WILLIAM J O'BRIEN

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi Expression of NADPH oxidase in rabbit corneal epithelial and stromal cells in culture
    WILLIAM J O'BRIEN
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, USA
    Invest Ophthalmol Vis Sci 47:853-63. 2006
  2. ncbi NADPH oxidase expression and production of superoxide by human corneal stromal cells
    WILLIAM J O'BRIEN
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI, USA
    Mol Vis 15:2535-43. 2009
  3. ncbi Expression of NADPH oxidase (NOX) 5 in rabbit corneal stromal cells
    Farhan Rizvi
    Departments of Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 7:e34440. 2012
  4. ncbi Properties of fiber cell plasma membranes isolated from the cortex and nucleus of the porcine eye lens
    Laxman Mainali
    Department of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Exp Eye Res 97:117-29. 2012
  5. ncbi Mitochondrial dysfunction links ceramide activated HRK expression and cell death
    Farhan Rizvi
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 6:e18137. 2011

Research Grants

  1. PATHOGENESIS OF HERPETIC KERATITIS
    WILLIAM O BRIEN; Fiscal Year: 2002
  2. Superoxide Production and Functions in Corneal Cells
    WILLIAM O BRIEN; Fiscal Year: 2007
  3. Superoxide Production and Functions in Corneal Cells
    WILLIAM J O apos BRIEN; Fiscal Year: 2010

Collaborators

  • Farhan Rizvi
  • WILLIAM O BRIEN
  • WILLIAM J O apos BRIEN
  • Laxman Mainali
  • Marija Raguz
  • Witold K Subczynski

Detail Information

Publications5

  1. ncbi Expression of NADPH oxidase in rabbit corneal epithelial and stromal cells in culture
    WILLIAM J O'BRIEN
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, USA
    Invest Ophthalmol Vis Sci 47:853-63. 2006
    ..The purpose of these studies was to determine whether corneal epithelial and stromal cells are capable of producing O2-* via an NADPH oxidase complex...
  2. ncbi NADPH oxidase expression and production of superoxide by human corneal stromal cells
    WILLIAM J O'BRIEN
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI, USA
    Mol Vis 15:2535-43. 2009
    ..via nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, a family of protein complexes believed to be responsible for the localized and limited production of O(2) (.-) with regulatory activity...
  3. ncbi Expression of NADPH oxidase (NOX) 5 in rabbit corneal stromal cells
    Farhan Rizvi
    Departments of Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 7:e34440. 2012
    ..Several isoforms of NOXes function as multi-protein complexes while NOX5 and DUOXs do not require the accessory proteins for their activity and possess calcium binding EF hands...
  4. ncbi Properties of fiber cell plasma membranes isolated from the cortex and nucleus of the porcine eye lens
    Laxman Mainali
    Department of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Exp Eye Res 97:117-29. 2012
    ..It is concluded that formation of rigid and practically impermeable domains is enhanced in the lens nucleus, indicating changes in membrane composition that may help to maintain low oxygen concentration in this lens region...
  5. ncbi Mitochondrial dysfunction links ceramide activated HRK expression and cell death
    Farhan Rizvi
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 6:e18137. 2011
    ..We have undertaken the present study to investigate the mechanism of death induced by C6 ceramide in cultures of human corneal stromal (HCSF) fibroblasts...

Research Grants7

  1. PATHOGENESIS OF HERPETIC KERATITIS
    WILLIAM O BRIEN; Fiscal Year: 2002
    ..The long-term goal is to understand the pathogenesis of edema in order to develop effective and specific alternatives to corticosteroids for the therapy of HSV-induced edema and stromal disease. ..
  2. Superoxide Production and Functions in Corneal Cells
    WILLIAM O BRIEN; Fiscal Year: 2007
    ..Completing the aims of this grant will provide insight required to develop new drugs to regulate superoxide production and maintain the corneal function following infection, injury or surgery. ..
  3. Superoxide Production and Functions in Corneal Cells
    WILLIAM J O apos BRIEN; Fiscal Year: 2010
    ..Completing the aims of this grant will provide insight required to develop new drugs to regulate superoxide production and maintain the corneal function following infection, injury or surgery. ..