in this setting...
  2. doi request reprint Influence of dose and frequency of antigen injection on IgE development in young children: a comparison of fire ant stings and tetanus immunizations
    Dennis R Ownby
    Medical College of Georgia, Department of Allergy and Immunology, Augusta, GA 30912 3790, USA
    Ann Allergy Asthma Immunol 103:337-41. 2009
    ..Previous studies suggest that small antigen doses given frequently are more likely to induce IgE production than are large antigen doses given infrequently...
  3. doi request reprint Variation of dust endotoxin concentrations by location and time within homes of young children
    Dennis R Ownby
    Department of Allergy and Immunology, Medical College of Georgia, Augusta, GA, USA
    Pediatr Allergy Immunol 21:533-40. 2010
    ..12 to 0.12). We conclude that a single measurement of endotoxin from a home dust sample provides an imprecise estimate of dust endotoxin concentrations in other locations within the home and over a relatively short observation interval...
  4. ncbi request reprint The relationship of physical activity and percentage of body fat to the risk of asthma in 8- to 10-year-old children
    Dennis R Ownby
    Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912 3790, USA
    J Asthma 44:885-9. 2007
    ..24 (95% CI 1.01-1.52, p = 0.045). Higher levels of physical activity were related to more diagnosed asthma...
  5. ncbi request reprint The relationship between seroatopy and symptoms of either allergic rhinitis or asthma
    Christina M Abraham
    Section of Allergy and Immunology, Medical College of Georgia, Augusta, GA 30912, USA
    J Allergy Clin Immunol 119:1099-104. 2007
    ..Epidemiologic data on allergic rhinitis and asthma are frequently based on self-reported symptoms...
  6. doi request reprint Prevalence of allergic sensitization to imported fire ants in children living in an endemic region of the southeastern United States
    Megan E Partridge
    Department of Allergy Immunology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Ann Allergy Asthma Immunol 100:54-8. 2008
    ..Imported fire ant (IFA) stings are common in children in the southeastern United States, but little is known about antibody responses to stings...
  7. ncbi request reprint Does exposure to dogs and cats in the first year of life influence the development of allergic sensitization?
    Dennis R Ownby
    Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912, USA
    Curr Opin Allergy Clin Immunol 3:517-22. 2003
    ....
  8. doi request reprint Differences in total and allergen specific IgE during pregnancy compared with 1 month and 1 year post partum
    Lee M Perry
    Section of Allergy and Immunology, Medical College of Georgia, Augusta, 30912 3790, USA
    Ann Allergy Asthma Immunol 103:342-7. 2009
    ..Pregnancy alters the function of many body systems, including the immune system. However, little is known regarding the effect of pregnancy on maternal IgE levels or atopy...
  9. ncbi request reprint Exposure to dogs and cats in the first year of life and risk of allergic sensitization at 6 to 7 years of age
    Dennis R Ownby
    Section of Allergy and Immunology, Department of Pediatrics, BG 1019, Medical College of Georgia, Augusta, GA 30912 3790, USA
    JAMA 288:963-72. 2002
    ..Childhood asthma is strongly associated with allergic sensitization. Studies have suggested that animal exposure during infancy reduces subsequent allergic sensitization...
  10. doi request reprint Pet dander and difficult-to-control asthma: The burden of illness
    Dennis R Ownby
    Department of Pediatrics, Medical College of Georgia, Augusta, 30912 3790, USA
    Allergy Asthma Proc 31:381-4. 2010
    ..The percentage of pet-associated excess asthma morbidity was estimated as a proportion of all asthma-related health care costs for the United States...
  11. ncbi request reprint Relationship between extremely low total serum IgE levels and rhinosinusitis
    Todd A Levin
    Section of Allergy and Immunology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Ann Allergy Asthma Immunol 97:650-2. 2006
    ..The few studies examining clinical manifestations in adults with serum IgE levels less than 2.0 IU/mL provide conflicting information...
  12. ncbi request reprint A review of natural-rubber latex allergy in health care workers
    Peter M Ranta
    Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912, USA
    Clin Infect Dis 38:252-6. 2004
    ..The use of low-allergen, nonpowdered NRL gloves substantially reduces airborne exposure to latex in most health care settings...
  13. ncbi request reprint Fire ants represent an important risk for anaphylaxis among residents of an endemic region
    Eric L Caplan
    Section of Allergy and Immunology, BG 1019, Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
    J Allergy Clin Immunol 111:1274-7. 2003
    ..Imported fire ants (IFA) represent a potential anaphylactic risk to IFA-sensitized individuals...
  14. ncbi request reprint Haemophilus influenzae type b meningitis in a fully immunized 2-year-old
    William A McCann
    Division of Asthma, Allergy, and Immunology, Medical College of Georgia, Augusta 30912, USA
    Ann Allergy Asthma Immunol 88:551-5. 2002
  15. ncbi request reprint Estrogen reduces carbachol-induced constriction of asthmatic airways by stimulating large-conductance voltage and calcium-dependent potassium channels
    Christiana Dimitropoulou
    Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 2300, USA
    Am J Respir Cell Mol Biol 32:239-47. 2005
    ..These studies suggest that, at physiologic concentrations, E(2) can prevent cholinergic-induced constriction of asthmatic tracheal rings by activating the nitric oxide-cGMP-protein kinase G pathway to increase BK(Ca) channel activity...
  16. doi request reprint Effect of depressive symptoms on asthma intervention in urban teens
    Lokesh Guglani
    Pediatric Pulmonary Division, Department of Pediatrics, Children s Hospital of Michigan, Detroit, MI 48201, USA
    Ann Allergy Asthma Immunol 109:237-242.e2. 2012
    ..The literature suggests that depression is an important comorbidity in asthma that can significantly influence disease management and quality of life (QOL)...
  17. pmc Tobacco smoke exposure and allergic sensitization in children: a propensity score analysis
    Suzanne L Havstad
    Department of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan, USA
    Respirology 17:1068-72. 2012
    ..Studies have shown that this relationship differs depending on maternal history of the disease. We employed the rigour of propensity score methods to assess this relationship using data from a birth cohort...
  18. ncbi request reprint Strategies for distinguishing asymptomatic latex sensitization from true occupational allergy or asthma
    Dennis R Ownby
    Section of Allergy and Immunology, Medical College of Georgia, Augusta 30912 3790, USA
    Ann Allergy Asthma Immunol 90:42-6. 2003
    ..To evaluate strategies for distinguishing those individuals with true occupational asthma caused by exposure to natural rubber latex from those individuals with allergic disease related to other allergens...
  19. ncbi request reprint The reproducibility of the allergy skin test scoring and interpretation by board-certified/board-eligible allergists
    William A McCann
    Department of Pediatrics, Medical College of Georgia, Augusta 30912, USA
    Ann Allergy Asthma Immunol 89:368-71. 2002
    ..Allergy skin testing is a cornerstone in the evaluation of the allergic patient. This seemingly simple test is subject to multiple variables that can affect the result...
  20. ncbi request reprint Ontogeny of the allergic inflammatory response
    Christina M Abraham
    Section of Allergy Immunology, Medical College of Georgia, 1120 15th Street, BG 1009, Augusta, GA 30912, USA
    Immunol Allergy Clin North Am 25:215-29, v. 2005
    ..After birth, it seems that many factors, including the frequency and severity of infections and the timing and intensity of allergen and animal exposures, continue to influence immune development...
  21. ncbi request reprint Antibiotic use in children who have asthma: results of retrospective database analysis
    Leila E Stallworth
    Medical College of Georgia, 1120 15th St, Augusta, GA 30912, USA
    J Manag Care Pharm 11:657-62. 2005
    ....
  22. ncbi request reprint A history of latex allergy
    Dennis R Ownby
    Section of Allergy and Immunology, Medical College of Georgia, GA 30912 1790, USA
    J Allergy Clin Immunol 110:S27-32. 2002
    ..This review concentrates on the history of latex use in medicine and the dramatic emergence of immediate-type latex allergy...
  23. ncbi request reprint Breastfeeding history and childhood allergic status in a prospective birth cohort
    Ganesa Wegienka
    Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, Michigan 48202, USA
    Ann Allergy Asthma Immunol 97:78-83. 2006
    ..Breastfeeding provides the best possible nutrition for newborns, but its role in the development of allergies is complex...
  24. ncbi request reprint Gene-environment interactions with CD14 C-260T and their relationship to total serum IgE levels in adults
    L Keoki Williams
    Department of Internal Medicine, Henry Ford Health System, Detroit, MI 48202, USA
    J Allergy Clin Immunol 118:851-7. 2006
    ..Furred pets might also influence IgE levels through their effects on endotoxin levels. However, how these factors interact to influence total IgE levels is not well known, especially in adults...
  25. doi request reprint Risk factors associated with transient wheezing in young children
    Michael R Simon
    Department of Internal Medicine and Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
    Allergy Asthma Proc 29:161-5. 2008
    ..6; 95% CI, 1.0-2.6; p = 0.048). We confirm previous observations that transient wheezing in young children is not associated with an atopic predisposition...
  26. ncbi request reprint The prevalence of latex-specific IgE in patients presenting to an urban emergency department
    Mary Grzybowski
    Department of Emergency Medicine, School of Medicine, and the Center for Healthcare Effectiveness Research, Wayne State University, Detroit, MI, USA
    Ann Emerg Med 40:411-9. 2002
    ..The overall aim of this study was to determine the prevalence of latex IgE seropositivity (L-IgE) in ED patients...
  27. ncbi request reprint Family history, dust mite exposure in early childhood, and risk for pediatric atopy and asthma
    Christine Cole Johnson
    Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Wayne State University, Detroit, MI 48202, USA
    J Allergy Clin Immunol 114:105-10. 2004
    ..Dust mite allergen exposure is considered a major determinant of sensitization to these allergens during childhood and a risk factor for pediatric asthma...
  28. ncbi request reprint The relationship between early fever and allergic sensitization at age 6 to 7 years
    L Keoki Williams
    Division of General Medicine, Department of Internal Medicine, Detroit, Mich, USA
    J Allergy Clin Immunol 113:291-6. 2004
    ..The hygiene hypothesis suggests that early infections might protect against later allergic sensitization...
  29. pmc Interpregnancy interval might affect the risk of childhood atopy
    Ganesa Wegienka
    J Allergy Clin Immunol 113:169-71. 2004
  30. ncbi request reprint Pediatric allergy
    Dennis R Ownby
    Curr Opin Allergy Clin Immunol 2:129-31. 2002
  31. ncbi request reprint The relationship of housing and household characteristics to the indoor concentrations of Der f 1, Der p 1, and Fel d 1 measured in dust and air samples
    Edward L Peterson
    Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, Michigan 48202, USA
    Ann Allergy Asthma Immunol 90:564-71. 2003
    ..Indoor dust mite and cat allergens have been related to the risk of atopic conditions. If allergen levels are influenced by modifiable residential characteristics, potential interventions to prevent disease could be deployed...
  32. ncbi request reprint Relationship of house-dust mite allergen exposure in children's bedrooms in infancy to bronchial hyperresponsiveness and asthma diagnosis by age 6 to 7
    Paul M Carter
    Henry Ford Health System, Division of Allergy, Detroit, Michigan, USA
    Ann Allergy Asthma Immunol 90:41-4. 2003
    ..Several studies have suggested that exposure to house-dust mite (HDM) allergen in infancy increases the risk of developing asthma...
  33. ncbi request reprint Clinical and laboratory-based methods in the diagnosis of natural rubber latex allergy
    Robert G Hamilton
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 110:S47-56. 2002
    ..The performance, advantages, and limitations of each diagnostic method are compared...
  34. ncbi request reprint Antibiotic exposure in early infancy and risk for childhood atopy
    Christine Cole Johnson
    Department of Biostatistics and Research Epidemiology, Henry Ford Health System, 1 Ford Place 5C, Detroit, MI 48202, USA
    J Allergy Clin Immunol 115:1218-24. 2005
    ..The increase in pediatric allergy and asthma parallels the increase in use of antibiotics. Antibiotics disturb the flora of the gastrointestinal tract, possibly perturbing the developing immune system...
  35. ncbi request reprint Environmental epidemiology of pediatric asthma and allergy
    Christine Cole Johnson
    Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, MI, USA
    Epidemiol Rev 24:154-75. 2002
  36. ncbi request reprint Timing and intensity of early fevers and the development of allergies and asthma
    L Keoki Williams
    Department of Internal Medicine, Center for Health Services Research, Henry Ford Health System, Detroit, MI 48202, USA
    J Allergy Clin Immunol 116:102-8. 2005
    ..Early childhood fevers appear to protect against later allergies and asthma. What is not known is the time in which fevers exert this effect and whether the degree of temperature increase is important...
  37. pmc Gene-environment interactions between CD14 C-260T and endotoxin exposure on Foxp3+ and Foxp3- CD4+ lymphocyte numbers and total serum IgE levels in early childhood
    L Keoki Williams
    Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan 48202, USA
    Ann Allergy Asthma Immunol 100:128-36. 2008
    ..Previously, we described gene-environment interactions between the endotoxin receptor polymorphism C-260T of the CD14 gene and endotoxin exposure on total serum IgE level; however, the mechanism of this interaction is not known...
  38. ncbi request reprint Birth order and cord immunoglobulin E: results using a high-sensitivity immunoglobulin E protocol
    Ganesa Wegienka
    Department of Biostatistics and Research Epidemiology, Henry Ford Hospital, Detroit, Mich 48202, USA
    Int Arch Allergy Immunol 145:305-12. 2008
    ..We further examined the relationship between birth order and cord blood IgE in a racially diverse birth cohort...
  39. ncbi request reprint Should nonatopic asthma get equal attention?
    Dennis R Ownby
    J Allergy Clin Immunol 120:1018-20. 2007
  40. pmc Blood lead level and risk of asthma
    Christine L M Joseph
    Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, Michigan 48202, USA
    Environ Health Perspect 113:900-4. 2005
    ..These results demonstrate the need for further exploration of the complex interrelationships between race, asthma phenotype, genetic susceptibilities, and socioenvironmental exposures, including lead...
  41. ncbi request reprint Airway hyperresponsiveness to methacholine at age 6 to 8 years in nonasthmatic patients is not related to increased health-care utilization for asthma in the ensuing 5 years: a longitudinal study of a birth cohort
    Jaroslaw P Siwik
    Henry Ford Health System, Detroit, MI, USA
    Chest 128:2420-6. 2005
    ..In addition, few studies have examined the relationship of airway hyperresponsiveness (AHR) to indicators of asthma severity such as health-care utilization...
  42. pmc The role of endotoxin and its receptors in allergic disease
    L Keoki Williams
    Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan 48202, USA
    Ann Allergy Asthma Immunol 94:323-32. 2005
    ..To summarize the existing literature on the association of endotoxin with respiratory diseases and allergic sensitization and to review the potentially modifying effects of endotoxin receptor polymorphisms...
  43. pmc Applying epidemiologic concepts of primary, secondary, and tertiary prevention to the elimination of racial disparities in asthma
    Christine L M Joseph
    Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, MI 48202, USA
    J Allergy Clin Immunol 117:233-40; quiz 241-2. 2006
    ..Once causative factors at each level of disease prevention are understood, this knowledge can be translated into clinical practice and public health policy...
  44. pmc Agreement between teenager and caregiver responses to questions about teenager's asthma
    Christine L M Joseph
    Biostatistics and Research Epidemiology, Detroit, Michigan 48202 USA
    J Asthma 43:119-24. 2006
    ..Agreement was weak for perceived asthma control and severity. Teen-caregiver agreement on asthma depends on the type of information being sought...
  45. ncbi request reprint Relationship between adherence to inhaled corticosteroids and poor outcomes among adults with asthma
    L Keoki Williams
    Department of Internal Medicine, Henry Ford Health System, Detoit, MI 48202, USA
    J Allergy Clin Immunol 114:1288-93. 2004
    ..However, overall adherence is poor among patients with asthma. Objective To estimate the proportion of poor asthma-related outcomes attributable to ICS nonadherence...
  46. ncbi request reprint Parental history of atopic disease: disease pattern and risk of pediatric atopy in offspring
    Sharon Hensley Alford
    The Henry Ford Health System, One Ford Place 5C, Detroit, MI 48202, USA
    J Allergy Clin Immunol 114:1046-50. 2004
    ..This approach has been applied in other diseases, such as cancer, to discriminate between predominantly inherited versus environmentally caused (sporadic) cases...
  47. ncbi request reprint Racial differences in allergen sensitivity
    Christine L M Joseph
    Chest 126:1004-5; author reply 1005. 2004
  48. pmc Identifying students with self-report of asthma and respiratory symptoms in an urban, high school setting
    Christine L M Joseph
    Department of Biostatistics and Research Epidemiology, Detroit, MI 48202, USA
    J Urban Health 84:60-9. 2007
    ..Itemized expenses are presented to facilitate modifications to reduce costs. This information may benefit providers, researchers, or administrators targeting similar populations...
  49. ncbi request reprint Race-ethnicity, crime, and other factors associated with adherence to inhaled corticosteroids
    L Keoki Williams
    Department of Internal Medicine, Henry Ford Health System, Detroit, MI 48202, USA
    J Allergy Clin Immunol 119:168-75. 2007
    ..Environmental stressors, such as crime exposure, which has been associated with asthma morbidity, might also predict ICS adherence...
  50. pmc A web-based, tailored asthma management program for urban African-American high school students
    Christine L M Joseph
    Senior Staff Epidemiologist, Henry Ford Health System, Department of Biostatistics and Research Epidemiology, Detroit, MI 48202, USA
    Am J Respir Crit Care Med 175:888-95. 2007
    ..Traditionally, urban youth are believed to be difficult to engage in health-related programs, both in terms of connecting and convincing...
  51. ncbi request reprint Does low birth weight help to explain the increased prevalence of asthma among African-Americans?
    Christine L M Joseph
    Henry Ford Health System, Department of Biostatistics and Research Epidemiology, Detroit, Michigan 48202, USA
    Ann Allergy Asthma Immunol 88:507-12. 2002
    ..Racial disparities in asthma prevalence are not fully explained. Previous studies have reported an association between low birth weight (LBW) and asthma. African-Americans are at a heightened risk for both conditions...