James C Oates

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. pmc Endothelial nitric oxide synthase reduces crescentic and necrotic glomerular lesions, reactive oxygen production, and MCP1 production in murine lupus nephritis
    Gary S Gilkeson
    Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America
    PLoS ONE 8:e64650. 2013
  2. pmc Overcoming the effects of matrix interference in the measurement of urine protein analytes
    Timothy P Taylor
    Medical University of South Carolina, Department of Medicine, Division of Nephrology, 96 Jonathan Lucas St, 829 Clinical Science Building, Charleston, SC 29425
    Biomark Insights 7:1-8. 2012
  3. pmc Altered monocyte and fibrocyte phenotype and function in scleroderma interstitial lung disease: reversal by caveolin-1 scaffolding domain peptide
    Elena Tourkina
    Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA
    Fibrogenesis Tissue Repair 4:15. 2011
  4. pmc Selective cyclooxygenase-2 inhibitor suppresses renal thromboxane production but not proliferative lesions in the MRL/lpr murine model of lupus nephritis
    Jim C Oates
    Ralph H Johnson VA Medical Center, Charleston, South Carolina, USA
    Am J Med Sci 341:101-5. 2011
  5. pmc The biology of reactive intermediates in systemic lupus erythematosus
    Jim C Oates
    Medical Service, Ralph H Johnson VA Medical Center, Charleston, SC 29425, USA
    Autoimmunity 43:56-63. 2010
  6. pmc Association of serum nitrate and nitrite levels with longitudinal assessments of disease activity and damage in systemic lupus erythematosus and lupus nephritis
    Jim C Oates
    Medical University of South Carolina, Charleston, South Carolina, USA
    Arthritis Rheum 58:263-72. 2008
  7. pmc Association of reactive oxygen and nitrogen intermediate and complement levels with apoptosis of peripheral blood mononuclear cells in lupus patients
    James C Oates
    Medical University of South Carolina, Department of Medicine, Division of Rheumatology, Charleston, SC 29425, USA
    Arthritis Rheum 56:3738-47. 2007
  8. ncbi request reprint Peroxisome proliferator-activated receptor gamma agonists: potential use for treating chronic inflammatory diseases
    James C Oates
    Medical Research Service, Ralph H Johnson VA Medical Center and the Medical University of South Carolina, Charleston 29425, USA
    Arthritis Rheum 46:598-605. 2002
  9. pmc The biology of nitric oxide and other reactive intermediates in systemic lupus erythematosus
    Jim C Oates
    Department of Medicine, Division of Rheumatology, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 912, PO Box 250637, Charleston, SC 29425, USA
    Clin Immunol 121:243-50. 2006
  10. ncbi request reprint Nitric oxide induces apoptosis in spleen lymphocytes from MRL/lpr mice
    Jim C Oates
    Medical University of South Carolina, Department of Medicine, Division of Rheumatology, 96 Jonathan Lucas Street, Suite 912, PO Box 250637, Charleston, SC 29425, USA
    J Investig Med 52:62-71. 2004

Research Grants

Collaborators

Detail Information

Publications19

  1. pmc Endothelial nitric oxide synthase reduces crescentic and necrotic glomerular lesions, reactive oxygen production, and MCP1 production in murine lupus nephritis
    Gary S Gilkeson
    Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America
    PLoS ONE 8:e64650. 2013
    ..These results suggest that modulation of eNOS may be a novel therapeutic approach to treating lupus nephritis...
  2. pmc Overcoming the effects of matrix interference in the measurement of urine protein analytes
    Timothy P Taylor
    Medical University of South Carolina, Department of Medicine, Division of Nephrology, 96 Jonathan Lucas St, 829 Clinical Science Building, Charleston, SC 29425
    Biomark Insights 7:1-8. 2012
    ..Therefore, dilution can be used as an effective technique for over-coming urine matrix effects in urine immunoassays. These results may be applicable to other biological fluids in which matrix components interfere with assay performance...
  3. pmc Altered monocyte and fibrocyte phenotype and function in scleroderma interstitial lung disease: reversal by caveolin-1 scaffolding domain peptide
    Elena Tourkina
    Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA
    Fibrogenesis Tissue Repair 4:15. 2011
    ....
  4. pmc Selective cyclooxygenase-2 inhibitor suppresses renal thromboxane production but not proliferative lesions in the MRL/lpr murine model of lupus nephritis
    Jim C Oates
    Ralph H Johnson VA Medical Center, Charleston, South Carolina, USA
    Am J Med Sci 341:101-5. 2011
    ....
  5. pmc The biology of reactive intermediates in systemic lupus erythematosus
    Jim C Oates
    Medical Service, Ralph H Johnson VA Medical Center, Charleston, SC 29425, USA
    Autoimmunity 43:56-63. 2010
    ..Understanding this interaction will be essential to determine mechanisms through which reactive intermediates induce cellular autoimmunity and contribute to a sustained innate immune response and organ damage in SLE...
  6. pmc Association of serum nitrate and nitrite levels with longitudinal assessments of disease activity and damage in systemic lupus erythematosus and lupus nephritis
    Jim C Oates
    Medical University of South Carolina, Charleston, South Carolina, USA
    Arthritis Rheum 58:263-72. 2008
    ..This study was undertaken to determine whether a marker of systemic nitric oxide (NO) production correlates with prospectively studied disease activity in human systemic lupus erythematosus (SLE) and lupus nephritis patients...
  7. pmc Association of reactive oxygen and nitrogen intermediate and complement levels with apoptosis of peripheral blood mononuclear cells in lupus patients
    James C Oates
    Medical University of South Carolina, Department of Medicine, Division of Rheumatology, Charleston, SC 29425, USA
    Arthritis Rheum 56:3738-47. 2007
    ..The objective of this study was to evaluate both processes in a parallel, prospective, longitudinal manner...
  8. ncbi request reprint Peroxisome proliferator-activated receptor gamma agonists: potential use for treating chronic inflammatory diseases
    James C Oates
    Medical Research Service, Ralph H Johnson VA Medical Center and the Medical University of South Carolina, Charleston 29425, USA
    Arthritis Rheum 46:598-605. 2002
  9. pmc The biology of nitric oxide and other reactive intermediates in systemic lupus erythematosus
    Jim C Oates
    Department of Medicine, Division of Rheumatology, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 912, PO Box 250637, Charleston, SC 29425, USA
    Clin Immunol 121:243-50. 2006
    ..Therapies designed to target iNOS activity or scavenge ROI and RNI are in development and may provide the means to reduce the pathogenic consequences of ROI and RNI in SLE...
  10. ncbi request reprint Nitric oxide induces apoptosis in spleen lymphocytes from MRL/lpr mice
    Jim C Oates
    Medical University of South Carolina, Department of Medicine, Division of Rheumatology, 96 Jonathan Lucas Street, Suite 912, PO Box 250637, Charleston, SC 29425, USA
    J Investig Med 52:62-71. 2004
    ..In vitro administration of NO may induce or decrease apoptosis depending on the cell type. Therefore, we hypothesized that NO induces MRL/lpr spleen lymphocyte apoptosis independent of Fas receptor engagement...
  11. ncbi request reprint Mediators of injury in lupus nephritis
    Jim C Oates
    Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
    Curr Opin Rheumatol 14:498-503. 2002
    ..In this article, the authors review recent reports that advance our understanding of LN disease mediators, from autoantibody production and immune complex deposition to end stage fibrosis...
  12. ncbi request reprint Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americans
    Jim C Oates
    Department of Medicine, Ralph H Johnson VA Medical Center VAMC and Medical University of South Carolina, Charleston 29425, USA
    J Rheumatol 30:60-7. 2003
    ..This study was designed to determine if these polymorphisms are associated with SLE...
  13. ncbi request reprint Inducible nitric oxide synthase inhibitors reduce urinary markers of systemic oxidant stress in murine proliferative lupus nephritis
    Chinedu J Njoku
    Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, USA
    J Investig Med 53:347-52. 2005
    ..We hypothesized that inhibition of iNOS activity would reduce ROS production in murine PLN...
  14. pmc Prediction of urinary protein markers in lupus nephritis
    Jim C Oates
    Department of Medicine, Medical University of South Carolina and Ralph H Johnson VA Medical Center, Charleston, Charleston, SC 29425, USA
    Kidney Int 68:2588-92. 2005
    ..Renal biopsy is currently the only way to accurately predict class and activity and chronicity indices. We propose to use patterns of abundance of urine proteins to identify class and disease indices...
  15. ncbi request reprint Distinct PKC isoforms mediate cell survival and DNA synthesis in thrombin-induced myofibroblasts
    Galina S Bogatkevich
    Division of Rheumatology and Immunology, Dept of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Physiol Lung Cell Mol Physiol 288:L190-201. 2005
    ..These data demonstrate that two distinct PKC isoforms mediate thrombin-induced resistance to apoptosis and proliferation and suggest that p21Cip1/WAF1 promotes both phenomena...
  16. pmc Inducible nitric oxide synthase inhibitor SD-3651 reduces proteinuria in MRL/lpr mice deficient in the NOS2 gene
    Chinedu Njoku
    Department of Medicine, Division of Rheumatology, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29525, USA
    J Investig Med 56:911-9. 2008
    ..Studies that elucidate this mechanism could provide a useful drug target for the treatment of nephritis...
  17. pmc Urine biomarkers predict the cause of glomerular disease
    Sanju A Varghese
    Department of Medicine, Division of Nephrology, Medical University of South Carolina, 96 Jonathan Lucas Street, P O Box 250623, Charleston, SC 29425, USA
    J Am Soc Nephrol 18:913-22. 2007
    ..The fingerprint of urine protein charge forms identifies the glomerular disease. The identified proteins are candidate biomarkers that can be tested in assays that are more amenable to clinical testing...
  18. pmc Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry
    Paula S Ramos
    Department of Medicine, Medical University of South Carolina, Charleston, SC, USA
    J Rheumatol 40:842-9. 2013
    ..We analyzed variation in reactive intermediate genes for association with SLE in 2 populations with African ancestry...
  19. ncbi request reprint Oral administration of a decaffeinated green tea (Camellia sinensis) extract did not alter urinary 8-epi-prostaglandin F(2 alpha), a biomarker for in-vivo lipid peroxidation
    Jennifer L Donovan
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    J Pharm Pharmacol 57:1365-9. 2005
    ..There were no significant differences in the excretion of urinary 8-epi-PGF(2 alpha) after treatment with green tea. We conclude that 14 days of green tea supplementation did not significantly alter in-vivo lipid peroxidation...

Research Grants2

  1. Role of nitric oxide and eicosanoids in lupus nepthritis
    James Oates; Fiscal Year: 2005
    ..In either event, future studies would address the use of selective COX-2 or TXA2 synthase inhibitors/receptor blockers, antioxidants, and/or PGI2/PGE2 agonists in conduction with iNOS inhibitors as therapies for LN. ..
  2. Urine protein markers of disease in lupus nephritis
    James Oates; Fiscal Year: 2005
    ..Due to the power of proteomic and ANN techniques, novel mediators of disease activity and damage should be identified and thus contribute to the development of more targeted therapies for LN. ..