Vani Nilakantan

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. pmc 20-HETE-mediated cytotoxicity and apoptosis in ischemic kidney epithelial cells
    Vani Nilakantan
    Department of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 294:F562-70. 2008
  2. pmc Differential patterns of peroxynitrite mediated apoptosis in proximal tubular epithelial cells following ATP depletion recovery
    Vani Nilakantan
    Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Apoptosis 13:621-33. 2008
  3. ncbi request reprint Favorable balance of anti-oxidant/pro-oxidant systems and ablated oxidative stress in Brown Norway rats in renal ischemia-reperfusion injury
    Vani Nilakantan
    Division of Transplant Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Mol Cell Biochem 304:1-11. 2007
  4. ncbi request reprint Post-translational modification of manganese superoxide dismutase in acutely rejecting cardiac transplants: role of inducible nitric oxide synthase
    Vani Nilakantan
    Division of Transplant Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Heart Lung Transplant 24:1591-9. 2005
  5. ncbi request reprint Variable effects of the mitoK(ATP) channel modulators diazoxide and 5-HD in ATP-depleted renal epithelial cells
    Vani Nilakantan
    Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Mol Cell Biochem 335:211-22. 2010
  6. ncbi request reprint Time-dependant protective effects of mangenese(III) tetrakis (1-methyl-4-pyridyl) porphyrin on mitochondrial function following renal ischemia-reperfusion injury
    Vani Nilakantan
    Kidney Disease Center, Medical College of Wisconsin, 53226, USA
    Free Radic Res 44:773-82. 2010
  7. ncbi request reprint Hierarchical change in antioxidant enzyme gene expression and activity in acute cardiac rejection: role of inducible nitric oxide synthase
    Vani Nilakantan
    Department of Surgery, Division of Transplant Surgery, Milwaukee, WI 53226, USA
    Mol Cell Biochem 270:39-47. 2005
  8. pmc Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells
    Huan Ling Liang
    Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Apoptosis 14:1176-89. 2009
  9. ncbi request reprint Treatment with {alpha}-phenyl-N-tert-butylnitrone, a free radical-trapping agent, abrogates inflammatory cytokine gene expression during alloimmune activation in rat cardiac allografts
    Galen M Pieper
    Division of Transplant Surgery, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    J Pharmacol Exp Ther 312:774-9. 2005
  10. ncbi request reprint Beneficial effect of alpha-tocopheryl succinate in rat cardiac transplants
    Thanh K Nguyen
    Department of Surgery, Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Heart Lung Transplant 25:707-15. 2006

Collaborators

Detail Information

Publications24

  1. pmc 20-HETE-mediated cytotoxicity and apoptosis in ischemic kidney epithelial cells
    Vani Nilakantan
    Department of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 294:F562-70. 2008
    ....
  2. pmc Differential patterns of peroxynitrite mediated apoptosis in proximal tubular epithelial cells following ATP depletion recovery
    Vani Nilakantan
    Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Apoptosis 13:621-33. 2008
    ..These data show that peroxynitrite induces apoptosis by activation of multiple pathways depending on length and severity of insult following ATP depletion-recovery...
  3. ncbi request reprint Favorable balance of anti-oxidant/pro-oxidant systems and ablated oxidative stress in Brown Norway rats in renal ischemia-reperfusion injury
    Vani Nilakantan
    Division of Transplant Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Mol Cell Biochem 304:1-11. 2007
    ..01) following IR. Collectively these results show that the resistance of the BN rat to renal IR injury is associated with a favorable balance of oxidant production vs. oxidant removal...
  4. ncbi request reprint Post-translational modification of manganese superoxide dismutase in acutely rejecting cardiac transplants: role of inducible nitric oxide synthase
    Vani Nilakantan
    Division of Transplant Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Heart Lung Transplant 24:1591-9. 2005
    ..In this study, we examined the effect of inducible nitric oxide synthase (iNOS) on MnSOD expression, activity and nitration in acutely rejecting cardiac transplants...
  5. ncbi request reprint Variable effects of the mitoK(ATP) channel modulators diazoxide and 5-HD in ATP-depleted renal epithelial cells
    Vani Nilakantan
    Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Mol Cell Biochem 335:211-22. 2010
    ..This study demonstrates that in cells that are sensitive to ATP depletion-recovery, mitoK(ATP) channels protect against ATP depletion-mediated cytotoxicity and apoptosis through Erk- and JNK-dependant mechanisms...
  6. ncbi request reprint Time-dependant protective effects of mangenese(III) tetrakis (1-methyl-4-pyridyl) porphyrin on mitochondrial function following renal ischemia-reperfusion injury
    Vani Nilakantan
    Kidney Disease Center, Medical College of Wisconsin, 53226, USA
    Free Radic Res 44:773-82. 2010
    ..05). In conclusion, MnTMPyP has biphasic effects in renal IRI, inhibiting mitochondrial dysfunction at the early phases of reperfusion and prevention of apoptosis following longer durations of reperfusion...
  7. ncbi request reprint Hierarchical change in antioxidant enzyme gene expression and activity in acute cardiac rejection: role of inducible nitric oxide synthase
    Vani Nilakantan
    Department of Surgery, Division of Transplant Surgery, Milwaukee, WI 53226, USA
    Mol Cell Biochem 270:39-47. 2005
    ..This suggests a differential role for iNOS in regulating post-translational modification of individual antioxidant enzymes in acute cardiac transplantation...
  8. pmc Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells
    Huan Ling Liang
    Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Apoptosis 14:1176-89. 2009
    ....
  9. ncbi request reprint Treatment with {alpha}-phenyl-N-tert-butylnitrone, a free radical-trapping agent, abrogates inflammatory cytokine gene expression during alloimmune activation in rat cardiac allografts
    Galen M Pieper
    Division of Transplant Surgery, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    J Pharmacol Exp Ther 312:774-9. 2005
    ..Thus, PBN retains significant anti-inflammatory properties through its action to down-regulate cytokine gene expression that contribute to protection against acute alloimmune activation in cardiac allografts...
  10. ncbi request reprint Beneficial effect of alpha-tocopheryl succinate in rat cardiac transplants
    Thanh K Nguyen
    Department of Surgery, Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Heart Lung Transplant 25:707-15. 2006
    ..In this study we examined the effects of a novel vitamin E analog, alpha-tocopheryl polyethylene glycol-100 succinate (alpha-TPGS), and low-dose cyclosporine (CsA) in the treatment of acute and delayed cardiac rejection...
  11. pmc MnTMPyP, a cell-permeant SOD mimetic, reduces oxidative stress and apoptosis following renal ischemia-reperfusion
    Huan Ling Liang
    Division of Transplant Surgery, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 296:F266-76. 2009
    ..These results suggest that MnTMPyP is effective in reducing apoptosis associated with renal I/R injury and that multiple signaling mechanisms are involved in ROS-mediated cell death following renal I/R injury...
  12. ncbi request reprint Variable efficacy of N6-(1-iminoethyl)-L-lysine in acute cardiac transplant rejection
    Galen M Pieper
    Division of Transplant Surgery, Department of Surgery, Cardiovascular Center, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Physiol Heart Circ Physiol 286:H525-34. 2004
    ..These studies have important implications in understanding the dual role of NO in acute rejection and help to reconcile discrepancies in the literature...
  13. ncbi request reprint Mechanisms of the protective action of diethyldithiocarbamate-iron complex on acute cardiac allograft rejection
    Galen M Pieper
    Division of Transplant Surgery, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 284:H1542-51. 2003
    ..Gene expression for the proinflammatory cytokine interferon-gamma was also decreased by DETC-Fe. Thus DETC-Fe limits NF-kappaB-dependent gene expression and possesses significant immunosuppressive properties...
  14. ncbi request reprint Antagonizing reactive oxygen by treatment with a manganese (III) metalloporphyrin-based superoxide dismutase mimetic in cardiac transplants
    Vani Nilakantan
    Department of Surgery, Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, Wis 53226, USA
    J Thorac Cardiovasc Surg 131:898-906. 2006
    ....
  15. pmc Reactive oxygen and reactive nitrogen as signaling molecules for caspase 3 activation in acute cardiac transplant rejection
    Galen M Pieper
    Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Antioxid Redox Signal 10:1031-40. 2008
    ..These studies indicate that both superoxide and NO (precursors of peroxynitrite formation) play a significant role in caspase 3 activation in cardiac allograft rejection...
  16. ncbi request reprint Oxidant-mediated apoptosis in proximal tubular epithelial cells following ATP depletion and recovery
    Cheryl J Maenpaa
    Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Free Radic Biol Med 44:518-26. 2008
    ..Our results suggest that oxidant mediated apoptosis via the mitochondrial pathway during the early phase of ATP depletion and by activation of the receptor-mediated apoptotic pathway following longer durations of injury...
  17. ncbi request reprint Protective mechanisms of a metalloporphyrinic peroxynitrite decomposition catalyst, WW85, in rat cardiac transplants
    Galen M Pieper
    Division of Transplant Surgery, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, Wisconsin 53226, USA
    J Pharmacol Exp Ther 314:53-60. 2005
    ..Rather, effects seem to be downstream on decreased protein nitration, decreased lipid peroxidation, and decreased PARP activation...
  18. doi request reprint MnTMPyP, a superoxide dismutase/catalase mimetic, decreases inflammatory indices in ischemic acute kidney injury
    Jordan Mortensen
    Division of Transplant Surgery, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Inflamm Res 60:299-307. 2011
    ..This study investigates the effect of a superoxide dismutase mimetic, MnTMPyP, on pro- and anti-inflammatory cytokines in acute renal ischemia-reperfusion (IR)...
  19. pmc Nitric oxide formation in acutely rejecting cardiac allografts correlates with GTP cyclohydrolase I activity
    Galen M Pieper
    Division of Transplant Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA
    Biochem J 391:541-7. 2005
    ..These findings provide insight into a potential pathway regulating NO bioactivity in graft rejection. Such knowledge may potentially assist in the design of newer strategies to prevent acute graft rejection...
  20. pmc Protective effect of Lifor solution in experimental renal ischemia-reperfusion injury
    Kevin R Regner
    Division of Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Surg Res 164:e291-7. 2010
    ..The current study compared the effectiveness of Lifor to University of Wisconsin solution (UW) in protecting rat kidneys from warm IR and cold storage injury...
  21. ncbi request reprint Recombinant p21 protein inhibits lymphocyte proliferation and transcription factors
    Ashwani K Khanna
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 174:7610-7. 2005
    ....
  22. pmc SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery
    Huan Ling Liang
    Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Free Radic Biol Med 49:1550-60. 2010
    ..These studies show that SOD1 and MitoTEMPO preserve mitochondrial integrity and attenuate ATP-DR-mediated necrosis and apoptosis...
  23. doi request reprint Chronic treatment with lisinopril decreases proliferative and apoptotic pathways in autosomal recessive polycystic kidney disease
    Guangfu Jia
    Department of Medicine, Division of Nephrology, Medical College of Wisconsin, 8701 Watertown Plank Road, HRC 4100, Milwaukee, WI 53226, USA
    Pediatr Nephrol 25:1139-46. 2010
    ..In all, these findings demonstrated that chronic ACE inhibition can beneficially alter proliferative and apoptotic pathways to promote therapeutic reductions in renal cyst development in ARPKD...
  24. ncbi request reprint Hyperoxic and hyperbaric-induced cardioprotection: role of nitric oxide synthase 3
    Bernadette P Cabigas
    Division of Pediatric Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Cardiovasc Res 72:143-51. 2006
    ..We determined whether the product of FIO2 x ATM (oxygen partial pressure) controls the extent of hyperoxic+hyperbaric-induced cardioprotection and involves activation of nitric oxide synthase (NOS)...