Research Topics
| Michael Foster OliveSummaryAffiliation: Medical University of South Carolina Country: USA Publications
Research Grants
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Detail Information
Publications
Effects of the mGluR2/3 agonist LY379268 and the mGluR5 antagonist MPEP on handling-induced convulsions during ethanol withdrawal in miceM Foster Olive
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences Medical University of South Carolina, Charleston, SC 29425 USA
Alcohol 42:191-7. 2008....- Protein kinase C isozymes as regulators of sensitivity to and self-administration of drugs of abuse-studies with genetically modified miceMichael Foster Olive
Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Behav Pharmacol 21:493-9. 2010.... - Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addictionM Foster Olive
Center for Drug and Alcohol Programs, Department of Psychiatry, Medical University of South Carolina, 67 President Street, MSC 861, Charleston, SC 29425, USA
Eur J Pharmacol 639:47-58. 2010.... - Metabotropic glutamate receptor ligands as potential therapeutics for addictionM Foster Olive
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, MSC 861, Charleston, SC 29425, USA
Curr Drug Abuse Rev 2:83-98. 2009..Finally, we will discuss the current status of mGluR ligands in human clinical trials... - N-Acetylcysteine reverses cocaine-induced metaplasticityKhaled Moussawi
Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue BSB410, Charleston, South Carolina, USA
Nat Neurosci 12:182-9. 2009..Our findings show that cocaine self-administration induces metaplasticity that inhibits further induction of synaptic plasticity, and this impairment can be reversed by NAC, a drug that also prevents relapse... 
Reinstatement of ethanol-seeking behavior following intravenous self-administration in Wistar ratsJustin T Gass
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Alcohol Clin Exp Res 31:1441-5. 2007..However, no studies to date have examined reinstatement of ethanol-seeking behavior in animals with a history of IV ethanol self-administration...- The safety of disulfiram for the treatment of alcohol and cocaine dependence in randomized clinical trials: guidance for clinical practiceRobert Malcolm
Medical University of South Carolina, Institute of Psychiatry, 67 President Street, MSC 861, Charleston, SC 29425, USA
Expert Opin Drug Saf 7:459-72. 2008..Disulfiram has demonstrated efficacy in six randomized clinical trials for the treatment of cocaine dependence, but is rarely used in clinical settings because of safety concerns... - Alcohol-seeking behavior is associated with increased glutamate transmission in basolateral amygdala and nucleus accumbens as measured by glutamate-oxidase-coated biosensorsJustin T Gass
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
Addict Biol 16:215-28. 2011..These results indicate that increases in glutamate transmission in the BLA and NAc core may be a neurochemical substrate of cue-evoked alcohol-seeking behavior... - Role of protein kinase C epsilon (PKCvarepsilon) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shellJustin T Gass
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, MSC 861, Charleston, SC 29425, USA
Psychopharmacology (Berl) 204:587-97. 2009.... - Glutamatergic substrates of drug addiction and alcoholismJustin T Gass
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
Biochem Pharmacol 75:218-65. 2008..Nonetheless, manipulation of glutamatergic neurotransmission appears to be a promising avenue of research in developing improved therapeutic agents for the treatment of drug addiction and alcoholism... - mGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in ratsJustin T Gass
Department of Psychiatry and Behavioral Sciences, Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, SC 29425, USA
Neuropsychopharmacology 34:820-33. 2009.... - Transcriptional profiling of the rat frontal cortex following administration of the mGlu5 receptor antagonists MPEP and MTEPJustin T Gass
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, 29425, USA
Eur J Pharmacol 584:253-62. 2008.... - Positive allosteric modulation of mGluR5 receptors facilitates extinction of a cocaine contextual memoryJustin T Gass
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Biol Psychiatry 65:717-20. 2009..The perseverance of the motivational salience of drug-associated memories is an obstacle to the successful treatment of drug addiction and is often a causative factor in triggering relapse... 
A role for mGluR5 receptors in intravenous methamphetamine self-administrationMegan P H Osborne
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA
Ann N Y Acad Sci 1139:206-11. 2008..These data suggest that mGluR5 receptors are involved in the reinforcing effects of methamphetamine, and that antagonists of this receptor may serve as novel pharmacologic agents for the treatment of addiction to methamphetamine...- Effects of acute acamprosate and homotaurine on ethanol intake and ethanol-stimulated mesolimbic dopamine releaseM Foster Olive
Ernest Gallo Clinic and Research Center, UCSF Department of Neurology, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
Eur J Pharmacol 437:55-61. 2002.... - The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanismM Foster Olive
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, 5858 Horton St, Suite 200, Emeryville, CA 94608, USA
Mol Pharmacol 67:349-55. 2005..Our data indicate that mGluR5 is coupled to PKCepsilon via a PI3K-dependent pathway and that PKCepsilon is required for the ability of the mGluR5 antagonist MPEP to reduce ethanol consumption... - Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, D-amphetamine, and the dopamine reuptake inhibitor GBR12909 in miceAndrew J McGeehan
Department of Neurology, Ernest Gallo Clinic and Research Center, University of California at San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
Psychopharmacology (Berl) 174:266-73. 2004.... - The mGluR5 antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuseAndrew J McGeehan
Department of Neurology, University of California at San Francisco, Emeryville, California 94608, USA
Synapse 47:240-2. 2003..When tested alone at the doses effective in reducing CPP, MPEP produced neither a place preference nor aversion. These data provide further support for a role of the mGluR5 receptor in the rewarding effects of cocaine... - A microdialysis study of extracellular levels of acamprosate and naltrexone in the rat brain following acute and repeated administrationCostanza Burattini
University of California, San Francisco, USA
Addict Biol 13:70-9. 2008.... - Elevated extracellular CRF levels in the bed nucleus of the stria terminalis during ethanol withdrawal and reduction by subsequent ethanol intakeM Foster Olive
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
Pharmacol Biochem Behav 72:213-20. 2002..These data demonstrate that extracellular CRF levels are increased in the BNST during ethanol withdrawal, and that these increases are reduced by subsequent ethanol intake... - The corticotropin-releasing factor/urocortin system and alcoholAndrey E Ryabinin
Department of Behavioral Neuroscience, Oregon Health and Sciences University, Portland 97201 3098, USA
Alcohol Clin Exp Res 26:714-22. 2002..Mehmert, R. Camarini, Joseph A. Kim, Heather N. Koenig, Michelle A. Nannini, and Clyde W. Hodge; and (5) Selective sensitivity of urocortin-containing neurons to alcohol self-administration, by Andrey E. Ryabinin and Ryan K. Bachtell... - The anti-relapse compound acamprosate inhibits the development of a conditioned place preference to ethanol and cocaine but not morphineAndrew J McGeehan
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, 5858 Horton Street, Emeryville, CA 94608, U.S.A
Br J Pharmacol 138:9-12. 2003..These data suggest that acamprosate can suppress the conditioned rewarding effects of ethanol and certain classes of abused substances... - Alcohol addictionM Foster Olive
Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, USA
Methods Mol Biol 233:555-70. 2003 - The anti-craving taurine derivative acamprosate: failure to extinguish morphine conditioned place preferenceM Foster Olive
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, California, USA
Adv Exp Med Biol 526:481-4. 2003 - The glucocorticoid receptor antagonist mifepristone reduces ethanol intake in rats under limited access conditionsHeather N Koenig
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
Psychoneuroendocrinology 29:999-1003. 2004..p.) was without effect on ethanol intake, and neither compound had an effect on water intake. These data confirm an active role of GRs in modulating voluntary ethanol consumption, particularly under conditions of limited access... - Role of the endogenous opioid system on the neuropsychopharmacological effects of ethanol: new insights about an old questionCarles Sanchis-Segura
Howard Florey Institute, University of Melbourne, Australia
Alcohol Clin Exp Res 29:1522-7. 2005..Grisel, Amanda J. Roberts, and George F. Koob; and () The mu-Opioid Receptor Modulates Acute Ethanol Sensitivity and Ethanol Withdrawal Severity by Sandra Ghozland... - Acamprosate attenuates cocaine- and cue-induced reinstatement of cocaine-seeking behavior in ratsM Scott Bowers
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, Emeryville, CA 94608, USA
Psychopharmacology (Berl) 195:397-406. 2007..Acamprosate (calcium acetylhomotaurinate) is a glutamatergic neuromodulator used for the treatment of alcoholism, but its potential efficacy in the treatment of psychostimulant addiction has not been explored...
Research Grants
- Control of Ethanol Intake by an mGluR5-PKCe PathwayM Olive; Fiscal Year: 2009..Further understanding of the contributions of mGluR5 and PKC5 signaling to these behaviors will hopefully translate into improved therapies for the treatment of alcoholism in humans. ..
- Metabotropic Glutamate Receptor Signaling and Extinction LearningM Olive; Fiscal Year: 2009..Such compounds could also be of potential use in extinction therapy of anxiety disorders such as post-traumatic stress disorder. ..
- Metabotropic Glutamate Receptor Signaling and Extinction LearningM Olive; Fiscal Year: 2007..Such compounds could also be of potential use in extinction therapy of anxiety disorders such as post-traumatic stress disorder. ..
- Control of ethanol intake by mGluR5-PKCepsilon pathwayM Olive; Fiscal Year: 2007..Together, these proposed preclinical studies will attempt to delineate a novel pharmacological target that may be used to treat various aspects of alcohol abuse and alcoholism. ..
- Taurine Regulation of Alcohol-Seeking BehaviorM Olive; Fiscal Year: 2004..abstract_text> ..
- mGluR5 antagonists for methamphetamine addictionM Olive; Fiscal Year: 2009....