Kasem Nithipatikom

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Requirement of cyclooxygenase-2 expression and prostaglandins for human prostate cancer cell invasion
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Clin Exp Metastasis 19:593-601. 2002
  2. ncbi request reprint 2-arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasion
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Cancer Res 64:8826-30. 2004
  3. pmc Inhibition of carcinoma cell motility by epoxyeicosatrienoic acid (EET) antagonists
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Cancer Sci 101:2629-36. 2010
  4. ncbi request reprint Characterization and application of Raman labels for confocal Raman microspectroscopic detection of cellular proteins in single cells
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Anal Biochem 322:198-207. 2003
  5. ncbi request reprint Elevated 12- and 20-hydroxyeicosatetraenoic acid in urine of patients with prostatic diseases
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Cancer Lett 233:219-25. 2006
  6. pmc Anti-proliferative effect of a putative endocannabinoid, 2-arachidonylglyceryl ether in prostate carcinoma cells
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Prostaglandins Other Lipid Mediat 94:34-43. 2011
  7. pmc A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Biochem Biophys Res Commun 332:1028-33. 2005
  8. pmc Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cells
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Endocrinology 153:29-41. 2012
  9. ncbi request reprint Liquid chromatographic-mass spectrometric determination of cyclooxygenase metabolites of arachidonic acid in cultured cells
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee 53226, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 785:135-45. 2003
  10. ncbi request reprint Effects of selective inhibition of cytochrome P-450 omega-hydroxylases and ischemic preconditioning in myocardial protection
    Kasem Nithipatikom
    Dept of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 290:H500-5. 2006

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Requirement of cyclooxygenase-2 expression and prostaglandins for human prostate cancer cell invasion
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Clin Exp Metastasis 19:593-601. 2002
    ..Further, PGD2 may represent a weak inhibitor and counteracts the effect of PGE2 in the cell invasion...
  2. ncbi request reprint 2-arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasion
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Cancer Res 64:8826-30. 2004
    ..The results suggest that cellular 2-AG, acting through the CB1 receptor, is an endogenous inhibitor of invasive prostate cancer cells...
  3. pmc Inhibition of carcinoma cell motility by epoxyeicosatrienoic acid (EET) antagonists
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Cancer Sci 101:2629-36. 2010
    ....
  4. ncbi request reprint Characterization and application of Raman labels for confocal Raman microspectroscopic detection of cellular proteins in single cells
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Anal Biochem 322:198-207. 2003
    ..8 nm. The detection of 12-lipoxygenase and cyclooxygenase-1 in single bovine coronary artery endothelial cells and the binding of angiotensin II to its receptors in zona glomerulosa cells was demonstrated...
  5. ncbi request reprint Elevated 12- and 20-hydroxyeicosatetraenoic acid in urine of patients with prostatic diseases
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Cancer Lett 233:219-25. 2006
    ..These results suggest that urinary free acids of 12-HETE and 20-HETE indicate an abnormality of the prostate gland...
  6. pmc Anti-proliferative effect of a putative endocannabinoid, 2-arachidonylglyceryl ether in prostate carcinoma cells
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Prostaglandins Other Lipid Mediat 94:34-43. 2011
    ..These results indicate therapeutic potentials of EC hydrolysis inhibitors and the enzymatically stable NE in prostate cancer...
  7. pmc A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Biochem Biophys Res Commun 332:1028-33. 2005
    ..These results demonstrate a new series of 2-AG hydrolysis inhibitors as a potential therapeutic approach for prostate cancer...
  8. pmc Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cells
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Endocrinology 153:29-41. 2012
    ..These results indicate the unique CB1 signaling and support the model that EC, through their autocrine activation of CB1 and subsequent repression of RhoA activity, suppress migration in prostate carcinoma cells...
  9. ncbi request reprint Liquid chromatographic-mass spectrometric determination of cyclooxygenase metabolites of arachidonic acid in cultured cells
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee 53226, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 785:135-45. 2003
    ..6-Keto-PGF(1alpha) was the major metabolite in these cells. The production of PGE(2) was threefold higher and PGD(2) was twofold higher in PC-3-S (invasive) cells than in PC-3-U (non-invasive) cells...
  10. ncbi request reprint Effects of selective inhibition of cytochrome P-450 omega-hydroxylases and ischemic preconditioning in myocardial protection
    Kasem Nithipatikom
    Dept of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 290:H500-5. 2006
    ....
  11. ncbi request reprint Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury
    Kasem Nithipatikom
    Dept of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 291:H537-42. 2006
    ..Finally, the protective effects of EETs are mediated by cardiac K(ATP) channels...
  12. pmc Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism
    Michael P Endsley
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA
    Int J Cancer 121:984-91. 2007
    ..Therefore, inhibitors of 2-AG hydrolysis could potentially serve as therapeutic agents for the treatment of prostate cancer. (c) 2007 Wiley-Liss, Inc...
  13. pmc Adrenic acid metabolites as endogenous endothelium-derived and zona glomerulosa-derived hyperpolarizing factors
    Phillip G Kopf
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wis 53226, USA
    Hypertension 55:547-54. 2010
    ..Thus, adrenic acid metabolites could function as endogenous endothelium-derived and zona glomerulosa-derived hyperpolarizing factors in the adrenal cortex and contribute to the regulation of adrenal blood flow...
  14. pmc Expression and function of fatty acid amide hydrolase in prostate cancer
    Michael P Endsley
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Cancer 123:1318-26. 2008
    ..These results suggest that FAAH regulates 2-AG hydrolysis and invasion of prostate carcinoma cells and is potentially involved in prostate tumorigenesis...
  15. pmc Evidence for role of epoxyeicosatrienoic acids in mediating ischemic preconditioning and postconditioning in dog
    Garrett J Gross
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 297:H47-52. 2009
    ..These results suggest a unique role for endogenous EETs in both IPC and POC...
  16. pmc Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart
    Garrett J Gross
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 294:H2838-44. 2008
    ..These data also suggest that 14,15-EEZE is not blocking the mitochondrial ATP-sensitive potassium channel as a mechanism for antagonizing the cardioprotective effects of the EETs...
  17. ncbi request reprint Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 288:H1344-51. 2005
    ..2-AG is further hydrolyzed to AA, which is metabolized to vasoactive eicosanoids. These studies reveal a role for 2-AG in EC AA release and the regulation of coronary tone...
  18. ncbi request reprint Inhibition of cytochrome P450omega-hydroxylase: a novel endogenous cardioprotective pathway
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Circ Res 95:e65-71. 2004
    ..The full text of this article is available online at http://circres.ahajournals.org...
  19. pmc Acute and chronic cardioprotection by the enkephalin analogue, Eribis peptide 94, is mediated via activation of nitric oxide synthase and adenosine triphosphate-regulated potassium channels
    Garrett J Gross
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Pharmacology 90:110-6. 2012
    ..Eribis peptide 94 (EP 94) is a new enkephalin derivative which potently binds to the µ- and δ-opioid receptor. In this study, we determined the effects of EP 94 and potential mechanism(s) involved in cardioprotection of the rat heart...
  20. doi request reprint Identification of 15-hydroxy-11,12-epoxyeicosatrienoic acid as a vasoactive 15-lipoxygenase metabolite in rabbit aorta
    Yuttana Chawengsub
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 294:H1348-56. 2008
    ..These results indicate that 15-H-11,12-EETA is produced by the aorta, hydrolyzed by sEH to 11,12,15-THETA, and mediates relaxations by membrane hyperpolarization. 15-H-11,12-EETA represents an endothelium-derived hyperpolarizing factor...
  21. ncbi request reprint Determination of cyclooxygenase and arachidonic acid metabolites in invasive human prostate cancer cells
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Adv Exp Med Biol 507:269-74. 2002
  22. ncbi request reprint Cytochrome P450 and arachidonic acid metabolites: role in myocardial ischemia/reperfusion injury revisited
    Garrett J Gross
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Cardiovasc Res 68:18-25. 2005
    ..The therapeutic potential of increasing EET concentrations and/or reducing 20-HETE concentrations will also be addressed...
  23. pmc Role of superoxide and thromboxane receptors in acute angiotensin II-induced vasoconstriction of rabbit vessels
    Sandra L Pfister
    Dept of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 300:H2064-71. 2011
    ..Results suggest the factor activating thromboxane receptors and contributing to angiotensin II vasoconstriction involves the superoxide-mediated generation of a 15-series isoprostane...
  24. ncbi request reprint Production of hydroxyeicosatetraenoic acids and prostaglandins by a novel rat microglial cell line
    David J Rademacher
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Neuroimmunol 149:130-41. 2004
    ..RTMGL1 synthesize 5-HETE from arachidonic acid (AA) likely via a 5-lipoxygenase (LO). Thus, RTMGL1 have morphological and histological characteristics of primary microglia and metabolize AA via both COX and LO pathways...
  25. ncbi request reprint Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism
    Erica J Carrier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226 0509, USA
    Mol Pharmacol 65:999-1007. 2004
    ..These data suggest that 2-AG activation of CB(2) receptors may contribute to the proliferative response of microglial cells, as occurs in neurodegenerative disorders...
  26. pmc Identification of 13-hydroxy-14,15-epoxyeicosatrienoic acid as an acid-stable endothelium-derived hyperpolarizing factor in rabbit arteries
    Yuttana Chawengsub
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 284:31280-90. 2009
    ..These studies demonstrate that 13-H-14,15-EETAs induces vascular relaxation via K(+) channel activation to cause SMC hyperpolarization. Thus, 13-H-14,15-EETA represents a new endothelial factor...
  27. pmc Structural characterization of monohydroxyeicosatetraenoic acids and dihydroxy- and trihydroxyeicosatrienoic acids by ESI-FTICR
    Lijie Cui
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Am Soc Mass Spectrom 19:569-85. 2008
    ..This study demonstrated the application of FTICR via the identification of regioisomers of trihydroxyeicosatrienoic acids in rabbit aorta samples...
  28. pmc Abdominal surgical incision induces remote preconditioning of trauma (RPCT) via activation of bradykinin receptors (BK2R) and the cytochrome P450 epoxygenase pathway in canine hearts
    Garrett J Gross
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, USA
    Cardiovasc Drugs Ther 25:517-22. 2011
    ..The epoxyeicosatrienoic acids (EETs) have also recently been shown to be antinociceptive and have been shown to mimic ischemic preconditioning (IPC) and postconditioning (POC) in dogs, therefore, we tested the role of the EETs in RPCT...
  29. ncbi request reprint Reticulocyte 15-lipoxygenase-I is important in acetylcholine-induced endothelium-dependent vasorelaxation in rabbit aorta
    Xin Tang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Arterioscler Thromb Vasc Biol 26:78-84. 2006
    ..These metabolites contribute to endothelium-dependent relaxations of rabbit aorta to AA and acetylcholine. We investigated the identity of rabbit aortic 15-LO and studied its importance in the regulation of vascular tone...
  30. ncbi request reprint Stable 5,6-epoxyeicosatrienoic acid analog relaxes coronary arteries through potassium channel activation
    Wenqi Yang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 45:681-6. 2005
    ..PDPAs only activate large conductance calcium-activated K+ channels...
  31. ncbi request reprint Cytochrome P450 omega-hydroxylase inhibition reduces infarct size during reperfusion via the sarcolemmal KATP channel
    Eric R Gross
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Mol Cell Cardiol 37:1245-9. 2004
    ..These data suggest a novel cardioprotective pathway involving CYP omega-hydroxylase inhibition and subsequent activation of the sK(ATP) channel during reperfusion...
  32. pmc Soluble epoxide hydrolase: a new target for cardioprotection
    Garrett J Gross
    Medical College of Wisconsin, Department of Pharmacology and Toxicology, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Curr Opin Investig Drugs 10:253-8. 2009
    ..These results and others obtained in models of myocardial stunning and hypertrophy suggest that inhibitors of EPHX2 or sEH have therapeutic potential in a broad range of cardiovascular diseases...
  33. pmc Angiotensin II relaxations of bovine adrenal cortical arteries: role of angiotensin II metabolites and endothelial nitric oxide
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 52:150-5. 2008
    ....
  34. ncbi request reprint Chronic administration of nitric oxide reduces angiotensin II receptor type 1 expression and aldosterone synthesis in zona glomerulosa cells
    Kasem Nithipatikom
    Dept of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Endocrinol Metab 287:E820-7. 2004
    ..This study demonstrates that chronic administration of NO inhibits aldosterone synthesis in ZG cells by downregulation of the expression of both AT1 receptors and cholesterol side-chain cleavage enzyme...
  35. ncbi request reprint Measurement of steroid synthesis in zona glomerulosa cells by liquid chromatography-electrospray ionization-mass spectrometry: inhibition by nitric oxide
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Anal Biochem 337:203-10. 2005
    ..The technique demonstrates the ability to determine the individual steroid in each enzymatic step of aldosterone synthesis and the activity of steroidogenic enzymes in adrenal ZG cells...
  36. pmc Protection from myocardial ischemia/reperfusion injury by a positive allosteric modulator of the A₃ adenosine receptor
    Lili Du
    Department of Pharmacology and the Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    J Pharmacol Exp Ther 340:210-7. 2012
    ..This is the first study to demonstrate efficacy of an A₃ AR allosteric enhancer in an in vivo model of infarction...
  37. pmc Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction
    Garrett J Gross
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, WI 53226, USA
    J Cardiovasc Pharmacol Ther 18:38-45. 2013
    ..3% ± 1.3%). The 2 EET antagonists completely blocked capsaicin-induced cardioprotection. These results clearly suggest that EETs mediate RPCT-, bradykinin- and capsaicin-induced cardioprotection in rat hearts...
  38. pmc Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts
    Garrett J Gross
    Dept of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 298:H2201-7. 2010
    ..Taken together, these results suggest that the major cardioprotective effects of the EETs depend on activation of a G(i/o) protein-coupled delta- and/or kappa-opioid receptor...
  39. ncbi request reprint Metabolism of adrenic acid to vasodilatory 1alpha,1beta-dihomo-epoxyeicosatrienoic acids by bovine coronary arteries
    Xiu Yu Yi
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 292:H2265-74. 2007
    ..Our results suggest a role of adrenic acid metabolites, specifically, DH-EETs as endothelium-derived hyperpolarizing factors in the coronary circulation...
  40. doi request reprint Review article: epoxyeicosatrienoic acids: novel mediators of cardioprotection
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Cardiovasc Pharmacol Ther 15:112-9. 2010
    ....
  41. pmc ROCK1 feedback regulation of the upstream small GTPase RhoA
    Alan T Tang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, United States
    Cell Signal 24:1375-80. 2012
    ....
  42. pmc Eribis peptide 94 reduces infarct size in rat hearts via activation of centrally located μ opioid receptors
    Garrett J Gross
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Cardiovasc Pharmacol 59:194-7. 2012
    ..These results suggest that EP 94 reduces infarct size (expressed as a percent of the area at risk) in the rat primarily via activation of central μ opioid receptors...
  43. pmc Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts
    Garrett J Gross
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Mol Cell Cardiol 42:687-91. 2007
    ....
  44. pmc The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Br J Pharmacol 139:1005-13. 2003
    ....
  45. pmc Simultaneous analysis of angiotensin peptides by LC-MS and LC-MS/MS: metabolism by bovine adrenal endothelial cells
    Lijie Cui
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Anal Biochem 369:27-33. 2007
    ..The results show that Ang II is metabolized by endothelial cells to Ang 1-7, Ang III, and Ang IV, with Ang 1-7 being the major metabolite...
  46. ncbi request reprint 12-lipoxygenase in opioid-induced delayed cardioprotection: gene array, mass spectrometric, and pharmacological analyses
    Hemal H Patel
    Medical College of Wisconsin, Department of Pharmacology and Toxicology, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Circ Res 92:676-82. 2003
    ..These data suggest that SNC-121 appears to enhance message and subsequently the activity and expression of 12-LO protein during times of stress, resulting in delayed cardioprotection...
  47. pmc Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts
    Garrett J Gross
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA Electronic address
    J Mol Cell Cardiol 59:20-9. 2013
    ....
  48. ncbi request reprint Metabolism of 12-hydroperoxyeicosatetraenoic acid to vasodilatory trioxilin C3 by rabbit aorta
    Sandra L Pfister
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Biochim Biophys Acta 1622:6-13. 2003
    ..6+/-1.3%). In conclusion, trioxilin C(3) acid was isolated and identified as a novel biologically active arachidonic acid metabolite formed by rabbit aorta when 12-lipoxygenase is supplied exogenously...
  49. pmc Development of epoxyeicosatrienoic acid analogs with in vivo anti-hypertensive actions
    John D Imig
    Department of Pharmacology and Toxicology, Medical College of Wisconsin Milwaukee, WI, USA
    Front Physiol 1:157. 2010
    ....
  50. ncbi request reprint Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide
    Hongtao Zhao
    Biophysics Research Institute and Free Radical Research Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Free Radic Biol Med 34:1359-68. 2003
    ..We conclude that the reaction between superoxide and HE forms a fluorescent marker product that is different from ethidium. Potential implications of this finding in intracellular detection and imaging of superoxide are discussed...
  51. pmc Role of epoxyeicosatrienoic acids in protecting the myocardium following ischemia/reperfusion injury
    John M Seubert
    Faculty of Pharmacy and Pharmaceutical Sciences, 3126 Dentistry Pharmacy Centre, University of Alberta, Edmonton, AB, Canada T6G 2N8
    Prostaglandins Other Lipid Mediat 82:50-9. 2007
    ..A better understanding of these relationships will facilitate identification of novel targets for the prevention and/or treatment of ischemic heart disease, a major worldwide public health problem...
  52. ncbi request reprint Endothelium-derived steroidogenic factor enhances angiotensin II-stimulated aldosterone release by bovine zona glomerulosa cells
    Craig J Hanke
    Department of Human Biology, University of Wisconsin Green Bay, Wisconsin 54301, USA
    Endocrinology 148:317-23. 2007
    ..These studies indicate that EDSF enhances the steroidogenic effect of AII. In the adrenal gland, ECs are in close anatomical relationship with ZG cells and may sensitize ZG cells to the steroidogenic action of AII by releasing EDSF...
  53. pmc Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression
    Sung Hee Chang
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030 3501, USA
    Proc Natl Acad Sci U S A 101:591-6. 2004
    ..These results define COX-2-derived PGE(2) as a potent inducer of angiogenic switch during mammary cancer progression...
  54. ncbi request reprint Membrane-potential-dependent inhibition of platelet adhesion to endothelial cells by epoxyeicosatrienoic acids
    Florian Krotz
    Institute of Physiology, Medizinische Poliklinik Innenstadt, Ludwig Maximilians University, Munchen, Germany
    Arterioscler Thromb Vasc Biol 24:595-600. 2004
    ..In many vessels, they are an endothelium-derived hyperpolarizing factor (EDHF). However, it is unknown whether they act as an EDHF on platelets and whether this has functional consequences...
  55. ncbi request reprint Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites
    Shouzou Wei
    Department of Medicine, Vanderbilt Medical School, Nashville, TN 37232, USA
    Anal Biochem 352:129-34. 2006
    ..Application of this methodology to the analysis of the liver endogenous EETs demonstrates stereospecific biosynthesis and corroborates the role of cytochrome P450 as the endogenous arachidonic acid epoxygenase...
  56. ncbi request reprint Development of enzyme immunoassays for 5,6-, 8,9-, 11,12-, and 14,15- EETs and the corresponding DHETs
    Diane M Sasaki
    Oxford Biomedical Research, P O Box 522, Oxford, MI 48371, USA
    Adv Exp Med Biol 507:531-6. 2002
  57. ncbi request reprint Induction of human cholesterol 7alpha-hydroxylase in HepG2 cells by 2,4,6-trihydroxyacetophenone
    Juree Charoenteeraboon
    Department of Biochemistry, Faculty of Science, Mahidol University, Rama VI Rd, Phyatai, Bangkok 10400, Thailand
    Eur J Pharmacol 515:43-6. 2005
    ..E.M.) of control. Moreover THA antagonized the inhibitory regulation of chenodeoxycholic acid on CYP7A1 mRNA expression. These results indicated that THA increases CYP7A1 activity in human HepG2 cells by stimulating mRNA transcription...
  58. ncbi request reprint Epoxy-keto derivative of linoleic acid stimulates aldosterone secretion
    Theodore L Goodfriend
    William S Middleton Memorial Veterans Hospital and Department of Medicine of the University of Wisconsin 53705, USA
    Hypertension 43:358-63. 2004
    ..Compounds like EKODE, derived from linoleic acid, may affect adrenal steroid production in humans and mediate some of the deleterious effects of obesity and oxidative stress, especially in blacks...