Hugh Myrick

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. ncbi request reprint New developments in the pharmacotherapy of alcohol dependence
    H Myrick
    Department of Psychiatry, Medical University of South Carolina, 67 President Street, P O Box 250861, Charleston, SC 29425, USA
    Am J Addict 10:3-15. 2001
  2. ncbi request reprint A double-blind evaluation of gabapentin on alcohol effects and drinking in a clinical laboratory paradigm
    Hugh Myrick
    Ralph H Johnson Department of Veterans Affairs Medical Center, Research and Development Service, Charleston, South Carolina, USA
    Alcohol Clin Exp Res 31:221-7. 2007
  3. ncbi request reprint A retrospective chart review comparing tiagabine and benzodiazepines for the treatment of alcohol withdrawal
    Hugh Myrick
    Institute of Psychiatry, MUSC, Charleston, South Carolina 29425, USA
    J Psychoactive Drugs 37:409-14. 2005
  4. ncbi request reprint Diagnosis and treatment of co-occurring affective disorders and substance use disorders
    Hugh Myrick
    Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Psychiatr Clin North Am 27:649-59. 2004
  5. ncbi request reprint Recent advances in the pharmacotherapy of alcoholism
    Hugh Myrick
    Alcohol Research Center, Medical University of South Carolina Department of Psychiatry and Behavioral Sciences, 67 President Street, Charleston, SC 29425, USA
    Curr Psychiatry Rep 6:332-8. 2004
  6. ncbi request reprint Modafinil: preclinical, clinical, and post-marketing surveillance--a review of abuse liability issues
    Hugh Myrick
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann Clin Psychiatry 16:101-9. 2004
  7. ncbi request reprint The use of divalproex in the treatment of addictive disorders
    Hugh Myrick
    Institute of Psychiatry 4N, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Psychopharmacol Bull 37:89-97. 2003
  8. ncbi request reprint Differential brain activity in alcoholics and social drinkers to alcohol cues: relationship to craving
    Hugh Myrick
    Department of Psychiatry and Behavioral Sciences, Alcohol Research Center, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Neuropsychopharmacology 29:393-402. 2004
  9. ncbi request reprint Clinical characteristics of under-reporters on urine drug screens in a cocaine treatment study
    Hugh Myrick
    Medical University of South Carolina, Department of Psychiatry, Center for Drug and Alcohol Programs, 67 President Street, Charleston, SC 29425, USA
    Am J Addict 11:255-61. 2002
  10. pmc A double-blind trial of gabapentin versus lorazepam in the treatment of alcohol withdrawal
    Hugh Myrick
    Ralph H Johnson Department of Veterans Affairs Medical Center, Research and Development Service, Charleston, SC, USA
    Alcohol Clin Exp Res 33:1582-8. 2009

Research Grants

Detail Information

Publications43

  1. ncbi request reprint New developments in the pharmacotherapy of alcohol dependence
    H Myrick
    Department of Psychiatry, Medical University of South Carolina, 67 President Street, P O Box 250861, Charleston, SC 29425, USA
    Am J Addict 10:3-15. 2001
    ..Finally, there will be a review of new data concerning the use of serotonin reuptake inhibitors in subtypes of alcoholism and the use of combination pharmacotherapy...
  2. ncbi request reprint A double-blind evaluation of gabapentin on alcohol effects and drinking in a clinical laboratory paradigm
    Hugh Myrick
    Ralph H Johnson Department of Veterans Affairs Medical Center, Research and Development Service, Charleston, South Carolina, USA
    Alcohol Clin Exp Res 31:221-7. 2007
    ..In addition, the ability of gabapentin to reduce alcohol craving and consumption was evaluated...
  3. ncbi request reprint A retrospective chart review comparing tiagabine and benzodiazepines for the treatment of alcohol withdrawal
    Hugh Myrick
    Institute of Psychiatry, MUSC, Charleston, South Carolina 29425, USA
    J Psychoactive Drugs 37:409-14. 2005
    ..12). The reduction in alcohol withdrawal symptoms and decreased tendency to relapse observed in patients treated with the anticonvulsant tiagabine suggests that a double-blind, placebo controlled trial may be warranted...
  4. ncbi request reprint Diagnosis and treatment of co-occurring affective disorders and substance use disorders
    Hugh Myrick
    Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Psychiatr Clin North Am 27:649-59. 2004
    ..In conclusion, although the co-occurrence of substance abuse and mood disorders is an important area in which recent developments provide cause for considerable optimism, much work remains to be done...
  5. ncbi request reprint Recent advances in the pharmacotherapy of alcoholism
    Hugh Myrick
    Alcohol Research Center, Medical University of South Carolina Department of Psychiatry and Behavioral Sciences, 67 President Street, Charleston, SC 29425, USA
    Curr Psychiatry Rep 6:332-8. 2004
    ..Data on naltrexone, acamprosate, and topiramate will be highlighted. In addition, data concerning the use of serotonin reuptake inhibitors in subtypes of alcoholism and the use of combination pharmacotherapy will be reviewed...
  6. ncbi request reprint Modafinil: preclinical, clinical, and post-marketing surveillance--a review of abuse liability issues
    Hugh Myrick
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann Clin Psychiatry 16:101-9. 2004
    ..Initial evidence suggests that modafinil has limited potential for large-scale abuse...
  7. ncbi request reprint The use of divalproex in the treatment of addictive disorders
    Hugh Myrick
    Institute of Psychiatry 4N, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Psychopharmacol Bull 37:89-97. 2003
    ..This article will review the literature regarding the use of valproate in treating alcohol withdrawal symptoms and in reducing the use of alcohol and cocaine...
  8. ncbi request reprint Differential brain activity in alcoholics and social drinkers to alcohol cues: relationship to craving
    Hugh Myrick
    Department of Psychiatry and Behavioral Sciences, Alcohol Research Center, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Neuropsychopharmacology 29:393-402. 2004
    ..This study suggests, as did our earlier study, that alcoholics and not social drinkers, when exposed to alcohol cues, have increased brain activity in areas that reportedly subserve craving for other addictive substances...
  9. ncbi request reprint Clinical characteristics of under-reporters on urine drug screens in a cocaine treatment study
    Hugh Myrick
    Medical University of South Carolina, Department of Psychiatry, Center for Drug and Alcohol Programs, 67 President Street, Charleston, SC 29425, USA
    Am J Addict 11:255-61. 2002
    ..Significant differences were found in cocaine use patterns and the prevalence of Axis I and Axis II disorders. This information may be important in guiding the judicious use of UDS in clinical and research settings...
  10. pmc A double-blind trial of gabapentin versus lorazepam in the treatment of alcohol withdrawal
    Hugh Myrick
    Ralph H Johnson Department of Veterans Affairs Medical Center, Research and Development Service, Charleston, SC, USA
    Alcohol Clin Exp Res 33:1582-8. 2009
    ..The aim of this study was to evaluate alcohol use and symptom reduction of gabapentin when compared with lorazepam in the treatment of alcohol withdrawal in a double-blinded randomized clinical trial...
  11. pmc Effect of naltrexone and ondansetron on alcohol cue-induced activation of the ventral striatum in alcohol-dependent people
    Hugh Myrick
    Research and Development Service, Ralph H Johnson Department of Veterans Affairs Medical Center, Charleston, SC, USA
    Arch Gen Psychiatry 65:466-75. 2008
    ..Medication for the treatment of alcoholism is currently not particularly robust. Neuroimaging techniques might predict which medications could be useful in the treatment of alcohol dependence...
  12. ncbi request reprint Utility of a new assay for carbohydrate-deficient transferrin (Biorad %CDT TIA) to monitor abstinence during a treatment outcome study
    H Myrick
    Ralph H Johnson Veterans Affairs Medical Center, Charleston, South Carolina 29401, USA
    Alcohol Clin Exp Res 25:1330-4. 2001
    ..The current study evaluates the utility of the newest method of measuring carbohydrate deficient transferrin (CDT) in monitoring the abstinence during a treatment outcome study...
  13. pmc The effect of aripiprazole on cue-induced brain activation and drinking parameters in alcoholics
    Hugh Myrick
    Ralph H Johnson Department of Veterans Affairs Medical Center, Research and Development Service, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Psychopharmacol 30:365-72. 2010
    ..The study provides both novel and valuable information regarding the effect of aripiprazole on cue-induced brain activation and voluntary drinking during treatment...
  14. pmc Effects of a GABA-ergic medication combination and initial alcohol withdrawal severity on cue-elicited brain activation among treatment-seeking alcoholics
    JOSEPH P SCHACHT
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 227:627-37. 2013
    ..However, few have combined the methodological rigor of a randomized clinical trial (RCT) with follow-up assessments to determine whether cue-elicited activation predicts relapse during treatment, the crux of alcoholism...
  15. ncbi request reprint Is cocaine desire reduced by N-acetylcysteine?
    Steven D LaRowe
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Psychiatry 164:1115-7. 2007
    ..Animal models suggest that N-acetylcysteine inhibits cocaine-seeking. The present pilot study evaluated whether N-acetylcysteine would suppress reactivity to cocaine-related cues in cocaine-dependent humans...
  16. pmc Gabapentin combined with naltrexone for the treatment of alcohol dependence
    Raymond F Anton
    Medical University of South Carolina, Institute of Psychiatry, SC 29425, USA
    Am J Psychiatry 168:709-17. 2011
    ..This clinical trial evaluated whether the combination of naltrexone and gabapentin was better than naltrexone alone and/or placebo during the early drinking cessation phase (first 6 weeks), and if so, whether this effect persisted...
  17. pmc Neurocognitive performance, alcohol withdrawal, and effects of a combination of flumazenil and gabapentin in alcohol dependence
    JOSEPH P SCHACHT
    Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Alcohol Clin Exp Res 35:2030-8. 2011
    ..2009). This study evaluated whether this finding is related to changes in neurocognitive performance, which is also affected by cortical GABA and glutamate tone...
  18. pmc Interacting effects of naltrexone and OPRM1 and DAT1 variation on the neural response to alcohol cues
    JOSEPH P SCHACHT
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuropsychopharmacology 38:414-22. 2013
    ..Further, 10R homozygotes who received NTX had less mPFC activation than 9R carriers. Polymorphic variation in OPRM1 and DAT1 should be considered in future studies of NTX, particularly regarding its effects on reward processing...
  19. ncbi request reprint Novel anticonvulsants in the treatment of alcoholism
    Sarah W Book
    Medical University of South Carolina, Department of Psychiatry and Behavioural Sciences, Charleston Alcohol Research Center, 67 President Street, Charleston, SC 29425, USA
    Expert Opin Investig Drugs 14:371-6. 2005
    ..Although none of these agents have yet been approved by the FDA, there is growing evidence in the literature to support their use...
  20. ncbi request reprint The differential effects of medication on mood, sleep disturbance, and work ability in outpatient alcohol detoxification
    Robert Malcolm
    Alcohol Research Center, Medical University of South Carolina, Charleston 29425, USA
    Am J Addict 11:141-50. 2002
    ..025). In this study of outpatients with mild to moderate alcohol withdrawal, carbamazepine was superior to lorazepam in reducing anxiety and improving sleep...
  21. pmc Impact of DCS-facilitated cue exposure therapy on brain activation to cocaine cues in cocaine dependence
    James J Prisciandaro
    Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, Clinical Neuroscience Division, 67 President Street, MSC861, Charleston, SC 29425, United States
    Drug Alcohol Depend 132:195-201. 2013
    ....
  22. pmc Aripiprazole effects on alcohol consumption and subjective reports in a clinical laboratory paradigm--possible influence of self-control
    Konstantin Voronin
    Alcohol Research Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Alcohol Clin Exp Res 32:1954-61. 2008
    ..The current clinical laboratory study was conducted to evaluate the safety and efficacy of aripiprazole as a potential agent to alter drinking and objective effects of alcohol...
  23. doi request reprint Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms
    Raymond F Anton
    Medical University of South Carolina, Charleston, SC, USA
    J Clin Psychopharmacol 29:334-42. 2009
    ..These results suggest a differential response to FMZ/GBP treatment, depending on pretreatment AW status that should be taken into account during future treatment trials...
  24. ncbi request reprint The use of divalproex in alcohol relapse prevention: a pilot study
    Kathleen T Brady
    Institute of Psychiatry and Behavioral Science, Center for Drug and Alcohol Programs, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Drug Alcohol Depend 67:323-30. 2002
    ..This is consistent with the findings of other investigators exploring the use of DVPX in schizophrenia, personality disorder and a number of other psychiatric disorders...
  25. ncbi request reprint Naltrexone combined with either cognitive behavioral or motivational enhancement therapy for alcohol dependence
    Raymond F Anton
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    J Clin Psychopharmacol 25:349-57. 2005
    ..Because CBT and naltrexone share common mechanisms of action, such as craving reduction and relapse prevention, these therapies are likely to be well suited to use in combination...
  26. pmc Stability of fMRI striatal response to alcohol cues: a hierarchical linear modeling approach
    JOSEPH P SCHACHT
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, SC, USA
    Neuroimage 56:61-8. 2011
    ....
  27. pmc Neural correlates of craving and resisting craving for tobacco in nicotine dependent smokers
    Karen J Hartwell
    Medical University of South Carolina, Charleston, 29425, USA
    Addict Biol 16:654-66. 2011
    ..Different strategies for resisting, such as distraction, activated different regions. Understanding the underlying neurobiology of resisting craving to smoke may identify new foci for treatments...
  28. ncbi request reprint Risk factors for delirium tremens: a retrospective chart review
    Tara Wright
    Department of Psychiatry and Behavioral Sciences, Alcohol Research Center, Medical University of South Carolina, Charleston, South Carolina, USA
    Am J Addict 15:213-9. 2006
    ..While not reaching statistical significance, there were differences in reason for admission and relapse rate upon follow-up between the groups...
  29. pmc Prospective associations between brain activation to cocaine and no-go cues and cocaine relapse
    James J Prisciandaro
    Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, Clinical Neuroscience Division, 67 President Street, Charleston, SC 29425, USA
    Drug Alcohol Depend 131:44-9. 2013
    ..The purpose of the present study was to use fMRI to investigate prospective associations between brain reactivity to cocaine and response inhibition cues and relapse to cocaine use...
  30. pmc Naltrexone modification of drinking effects in a subacute treatment and bar-lab paradigm: influence of OPRM1 and dopamine transporter (SLC6A3) genes
    Raymond F Anton
    Institute of Psychiatry, Medical University of South Carolina, 67 President St, Charleston, SC 29425, USA
    Alcohol Clin Exp Res 36:2000-7. 2012
    ....
  31. ncbi request reprint Impact of lifetime alcohol quit attempts and medicated detoxifications on time to relapse during an index alcohol detoxification
    Tara M Wright
    From the Center for Drug and Alcohol Program TMW, hm, RM, PR, EB, SH, RA, Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, Charleston, SC and Ralph H Johnson Department of Veteran Affairs Medical Center HM, Research and Development Service, Charleston, SC
    J Addict Med 1:15-20. 2007
    ....
  32. pmc Functional neuroimaging studies of alcohol cue reactivity: a quantitative meta-analysis and systematic review
    JOSEPH P SCHACHT
    Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, 29425, USA
    Addict Biol 18:121-33. 2013
    ..Prevention and treatment for AUD should consider interventions that may reduce cue-elicited activation of these areas...
  33. doi request reprint Brain activation to cocaine cues and motivation/treatment status
    James J Prisciandaro
    Department of Psychiatry and Behavioral Sciences, Clinical Neuroscience Division, Medical University of South Carolina, Charleston, SC, USA
    Addict Biol 19:240-9. 2014
    ....
  34. doi request reprint A pilot trial of neuropsychological evaluations conducted via telemedicine in the Veterans Health Administration
    Travis H Turner
    Mental Health Service Line, Ralph H Johnson Department of Veterans Affairs Medical Center, Charleston, South Carolina 29401, USA
    Telemed J E Health 18:662-7. 2012
    ..Return trips for feedback compound complications. Accordingly, we initiated a pilot trial of neuropsychological evaluation and feedback via telemedicine (i.e., clinical videoconferencing)...
  35. ncbi request reprint Beliefs as a predictor of relapse in alcohol-dependent Turkish men
    Hakan Turkcapar
    Medical University of South Carolina Institute of Psychiatry, 67 President Street, P O Box 250861, Room 502N, Charleston, South Carolina 29425, USA
    J Stud Alcohol 66:848-51. 2005
    ..The aim of the current study was to evaluate the role of beliefs about alcohol use and craving on predicting relapse as stated in Beck's cognitive theory of alcoholism in detoxified alcohol-dependent patients...
  36. ncbi request reprint Pregabalin is effective against behavioral and electrographic seizures during alcohol withdrawal
    Howard C Becker
    Charleston Alcohol Research Center, Center for Drug and Alcohol Programs, Institute of Psychiatry, 67 President Street, Charleston, SC 29425, USA
    Alcohol Alcohol 41:399-406. 2006
    ....
  37. pmc Safety and tolerability of N-acetylcysteine in cocaine-dependent individuals
    Steven D LaRowe
    Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Addict 15:105-10. 2006
    ..These preliminary results suggest that NAC is well tolerated in healthy, cocaine-dependent individuals and may reduce cocaine-related withdrawal symptoms and craving...
  38. doi request reprint Prolonged exposure therapy for combat-related posttraumatic stress disorder: an examination of treatment effectiveness for veterans of the wars in Afghanistan and Iraq
    Peter W Tuerk
    Ralph H Johnson VA Medical Center, Mental Health Service, Charleston, SC 29401, United States
    J Anxiety Disord 25:397-403. 2011
    ..Results indicate that PE in regular VA mental healthcare contexts can be as effective as when implemented in carefully conducted RCTs...
  39. ncbi request reprint Health service use among persons with comorbid bipolar and substance use disorders
    Marcia L Verduin
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, P O Box 250861, Charleston, South Carolina 29425, USA
    Psychiatr Serv 56:475-80. 2005
    ..This study tested the hypothesis that patients with comorbid bipolar and substance use disorders use health services to a greater extent than patients with either bipolar or substance use disorder alone...
  40. ncbi request reprint The maximum-likelihood strategy for determining transcranial magnetic stimulation motor threshold, using parameter estimation by sequential testing is faster than conventional methods with similar precision
    Alexander Mishory
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston 29425, USA
    J ECT 20:160-5. 2004
    ....
  41. ncbi request reprint Telehealth service delivery for persons with alcoholism
    B Christopher Frueh
    Medical University of South Carolina, South Carolina, USA
    J Telemed Telecare 11:372-5. 2005
    ..The results demonstrate the feasibility of using videoconferencing for service delivery to adults with AUD, and encourage the future performance of randomized controlled trials...
  42. ncbi request reprint Combat posttraumatic stress disorder, substance use disorders, and traumatic brain injury
    Kathleen T Brady
    From the Department of Psychiatry K T B, S E B, M E S, and Mental Health Service Line K T B, P T, H M, Ralph H Johnson VA Medical Center, Medical University of South Carolina, Charleston, SC and PTSD Clinical Team A E W, San Francisco VAMC, University of California, San Francisco, CA
    J Addict Med 3:179-88. 2009
    ..Careful assessment of these conditions is critical and may be complicated by symptom overlap. More research targeting integrated interventions for these conditions is needed to establish optimal treatments...
  43. ncbi request reprint Modafinil and cocaine interactions
    Robert Malcolm
    Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Drug Alcohol Abuse 32:577-87. 2006
    ..Modafinil significantly dampened scores on Visual Analog Scale measures as compared to baseline cocaine conditions. No significant alterations in labs occurred. Further outpatient trials of modafinil appear to be warranted...

Research Grants1

  1. TRAINING IN FUNCTIONAL IMAGING AND ALCOHOL WITHDRAWAL
    DONALD MYRICK; Fiscal Year: 2004
    ....