JOHN MOULDER

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. pmc Captopril and losartan for mitigation of renal injury caused by single-dose total-body irradiation
    John E Moulder
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Radiat Res 175:29-36. 2011
  2. ncbi Treatment of radiation nephropathy with ACE inhibitors and AII type-1 and type-2 receptor antagonists
    J E Moulder
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Curr Pharm Des 13:1317-25. 2007
  3. ncbi Future strategies for mitigation and treatment of chronic radiation-induced normal tissue injury
    John E Moulder
    Radiation Oncology and Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    Semin Radiat Oncol 17:141-8. 2007
  4. ncbi Mobile phones, mobile phone base stations and cancer: a review
    J E Moulder
    Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Radiat Biol 81:189-203. 2005
  5. ncbi Impact of angiotensin II type 2 receptor blockade on experimental radiation nephropathy
    John E Moulder
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Radiat Res 161:312-7. 2004
  6. ncbi Post-irradiation approaches to treatment of radiation injuries in the context of radiological terrorism and radiation accidents: a review
    J E Moulder
    Radiation Oncology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Int J Radiat Biol 80:3-10. 2004
  7. ncbi Dietary sodium modification and experimental radiation nephropathy
    J E Moulder
    Department of Radiation Oncology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Int J Radiat Biol 78:903-11. 2002
  8. ncbi Radiobiology of nuclear terrorism: report on an interagency workshop (Bethesda, MD, December 17-18, 2001)
    John E Moulder
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Radiat Oncol Biol Phys 54:327-8. 2002
  9. ncbi Report on an interagency workshop on the radiobiology of nuclear terrorism. Molecular and cellular biology dose (1-10 Sv) radiation and potential mechanisms of radiation protection (Bethesda, Maryland, December 17-18, 2001)
    John E Moulder
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Radiat Res 158:118-24. 2002
  10. ncbi Angiotensin II blockade reduces radiation-induced proliferation in experimental radiation nephropathy
    John E Moulder
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Radiat Res 157:393-401. 2002

Research Grants

  1. KIDNEY RESPONSE TO RADIATION AND CHEMOTHERAPY
    JOHN MOULDER; Fiscal Year: 2001
  2. KIDNEY RESPONSE TO RADIATION AND CHEMOTHERAPY
    JOHN MOULDER; Fiscal Year: 2006
  3. KIDNEY RESPONSE TO FRACTIONED RADIATION
    JOHN MOULDER; Fiscal Year: 1980
  4. KIDNEY RESPONSE TO RADIATION AND CHEMOTHERAPY
    JOHN MOULDER; Fiscal Year: 1993
  5. KIDNEY RESPONSE TO RADIATION AND CHEMOTHERAPY
    JOHN MOULDER; Fiscal Year: 1991

Detail Information

Publications40

  1. pmc Captopril and losartan for mitigation of renal injury caused by single-dose total-body irradiation
    John E Moulder
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Radiat Res 175:29-36. 2011
    ..This lays the necessary groundwork for pivotal rodent studies under the FDA Animal Efficacy Rule and provides an outline of how the FDA-required large-animal studies could be designed...
  2. ncbi Treatment of radiation nephropathy with ACE inhibitors and AII type-1 and type-2 receptor antagonists
    J E Moulder
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Curr Pharm Des 13:1317-25. 2007
    ....
  3. ncbi Future strategies for mitigation and treatment of chronic radiation-induced normal tissue injury
    John E Moulder
    Radiation Oncology and Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    Semin Radiat Oncol 17:141-8. 2007
    ....
  4. ncbi Mobile phones, mobile phone base stations and cancer: a review
    J E Moulder
    Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Radiat Biol 81:189-203. 2005
    ....
  5. ncbi Impact of angiotensin II type 2 receptor blockade on experimental radiation nephropathy
    John E Moulder
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Radiat Res 161:312-7. 2004
    ..We speculate that the beneficial effect of the angiotensin II type 2 receptor blocker is due to a reduction in radiation-induced renal cell proliferation or fibrosis...
  6. ncbi Post-irradiation approaches to treatment of radiation injuries in the context of radiological terrorism and radiation accidents: a review
    J E Moulder
    Radiation Oncology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Int J Radiat Biol 80:3-10. 2004
    ..This review discusses recent advances in the knowledge about how radiation injuries from such events might be treated pharmacologically, and the practical barriers to clinical utilization of these approaches...
  7. ncbi Dietary sodium modification and experimental radiation nephropathy
    J E Moulder
    Department of Radiation Oncology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Int J Radiat Biol 78:903-11. 2002
    ....
  8. ncbi Radiobiology of nuclear terrorism: report on an interagency workshop (Bethesda, MD, December 17-18, 2001)
    John E Moulder
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Radiat Oncol Biol Phys 54:327-8. 2002
  9. ncbi Report on an interagency workshop on the radiobiology of nuclear terrorism. Molecular and cellular biology dose (1-10 Sv) radiation and potential mechanisms of radiation protection (Bethesda, Maryland, December 17-18, 2001)
    John E Moulder
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Radiat Res 158:118-24. 2002
    ....
  10. ncbi Angiotensin II blockade reduces radiation-induced proliferation in experimental radiation nephropathy
    John E Moulder
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Radiat Res 157:393-401. 2002
    ....
  11. ncbi Retinoic acid exacerbates experimental radiation nephropathy
    John E Moulder
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Radiat Res 157:199-203. 2002
    ....
  12. ncbi Neutrophil cathepsin G is specifically decreased under vitamin A deficiency
    S S Twining
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee 53226, USA
    Biochim Biophys Acta 1317:112-8. 1996
    ..The low levels of cathepsin G may contribute to differences in the inflammatory process observed under vitamin A deficiency...
  13. doi Propagation of giant migrating contractions between the small intestine, cecum and colon during radiation
    M F Otterson
    Cancer Center and Digestive Diseases Center, Medical College of Wisconsin and Zablocki Veterans Affairs Medical Center, Milwaukee, WI, USA
    Neurogastroenterol Motil 22:919-26. 2010
    ..These contractions contribute to the diarrhea and cramping after radiation therapy and are coordinated with one another across the ileocolonic (IC) junction...
  14. ncbi Vitamin A deficiency alters rat neutrophil function
    S S Twining
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee 53226, USA
    J Nutr 127:558-65. 1997
    ..The elucidated alterations in neutrophil function in vitamin A deficient rats probably contribute to the altered ability of vitamin A deficient rats to fight infections...
  15. ncbi Angiotensin converting enzyme inhibitor captopril does not prevent acute gastrointestinal radiation damage in the rat
    J E Moulder
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee 53226, USA
    Radiat Oncol Investig 5:50-3. 1997
    ..Clearly, it should not be assumed that captopril will modulate radiation reactions in all tissues...
  16. ncbi End-stage renal disease (ESRD)after bone marrow transplantation: poor survival compar ed to other causes of ESRD
    E P Cohen
    Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisc, USA
    Nephron 79:408-12. 1998
    ..This was true for both diabetic and nondiabetic ESRD (both p < 0.03). These data demonstrate the poor outcome of ESRD after BMT which emphasizes the need for a better understanding of chronic renal failure after BMT...
  17. ncbi Stenotic glomerulotubular necks in radiation nephropathy
    E P Cohen
    Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Pathol 190:484-8. 2000
    ....
  18. ncbi ACE inhibitors and AII receptor antagonists in the treatment and prevention of bone marrow transplant nephropathy
    J E Moulder
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Curr Pharm Des 9:737-49. 2003
    ....
  19. ncbi Parathyroidectomy in chronic renal failure: has medical care reduced the need for surgery?
    E P Cohen
    Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisc, USA
    Nephron 89:271-3. 2001
    ..It is likely that improved medical and dialysis care has enabled this result...
  20. ncbi Early detection of radiation-induced glomerular injury by albumin permeability assay
    M Sharma
    Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA
    Radiat Res 155:474-80. 2001
    ..We conclude that glomerular protein permeability of irradiated rats increases in a dose-dependent manner immediately after irradiation and that it appears to be independent of hemodynamic or systemic influences...
  21. ncbi Loss of renal function following bone marrow transplantation: an analysis of angiotensin converting enzyme D/I polymorphism and other clinical risk factors
    M B Juckett
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Bone Marrow Transplant 27:451-6. 2001
    ..026). We conclude that the ACE genotype does not seem to influence survival, but the DD genotype may be protective against renal injury after BMT. Furthermore, we confirm that renal shielding during TBI reduces the renal injury after BMT...
  22. pmc Vascular injury after whole thoracic x-ray irradiation in the rat
    S N Ghosh
    Department of Medicine, Division of Pulmonary and Critical Care, Medical College of Wisconsin, Milwaukee, WI, USA
    Int J Radiat Oncol Biol Phys 74:192-9. 2009
    ..To study vascular injury after whole thoracic irradiation with single sublethal doses of X-rays in the rat and to develop markers that might predict the severity of injury...
  23. ncbi The renin-angiotensin system in experimental radiation nephropathy
    Eric P Cohen
    Department of Medicine, Division of Nephrology, Medical College of Wisconsin, Froedtert Memorial Lutheran Hospital, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    J Lab Clin Med 139:251-7. 2002
    ..We hypothesize that even the normal activity of the RAS contributes to injury after kidney irradiation, possibly by supporting the proliferation of cells that carry potentially lethal radiation injuries...
  24. pmc Renal dysfunction after total body irradiation: dose-effect relationship: in regard to Kal and van Kempen-Harteveld (Int J Radiat Oncol Biol Phys 2006;65:1228-1232)
    John E Moulder
    Int J Radiat Oncol Biol Phys 67:319; author reply 319-20. 2007
  25. ncbi Effect of an angiotensin II receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor-beta (TGF-beta) and alpha-actomyosin (alpha SMA), important mediators of radiation-induced pneumopathy and lung fibrosis
    Agostino Molteni
    Department of Pathology and Basic Medicinal Science, University of Missouri at Kansas City, Truman Medical Center, Kansas City, MO 64108, USA
    Curr Pharm Des 13:1307-16. 2007
    ....
  26. pmc Role of the angiotensin II type-2 receptor in radiation nephropathy
    Eric P Cohen
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Transl Res 150:106-15. 2007
    ..The effect of AT(2) blockade in radiation nephropathy cannot be explained by binding to the AT(1) receptor, and the efficacy of the AT(1) blockade in the same model cannot be explained by unopposed overstimulation of the AT(2) receptor...
  27. pmc Captopril to mitigate chronic renal failure after hematopoietic stem cell transplantation: a randomized controlled trial
    Eric P Cohen
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Radiat Oncol Biol Phys 70:1546-51. 2008
    ..To test whether the angiotensin-converting enzyme inhibitor captopril was effective in mitigating chronic renal failure after hematopoietic stem cell transplantation (HSCT)...
  28. ncbi Loss of albumin and megalin binding to renal cubilin in rats results in albuminuria after total body irradiation
    Raghunatha R Yammani
    Department of Medicine, Division of Gastroenterology and Hepatology, Medical College of Wisconsin and Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 283:R339-46. 2002
    ..Furthermore, these results also suggest that albumin and IF-Cbl binding to cubilin occur at distinct sites and that in the rat renal BBM, CIMPR interacts with both cubilin and megalin...
  29. ncbi Potential deployment of angiotensin I converting enzyme inhibitors and of angiotensin II type 1 and type 2 receptor blockers in cancer chemotherapy
    Agostino Molteni
    University of Missouri Kansas City School of Medicine, Kansas City Missouri, USA
    Anticancer Agents Med Chem 6:451-60. 2006
    ..Several such trials are currently in process. If these trials confirm the experimental and retrospective studies, these agents will provide a significant contribution to the therapeutic treatment of many malignancies in humans...
  30. ncbi Arachidonic acid metabolites mediate the radiation-induced increase in glomerular albumin permeability
    Mukut Sharma
    Division of Nephrology and the Kidney Disease Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Exp Biol Med (Maywood) 231:99-106. 2006
    ..Understanding of the early epigenetic effects of irradiation may lead to new intervention strategies against radiation-induced injury of normal tissues...
  31. ncbi Radiation induces endothelial dysfunction in murine intestinal arterioles via enhanced production of reactive oxygen species
    Ossama A Hatoum
    Division of Cardiovascular Medicine, Froedtert Memorial Lutheran Hospital, VA Medical Center, Medical College of Wisconsin, Milwaukee, WI, USA
    Arterioscler Thromb Vasc Biol 26:287-94. 2006
    ..The objectives of this study were to assess the acute effect of irradiation on acetylcholine (Ach)-induced dilation of gut submucosal microvessels...
  32. ncbi Successful treatment of radiation nephropathy with angiotensin II blockade
    Eric P Cohen
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    Int J Radiat Oncol Biol Phys 55:190-3. 2003
    ..The aim of this report is to document the successful treatment of radiation nephropathy...
  33. ncbi Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: report of a workshop at Bethesda, Maryland, December 17-18, 2001
    C Norman Coleman
    Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Radiat Res 159:812-34. 2003
    ..Communicate knowledge of the effects of radiation exposure to the general public and to investigators, policy makers and agencies involved in response to nuclear accidents/events and protection/treatment of the general public...
  34. ncbi Pharmacological intervention to prevent or ameliorate chronic radiation injuries
    John E Moulder
    Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Semin Radiat Oncol 13:73-84. 2003
    ....
  35. ncbi Medicine. Modulation of radiation injury
    C Norman Coleman
    Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA
    Science 304:693-4. 2004
  36. ncbi Publishing negative results: the problem of publication bias
    Sara Rockwell
    Radiat Res 165:623-5. 2006
  37. pmc Structural and functional alterations in the rat lung following whole thoracic irradiation with moderate doses: injury and recovery
    Rong Zhang
    Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, China
    Int J Radiat Biol 84:487-97. 2008
    ..To characterize structural and functional injuries following a single dose of whole-thorax irradiation that might be survivable after a nuclear attack/accident...
  38. ncbi Parathyroidectomy in ESRD
    Eric P Cohen
    Kidney Int 66:459; author reply 459. 2004
  39. ncbi Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003
    Helen B Stone
    National Cancer Institute, Bethesda, Maryland 20892, USA
    Radiat Res 162:711-28. 2004
    ....
  40. ncbi Critiquing unpublished theories
    John E Moulder
    Radiat Res 159:1-2. 2003

Research Grants27

  1. KIDNEY RESPONSE TO RADIATION AND CHEMOTHERAPY
    JOHN MOULDER; Fiscal Year: 2001
    ..7) To determine the conditions under which pulsed low dose rate (LDR) and continuous LDR produce clinically equivalent normal tissue injury. ..
  2. KIDNEY RESPONSE TO RADIATION AND CHEMOTHERAPY
    JOHN MOULDER; Fiscal Year: 2006
    ..4) Complete the randomized, prospective, trial of the use of ACE inhibitors to prevent the development of radiation nephropathy in BMT patients. ..
  3. KIDNEY RESPONSE TO FRACTIONED RADIATION
    JOHN MOULDER; Fiscal Year: 1980
    ..Some of the animals surviving the first course of treatment will be given a second fractionated treatment 6 to 18 months later...
  4. KIDNEY RESPONSE TO RADIATION AND CHEMOTHERAPY
    JOHN MOULDER; Fiscal Year: 1993
    ..Complete the on-going study of whether nephrotoxic drugs used in conjunction with BMT enhance or accelerate the development of radiation nephritis...
  5. KIDNEY RESPONSE TO RADIATION AND CHEMOTHERAPY
    JOHN MOULDER; Fiscal Year: 1991
    ..b) How does treatment with nephrotoxic chemotherapeutic agents affect tolerance to subsequent renal radiation? c) How does treatment with nephrotoxic agents affect the development of nephritis from previous renal irradiation?..