Charles Myers

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi The effects of chromium(VI) on the thioredoxin system: implications for redox regulation
    Charles R Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Free Radic Biol Med 52:2091-107. 2012
  2. ncbi The outer membrane protein Omp35 affects the reduction of Fe(III), nitrate, and fumarate by Shewanella oneidensis MR-1
    Tamara M Maier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, 53226, USA
    BMC Microbiol 4:23. 2004
  3. ncbi The effects of acrolein on the thioredoxin system: implications for redox-sensitive signaling
    Charles R Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Mol Nutr Food Res 55:1361-74. 2011
  4. ncbi The pro-oxidant chromium(VI) inhibits mitochondrial complex I, complex II, and aconitase in the bronchial epithelium: EPR markers for Fe-S proteins
    Charles R Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Free Radic Biol Med 49:1903-15. 2010
  5. ncbi The outer membrane cytochromes of Shewanella oneidensis MR-1 are lipoproteins
    C R Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Lett Appl Microbiol 39:466-70. 2004
  6. ncbi Shewanella oneidensis MR-1 restores menaquinone synthesis to a menaquinone-negative mutant
    Charles R Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Appl Environ Microbiol 70:5415-25. 2004
  7. ncbi Cell surface exposure of the outer membrane cytochromes of Shewanella oneidensis MR-1
    C R Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA
    Lett Appl Microbiol 37:254-8. 2003
  8. ncbi MtrB is required for proper incorporation of the cytochromes OmcA and OmcB into the outer membrane of Shewanella putrefaciens MR-1
    Charles R Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Appl Environ Microbiol 68:5585-94. 2002
  9. ncbi Vanadium(V) reduction by Shewanella oneidensis MR-1 requires menaquinone and cytochromes from the cytoplasmic and outer membranes
    Judith M Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Appl Environ Microbiol 70:1405-12. 2004
  10. ncbi Genetic complementation of an outer membrane cytochrome omcB mutant of Shewanella putrefaciens MR-1 requires omcB plus downstream DNA
    Judith M Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Appl Environ Microbiol 68:2781-93. 2002

Research Grants

  1. OUTER MEMBRANE CYTOCHROMES--TOPOLOGY AND FUNCTION
    Charles Myers; Fiscal Year: 2002
  2. Human Lung Chromium Toxicity: Role of cytochrome b5
    Charles Myers; Fiscal Year: 2007

Collaborators

  • Tamara M Maier
  • Judith M Myers
  • William E Antholine
  • Griselda R Borthiry
  • Adam Szadkowski

Detail Information

Publications14

  1. ncbi The effects of chromium(VI) on the thioredoxin system: implications for redox regulation
    Charles R Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Free Radic Biol Med 52:2091-107. 2012
    ....
  2. ncbi The outer membrane protein Omp35 affects the reduction of Fe(III), nitrate, and fumarate by Shewanella oneidensis MR-1
    Tamara M Maier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, 53226, USA
    BMC Microbiol 4:23. 2004
    ..In this study, the role for an anaerobically upregulated 35-kDa OM protein (Omp35) in the use of anaerobic electron acceptors was explored...
  3. ncbi The effects of acrolein on the thioredoxin system: implications for redox-sensitive signaling
    Charles R Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Mol Nutr Food Res 55:1361-74. 2011
    ..Overall, the disruption of the TrxR/Trx system by acrolein could be significant early and prolonged events that affect many aspects of redox-sensitive signaling and oxidant stress...
  4. ncbi The pro-oxidant chromium(VI) inhibits mitochondrial complex I, complex II, and aconitase in the bronchial epithelium: EPR markers for Fe-S proteins
    Charles R Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Free Radic Biol Med 49:1903-15. 2010
    ..The EPR spectra simultaneously showed signals for Cr(V) and Cr(III), which verify Cr(VI) exposure and its intracellular reductive activation...
  5. ncbi The outer membrane cytochromes of Shewanella oneidensis MR-1 are lipoproteins
    C R Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Lett Appl Microbiol 39:466-70. 2004
    ..To determine if the outer membrane (OM) cytochromes OmcA and OmcB of the metal-reducing bacterium Shewanella oneidensis MR-1 are lipoproteins, and to assess cell surface exposure of the cytochromes by radioiodination...
  6. ncbi Shewanella oneidensis MR-1 restores menaquinone synthesis to a menaquinone-negative mutant
    Charles R Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Appl Environ Microbiol 70:5415-25. 2004
    ..This ability to restore MK synthesis in CMA-1 explains the cross-feeding results and challenges the previous hypothesis that this substance represents a redox shuttle that facilitates metal respiration...
  7. ncbi Cell surface exposure of the outer membrane cytochromes of Shewanella oneidensis MR-1
    C R Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA
    Lett Appl Microbiol 37:254-8. 2003
    ..To determine if the outer membrane (OM) cytochromes of the metal-reducing bacterium Shewanella oneidensis MR-1 are exposed on the cell surface...
  8. ncbi MtrB is required for proper incorporation of the cytochromes OmcA and OmcB into the outer membrane of Shewanella putrefaciens MR-1
    Charles R Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Appl Environ Microbiol 68:5585-94. 2002
    ..Therefore, even if MtrF were mislocalized in MTRB1, it would not contribute to the loss of metal reduction activity in this strain...
  9. ncbi Vanadium(V) reduction by Shewanella oneidensis MR-1 requires menaquinone and cytochromes from the cytoplasmic and outer membranes
    Judith M Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Appl Environ Microbiol 70:1405-12. 2004
    ..This is the first report delineating specific electron transport components that are required for V(V) reduction and of a role for OM cytochromes in the reduction of a soluble metal species...
  10. ncbi Genetic complementation of an outer membrane cytochrome omcB mutant of Shewanella putrefaciens MR-1 requires omcB plus downstream DNA
    Judith M Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Appl Environ Microbiol 68:2781-93. 2002
    ..The results suggest that the DNA downstream of omcB must be present in cis in order to restore Fe(III) reduction, MnO2 reduction, OM cytochrome content, and the localization of OmcA and OmcB to the OM...
  11. ncbi Acrolein oxidizes the cytosolic and mitochondrial thioredoxins in human endothelial cells
    Adam Szadkowski
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Toxicology 243:164-76. 2008
    ..5 microM acrolein. Given the critical role of the thioredoxins in cell survival, the ability of acrolein to oxidize both thioredoxins should be taken into account for a thorough understanding of its cytotoxic effects...
  12. ncbi Reductive activation of hexavalent chromium by human lung epithelial cells: generation of Cr(V) and Cr(V)-thiol species
    Griselda R Borthiry
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Inorg Biochem 102:1449-62. 2008
    ..In clonogenic assays, the cells were very sensitive to Na(2)CrO(4) and ZnCrO(4), but considerably less sensitive to PbCrO(4)...
  13. ncbi Hexavalent chromium causes the oxidation of thioredoxin in human bronchial epithelial cells
    Judith M Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Toxicology 246:222-33. 2008
    ..The ability of Cr(VI) to cause Trx oxidation in cells could contribute to its cytotoxic effects, and could have important implications for cell survival, redox-sensitive cell signaling, and the cells' tolerance of other oxidant insults...
  14. ncbi Identification of the gene encoding the sole physiological fumarate reductase in Shewanella oneidensis MR-1
    Tamara M Maier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Basic Microbiol 43:312-27. 2003
    ..Surprisingly, the fumarate reductase gene plus 0.77-kb upstream DNA from S. frigidimarina NCIMB400 did not complement CMTn-3...

Research Grants10

  1. OUTER MEMBRANE CYTOCHROMES--TOPOLOGY AND FUNCTION
    Charles Myers; Fiscal Year: 2002
    ..They will also contribute to environmental health by expanding our knowledge on the mechanisms by which manganese, iron, and various heavy metals are mobilized into water supplies. ..
  2. Human Lung Chromium Toxicity: Role of cytochrome b5
    Charles Myers; Fiscal Year: 2007
    ..They will provide a deeper understanding of the mechanisms underlying Cr(VI) toxicity in human lung, and will lead to new insights on the role of b5 in toxicant activation ..