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Species | Paul M O'ConnorSummaryAffiliation: Medical College of Wisconsin Country: USA Publications
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Publications
Modulation of pressure-natriuresis by renal medullary reactive oxygen species and nitric oxidePaul M O'Connor
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53202, USA
Curr Hypertens Rep 12:86-92. 2010....
A novel amiloride-sensitive h+ transport pathway mediates enhanced superoxide production in thick ascending limb of salt-sensitive rats, not na+/h+ exchangePaul M O'Connor
Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53202, USA
Hypertension 54:248-54. 2009..We concluded that only H(+) efflux through a specific, as-yet-unidentified, amiloride-sensitive H(+) channel promotes O(2)(.-) production in the medullary thick ascending limb and that this channel is upregulated in SS rats...- Enhanced amiloride-sensitive superoxide production in renal medullary thick ascending limb of Dahl salt-sensitive ratsPaul M O'Connor
Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53202, USA
Am J Physiol Renal Physiol 295:F726-33. 2008..Amiloride-sensitive O(2)(-) production is likely to contribute to augmented outer medullary O(2)(-) production observed in SS rats during both normal and high NaCl diets... - Dynamic convergence and divergence of renal genomic and biological pathways in protection from Dahl salt-sensitive hypertensionLimin Lu
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Physiol Genomics 41:63-70. 2010.... - Role of renal perfusion pressure versus angiotensin II on renal oxidative stress in angiotensin II-induced hypertensive ratsAaron J Polichnowski
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Hypertension 55:1425-30. 2010..In summary, this study demonstrates that elevated RPP is directly responsible for the excess albuminuria in Ang II-infused rats, whereas both elevated RPP and Ang II directly contribute to the observed renal oxidative stress... 
Genomic map of cardiovascular phenotypes of hypertension in female Dahl S ratsCarol Moreno
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226-0509, USA
Physiol Genomics 15:243-57. 2003..The development of a female rat systems biology map of cardiovascular function represents the first attempt to prioritize those regions of the genome important for development of hypertension and end organ damage in female rats...- Novel role of fumarate metabolism in dahl-salt sensitive hypertensionZhongmin Tian
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Hypertension 54:255-60. 2009..These data suggest a novel role for fumarate metabolism in salt-induced hypertension and renal medullary oxidative stress... - Effect of sodium delivery on superoxide and nitric oxide in the medullary thick ascending limbMichiaki Abe
Dept. of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Am J Physiol Renal Physiol 291:F350-7. 2006..This may lead to reduction in medullary blood flow and promote hypoxia and tubular necrosis within the renal medulla during in hypertension... - Multiple blood pressure loci on rat chromosome 13 attenuate development of hypertension in the Dahl S hypertensive ratCarol Moreno
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53266, USA
Physiol Genomics 31:228-35. 2007..We conclude from these studies that there are four regions within chromosome 13 containing genes that interact epistatically and influence arterial pressure... - Increased renal medullary H2O2 leads to hypertensionAyako Makino
Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Hypertension 42:25-30. 2003.... - Enhanced superoxide production in renal outer medulla of Dahl salt-sensitive rats reduces nitric oxide tubular-vascular cross-talkTakefumi Mori
Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Hypertension 49:1336-41. 2007..Diffusion of O(2)(*-) from mTAL to surrounding tissue could contribute to reduced bioavailability of NO, reductions of medullary blood flow, and interstitial fibrosis in the outer medulla of SS/Mcwi rats... - Effects of renal perfusion pressure on renal medullary hydrogen peroxide and nitric oxide productionChunhua Jin
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Hypertension 53:1048-53. 2009.... - Identifying physiological origins of baroreflex dysfunction in salt-sensitive hypertension in the Dahl SS ratScott M Bugenhagen
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Physiol Genomics 42:23-41. 2010.... - Consomic strategies to localize genomic regions related to vascular reactivity in the Dahl salt-sensitive ratMary Pat Kunert
University of Wisconsin Milwaukee, College of Nursing, Milwaukee, Wisconsin 53211, USA
Physiol Genomics 26:218-25. 2006..Because the BN chromosome is removed from its native background and the SS rat loses a native chromosome, it is also necessary to consider the contribution of changes in gene-to-gene interaction... - High perfusion pressure accelerates renal injury in salt-sensitive hypertensionTakefumi Mori
Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
J Am Soc Nephrol 19:1472-82. 2008..We conclude that elevations of RPP contribute significantly to the fibrosis and epithelial-to-mesenchymal transition found in the early phases of hypertension in the salt-sensitive rat... - Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertensionDi Feng
Physiology Department, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Cell Metab 15:201-8. 2012..These rats exhibited a significant reduction of salt-sensitive hypertension and renal medullary oxidative stress and injury. p67(phox) could represent a target for salt-sensitive hypertension therapy... - Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin IIMagdalena Alonso-Galicia
Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 59226, USA
Am J Physiol Regul Integr Comp Physiol 283:R60-8. 2002.... - Angiotensin II-NAD(P)H oxidase-stimulated superoxide modifies tubulovascular nitric oxide cross-talk in renal outer medullaTakefumi Mori
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Hypertension 42:588-93. 2003..We conclude that AngII stimulates O2*- production in mTAL via the NAD(P)H oxidase pathway and that interactions of O2*- and NO ultimately determine the effectiveness of in situ free-radical cross-talk between the mTAL and the VR... - Gene expression reveals vulnerability to oxidative stress and interstitial fibrosis of renal outer medulla to nonhypertensive elevations of ANG IIBaozhi Yuan
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Am J Physiol Regul Integr Comp Physiol 284:R1219-30. 2003.... - Pressure-induced renal injury in angiotensin II versus norepinephrine-induced hypertensive ratsAaron J Polichnowski
Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Hypertension 54:1269-77. 2009.... - Renal medullary microRNAs in Dahl salt-sensitive rats: miR-29b regulates several collagens and related genesYong Liu
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wis, USA
Hypertension 55:974-82. 2010..The result demonstrated broad effects of miR-29b on a large number of collagens and genes related to the extracellular matrix and suggested involvement of miR-29b in the protection from renal medullary injury in SS-13(BN) rats... - NAD(P)H oxidase and renal epithelial ion transportCarlos Schreck
Mount Sinai School of Medicine, New York, NY, USA
Am J Physiol Regul Integr Comp Physiol 300:R1023-9. 2011..We will first review the role of NADPH oxidase on renal Na(+) and K(+) transport. Finally, we will review the relationship between tubular H(+) efflux and NADPH oxidase activity... - Increased H(2)O(2) counteracts the vasodilator and natriuretic effects of superoxide dismutation by tempol in renal medullaYa-Fei Chen
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Am J Physiol Regul Integr Comp Physiol 285:R827-33. 2003..This counteracting effect of H2O2 may limit the use of tempol as an antihypertensive agent under exaggerated oxidative stress in the kidney... - Renal regional proteomes in young Dahl salt-sensitive ratsZhongmin Tian
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Hypertension 51:899-904. 2008.... - Renal medullary tissue oxygenation is dependent on both cortical and medullary blood flowPaul M O'Connor
Dept of Physiology, Medical College of Wisconsin, 8071 Watertown Plank Road, Milwaukee, WI 53266, USA
Am J Physiol Renal Physiol 290:F688-94. 2006..Thus, although cortical and medullary blood flow may be independently regulated, medullary oxygenation may be compromised during moderate to severe cortical ischemia even when medullary blood flow is maintained... - Efficient transgenic rat production by a lentiviral vectorMieczyslaw Michalkiewicz
Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Am J Physiol Heart Circ Physiol 293:H881-94. 2007..Thus lentiviral transgenesis provides a powerful tool for the production of transgenic inbred rats and will enhance the usefulness of this species in gene discovery and target validation studies... - Renal medullary genes in salt-sensitive hypertension: a chromosomal substitution and cDNA microarray studyMingyu Liang
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Physiol Genomics 8:139-49. 2002..These results should provide an informative source for designing future functional studies in salt-sensitive hypertension... - Renal medullary oxidative stress, pressure-natriuresis, and hypertensionAllen W Cowley
Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Hypertension 52:777-86. 2008 - Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH ratsDavid L Mattson
Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Am J Physiol Renal Physiol 293:F1905-14. 2007..The present data indicate that genes that can modify l-NAME-induced hypertension and proteinuria are on chromosomes 1, 15, 16, 18, and 20... - Renal injury in angiotensin II+L-NAME-induced hypertensive rats is independent of elevated blood pressureAaron J Polichnowski
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Am J Physiol Renal Physiol 300:F1008-16. 2011.... - Molecular networks in Dahl salt-sensitive hypertension based on transcriptome analysis of a panel of consomic ratsMingyu Liang
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Physiol Genomics 34:54-64. 2008.... - Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal diseaseDavid L Mattson
Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Am J Physiol Renal Physiol 295:F837-42. 2008..Furthermore, this consomic rat panel provides a stable genetic platform that can facilitate further gene mapping by either linkage studies or the breeding of congenic and subcongenic rats... - MicroRNA: a new frontier in kidney and blood pressure researchMingyu Liang
Dept of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Am J Physiol Renal Physiol 297:F553-8. 2009..Further progress in the understanding of miRNA biogenesis and action and technical improvements for target identification and miRNA manipulation will be important for studying miRNAs in renal function and blood pressure regulation... - NO synthase uncoupling in the kidney of Dahl S rats: role of dihydrobiopterinNorman E Taylor
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Hypertension 48:1066-71. 2006..Based on the shift of BH(4) to BH(2) and the observation of l-NAME inhibitable superoxide production, we conclude that NOS uncoupling occurs in the renal medulla of hypertensive SS rats fed a high-salt diet... - The genetic dissection of essential hypertensionAllen W Cowley
Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
Nat Rev Genet 7:829-40. 2006..Together with the computational reconstruction of regulatory networks, these methods provide opportunities to significantly advance our understanding of the underlying aetiology of hypertension... - Renal oxidative stress in medullary thick ascending limbs produced by elevated NaCl and glucoseTakefumi Mori
Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Hypertension 43:341-6. 2004..We conclude that elevations of extracellular NaCl, D-glucose, or T3 levels can activate both the Na+/K+-ATPase pump and Na+/H+ exchanger in mTAL, which, in turn, is associated with increased intracellular concentrations of superoxide... - Application of chromosomal substitution techniques in gene-function discoveryAllen W Cowley
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
J Physiol 554:46-55. 2004..Consomic rat strains are proving to be a unique scientific resource that greatly extends our understanding of genes and complex normal and pathological function... - High throughput gene expression profiling: a molecular approach to integrative physiologyMingyu Liang
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
J Physiol 554:22-30. 2004..With a keen sense of homeostasis, global regulation, and quantitative analysis, integrative physiologists are uniquely positioned to apply these techniques to enhance the understanding of complex physiological functions... - Influence of diet and genetics on hypertension and renal disease in Dahl salt-sensitive ratsDavid L Mattson
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Physiol Genomics 16:194-203. 2004..These data demonstrate a significant influence of diet composition on salt-induced hypertension and renal disease in the Dahl SS/Mcw rat... - Quantitative assessment of the importance of dye switching and biological replication in cDNA microarray studiesMingyu Liang
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Physiol Genomics 14:199-207. 2003..Recommendations regarding the use of these procedures were proposed... - Role of renal NO production in the regulation of medullary blood flowAllen W Cowley
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Am J Physiol Regul Integr Comp Physiol 284:R1355-69. 2003..It is concluded that NO production in the renal medulla plays a very important role in sodium and water homeostasis and the long-term control of arterial pressure... - Insights into Dahl salt-sensitive hypertension revealed by temporal patterns of renal medullary gene expressionMingyu Liang
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Physiol Genomics 12:229-37. 2003.... - Identification of hypertension-related QTLs in African American sib pairsTheodore A Kotchen
Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA
Hypertension 40:634-9. 2002..Focusing on hypertension-related phenotypes is a promising approach for identifying the genetic determinants of hypertension... - Tubulovascular nitric oxide crosstalk: buffering of angiotensin II-induced medullary vasoconstrictionJeffrey G Dickhout
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wis 53226, USA
Circ Res 91:487-93. 2002..We conclude that Ang II increases [Ca2+]i in pericytes of the descending vasa recta as part of its constrictor action and that this vasoconstriction is buffered by the NO from the surrounding tubular elements, such as mTALs... - Role of pressure in angiotensin II-induced renal injury: chronic servo-control of renal perfusion pressure in ratsTakefumi Mori
Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Hypertension 43:752-9. 2004..We conclude that the preferential juxtamedullary injury found in Ang II hypertension is largely induced by pressure and is probably mediated through the TGF-beta and NF-kappaB pathway... - Vasopressin increases intracellular NO concentration via Ca(2+) signaling in inner medullary collecting ductTakefumi Mori
Department of Physiology, Medical College of Wisconsin, Milwaukee 53326, USA
Hypertension 39:465-9. 2002..We conclude that AVP mobilizes Ca(2+) to produce NO in IMCDs... - Transcriptome analysis and kidney research: toward systems biologyMingyu Liang
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Kidney Int 67:2114-22. 2005.... - NADPH oxidase in the renal medulla causes oxidative stress and contributes to salt-sensitive hypertension in Dahl S ratsNorman E Taylor
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Hypertension 47:692-8. 2006..We conclude that excess renal medullary superoxide production in SS rats contributes to salt-induced hypertension, and NADPH oxidase is the major source of the excess superoxide... - Physiology and genomics: toward systems biologyAllen W Cowley
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Sheng Li Xue Bao 58:1-4. 2006.... - BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced ratAnne E Kwitek
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Physiol Genomics 25:303-13. 2006..These data provide a baseline for physiological comparison of traits related to cardiovascular, lung, blood, and renal function in the sequenced BN rats relative to the major strains of rats studied in biomedical research... - Effect of renal medullary H2O2 on salt-induced hypertension and renal injuryNorman E Taylor
Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Am J Physiol Regul Integr Comp Physiol 289:R1573-9. 2005..These data show that medullary production of H2O2 may contribute to salt-induced hypertension in SS rats and that chromosome 13 of the Brown Norway contains gene(s) that protect against renal medullary oxidant stress... - Substitution of chromosome 1 ameliorates L-NAME hypertension and renal disease in the fawn-hooded hypertensive ratDavid L Mattson
Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Am J Physiol Renal Physiol 288:F1015-22. 2005..Qualitatively similar results were obtained from female FHH, FHH-1BN, and BN rats. The present results indicate that genes contributing to l-NAME-induced hypertension and renal disease are found on chromosome 1 of the FHH rat... - Vasopressin-induced nitric oxide production in rat inner medullary collecting duct is dependent on V2 receptor activation of the phosphoinositide pathwayPaul M O'Connor
Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Am J Physiol Renal Physiol 293:F526-32. 2007..We conclude that AVP-induced NO production in IMCD is dependent on V2R activation of the phosphoinositide pathway and the mobilization of Ca(2+) from both intracellular and extracellular pools... - Structural antioxidant defense mechanisms in the mammalian and nonmammalian kidney: different solutions to the same problem?Paul M O'Connor
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Am J Physiol Regul Integr Comp Physiol 299:R723-7. 2010..Thus, we hypothesize the evolution of structural antioxidant mechanisms that are anatomically divergent but functionally homologous in the mammalian and nonmammalian kidney... - Hyperaldosteronism and hypertension: ethnic differencesClarence E Grim
Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Hypertension 45:766-72. 2005..These observations are consistent with the hypothesis that aldosterone-induced volume expansion is an important contributor to hypertension, especially in blacks... - Increased renal medullary oxidative stress produces hypertensionAyako Makino
Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
Hypertension 39:667-72. 2002..The present experiments indicate that an increase in superoxide concentration within the renal medulla selectively reduces medullary blood flow resulting in chronic hypertension... - Renal oxygen delivery: matching delivery to metabolic demandPaul M O'Connor
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53202, USA
Clin Exp Pharmacol Physiol 33:961-7. 2006..The roles of these mechanisms in the control of renal oxygenation, as well as how dysfunction of these mechanisms may lead to renal hypoxia, are discussed... - Genomics and homeostasisAllen W Cowley
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Am J Physiol Regul Integr Comp Physiol 284:R611-27. 2003..The previously unimaginable goal of connecting approximately 36,000 genes to the complex functions of mammalian systems is indeed well underway... - Identification of persistently altered gene expression in the kidney after functional recovery from ischemic acute renal failureDavid P Basile
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Am J Physiol Renal Physiol 288:F953-63. 2005..In summary, genes with known inflammatory, remodeling, and vasoactive activities were identified in rat kidneys after recovery from ARF, some of which may play a role in altering long-term renal function after recovery from ARF... - Cytochrome P-450-dependent metabolism of arachidonic acid in the kidney of rats with diabetes insipidusAlbert Sarkis
Department of Physiology, Medical College of Wisconsin, Milwaukee, 53226, USA
Am J Physiol Renal Physiol 289:F1333-40. 2005....