Research Topics
| Hugh MyrickSummaryAffiliation: Medical University of South Carolina Country: USA Publications
Research Grants
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Detail Information
Publications
New developments in the pharmacotherapy of alcohol dependenceH Myrick
Department of Psychiatry, Medical University of South Carolina, 67 President Street, P O Box 250861, Charleston, SC 29425, USA
Am J Addict 10:3-15. 2001..Finally, there will be a review of new data concerning the use of serotonin reuptake inhibitors in subtypes of alcoholism and the use of combination pharmacotherapy...
Effect of naltrexone and ondansetron on alcohol cue-induced activation of the ventral striatum in alcohol-dependent peopleHugh Myrick
Research and Development Service, Ralph H Johnson Department of Veterans Affairs Medical Center, Charleston, SC, USA
Arch Gen Psychiatry 65:466-75. 2008..Medication for the treatment of alcoholism is currently not particularly robust. Neuroimaging techniques might predict which medications could be useful in the treatment of alcohol dependence...- A double-blind evaluation of gabapentin on alcohol effects and drinking in a clinical laboratory paradigmHugh Myrick
Ralph H Johnson Department of Veterans Affairs Medical Center, Research and Development Service, Charleston, South Carolina, USA
Alcohol Clin Exp Res 31:221-7. 2007..In addition, the ability of gabapentin to reduce alcohol craving and consumption was evaluated... 
The effect of aripiprazole on cue-induced brain activation and drinking parameters in alcoholicsHugh Myrick
Ralph H Johnson Department of Veterans Affairs Medical Center, Research and Development Service, Medical University of South Carolina, Charleston, SC 29425, USA
J Clin Psychopharmacol 30:365-72. 2010..The study provides both novel and valuable information regarding the effect of aripiprazole on cue-induced brain activation and voluntary drinking during treatment...- A retrospective chart review comparing tiagabine and benzodiazepines for the treatment of alcohol withdrawalHugh Myrick
Institute of Psychiatry, MUSC, Charleston, South Carolina 29425, USA
J Psychoactive Drugs 37:409-14. 2005..12). The reduction in alcohol withdrawal symptoms and decreased tendency to relapse observed in patients treated with the anticonvulsant tiagabine suggests that a double-blind, placebo controlled trial may be warranted... - A double-blind trial of gabapentin versus lorazepam in the treatment of alcohol withdrawalHugh Myrick
Ralph H Johnson Department of Veterans Affairs Medical Center, Research and Development Service, Charleston, SC, USA
Alcohol Clin Exp Res 33:1582-8. 2009..The aim of this study was to evaluate alcohol use and symptom reduction of gabapentin when compared with lorazepam in the treatment of alcohol withdrawal in a double-blinded randomized clinical trial... - Diagnosis and treatment of co-occurring affective disorders and substance use disordersHugh Myrick
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
Psychiatr Clin North Am 27:649-59. 2004..In conclusion, although the co-occurrence of substance abuse and mood disorders is an important area in which recent developments provide cause for considerable optimism, much work remains to be done... - Recent advances in the pharmacotherapy of alcoholismHugh Myrick
Alcohol Research Center, Medical University of South Carolina Department of Psychiatry and Behavioral Sciences, 67 President Street, Charleston, SC 29425, USA
Curr Psychiatry Rep 6:332-8. 2004..Data on naltrexone, acamprosate, and topiramate will be highlighted. In addition, data concerning the use of serotonin reuptake inhibitors in subtypes of alcoholism and the use of combination pharmacotherapy will be reviewed... - Clinical characteristics of under-reporters on urine drug screens in a cocaine treatment studyHugh Myrick
Medical University of South Carolina, Department of Psychiatry, Center for Drug and Alcohol Programs, 67 President Street, Charleston, SC 29425, USA
Am J Addict 11:255-61. 2002..Significant differences were found in cocaine use patterns and the prevalence of Axis I and Axis II disorders. This information may be important in guiding the judicious use of UDS in clinical and research settings... - Modafinil: preclinical, clinical, and post-marketing surveillance--a review of abuse liability issuesHugh Myrick
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Ann Clin Psychiatry 16:101-9. 2004..Initial evidence suggests that modafinil has limited potential for large-scale abuse... - The use of divalproex in the treatment of addictive disordersHugh Myrick
Institute of Psychiatry 4N, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
Psychopharmacol Bull 37:89-97. 2003..This article will review the literature regarding the use of valproate in treating alcohol withdrawal symptoms and in reducing the use of alcohol and cocaine... - Utility of a new assay for carbohydrate-deficient transferrin (Biorad %CDT TIA) to monitor abstinence during a treatment outcome studyH Myrick
Ralph H Johnson Veterans Affairs Medical Center, Charleston, South Carolina 29401, USA
Alcohol Clin Exp Res 25:1330-4. 2001..The current study evaluates the utility of the newest method of measuring carbohydrate deficient transferrin (CDT) in monitoring the abstinence during a treatment outcome study... - Differential brain activity in alcoholics and social drinkers to alcohol cues: relationship to cravingHugh Myrick
Department of Psychiatry and Behavioral Sciences, Alcohol Research Center, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
Neuropsychopharmacology 29:393-402. 2004..This study suggests, as did our earlier study, that alcoholics and not social drinkers, when exposed to alcohol cues, have increased brain activity in areas that reportedly subserve craving for other addictive substances... - Is cocaine desire reduced by N-acetylcysteine?Steven D LaRowe
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
Am J Psychiatry 164:1115-7. 2007..Animal models suggest that N-acetylcysteine inhibits cocaine-seeking. The present pilot study evaluated whether N-acetylcysteine would suppress reactivity to cocaine-related cues in cocaine-dependent humans... - Gabapentin combined with naltrexone for the treatment of alcohol dependenceRaymond F Anton
Medical University of South Carolina, Institute of Psychiatry, SC 29425, USA
Am J Psychiatry 168:709-17. 2011..This clinical trial evaluated whether the combination of naltrexone and gabapentin was better than naltrexone alone and/or placebo during the early drinking cessation phase (first 6 weeks), and if so, whether this effect persisted... - Neurocognitive performance, alcohol withdrawal, and effects of a combination of flumazenil and gabapentin in alcohol dependenceJOSEPH P SCHACHT
Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Alcohol Clin Exp Res 35:2030-8. 2011..2009). This study evaluated whether this finding is related to changes in neurocognitive performance, which is also affected by cortical GABA and glutamate tone... - Novel anticonvulsants in the treatment of alcoholismSarah W Book
Medical University of South Carolina, Department of Psychiatry and Behavioural Sciences, Charleston Alcohol Research Center, 67 President Street, Charleston, SC 29425, USA
Expert Opin Investig Drugs 14:371-6. 2005..Although none of these agents have yet been approved by the FDA, there is growing evidence in the literature to support their use... - The differential effects of medication on mood, sleep disturbance, and work ability in outpatient alcohol detoxificationRobert Malcolm
Alcohol Research Center, Medical University of South Carolina, Charleston 29425, USA
Am J Addict 11:141-50. 2002..025). In this study of outpatients with mild to moderate alcohol withdrawal, carbamazepine was superior to lorazepam in reducing anxiety and improving sleep... - Aripiprazole effects on alcohol consumption and subjective reports in a clinical laboratory paradigm--possible influence of self-controlKonstantin Voronin
Alcohol Research Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Alcohol Clin Exp Res 32:1954-61. 2008..The current clinical laboratory study was conducted to evaluate the safety and efficacy of aripiprazole as a potential agent to alter drinking and objective effects of alcohol... - Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptomsRaymond F Anton
Medical University of South Carolina, Charleston, SC, USA
J Clin Psychopharmacol 29:334-42. 2009..These results suggest a differential response to FMZ/GBP treatment, depending on pretreatment AW status that should be taken into account during future treatment trials... - The use of divalproex in alcohol relapse prevention: a pilot studyKathleen T Brady
Institute of Psychiatry and Behavioral Science, Center for Drug and Alcohol Programs, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
Drug Alcohol Depend 67:323-30. 2002..This is consistent with the findings of other investigators exploring the use of DVPX in schizophrenia, personality disorder and a number of other psychiatric disorders... - Naltrexone combined with either cognitive behavioral or motivational enhancement therapy for alcohol dependenceRaymond F Anton
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
J Clin Psychopharmacol 25:349-57. 2005..Because CBT and naltrexone share common mechanisms of action, such as craving reduction and relapse prevention, these therapies are likely to be well suited to use in combination... - Stability of fMRI striatal response to alcohol cues: a hierarchical linear modeling approachJOSEPH P SCHACHT
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, SC, USA
Neuroimage 56:61-8. 2011.... - Neural correlates of craving and resisting craving for tobacco in nicotine dependent smokersKaren J Hartwell
Medical University of South Carolina, Charleston, 29425, USA
Addict Biol 16:654-66. 2011..Different strategies for resisting, such as distraction, activated different regions. Understanding the underlying neurobiology of resisting craving to smoke may identify new foci for treatments... - Risk factors for delirium tremens: a retrospective chart reviewTara Wright
Department of Psychiatry and Behavioral Sciences, Alcohol Research Center, Medical University of South Carolina, Charleston, South Carolina, USA
Am J Addict 15:213-9. 2006..While not reaching statistical significance, there were differences in reason for admission and relapse rate upon follow-up between the groups... - Impact of lifetime alcohol quit attempts and medicated detoxifications on time to relapse during an index alcohol detoxificationTara M Wright
From the Center for Drug and Alcohol Program TMW, hm, RM, PR, EB, SH, RA, Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, Charleston, SC and Ralph H Johnson Department of Veteran Affairs Medical Center HM, Research and Development Service, Charleston, SC
J Addict Med 1:15-20. 2007.... - Pregabalin is effective against behavioral and electrographic seizures during alcohol withdrawalHoward C Becker
Charleston Alcohol Research Center, Center for Drug and Alcohol Programs, Institute of Psychiatry, 67 President Street, Charleston, SC 29425, USA
Alcohol Alcohol 41:399-406. 2006.... - Beliefs as a predictor of relapse in alcohol-dependent Turkish menHakan Turkcapar
Medical University of South Carolina Institute of Psychiatry, 67 President Street, P.O. Box 250861, Room 502N, Charleston, South Carolina 29425, USA
J Stud Alcohol 66:848-51. 2005..These factors could have a direct clinical application for predicting relapse to drinking in male alcohol-dependent patients... - Safety and tolerability of N-acetylcysteine in cocaine-dependent individualsSteven D LaRowe
Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Am J Addict 15:105-10. 2006..These preliminary results suggest that NAC is well tolerated in healthy, cocaine-dependent individuals and may reduce cocaine-related withdrawal symptoms and craving... - Prolonged exposure therapy for combat-related posttraumatic stress disorder: an examination of treatment effectiveness for veterans of the wars in Afghanistan and IraqPeter W Tuerk
Ralph H Johnson VA Medical Center, Mental Health Service, Charleston, SC 29401, United States
J Anxiety Disord 25:397-403. 2011..Results indicate that PE in regular VA mental healthcare contexts can be as effective as when implemented in carefully conducted RCTs... - Telehealth service delivery for persons with alcoholismB Christopher Frueh
Medical University of South Carolina, South Carolina, USA
J Telemed Telecare 11:372-5. 2005..The results demonstrate the feasibility of using videoconferencing for service delivery to adults with AUD, and encourage the future performance of randomized controlled trials... - The maximum-likelihood strategy for determining transcranial magnetic stimulation motor threshold, using parameter estimation by sequential testing is faster than conventional methods with similar precisionAlexander Mishory
Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston 29425, USA
J ECT 20:160-5. 2004.... - Health service use among persons with comorbid bipolar and substance use disordersMarcia L Verduin
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, P O Box 250861, Charleston, South Carolina 29425, USA
Psychiatr Serv 56:475-80. 2005..This study tested the hypothesis that patients with comorbid bipolar and substance use disorders use health services to a greater extent than patients with either bipolar or substance use disorder alone... - Functional neuroimaging studies of alcohol cue reactivity: a quantitative meta-analysis and systematic reviewJOSEPH P SCHACHT
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA Ralph H Johnson Department of Veterans Affairs Medical Center, Charleston, SC, USA
Addict Biol 18:121-33. 2013..Prevention and treatment for AUD should consider interventions that may reduce cue-elicited activation of these areas... - Naltrexone Modification of Drinking Effects in a Subacute Treatment and Bar-Lab Paradigm: Influence of OPRM1 and Dopamine Transporter (SLC6A3) GenesRaymond F Anton
Medical University of South Carolina, Charleston, South Carolina
Alcohol Clin Exp Res 36:2000-7. 2012.... - Combat posttraumatic stress disorder, substance use disorders, and traumatic brain injuryKathleen T Brady
From the Department of Psychiatry K T B, S E B, M E S, and Mental Health Service Line K T B, P T, H M, Ralph H Johnson VA Medical Center, Medical University of South Carolina, Charleston, SC and PTSD Clinical Team A E W, San Francisco VAMC, University of California, San Francisco, CA
J Addict Med 3:179-88. 2009..Careful assessment of these conditions is critical and may be complicated by symptom overlap. More research targeting integrated interventions for these conditions is needed to establish optimal treatments... - Modafinil and cocaine interactionsRobert Malcolm
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Am J Drug Alcohol Abuse 32:577-87. 2006..Modafinil significantly dampened scores on Visual Analog Scale measures as compared to baseline cocaine conditions. No significant alterations in labs occurred. Further outpatient trials of modafinil appear to be warranted...
Research Grants
- TRAINING IN FUNCTIONAL IMAGING AND ALCOHOL WITHDRAWALDONALD MYRICK; Fiscal Year: 2004....