M S Mozaffari

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. pmc Effect of beta-alanine treatment on mitochondrial taurine level and 5-taurinomethyluridine content
    Chian Ju Jong
    Department of Pharmacology, University of South Alabama, College of Medicine, Mobile, Alabama 36688, USA
    J Biomed Sci 17:S25. 2010
  2. doi Mitochondrial complex I and NAD(P)H oxidase are major sources of exacerbated oxidative stress in pressure-overloaded ischemic-reperfused hearts
    Mahmood S Mozaffari
    Department of Oral Biology, CL 2134, School of Dentistry, Medical College of Georgia, Augusta, GA 30012 1128, USA
    Basic Res Cardiol 106:287-97. 2011
  3. pmc Effects of chromium picolinate on glycemic control and kidney of the obese Zucker rat
    Mahmood S Mozaffari
    Department of Oral Biology, School of Dentistry, Medical College of Georgia Augusta, Georgia 30912, USA
    Nutr Metab (Lond) 6:51. 2009
  4. ncbi Effect of hypertension and hypertension-glucose intolerance on myocardial ischemic injury
    Mahmood S Mozaffari
    Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia School of Dentistry, Augusta, GA 30912 1128, USA
    Hypertension 42:1042-9. 2003
  5. doi Myocardial ischemic-reperfusion injury in a rat model of metabolic syndrome
    Mahmood S Mozaffari
    Department of Oral Biology, Medical College of Georgia School of Dentistry, Augusta, Georgia, USA
    Obesity (Silver Spring) 16:2253-8. 2008
  6. doi Effect of pressure overload on cardioprotection of mitochondrial KATP channels and GSK-3beta: interaction with the MPT pore
    Mahmood S Mozaffari
    Department of Oral Biology, Medical College of Georgia School of Dentistry, Augusta, Georgia, USA
    Am J Hypertens 21:570-5. 2008
  7. ncbi Effects of dietary salt and fat on taurine excretion in healthy and diseased rats
    Mahmood S Mozaffari
    Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia School of Dentistry, Augusta, Georgia 30912, USA
    Adv Exp Med Biol 583:173-80. 2006
  8. ncbi Effects of chronic chromium picolinate treatment in uninephrectomized rat
    Mahmood S Mozaffari
    Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia, Augusta, GA 30912 1128, USA
    Metabolism 54:1243-9. 2005
  9. ncbi Effects of excess salt and fat intake on myocardial function and infarct size in rat
    Mahmood S Mozaffari
    Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia School of Dentistry, Augusta, GA 30912 1128, USA
    Life Sci 78:1808-13. 2006
  10. ncbi Mechanisms underlying afterload-induced exacerbation of myocardial infarct size: role of T-type Ca2+ channel
    Mahmood S Mozaffari
    Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia School of Dentistry, Augusta, GA 30912, USA
    Hypertension 47:912-9. 2006

Research Grants

  1. Is chromium picolinate renoprotective in diabetes?
    Mahmood Mozaffari; Fiscal Year: 2007

Collaborators

Detail Information

Publications32

  1. pmc Effect of beta-alanine treatment on mitochondrial taurine level and 5-taurinomethyluridine content
    Chian Ju Jong
    Department of Pharmacology, University of South Alabama, College of Medicine, Mobile, Alabama 36688, USA
    J Biomed Sci 17:S25. 2010
    ..The present study examines the effect of taurine deficiency on the first step of mitochondrial protein synthesis regulation by taurine, namely, the formation of taurinomethyluridine containing tRNA...
  2. doi Mitochondrial complex I and NAD(P)H oxidase are major sources of exacerbated oxidative stress in pressure-overloaded ischemic-reperfused hearts
    Mahmood S Mozaffari
    Department of Oral Biology, CL 2134, School of Dentistry, Medical College of Georgia, Augusta, GA 30012 1128, USA
    Basic Res Cardiol 106:287-97. 2011
    ....
  3. pmc Effects of chromium picolinate on glycemic control and kidney of the obese Zucker rat
    Mahmood S Mozaffari
    Department of Oral Biology, School of Dentistry, Medical College of Georgia Augusta, Georgia 30912, USA
    Nutr Metab (Lond) 6:51. 2009
    ..Therefore, we tested the hypothesis that Cr(pic)3 treatment of obese Zucker rats (OZR) exacerbates renal abnormalities associated with dysglycemia...
  4. ncbi Effect of hypertension and hypertension-glucose intolerance on myocardial ischemic injury
    Mahmood S Mozaffari
    Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia School of Dentistry, Augusta, GA 30912 1128, USA
    Hypertension 42:1042-9. 2003
    ..Furthermore, exacerbation of cell death at elevated afterload pressure indicates the potential benefit of aggressive antihypertensive therapy...
  5. doi Myocardial ischemic-reperfusion injury in a rat model of metabolic syndrome
    Mahmood S Mozaffari
    Department of Oral Biology, Medical College of Georgia School of Dentistry, Augusta, Georgia, USA
    Obesity (Silver Spring) 16:2253-8. 2008
    ..These findings are of relevance to the metabolic syndrome that manifests as a cluster of insulin resistance, dyslipidemia, and systemic hypertension...
  6. doi Effect of pressure overload on cardioprotection of mitochondrial KATP channels and GSK-3beta: interaction with the MPT pore
    Mahmood S Mozaffari
    Department of Oral Biology, Medical College of Georgia School of Dentistry, Augusta, Georgia, USA
    Am J Hypertens 21:570-5. 2008
    ....
  7. ncbi Effects of dietary salt and fat on taurine excretion in healthy and diseased rats
    Mahmood S Mozaffari
    Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia School of Dentistry, Augusta, Georgia 30912, USA
    Adv Exp Med Biol 583:173-80. 2006
    ..Nonetheless, kidney taurine content was similar in the 4 groups. Taken together, the data suggest that dietary constituents and preexisting systemic disorders are important modulators of renal handling of taurine...
  8. ncbi Effects of chronic chromium picolinate treatment in uninephrectomized rat
    Mahmood S Mozaffari
    Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia, Augusta, GA 30912 1128, USA
    Metabolism 54:1243-9. 2005
    ..Rather, the treatment improved the ability of the animal to dispose of an acute isotonic saline volume load, suggesting preservation of renal function in the UNX rat...
  9. ncbi Effects of excess salt and fat intake on myocardial function and infarct size in rat
    Mahmood S Mozaffari
    Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia School of Dentistry, Augusta, GA 30912 1128, USA
    Life Sci 78:1808-13. 2006
    ..In conclusion, short-term intake of a high fat diet, which significantly increases body weight, does not worsen ischemia-reperfusion injury although the treatment prevents the reduction of infarct size associated with high salt feeding...
  10. ncbi Mechanisms underlying afterload-induced exacerbation of myocardial infarct size: role of T-type Ca2+ channel
    Mahmood S Mozaffari
    Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia School of Dentistry, Augusta, GA 30912, USA
    Hypertension 47:912-9. 2006
    ..The data also uncovered an important link between pressure-mediated exacerbation of infarct size and T-type Ca2+ channel activity...
  11. doi Effect of pressure overload on cardioprotection via PI3K-Akt: comparison of postconditioning, insulin, and pressure unloading
    Mahmood S Mozaffari
    Department of Oral Biology, Medical College of Georgia School of Dentistry, Augusta, Georgia, USA
    Am J Hypertens 23:668-74. 2010
    ....
  12. ncbi Effects of taurine and enalapril on kidney function of the hypertensive glucose-intolerant rat
    Mahmood S Mozaffari
    Department of Oral Biology and Maxillofacial Pathology, CB 3710, Medical College of Georgia School of Dentistry, Augusta, GA 30912 1128, USA
    Am J Hypertens 16:673-80. 2003
    ....
  13. pmc Submandibular gland and caries susceptibility in the obese Zucker rat
    Mahmood S Mozaffari
    Department of Oral Biology, Medical College of Georgia School of Dentistry, Augusta, Georgia 30912 1128, USA
    J Oral Pathol Med 40:194-200. 2011
    ..We also examined the potential impact of chromium picolinate (Cr(Pic)3), a nutritional supplement suggested to improve glycemic control, on the aforementioned parameters...
  14. ncbi Renal adenosine A3 receptors in the rat: assessment of functional role
    M S Mozaffari
    Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia, Augusta 30912 1128, USA
    Can J Physiol Pharmacol 78:428-32. 2000
    ....
  15. pmc Differential effects of taurine treatment and taurine deficiency on the outcome of renal ischemia reperfusion injury
    Mahmood S Mozaffari
    Department of Oral Biology, Medical College of Georgia School of Dentistry, Augusta, Georgia 30912, USA
    J Biomed Sci 17:S32. 2010
    ..Collectively, the results indicate that body taurine status is a major determinant of renal IR injury...
  16. ncbi Taurine modulates arginine vasopressin-mediated regulation of renal function
    M S Mozaffari
    Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia, Augusta 30912 1128, USA
    J Cardiovasc Pharmacol 37:742-50. 2001
    ..These observations suggest that taurine modulates renal function, and, thereby, body fluid homeostasis, through an AVP-dependent mechanism...
  17. ncbi Impaired saline-stimulated diuresis and natriuresis in the conscious hypertensive glucose-intolerant rat
    Mahmood S Mozaffari
    Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia School of Dentistry, Augusta 30912 1128, USA
    Am J Hypertens 15:58-65. 2002
    ..Therefore, we tested the hypothesis that chronic glucose intolerance leads to abnormal renal function, a condition also exacerbated by concurrent systemic hypertension...
  18. ncbi Taurine in submandibular gland of the rat: effect of muscarinic drugs
    Mahmood S Mozaffari
    Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta, GA 30912 1128, USA
    J Histochem Cytochem 50:527-32. 2002
    ..In conclusion, the submandibular gland contains an appreciable amount of taurine, primarily in the striated ducts, that can be decreased by chronic muscarinic receptor blockade...
  19. ncbi Chronic taurine treatment ameliorates reduction in saline-induced diuresis and natriuresis
    Mahmood S Mozaffari
    Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia School of Dentistry, Augusta, Georgia 30912 1128, USA
    Kidney Int 61:1750-9. 2002
    ..Both the modulation of tissue taurine stores and the exogenous administration of taurine are known to affect renal function. Therefore, it is likely that taurine therapy could benefit the dysfunctional kidney...
  20. ncbi Renoprotective effects of chronic candesartan treatment in uninephrectomized rat
    Mahmood S Mozaffari
    Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia School of Dentistry, Augusta, Georgia 30912, USA
    J Cardiovasc Pharmacol 41:81-8. 2003
    ..In conclusion, chronic blockade of the angiotensin II receptors exerts hypotensive and renoprotective effects in the aging uninephrectomized rat...
  21. ncbi Accelerated NaCl-induced hypertension in taurine-deficient rat: role of renal function
    M S Mozaffari
    Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Kidney Int 70:329-37. 2006
    ..In conclusion, taurine deficiency modulates renal adaptation to combined uninephrectomy and dietary NaCl excess, resulting in an accelerated development of hypertension...
  22. ncbi Renal responses to hypertonic saline infusion in salt-sensitive spontaneously hypertensive rats
    M S Mozaffari
    Department of Oral Biology Pharmacology, School of Dentistry, Medical College of Georgia, Augusta 30912 1128, USA
    Am J Med Sci 314:370-6. 1997
    ..Therefore, the deficits in renal function observed in SHR-S after volume loading are not reflected in a renal deficit to hypertonic saline challenge...
  23. ncbi NaCl-induced hypertensive rat model of non-insulin-dependent diabetes: role of sympathetic modulation
    M S Mozaffari
    Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia School of Dentistry, Augusta, USA
    Am J Hypertens 13:540-6. 2000
    ..Moreover, enhancement of the sympathetic pathway plays an important role in the regulation of arterial pressure in the hypertensive NIDD rat...
  24. ncbi Effects of dental resin components on vascular reactivity
    William F Maddux
    Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta, Georgia 30912 1128, USA
    J Biomed Mater Res 61:572-80. 2002
    ..These phenomena may play a role in tissue homeostasis and certain pathophysiological conditions associated with the application of resin materials to the oral environment...
  25. ncbi Effects of chromium picolinate on vascular reactivity and cardiac ischemia-reperfusion injury in spontaneously hypertensive rats
    Worku Abebe
    Department of Oral Biology, CL 2136, School of Dentistry, Medical College of Georgia, Augusta, Georgia 30912 1128, USA
    Pharmacol Rep 62:674-82. 2010
    ..Additionally, while the treatment does not affect infarct size, it improves functional recovery of the viable portion of the myocardium following IRI...
  26. ncbi Effect of taurine deficiency on adenosine receptor-mediated relaxation of the rat aorta
    Worku Abebe
    Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, CB 3710, Medical College of Georgia, Augusta, GA 30912 1128, USA
    Vascul Pharmacol 40:219-28. 2003
    ..Given the recognized role of adenosine in the vasculature, these alterations suggest taurine-mediated modulation of blood flow regulation...
  27. ncbi Taurine depletion alters vascular reactivity in rats
    Worku Abebe
    Department of Oral Biology and Maxillofacial Pathology, CB 3710, School of Dentistry, Medical College of Georgia, Augusta, GA 30912 1128, USA
    Can J Physiol Pharmacol 81:903-9. 2003
    ..These vascular alterations could be of potential consequence in pathological conditions associated with taurine deficiency...
  28. ncbi Vascular reactivity changes in glucose-intolerant rat
    Worku Abebe
    Department of Oral Biology and Maxillofacial Pathology School of Dentistry, Medical College of Georgia, Augusta, GA 30912 1128, USA
    J Cardiovasc Pharmacol 50:590-7. 2007
    ..While these findings warrant further investigations, such vascular alterations during the prediabetes stage of glucose intolerance can be a predisposing factor for the eventual development of cardiovascular complications...
  29. ncbi Effects of chronic taurine treatment on reactivity of the rat aorta
    W Abebe
    Department of Oral Biology and Maxillofacial Pathology School of Dentistry, Medical College of Georgia, Augusta 30912 1128, USA
    Amino Acids 19:615-23. 2000
    ..Our results suggest that taurine treatment attenuates vascular contractility nonspecifically and this effect is partly mediated via the endothelium...
  30. ncbi Taurine-depleted heart and afterload pressure
    Mahmood S Mozaffari
    Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia, Augusta, Georgia, USA
    Adv Exp Med Biol 526:57-63. 2003
  31. ncbi Insulin-exacerbated hypertension in captopril-treated spontaneously hypertensive rats: role of sympathoexcitation
    Sanya Roysommuti
    Department of Cell Biology, University of Alabama at Birmingham, 35294 0006, USA
    Can J Physiol Pharmacol 81:1036-41. 2003
    ..These data indicate that in SHR, the ability of insulin to increase blood pressure is closely related to sympathoexcitation, which is unresponsive to blockade of angiotensin-converting enzyme...
  32. ncbi DNA damage and expression of checkpoint genes p21(WAF1/CIP1) and 14-3-3 sigma in taurine-deficient cardiomyocytes
    Olga Golubnitschaja
    Department of Radiology, Division of Molecular Experimental Radiology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Biochem Pharmacol 66:511-7. 2003
    ..We also carried out quantitative determination of DNA damage...

Research Grants1

  1. Is chromium picolinate renoprotective in diabetes?
    Mahmood Mozaffari; Fiscal Year: 2007
    ..Further, the studies will address the prevailing concern and controversy regarding clastogenic potential of Cr(pic)3, an aspect that remains to be established using relevant animal models of type 2 diabetes. ..