Z Nahas

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. ncbi request reprint Left prefrontal transcranial magnetic stimulation (TMS) treatment of depression in bipolar affective disorder: a pilot study of acute safety and efficacy
    Ziad Nahas
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston 29425, USA
    Bipolar Disord 5:40-7. 2003
  2. pmc Inverse effects of oxytocin on attributing mental activity to others in depressed and healthy subjects: a double-blind placebo controlled FMRI study
    David Pincus
    Summa Health, Akron OH, USA
    Front Psychiatry 1:134. 2010
  3. ncbi request reprint Repetitive transcranial magnetic stimulation: perspectives for application in the treatment of bipolar and unipolar disorders
    Z Nahas
    Department of Psychiatry, Institute of Psychiatry, Medical University of South Carolina, Charleston 29403, USA
    Bipolar Disord 1:73-80. 1999
  4. ncbi request reprint Brain effects of TMS delivered over prefrontal cortex in depressed adults: role of stimulation frequency and coil-cortex distance
    Z Nahas
    Brain Stimulation Laboratory, Functional Neuroimaging Research Division, Departments of Psychiatry, Radiology, and Neurology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neuropsychiatry Clin Neurosci 13:459-70. 2001
  5. ncbi request reprint Vagus nerve stimulation (VNS) for depression: what do we know now and what should be done next?
    Ziad Nahas
    Mood Disorders Program, Medical Director of Brain Stimulation Laboratory Institute of Psychiatry, 67 President Street, Room 502 North, Charleston, SC 29403, USA
    Curr Psychiatry Rep 8:445-51. 2006
  6. ncbi request reprint Two-year outcome of vagus nerve stimulation (VNS) for treatment of major depressive episodes
    Ziad Nahas
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29403, USA
    J Clin Psychiatry 66:1097-104. 2005
  7. pmc Bilateral epidural prefrontal cortical stimulation for treatment-resistant depression
    Ziad Nahas
    Department of Psychiatry, Mood Disorders Program and Brain Stimulation Laboratory, Medical University of South Carolina, Charleston, South Carolina, USA
    Biol Psychiatry 67:101-9. 2010
  8. ncbi request reprint Serial vagus nerve stimulation functional MRI in treatment-resistant depression
    Ziad Nahas
    Department of Psychiatry, Brain Stimulation Laboratory, Mood Disorders Program, Institute of Psychiatry, Charleston, SC 29403, USA
    Neuropsychopharmacology 32:1649-60. 2007
  9. ncbi request reprint Augmenting atypical antipsychotics with a cognitive enhancer (donepezil) improves regional brain activity in schizophrenia patients: a pilot double-blind placebo controlled BOLD fMRI study
    Ziad Nahas
    Brain Stimulation Laboratory, Center for Advanced Imaging Research, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Neurocase 9:274-82. 2003
  10. ncbi request reprint Lack of significant changes on magnetic resonance scans before and after 2 weeks of daily left prefrontal repetitive transcranial magnetic stimulation for depression
    Z Nahas
    Department of Psychiatry, The Medical University of South Carolina, Charleston 29425, USA
    J ECT 16:380-90. 2000

Research Grants

Detail Information

Publications77

  1. ncbi request reprint Left prefrontal transcranial magnetic stimulation (TMS) treatment of depression in bipolar affective disorder: a pilot study of acute safety and efficacy
    Ziad Nahas
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston 29425, USA
    Bipolar Disord 5:40-7. 2003
    ..We designed and carried out the following left prefrontal rTMS study to determine the safety, feasibility, and potential efficacy of using TMS to treat the depressive symptoms of bipolar affective disorder (BPAD)...
  2. pmc Inverse effects of oxytocin on attributing mental activity to others in depressed and healthy subjects: a double-blind placebo controlled FMRI study
    David Pincus
    Summa Health, Akron OH, USA
    Front Psychiatry 1:134. 2010
    ..Further studies are needed to explore long-term exposure to pro-social neuropeptides on mood in depressed populations and assess their clinical relevance...
  3. ncbi request reprint Repetitive transcranial magnetic stimulation: perspectives for application in the treatment of bipolar and unipolar disorders
    Z Nahas
    Department of Psychiatry, Institute of Psychiatry, Medical University of South Carolina, Charleston 29403, USA
    Bipolar Disord 1:73-80. 1999
    ..TMS researchers have thus postulated that dorsolateral prefrontal cortex (DLPFC) stimulation might change brain activity both locally and in paralimbic areas through transynaptic connections, and alter mood...
  4. ncbi request reprint Brain effects of TMS delivered over prefrontal cortex in depressed adults: role of stimulation frequency and coil-cortex distance
    Z Nahas
    Brain Stimulation Laboratory, Functional Neuroimaging Research Division, Departments of Psychiatry, Radiology, and Neurology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neuropsychiatry Clin Neurosci 13:459-70. 2001
    ....
  5. ncbi request reprint Vagus nerve stimulation (VNS) for depression: what do we know now and what should be done next?
    Ziad Nahas
    Mood Disorders Program, Medical Director of Brain Stimulation Laboratory Institute of Psychiatry, 67 President Street, Room 502 North, Charleston, SC 29403, USA
    Curr Psychiatry Rep 8:445-51. 2006
    ..Further clinical studies, in addition to prospective cost utilization and health economic investigations, are needed to better understand VNS therapy and the impact it holds on TRD care...
  6. ncbi request reprint Two-year outcome of vagus nerve stimulation (VNS) for treatment of major depressive episodes
    Ziad Nahas
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29403, USA
    J Clin Psychiatry 66:1097-104. 2005
    ..We examined the effects of adjunctive VNS over 24 months in this cohort...
  7. pmc Bilateral epidural prefrontal cortical stimulation for treatment-resistant depression
    Ziad Nahas
    Department of Psychiatry, Mood Disorders Program and Brain Stimulation Laboratory, Medical University of South Carolina, Charleston, South Carolina, USA
    Biol Psychiatry 67:101-9. 2010
    ..We chose to pilot the safety and therapeutic benefits of chronic and intermittent epidural prefrontal cortical stimulation (EpCS) in patients with treatment-resistant depression...
  8. ncbi request reprint Serial vagus nerve stimulation functional MRI in treatment-resistant depression
    Ziad Nahas
    Department of Psychiatry, Brain Stimulation Laboratory, Mood Disorders Program, Institute of Psychiatry, Charleston, SC 29403, USA
    Neuropsychopharmacology 32:1649-60. 2007
    ..Future interleaved VNS/fMRI studies to confirm these findings and further clarify the regional neurobiological effects of VNS...
  9. ncbi request reprint Augmenting atypical antipsychotics with a cognitive enhancer (donepezil) improves regional brain activity in schizophrenia patients: a pilot double-blind placebo controlled BOLD fMRI study
    Ziad Nahas
    Brain Stimulation Laboratory, Center for Advanced Imaging Research, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Neurocase 9:274-82. 2003
    ..This pilot study supports the cingulate's role in modulating cognition and neuronal connectivity in schizophrenia...
  10. ncbi request reprint Lack of significant changes on magnetic resonance scans before and after 2 weeks of daily left prefrontal repetitive transcranial magnetic stimulation for depression
    Z Nahas
    Department of Psychiatry, The Medical University of South Carolina, Charleston 29425, USA
    J ECT 16:380-90. 2000
    ..In conclusion, 10 days of daily prefrontal rTMS at these intensities and frequencies does not cause observable structural changes on MR scans in depressed adults...
  11. ncbi request reprint Safety and benefits of distance-adjusted prefrontal transcranial magnetic stimulation in depressed patients 55-75 years of age: a pilot study
    Ziad Nahas
    Brain Stimulation Laboratory, Institute of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Depress Anxiety 19:249-56. 2004
    ....
  12. ncbi request reprint Safety and feasibility of repetitive transcranial magnetic stimulation in the treatment of anxious depression in pregnancy: a case report
    Z Nahas
    Department of Psychiatry, Medical University of South Carolina, Charleston 29425, USA
    J Clin Psychiatry 60:50-2. 1999
    ..Several double-blind placebo-controlled studies have explored the efficacy of repetitive transcranial magnetic stimulation (rTMS) in depression...
  13. ncbi request reprint Feasibility of vagus nerve stimulation-synchronized blood oxygenation level-dependent functional MRI
    D E Bohning
    Center for Advanced Imaging Research, Department of Radiology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Invest Radiol 36:470-9. 2001
    ..Our objective was to develop a methodology for performing VNS-synchronized functional magnetic resonance imaging (VNS-fMRI) and then to demonstrate its feasibility for studying VNS effects...
  14. ncbi request reprint A double-blind placebo-controlled case study of the use of donepezil to improve cognition in a schizoaffective disorder patient: functional MRI correlates
    S C Risch
    Institute of Psychiatry, Medical University of South Carolina, 67 President Street, Room 502N, PO Box 250861, Charleston, SC 29425, USA
    Neurocase 7:105-10. 2001
    ..Further studies of donepezil augmentation of neuroleptics in schizophrenia are warranted...
  15. ncbi request reprint How coil-cortex distance relates to age, motor threshold, and antidepressant response to repetitive transcranial magnetic stimulation
    F A Kozel
    Functional Neuroimaging Division and the Brain Magnetic Stimulation Laboratories, Department of Psychiatry, Medical University of South Carolina, Charleston 29425, USA
    J Neuropsychiatry Clin Neurosci 12:376-84. 2000
    ..The rTMS antidepressant responders, however, were significantly younger (t=-2.430, P<0.05), and there appears to be a maximum threshold of age and distance to prefrontal cortex for response...
  16. ncbi request reprint Echoplanar BOLD fMRI of brain activation induced by concurrent transcranial magnetic stimulation
    D E Bohning
    Department of Radiology, Medical University of South Carolina, Charleston 29425, USA
    Invest Radiol 33:336-40. 1998
    ..The authors demonstrate the feasibility of combining transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI) inside an MR scanner to noninvasively stimulate and image regional brain activity...
  17. ncbi request reprint Unilateral left prefrontal transcranial magnetic stimulation (TMS) produces intensity-dependent bilateral effects as measured by interleaved BOLD fMRI
    Z Nahas
    Brain Stimulation Laboratory, Psychiatry Department, Medical University of South Carolina (MUSC, Charleston, South Carolina 29425, USA
    Biol Psychiatry 50:712-20. 2001
    ..Higher prefrontal TMS stimulation intensity produces greater local and contralateral activation. Importantly, unilateral prefrontal TMS produces bilateral effects, and TMS at 80% MT produces only minimal prefrontal cortex activation...
  18. ncbi request reprint Acute vagus nerve stimulation using different pulse widths produces varying brain effects
    Qiwen Mu
    Brain Stimulation Laboratory, Medical University of South Carolina, Institute of Psychiatry 502N, 67 President Street, Charleston, SC 29425, USA
    Biol Psychiatry 55:816-25. 2004
    ....
  19. ncbi request reprint The transcranial magnetic stimulation motor threshold depends on the distance from coil to underlying cortex: a replication in healthy adults comparing two methods of assessing the distance to cortex
    K A McConnell
    Functional Neuroimaging Division, Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Biol Psychiatry 49:454-9. 2001
    ..Distance to prefontal cortex is not correlated with MT, raising questions about the common practice of dosing prefontal stimulation using MT determined over motor cortex...
  20. ncbi request reprint BOLD-f MRI response to single-pulse transcranial magnetic stimulation (TMS)
    D E Bohning
    Functional Neuroimaging Research Division, Department of Radiology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Magn Reson Imaging 11:569-74. 2000
    ..0%-1.5% signal increase) was comparable in both level and duration to the auditory cortex response to the sound accompanying the TMS pulse (1.5% -2.0% signal increase)...
  21. ncbi request reprint Motor cortex brain activity induced by 1-Hz transcranial magnetic stimulation is similar in location and level to that for volitional movement
    D E Bohning
    Department of Radiology, Medical University of South Carolina, Charleston 29425, USA
    Invest Radiol 35:676-83. 2000
    ....
  22. ncbi request reprint Effect of St. John's wort (Hypericum perforatum) on cytochrome P-450 2D6 and 3A4 activity in healthy volunteers
    J S Markowitz
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston 29425, USA
    Life Sci 66:PL133-9. 2000
    ..These results suggest that St. John's wort, when taken at recommended doses for depression, is unlikely to inhibit CYP 2D6 or CYP 3A4 activity...
  23. ncbi request reprint Donepezil effects on mood in patients with schizophrenia and schizoaffective disorder
    S Craig Risch
    Department of Psychiatry, University of California, San Francisco, CA 94143 0984, USA
    Int J Neuropsychopharmacol 9:603-5. 2006
    ..Thus, in this study, donepezil did not induce or worsen depressive symptoms in schizophrenic and schizoaffective disorder patients...
  24. ncbi request reprint Feasibility of using fMRI to study mothers responding to infant cries
    J P Lorberbaum
    Department of Psychiatry, Medical University of South Carolina, Charleston 29425, USA
    Depress Anxiety 10:99-104. 1999
    ..e., child neglect), offspring temperament, or offspring depression or anxiety...
  25. ncbi request reprint Single-dose pharmacokinetics of methylphenidate in CYP2D6 extensive and poor metabolizers
    C L DeVane
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425, USA
    J Clin Psychopharmacol 20:347-9. 2000
    ..These data suggest a lack of involvement of CYP2D6 in the metabolism of MPH. Drugs that are inhibitors of CYP2D6 when taken concurrently with MPH should not affect its plasma concentration...
  26. ncbi request reprint Activation of prefrontal cortex and anterior thalamus in alcoholic subjects on exposure to alcohol-specific cues
    M S George
    Radiology Department, Medical University of South Carolina, 171 Ashley Ave, Charleston, SC 29425, USA
    Arch Gen Psychiatry 58:345-52. 2001
    ....
  27. pmc Motor threshold in transcranial magnetic stimulation: the impact of white matter fiber orientation and skull-to-cortex distance
    Tal Herbsman
    Mood Disorders Program and Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Hum Brain Mapp 30:2044-55. 2009
    ..82, F = 20.27, P < 0.0001) in measurements of MT. The corticospinal tract's anterior-posterior direction alone contributes 13% of the variance explained...
  28. ncbi request reprint BOLD fMRI response to direct stimulation (transcranial magnetic stimulation) of the motor cortex shows no decline with age
    K A McConnell
    Departments of Radiology, Brain Stimulation Laboratory, Medical University of South Carolina, USA
    J Neural Transm 110:495-507. 2003
    ..Direct neuronal stimulation by TMS produced similar fMRI signal increases in both groups, suggesting that cortical physiology itself may not necessarily decline with age...
  29. ncbi request reprint Ethylphenidate formation in human subjects after the administration of a single dose of methylphenidate and ethanol
    J S Markowitz
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina, USA
    Drug Metab Dispos 28:620-4. 2000
    ..g., in the abuse of methylphenidate and ethanol, the metabolite ethylphenidate may contribute to drug effects...
  30. ncbi request reprint Reducing pain and unpleasantness during repetitive transcranial magnetic stimulation
    Jeffrey J Borckardt
    Medical University of South Carolina, Charleston, SC, USA
    J ECT 22:259-64. 2006
    ..More systematic research is needed on the effectiveness of different strategies for reducing rTMS-related pain and discomfort...
  31. ncbi request reprint Brain stimulation for the treatment of psychiatric disorders
    Mark S George
    Brain Stimulation Laboratory and Mood Disorders Clinic, Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Curr Opin Psychiatry 20:250-4; discussion 247-9. 2007
    ..The methods in this class range from non-invasive (transcranial magnetic stimulation) to invasive brain surgery (deep brain stimulation)...
  32. ncbi request reprint Vagus nerve stimulation for the treatment of depression and other neuropsychiatric disorders
    Mark S George
    Institute of Psychiatry MUSC, Brain Stimulation Laboratory, 67 President Street, Room 502 North, Charleston, SC 29425, USA
    Expert Rev Neurother 7:63-74. 2007
    ..Much more research is needed regarding exactly how to refine and deliver the electrical pulses and how this differentially affects brain function in health and disease...
  33. ncbi request reprint A single 20 mg dose of dihydrexidine (DAR-0100), a full dopamine D1 agonist, is safe and tolerated in patients with schizophrenia
    Mark S George
    Brain Stimulation Laboratory BSL, Psychiatry Department, Medical University of South Carolina MUSC 29425, United States
    Schizophr Res 93:42-50. 2007
    ..No medication interactions were seen. Thus, a single subcutaneous dose of dihydrexidine is tolerated and safe in patients with schizophrenia and does not produce delayed clinical or neuropsychological improvements...
  34. ncbi request reprint Estimating resting motor thresholds in transcranial magnetic stimulation research and practice: a computer simulation evaluation of best methods
    Jeffrey J Borckardt
    Brain Stimulation Laboratory, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, USA
    J ECT 22:169-75. 2006
    ..The current study investigates the accuracy and efficiency of 5 different approaches to motor threshold assessment for TMS research and practice applications...
  35. pmc Fifteen minutes of left prefrontal repetitive transcranial magnetic stimulation acutely increases thermal pain thresholds in healthy adults
    Jeffery J Borckardt
    Depart of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Pain Res Manag 12:287-90. 2007
    ..There is, however, emerging brain imaging evidence that the left prefrontal cortex is involved in pain inhibition in humans...
  36. pmc Neurocognitive deficits and prefrontal cortical atrophy in patients with schizophrenia
    Leonardo Bonilha
    Department of Neurology, Medical University of South Carolina, Charleston, SC, USA
    Schizophr Res 101:142-51. 2008
    ..We investigated the relationship between prefrontal cortical atrophy as measured by MRI and the neuropsychological performance of participants diagnosed with DSM-IV-TR schizophrenia...
  37. doi request reprint A pilot study of vagus nerve stimulation (VNS) for treatment-resistant anxiety disorders
    Mark S George
    Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Brain Stimul 1:112-21. 2008
    ....
  38. doi request reprint Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham-controlled randomized trial
    Mark S George
    Brain Stimulation Division, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Arch Gen Psychiatry 67:507-16. 2010
    ..Daily left prefrontal repetitive transcranial magnetic stimulation (rTMS) has been studied as a potential treatment for depression, but previous work had mixed outcomes and did not adequately mask sham conditions...
  39. doi request reprint Interleaved transcranial magnetic stimulation and fMRI suggests that lamotrigine and valproic acid have different effects on corticolimbic activity
    Xingbao Li
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, 502N, 67 President St, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 209:233-44. 2010
    ..A previous study showed that lamotrigine (LTG) inhibited brain activation induced when TMS was applied over motor cortex, whereas it increased activation induced by TMS applied over prefrontal cortex...
  40. pmc Significant analgesic effects of one session of postoperative left prefrontal cortex repetitive transcranial magnetic stimulation: a replication study
    Jeffrey J Borckardt
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina MUSC, Charleston, SC 29425, USA
    Brain Stimul 1:122-7. 2008
    ..This study sought to test this finding for replication and to more accurately estimate the effect size of this brief intervention on postoperative morphine use and postoperative pain and mood ratings...
  41. pmc A pilot study investigating the effects of fast left prefrontal rTMS on chronic neuropathic pain
    Jeffrey J Borckardt
    Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Pain Med 10:840-9. 2009
    ..It is unclear whether the motor cortex is the only effective cortical target for managing neuropathic pain, and no published studies to date have investigated the effects of prefrontal stimulation on neuropathic pain...
  42. ncbi request reprint Relapse rates with long-term antidepressant drug therapy: a meta-analysis
    Nolan Williams
    Mood Disorders Program, Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina, USA
    Hum Psychopharmacol 24:401-8. 2009
    ..The goal of this work was to conduct a meta-analysis that would incorporate the most recent trials and evaluate their overall level of efficacy and relapse prevention over time...
  43. doi request reprint Lamotrigine and valproic acid have different effects on motorcortical neuronal excitability
    Xingbao Li
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, MUSC IOP, 502 N, 67 President Street, Charleston, SC, 29425, USA
    J Neural Transm 116:423-9. 2009
    ..07, P < 0.05) and enhanced by valproic acid (t = 2.39, P < 0.05). Lamotrigine and valproic acid have different effects on cortical neuronal excitability as demonstrated by TMS...
  44. pmc Focal electrically administered therapy: device parameter effects on stimulus perception in humans
    Jeffrey J Borckardt
    Psychiatry Department, Medical University of South Carolina, Charleston, SC 29425, USA
    J ECT 25:91-8. 2009
    ..This study used a simpler paradigm and evaluated the effects of different stimulation parameters on subjective perception of the quality and location of scalp pain...
  45. ncbi request reprint A single 20 mg dose of the full D1 dopamine agonist dihydrexidine (DAR-0100) increases prefrontal perfusion in schizophrenia
    Qiwen Mu
    Brain Stimulation Laboratory, Institute of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Schizophr Res 94:332-41. 2007
    ..These data are consistent with the hypothesis formulated from studies of non-human primates that dihydrexidine and other D1 agonists may be able to modulate prefrontal dopaminergic function...
  46. ncbi request reprint Postoperative left prefrontal repetitive transcranial magnetic stimulation reduces patient-controlled analgesia use
    Jeffrey J Borckardt
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, SC, USA
    Anesthesiology 105:557-62. 2006
    ..No studies have investigated the effects of prefrontal cortex stimulation using transcranial magnetic stimulation on postoperative pain...
  47. ncbi request reprint Mechanisms and the current state of transcranial magnetic stimulation
    Mark S George
    Psychiatry Department, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    CNS Spectr 8:496-514. 2003
    ..TMS' ability to non-invasively and focally stimulate the brain of an awake human is proving to be a most important development for neuroscience in general, and neuropsychiatry in particular...
  48. ncbi request reprint Transcranial magnetic stimulation
    Mark S George
    Department of Psychiatry, 502 North, Institute of Psychiatry, Medical University of South Carolina, 67 President Street, Charleston, SC, USA
    Neurosurg Clin N Am 14:283-301. 2003
    ..Whatever road the future takes, TMS is an important new tool that will likely be of interest to neurosurgeons over the next 20 years and perhaps even longer...
  49. ncbi request reprint Acute left prefrontal transcranial magnetic stimulation in depressed patients is associated with immediately increased activity in prefrontal cortical as well as subcortical regions
    Xingbao Li
    Brain Stimulation Laboratory, Department of Psychiatry, Charleston, South Carolina 29425, USA
    Biol Psychiatry 55:882-90. 2004
    ....
  50. ncbi request reprint The maximum-likelihood strategy for determining transcranial magnetic stimulation motor threshold, using parameter estimation by sequential testing is faster than conventional methods with similar precision
    Alexander Mishory
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston 29425, USA
    J ECT 20:160-5. 2004
    ....
  51. ncbi request reprint A pilot study of functional magnetic resonance imaging brain correlates of deception in healthy young men
    F Andrew Kozel
    Center for Advanced Imaging Research, Department of Psychiatry, Medical University of South Carolina, South Carolina, USA
    J Neuropsychiatry Clin Neurosci 16:295-305. 2004
    ..Individually and as a group, EDA correlated with blood flow changes in the OFCx and AC. Specific brain regions were activated during deception, but the present technique lacks good predictive power for individuals...
  52. ncbi request reprint Prefrontal cortex transcranial magnetic stimulation does not change local diffusion: a magnetic resonance imaging study in patients with depression
    Xingbao Li
    Brain Stimulation Laboratory, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Cogn Behav Neurol 16:128-35. 2003
    ....
  53. ncbi request reprint Can left prefrontal rTMS be used as a maintenance treatment for bipolar depression?
    Xingbao Li
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, 67 President Street, Room 502 North, PO Box 250861, Charleston, SC 29425, USA
    Depress Anxiety 20:98-100. 2004
    ..9) over the year. These data suggest but do not prove that TMS might eventually be used as an adjunctive maintenance treatment for at least some patients with bipolar depression. Much work remains...
  54. ncbi request reprint Acute and long-term VNS effects on pain perception in a case of treatment-resistant depression
    Jeffrey J Borckardt
    Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Neurocase 12:216-20. 2006
    ..If the acutely increased sensitivity sets the stage for the slower chronic anti-pain effects, the increased acute sensitivity does not disappear. Acute and chronic effects of VNS on pain perception merit further research...
  55. ncbi request reprint BOLD-fMRI response vs. transcranial magnetic stimulation (TMS) pulse-train length: testing for linearity
    Daryl E Bohning
    Department of Radiology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Magn Reson Imaging 17:279-90. 2003
    ..To measure motor and auditory cortex blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) response to impulse-like transcranial magnetic stimulation (TMS) pulses as a function of train length...
  56. ncbi request reprint Mechanisms and state of the art of transcranial magnetic stimulation
    Mark S George
    Psychiatry Departmemt, Center for Advanced Imaging Research, Medical University of South Carolina, Charleston, SC 29425, USA
    J ECT 18:170-81. 2002
    ..This article reviews the major recent advances with this interesting noninvasive technique for stimulating the brain, critically reviewing the data on whether TMS has anticonvulsant effects or modulates cortical-limbic loops...
  57. ncbi request reprint Decreased cortical response to verbal working memory following sleep deprivation
    Qiwen Mu
    Brain Stimulation Laboratory, Medical University of South Carolina, Charleston 29425, USA
    Sleep 28:55-67. 2005
    ..To investigate the cerebral hemodynamic response to verbal working memory following sleep deprivation...
  58. ncbi request reprint Decreased brain activation during a working memory task at rested baseline is associated with vulnerability to sleep deprivation
    Qiwen Mu
    Brain Stimulation Laboratory, Medical University of South Carolina IOP, 502 N, 67 President St, Charleston, SC 29425, USA
    Sleep 28:433-46. 2005
    ..To examine whether differences in patterns of brain activation under baseline conditions relate to the differences in sleep-deprivation vulnerability...
  59. ncbi request reprint Tolerability and safety of high daily doses of repetitive transcranial magnetic stimulation in healthy young men
    Berry Anderson
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, 29425, USA
    J ECT 22:49-53. 2006
    ..Despite this intense treatment regimen, we failed to produce significant side effects. Doses of up to 12,960 pulses per day appear safe and tolerable in healthy young men...
  60. ncbi request reprint Vagus nerve stimulation (VNS) synchronized BOLD fMRI suggests that VNS in depressed adults has frequency/dose dependent effects
    Mikhail Lomarev
    Department of Radiology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA
    J Psychiatr Res 36:219-27. 2002
    ..g. hearing a tone)...
  61. ncbi request reprint Vagus nerve stimulation (VNS) for major depressive episodes: one year outcomes
    Lauren B Marangell
    Department of Psychiatry, Baylor College of Medicine, One Baylor Plaza, BCM 350, Houston, TX 77030, USA
    Biol Psychiatry 51:280-7. 2002
    ..This open, naturalistic follow-up study was conducted to determine whether the initial promising effects were sustained, and whether changes in function would be observed...
  62. ncbi request reprint Interleaved transcranial magnetic stimulation/functional MRI confirms that lamotrigine inhibits cortical excitability in healthy young men
    Xingbao Li
    Brain Stimulation Laboratory, Center for Advanced Imaging Research CAIR, Medical University of South Carolina MUSC, Charleston, SC 29425, USA
    Neuropsychopharmacology 29:1395-407. 2004
    ..Furthermore, the interleaved TMS/fMRI technique may be a useful tool for investigating regional brain effects of psychoactive compounds...
  63. ncbi request reprint Vagus nerve stimulation therapy: a research update
    Mark S George
    502 North, IoP, Department of Psychiatry, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Neurology 59:S56-61. 2002
    ....
  64. ncbi request reprint Transcranial magnetic stimulation (TMS) as a research tool in Tourette syndrome and related disorders
    M S George
    Functional Neuroimaging Division and Brain Magnetic Stimulation Laboratory, Psychiatry Department, Medical University of South Carolina, Psychiatry Department, Ralph H. Johnson VA Medical Center, Charleston, South Carolina, USA
    Adv Neurol 85:225-35. 2001
    ..These areas of applying TMS to understanding and perhaps treating TS show much promise. Nonetheless, a great deal of basic work is likely needed before TMS can be fully used as a research tool or treatment modality for TS...
  65. ncbi request reprint A pilot safety study of repetitive transcranial magnetic stimulation (rTMS) in Tourette's syndrome
    Jeong Ho Chae
    Brain Stimulation Laboratory, Psychiatry Department, Medical University of South Carolina, Charleston, South Carolina, USA
    Cogn Behav Neurol 17:109-17. 2004
    ..We administered repetitive transcranial magnetic stimulation over prefrontal cortex or motor cortex, with either fast or slow repetitive transcranial magnetic stimulation, to 8 Tourette's syndrome patients...
  66. doi request reprint Cost-effectiveness of transcranial magnetic stimulation in the treatment of major depression: a health economics analysis
    Kit N Simpson
    Medical University of South Carolina, 67 President Street, Room 502N, Charleston, SC, 29403, USA
    Adv Ther 26:346-68. 2009
    ..The incremental cost-effectiveness and the direct cost burden compared with sham treatment were estimated, and compared with the current standard of care...
  67. ncbi request reprint Novel treatments of mood disorders based on brain circuitry (ECT, MST, TMS, VNS, DBS)
    Mark S George
    Brain Stimulation Laboratory and the Department of Psychiatry, Center for Advanced Imaging Research at the Medical University of South Carolina, Charleston, SC, USA
    Semin Clin Neuropsychiatry 7:293-304. 2002
    ..These novel treatments are thus the translational tools to bridge from advances in brain imaging, into new treatments for depressed patients...
  68. ncbi request reprint A review of functional neuroimaging studies of vagus nerve stimulation (VNS)
    Jeong Ho Chae
    The Center for Advanced Imaging Research and Brain Stimulation Laboratory, Medical University of South Carolina, Charleston, SC 29425, USA
    J Psychiatr Res 37:443-55. 2003
    ..These include the thalamus, cerebellum, orbitofrontal cortex, limbic system, hypothalamus, and medulla. Functional neuroimaging studies have the potential to provide greater insight into the brain circuitry behind the activity of VNS...
  69. doi request reprint More lateral and anterior prefrontal coil location is associated with better repetitive transcranial magnetic stimulation antidepressant response
    Tal Herbsman
    Department of Psychiatry, Brain Stimulation Laboratory, Center for Advanced Imaging Research, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Biol Psychiatry 66:509-15. 2009
    ..This study is a post hoc analysis of data from a large repetitive TMS (rTMS) trial in which we examined the variability of coil placement and how it affects antidepressant efficacy...
  70. ncbi request reprint Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial
    H Brent Solvason
    Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Philadelphia, PA 19014, USA
    Biol Psychiatry 62:1208-16. 2007
    ..We tested whether transcranial magnetic stimulation (TMS) over the left dorsolateral prefrontal cortex (DLPFC) is effective and safe in the acute treatment of major depression...
  71. ncbi request reprint Vagus nerve stimulation acutely alters food craving in adults with depression
    Jamie S Bodenlos
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 165 Cannon Street, 3rd Floor, P O Box 250852, Charleston, SC 29425, USA
    Appetite 48:145-53. 2007
    ..Further studies are warranted addressing how acute or chronic VNS might modify eating behavior and weight...
  72. pmc Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats
    Ziad Nahas
    Mood Disorders Program, University of South Carolina, Charleston, SC 29425, USA
    Behav Brain Res 197:41-4. 2009
    ..The availability of anti-ceramidase pro-apoptocic compound (LCL385) provides an opportunity to test in vivo the relation between hippocampal apopotosis and learned helplessness...
  73. ncbi request reprint Emotion facilitates action: a transcranial magnetic stimulation study of motor cortex excitability during picture viewing
    Greg Hajcak
    Department of Psychology, Stony Brook University, Stony Brook, New York 11794 2500, USA
    Psychophysiology 44:91-7. 2007
    ..Thus, viewing arousing stimuli, regardless of valence, increased motor cortex excitability. Implications and directions for future research are discussed...
  74. ncbi request reprint Functional neuroanatomy of subcomponent cognitive processes involved in verbal working memory
    Jeffrey S Bedwell
    Department of Psychology, University of Central Florida, Orlando, Florida 32816 1390, USA
    Int J Neurosci 115:1017-32. 2005
    ..Several other brain regions showed activation limited to specific subcomponent processes...
  75. ncbi request reprint Double-blind donepezil-placebo crossover augmentation study of atypical antipsychotics in chronic, stable schizophrenia: a pilot study
    S Craig Risch
    Langley Porter Psychiatric Institute, University of California San Francisco 94143 0984, USA
    Schizophr Res 93:131-5. 2007
    ..018, n=13). These results are discussed with respect to other studies using cholinesterase inhibitors as an augmentation strategy in schizophrenia...
  76. ncbi request reprint Transcranial magnetic stimulation for treating psychiatric conditions: what have we learned so far?
    Ziad Nahas
    Can J Psychiatry 53:553-4. 2008

Research Grants3

  1. DBS and Rodent Antidepressant- Screen Models
    Ziad Nahas; Fiscal Year: 2007
    ..Future work will bridge between validating these findings in more comprehensive models of depression and clinical investigations of the DBS antidepressant effect in patients with treatment resistant depression. ..