Research Topics
Genomes and Genes | Vani NilakantanSummaryAffiliation: Medical College of Wisconsin Country: USA Publications
| Collaborators
|
Detail Information
Publications
20-HETE-mediated cytotoxicity and apoptosis in ischemic kidney epithelial cellsVani Nilakantan
Department of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Am J Physiol Renal Physiol 294:F562-70. 2008....- Differential patterns of peroxynitrite mediated apoptosis in proximal tubular epithelial cells following ATP depletion recoveryVani Nilakantan
Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Apoptosis 13:621-33. 2008..These data show that peroxynitrite induces apoptosis by activation of multiple pathways depending on length and severity of insult following ATP depletion-recovery... 
Favorable balance of anti-oxidant/pro-oxidant systems and ablated oxidative stress in Brown Norway rats in renal ischemia-reperfusion injuryVani Nilakantan
Division of Transplant Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Mol Cell Biochem 304:1-11. 2007..01) following IR. Collectively these results show that the resistance of the BN rat to renal IR injury is associated with a favorable balance of oxidant production vs. oxidant removal...- Post-translational modification of manganese superoxide dismutase in acutely rejecting cardiac transplants: role of inducible nitric oxide synthaseVani Nilakantan
Division of Transplant Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Heart Lung Transplant 24:1591-9. 2005..In this study, we examined the effect of inducible nitric oxide synthase (iNOS) on MnSOD expression, activity and nitration in acutely rejecting cardiac transplants... 
Variable effects of the mitoK(ATP) channel modulators diazoxide and 5-HD in ATP-depleted renal epithelial cellsVani Nilakantan
Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Mol Cell Biochem 335:211-22. 2010..This study demonstrates that in cells that are sensitive to ATP depletion-recovery, mitoK(ATP) channels protect against ATP depletion-mediated cytotoxicity and apoptosis through Erk- and JNK-dependant mechanisms...- Time-dependant protective effects of mangenese(III) tetrakis (1-methyl-4-pyridyl) porphyrin on mitochondrial function following renal ischemia-reperfusion injuryVani Nilakantan
Kidney Disease Center, Medical College of Wisconsin, 53226, USA
Free Radic Res 44:773-82. 2010..05). In conclusion, MnTMPyP has biphasic effects in renal IRI, inhibiting mitochondrial dysfunction at the early phases of reperfusion and prevention of apoptosis following longer durations of reperfusion... - Hierarchical change in antioxidant enzyme gene expression and activity in acute cardiac rejection: role of inducible nitric oxide synthaseVani Nilakantan
Department of Surgery, Division of Transplant Surgery, Milwaukee, WI 53226, USA
Mol Cell Biochem 270:39-47. 2005..This suggests a differential role for iNOS in regulating post-translational modification of individual antioxidant enzymes in acute cardiac transplantation... - Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cellsHuan Ling Liang
Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Apoptosis 14:1176-89. 2009.... - Treatment with {alpha}-phenyl-N-tert-butylnitrone, a free radical-trapping agent, abrogates inflammatory cytokine gene expression during alloimmune activation in rat cardiac allograftsGalen M Pieper
Division of Transplant Surgery, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
J Pharmacol Exp Ther 312:774-9. 2005..Thus, PBN retains significant anti-inflammatory properties through its action to down-regulate cytokine gene expression that contribute to protection against acute alloimmune activation in cardiac allografts... - Beneficial effect of alpha-tocopheryl succinate in rat cardiac transplantsThanh K Nguyen
Department of Surgery, Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Heart Lung Transplant 25:707-15. 2006..This might explain the equipotent action of alpha-TPGS vs low-dose CsA and its action to potentiate graft survival and limit graft rejection and dysfunction... - MnTMPyP, a cell-permeant SOD mimetic, reduces oxidative stress and apoptosis following renal ischemia-reperfusionHuan Ling Liang
Division of Transplant Surgery, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Am J Physiol Renal Physiol 296:F266-76. 2009..These results suggest that MnTMPyP is effective in reducing apoptosis associated with renal I/R injury and that multiple signaling mechanisms are involved in ROS-mediated cell death following renal I/R injury... - Variable efficacy of N6-(1-iminoethyl)-L-lysine in acute cardiac transplant rejectionGalen M Pieper
Division of Transplant Surgery, Department of Surgery, Cardiovascular Center, Medical College of Wisconsin, Milwaukee 53226, USA
Am J Physiol Heart Circ Physiol 286:H525-34. 2004..These studies have important implications in understanding the dual role of NO in acute rejection and help to reconcile discrepancies in the literature... - Mechanisms of the protective action of diethyldithiocarbamate-iron complex on acute cardiac allograft rejectionGalen M Pieper
Division of Transplant Surgery, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
Am J Physiol Heart Circ Physiol 284:H1542-51. 2003..Gene expression for the proinflammatory cytokine interferon-gamma was also decreased by DETC-Fe. Thus DETC-Fe limits NF-kappaB-dependent gene expression and possesses significant immunosuppressive properties... - Antagonizing reactive oxygen by treatment with a manganese (III) metalloporphyrin-based superoxide dismutase mimetic in cardiac transplantsVani Nilakantan
Department of Surgery, Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, Wis 53226, USA
J Thorac Cardiovasc Surg 131:898-906. 2006..CONCLUSIONS: The mechanism of the beneficial effect of MnTmPyP on graft function appear related, in part, to scavenging O2*- and by decreasing apoptotic signaling rather than an effect on inflammatory cytokine gene expression... - Reactive oxygen and reactive nitrogen as signaling molecules for caspase 3 activation in acute cardiac transplant rejectionGalen M Pieper
Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Antioxid Redox Signal 10:1031-40. 2008..These studies indicate that both superoxide and NO (precursors of peroxynitrite formation) play a significant role in caspase 3 activation in cardiac allograft rejection... - Oxidant-mediated apoptosis in proximal tubular epithelial cells following ATP depletion and recoveryCheryl J Maenpaa
Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Free Radic Biol Med 44:518-26. 2008..Our results suggest that oxidant mediated apoptosis via the mitochondrial pathway during the early phase of ATP depletion and by activation of the receptor-mediated apoptotic pathway following longer durations of injury... - Protective mechanisms of a metalloporphyrinic peroxynitrite decomposition catalyst, WW85, in rat cardiac transplantsGalen M Pieper
Division of Transplant Surgery, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, Wisconsin 53226, USA
J Pharmacol Exp Ther 314:53-60. 2005..Rather, effects seem to be downstream on decreased protein nitration, decreased lipid peroxidation, and decreased PARP activation... - MnTMPyP, a superoxide dismutase/catalase mimetic, decreases inflammatory indices in ischemic acute kidney injuryJordan Mortensen
Division of Transplant Surgery, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Inflamm Res 60:299-307. 2011..This study investigates the effect of a superoxide dismutase mimetic, MnTMPyP, on pro- and anti-inflammatory cytokines in acute renal ischemia-reperfusion (IR)... - Nitric oxide formation in acutely rejecting cardiac allografts correlates with GTP cyclohydrolase I activityGalen M Pieper
Division of Transplant Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA
Biochem J 391:541-7. 2005..These findings provide insight into a potential pathway regulating NO bioactivity in graft rejection. Such knowledge may potentially assist in the design of newer strategies to prevent acute graft rejection... - Protective effect of Lifor solution in experimental renal ischemia-reperfusion injuryKevin R Regner
Division of Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Surg Res 164:e291-7. 2010..The current study compared the effectiveness of Lifor to University of Wisconsin solution (UW) in protecting rat kidneys from warm IR and cold storage injury... - Recombinant p21 protein inhibits lymphocyte proliferation and transcription factorsAshwani K Khanna
Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
J Immunol 174:7610-7. 2005.... - SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recoveryHuan Ling Liang
Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Free Radic Biol Med 49:1550-60. 2010..These studies show that SOD1 and MitoTEMPO preserve mitochondrial integrity and attenuate ATP-DR-mediated necrosis and apoptosis... - Chronic treatment with lisinopril decreases proliferative and apoptotic pathways in autosomal recessive polycystic kidney diseaseGuangfu Jia
Department of Medicine, Division of Nephrology, Medical College of Wisconsin, 8701 Watertown Plank Road, HRC 4100, Milwaukee, WI 53226, USA
Pediatr Nephrol 25:1139-46. 2010..In all, these findings demonstrated that chronic ACE inhibition can beneficially alter proliferative and apoptotic pathways to promote therapeutic reductions in renal cyst development in ARPKD... - Hyperoxic and hyperbaric-induced cardioprotection: role of nitric oxide synthase 3Bernadette P Cabigas
Division of Pediatric Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Cardiovasc Res 72:143-51. 2006..We determined whether the product of FIO2 x ATM (oxygen partial pressure) controls the extent of hyperoxic+hyperbaric-induced cardioprotection and involves activation of nitric oxide synthase (NOS)...