Research Topics
| Alfred NicolosiSummaryAffiliation: Medical College of Wisconsin Country: USA Publications
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Detail Information
Publications
Gadolinium prevents stretch-mediated contractile dysfunction in isolated papillary musclesA C Nicolosi
Department of Surgery, The Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Am J Physiol Heart Circ Physiol 280:H1122-8. 2001..64 +/- 0.05), but DHP did not (T(max) = 0.48 +/- 0.04). These data suggest that overstretching of the myocardium contributes to contractile abnormalities via SA channels that are distinct from L-type calcium channels...- Invited commentaryAlfred Nicolosi
Division of Cardiothoracic Surgery, Medical College of Wisconsin, Froedtert Memorial Lutheran Hospital, 9200 W Wisconsin Ave, Milwaukee, WI 53226-0099, USA
Ann Thorac Surg 84:822. 2007 - Effects of gadolinium on regionally stunned myocardium: temporal considerationsAlfred C Nicolosi
Department of Surgery Division of Cardiothoracic Surgery, The Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Surg Res 139:286-91. 2007..This study sought to determine whether giving Gd(3+) during ischemia or during reperfusion also ameliorates stunning, as these temporal relationships could help determine the clinical utility of this novel agent... 
Gadolinium limits myocardial infarction in the rat: dose-response, temporal relations and mechanismsAlfred C Nicolosi
Division of Cardiothoracic Surgery, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
J Mol Cell Cardiol 44:345-51. 2008..The mechanism underlying Gd-induced preconditioning appears to be multi-factorial, involving JAK-2, STAT-3 and p44 MAPK pathways, as well as K(ATP) channels...- Gadolinium attenuates regional stunning in the canine heart in vivoAlfred C Nicolosi
Division of Cardiothoracic Surgery, The Medical College of Wisconsin, Milwaukee, USA
J Thorac Cardiovasc Surg 124:57-62. 2002..The present study tested the hypothesis that gadolinium would also attenuate regional myocardial stunning in an in vivo model... - Perioperative considerations in the patient with a left ventricular assist deviceAlfred C Nicolosi
Department of Surgery (Division of Cardiothoracic Surgery, the Medical College of Wisconsin and the Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee 53226, USA
Anesthesiology 98:565-70. 2003 - Diabetes mellitus impairs vasodilation to hypoxia in human coronary arterioles: reduced activity of ATP-sensitive potassium channelsHiroto Miura
Department of Veterans Affairs Medical Center, Milwaukee, Wis, USA
Circ Res 92:151-8. 2003..We conclude that DM impairs human coronary arteriolar dilation to K(ATP) opening, leading to reduced dilation to hypoxia. This reduction in K(ATP) function could contribute to the greater cardiovascular mortality and morbidity in DM... - Antagonists of stretch-activated ion channels restore contractile function in hamster dilated cardiomyopathyAlfred C Nicolosi
Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
J Heart Lung Transplant 23:1003-7. 2004..They do not alter contractile function in normal muscle. These data suggest an important role of SACs in the contractile dysfunction of DCM and further suggest that SAC antagonists may represent novel therapy in heart failure... - Mitochondrial sources of H2O2 generation play a key role in flow-mediated dilation in human coronary resistance arteriesYanping Liu
Department of Internal Medicine, Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, Wis 53226, USA
Circ Res 93:573-80. 2003..05). Neither cyanide nor apocynin altered flow-induced dilation. These results suggest that shear stress induced H2O2 formation, and flow-induced dilation is derived from O2*- originating from mitochondrial respiration... - Mechanism of thrombin-induced vasodilation in human coronary arteriolesJohn J Bosnjak
Medical College of Wisconsin, Cardiovascular Center, Milwaukee, Wisconsin 53226, USA
Am J Physiol Heart Circ Physiol 284:H1080-6. 2003..We speculate that an endothelium-derived hyperpolarizing factor contributes to Thromb-induced dilation in HCA... - A novel approach to the management of tracheoinnominate artery fistulaMario G Gasparri
Division of Cardiothoracic Surgery, The Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Ann Thorac Surg 77:1424-6. 2004..A 75-year-old gentleman with tracheoinnominate fistula is reported. The issues regarding the surgical approach to this problem are reviewed and a creation of an aorto-axillary bypass graft described... - A widened mediastinum in a patient with a left parasternal stab woundZafar Iqbal
Department of Anesthesiology, Medical College of Wisconsin and Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, WI 53226, USA
J Cardiothorac Vasc Anesth 21:307-9. 2007 - Perioperative implications of charcot-marie-tooth disease during coronary artery bypass graft surgeryVijayashree Shankar
Department of Anesthesiology, Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee, WI 53295, USA
J Cardiothorac Vasc Anesth 21:567-9. 2007 - Increased incidence of radial artery calcification in patients with diabetes mellitusAlfred C Nicolosi
Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Surg Res 102:1-5. 2002..Preoperative imaging of the RA should be considered in diabetic CAB candidates and perhaps in nondiabetics with multiple risk factors to avoid unnecessary forearm exploration or inadvertent use of a diseased conduit...