Research Topics
Species | M S MozaffariSummaryAffiliation: Medical College of Georgia Country: USA Publications
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Publications
Effect of beta-alanine treatment on mitochondrial taurine level and 5-taurinomethyluridine contentChian Ju Jong
Department of Pharmacology, University of South Alabama, College of Medicine, Mobile, Alabama 36688, USA
J Biomed Sci 17:S25. 2010..The present study examines the effect of taurine deficiency on the first step of mitochondrial protein synthesis regulation by taurine, namely, the formation of taurinomethyluridine containing tRNA...
Mitochondrial complex I and NAD(P)H oxidase are major sources of exacerbated oxidative stress in pressure-overloaded ischemic-reperfused heartsMahmood S Mozaffari
Department of Oral Biology, CL 2134, School of Dentistry, Medical College of Georgia, Augusta, GA 30012 1128, USA
Basic Res Cardiol 106:287-97. 2011....- Effects of chromium picolinate on glycemic control and kidney of the obese Zucker ratMahmood S Mozaffari
Department of Oral Biology, School of Dentistry, Medical College of Georgia Augusta, Georgia 30912, USA
Nutr Metab (Lond) 6:51. 2009..Therefore, we tested the hypothesis that Cr(pic)3 treatment of obese Zucker rats (OZR) exacerbates renal abnormalities associated with dysglycemia... 
Effect of hypertension and hypertension-glucose intolerance on myocardial ischemic injuryMahmood S Mozaffari
Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia School of Dentistry, Augusta, GA 30912 1128, USA
Hypertension 42:1042-9. 2003..Furthermore, exacerbation of cell death at elevated afterload pressure indicates the potential benefit of aggressive antihypertensive therapy...- Myocardial ischemic-reperfusion injury in a rat model of metabolic syndromeMahmood S Mozaffari
Department of Oral Biology, Medical College of Georgia School of Dentistry, Augusta, Georgia, USA
Obesity (Silver Spring) 16:2253-8. 2008..These findings are of relevance to the metabolic syndrome that manifests as a cluster of insulin resistance, dyslipidemia, and systemic hypertension... - Effect of pressure overload on cardioprotection of mitochondrial KATP channels and GSK-3beta: interaction with the MPT poreMahmood S Mozaffari
Department of Oral Biology, Medical College of Georgia School of Dentistry, Augusta, Georgia, USA
Am J Hypertens 21:570-5. 2008.... - Effects of dietary salt and fat on taurine excretion in healthy and diseased ratsMahmood S Mozaffari
Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia School of Dentistry, Augusta, Georgia 30912, USA
Adv Exp Med Biol 583:173-80. 2006..Nonetheless, kidney taurine content was similar in the 4 groups. Taken together, the data suggest that dietary constituents and preexisting systemic disorders are important modulators of renal handling of taurine... - Effects of chronic chromium picolinate treatment in uninephrectomized ratMahmood S Mozaffari
Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia, Augusta, GA 30912 1128, USA
Metabolism 54:1243-9. 2005..Rather, the treatment improved the ability of the animal to dispose of an acute isotonic saline volume load, suggesting preservation of renal function in the UNX rat... - Effects of excess salt and fat intake on myocardial function and infarct size in ratMahmood S Mozaffari
Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia School of Dentistry, Augusta, GA 30912 1128, USA
Life Sci 78:1808-13. 2006..In conclusion, short-term intake of a high fat diet, which significantly increases body weight, does not worsen ischemia-reperfusion injury although the treatment prevents the reduction of infarct size associated with high salt feeding... - Mechanisms underlying afterload-induced exacerbation of myocardial infarct size: role of T-type Ca2+ channelMahmood S Mozaffari
Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia School of Dentistry, Augusta, GA 30912, USA
Hypertension 47:912-9. 2006..The data also uncovered an important link between pressure-mediated exacerbation of infarct size and T-type Ca2+ channel activity... - Effect of pressure overload on cardioprotection via PI3K-Akt: comparison of postconditioning, insulin, and pressure unloadingMahmood S Mozaffari
Department of Oral Biology, Medical College of Georgia School of Dentistry, Augusta, Georgia, USA
Am J Hypertens 23:668-74. 2010.... - Effects of taurine and enalapril on kidney function of the hypertensive glucose-intolerant ratMahmood S Mozaffari
Department of Oral Biology and Maxillofacial Pathology, CB 3710, Medical College of Georgia School of Dentistry, Augusta, GA 30912 1128, USA
Am J Hypertens 16:673-80. 2003.... - Submandibular gland and caries susceptibility in the obese Zucker ratMahmood S Mozaffari
Department of Oral Biology, Medical College of Georgia School of Dentistry, Augusta, Georgia 30912 1128, USA
J Oral Pathol Med 40:194-200. 2011..We also examined the potential impact of chromium picolinate (Cr(Pic)3), a nutritional supplement suggested to improve glycemic control, on the aforementioned parameters... - Renal adenosine A3 receptors in the rat: assessment of functional roleM S Mozaffari
Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia, Augusta 30912 1128, USA
Can J Physiol Pharmacol 78:428-32. 2000.... - Differential effects of taurine treatment and taurine deficiency on the outcome of renal ischemia reperfusion injuryMahmood S Mozaffari
Department of Oral Biology, Medical College of Georgia School of Dentistry, Augusta, Georgia 30912, USA
J Biomed Sci 17:S32. 2010..Collectively, the results indicate that body taurine status is a major determinant of renal IR injury... - Taurine modulates arginine vasopressin-mediated regulation of renal functionM S Mozaffari
Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia, Augusta 30912 1128, USA
J Cardiovasc Pharmacol 37:742-50. 2001..These observations suggest that taurine modulates renal function, and, thereby, body fluid homeostasis, through an AVP-dependent mechanism... - Impaired saline-stimulated diuresis and natriuresis in the conscious hypertensive glucose-intolerant ratMahmood S Mozaffari
Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia School of Dentistry, Augusta 30912 1128, USA
Am J Hypertens 15:58-65. 2002..Therefore, we tested the hypothesis that chronic glucose intolerance leads to abnormal renal function, a condition also exacerbated by concurrent systemic hypertension... - Taurine in submandibular gland of the rat: effect of muscarinic drugsMahmood S Mozaffari
Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta, GA 30912 1128, USA
J Histochem Cytochem 50:527-32. 2002..In conclusion, the submandibular gland contains an appreciable amount of taurine, primarily in the striated ducts, that can be decreased by chronic muscarinic receptor blockade... - Chronic taurine treatment ameliorates reduction in saline-induced diuresis and natriuresisMahmood S Mozaffari
Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia School of Dentistry, Augusta, Georgia 30912 1128, USA
Kidney Int 61:1750-9. 2002..Both the modulation of tissue taurine stores and the exogenous administration of taurine are known to affect renal function. Therefore, it is likely that taurine therapy could benefit the dysfunctional kidney... - Renoprotective effects of chronic candesartan treatment in uninephrectomized ratMahmood S Mozaffari
Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia School of Dentistry, Augusta, Georgia 30912, USA
J Cardiovasc Pharmacol 41:81-8. 2003..In conclusion, chronic blockade of the angiotensin II receptors exerts hypotensive and renoprotective effects in the aging uninephrectomized rat... - Accelerated NaCl-induced hypertension in taurine-deficient rat: role of renal functionM S Mozaffari
Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia, Augusta, Georgia 30912, USA
Kidney Int 70:329-37. 2006..In conclusion, taurine deficiency modulates renal adaptation to combined uninephrectomy and dietary NaCl excess, resulting in an accelerated development of hypertension... - Renal responses to hypertonic saline infusion in salt-sensitive spontaneously hypertensive ratsM S Mozaffari
Department of Oral Biology Pharmacology, School of Dentistry, Medical College of Georgia, Augusta 30912 1128, USA
Am J Med Sci 314:370-6. 1997..Therefore, the deficits in renal function observed in SHR-S after volume loading are not reflected in a renal deficit to hypertonic saline challenge... - NaCl-induced hypertensive rat model of non-insulin-dependent diabetes: role of sympathetic modulationM S Mozaffari
Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia School of Dentistry, Augusta, USA
Am J Hypertens 13:540-6. 2000..Moreover, enhancement of the sympathetic pathway plays an important role in the regulation of arterial pressure in the hypertensive NIDD rat... - Effects of dental resin components on vascular reactivityWilliam F Maddux
Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta, Georgia 30912-1128, USA
J Biomed Mater Res 61:572-80. 2002..These phenomena may play a role in tissue homeostasis and certain pathophysiological conditions associated with the application of resin materials to the oral environment... - Effects of chromium picolinate on vascular reactivity and cardiac ischemia-reperfusion injury in spontaneously hypertensive ratsWorku Abebe
Department of Oral Biology, CL 2136, School of Dentistry, Medical College of Georgia, Augusta, Georgia 30912 1128, USA
Pharmacol Rep 62:674-82. 2010..Additionally, while the treatment does not affect infarct size, it improves functional recovery of the viable portion of the myocardium following IRI... - Effect of taurine deficiency on adenosine receptor-mediated relaxation of the rat aortaWorku Abebe
Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, CB 3710, Medical College of Georgia, Augusta, GA 30912 1128, USA
Vascul Pharmacol 40:219-28. 2003..Given the recognized role of adenosine in the vasculature, these alterations suggest taurine-mediated modulation of blood flow regulation... - Taurine depletion alters vascular reactivity in ratsWorku Abebe
Department of Oral Biology and Maxillofacial Pathology, CB 3710, School of Dentistry, Medical College of Georgia, Augusta, GA 30912 1128, USA
Can J Physiol Pharmacol 81:903-9. 2003..These vascular alterations could be of potential consequence in pathological conditions associated with taurine deficiency... - Vascular reactivity changes in glucose-intolerant ratWorku Abebe
Department of Oral Biology and Maxillofacial Pathology School of Dentistry, Medical College of Georgia, Augusta, GA 30912 1128, USA
J Cardiovasc Pharmacol 50:590-7. 2007..While these findings warrant further investigations, such vascular alterations during the prediabetes stage of glucose intolerance can be a predisposing factor for the eventual development of cardiovascular complications... - Effects of chronic taurine treatment on reactivity of the rat aortaW Abebe
Department of Oral Biology and Maxillofacial Pathology School of Dentistry, Medical College of Georgia, Augusta 30912 1128, USA
Amino Acids 19:615-23. 2000..Our results suggest that taurine treatment attenuates vascular contractility nonspecifically and this effect is partly mediated via the endothelium... - Taurine-depleted heart and afterload pressureMahmood S Mozaffari
Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia, Augusta, Georgia, USA
Adv Exp Med Biol 526:57-63. 2003 - Insulin-exacerbated hypertension in captopril-treated spontaneously hypertensive rats: role of sympathoexcitationSanya Roysommuti
Department of Cell Biology, University of Alabama at Birmingham, 35294-0006, USA
Can J Physiol Pharmacol 81:1036-41. 2003..These data indicate that in SHR, the ability of insulin to increase blood pressure is closely related to sympathoexcitation, which is unresponsive to blockade of angiotensin-converting enzyme... - DNA damage and expression of checkpoint genes p21(WAF1/CIP1) and 14-3-3 sigma in taurine-deficient cardiomyocytesOlga Golubnitschaja
Department of Radiology, Division of Molecular Experimental Radiology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
Biochem Pharmacol 66:511-7. 2003..We also carried out quantitative determination of DNA damage...
Research Grants
- Is chromium picolinate renoprotective in diabetes?Mahmood Mozaffari; Fiscal Year: 2007..Further, the studies will address the prevailing concern and controversy regarding clastogenic potential of Cr(pic)3, an aspect that remains to be established using relevant animal models of type 2 diabetes. ..