Kouros Motamed

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. ncbi request reprint Fibroblast growth factor receptor-1 mediates the inhibition of endothelial cell proliferation and the promotion of skeletal myoblast differentiation by SPARC: a role for protein kinase A
    Kouros Motamed
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104 2046, USA
    J Cell Biochem 90:408-23. 2003
  2. pmc Secreted protein acidic and rich in cysteine deficiency ameliorates renal inflammation and fibrosis in angiotensin hypertension
    Matthew J Socha
    Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd, CB 3306, Augusta, GA 30912, USA
    Am J Pathol 171:1104-12. 2007
  3. ncbi request reprint SPARC regulates TGF-beta1-dependent signaling in primary glomerular mesangial cells
    Aleksandar Francki
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104, USA
    J Cell Biochem 91:915-25. 2004
  4. ncbi request reprint SPARC regulates cell cycle progression in mesangial cells via its inhibition of IGF-dependent signaling
    Aleksandar Francki
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104, USA
    J Cell Biochem 88:802-11. 2003
  5. ncbi request reprint Inhibition of PDGF-stimulated and matrix-mediated proliferation of human vascular smooth muscle cells by SPARC is independent of changes in cell shape or cyclin-dependent kinase inhibitors
    Kouros Motamed
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104, USA
    J Cell Biochem 84:759-71. 2002
  6. pmc SPARC inhibits LPA-mediated mesothelial-ovarian cancer cell crosstalk
    Neveen A Said
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    Neoplasia 9:23-35. 2007
  7. pmc Secreted protein acidic and rich in cysteine (SPARC) inhibits integrin-mediated adhesion and growth factor-dependent survival signaling in ovarian cancer
    Neveen Said
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    Am J Pathol 170:1054-63. 2007
  8. ncbi request reprint Protein kinase C and downstream signaling pathways in a three-dimensional model of phorbol ester-induced angiogenesis
    Caroline J Taylor
    Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912, USA
    Angiogenesis 9:39-51. 2006
  9. pmc Absence of host-secreted protein acidic and rich in cysteine (SPARC) augments peritoneal ovarian carcinomatosis
    Neveen Said
    Department of Pathology, Medical College of Georgia, Augusta, 30912, USA
    Am J Pathol 167:1739-52. 2005
  10. ncbi request reprint Cell-based and direct gene transfer-induced angiogenesis via a secreted chimeric fibroblast growth factor-1 (sp-FGF-1) in the chick chorioallantoic membrane (CAM)
    Reza Forough
    Department of Medical Physiology and Cardiovascular Research Institute, College of Medicine, The Texas A and M University System Health Science Center, College Station, TX 77843, USA
    Angiogenesis 6:47-54. 2003

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Fibroblast growth factor receptor-1 mediates the inhibition of endothelial cell proliferation and the promotion of skeletal myoblast differentiation by SPARC: a role for protein kinase A
    Kouros Motamed
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104 2046, USA
    J Cell Biochem 90:408-23. 2003
    ..SPARC thus modulates the mitogenic effect of FGF-2 downstream from FGFR1 by selective regulation of the MAPK signaling cascade...
  2. pmc Secreted protein acidic and rich in cysteine deficiency ameliorates renal inflammation and fibrosis in angiotensin hypertension
    Matthew J Socha
    Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd, CB 3306, Augusta, GA 30912, USA
    Am J Pathol 171:1104-12. 2007
    ..These results identify SPARC as an effector of ANG II signaling and suggest an important role for SPARC in mediating ANG II-induced oxidative stress, inflammation, and fibrosis...
  3. ncbi request reprint SPARC regulates TGF-beta1-dependent signaling in primary glomerular mesangial cells
    Aleksandar Francki
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104, USA
    J Cell Biochem 91:915-25. 2004
    ..That SPARC is directly involved in the regulation of the TGF-beta1 signaling cascade is consistent with the paradigm that matricellular proteins modulate interactions among cells, growth factors, and their respective receptors...
  4. ncbi request reprint SPARC regulates cell cycle progression in mesangial cells via its inhibition of IGF-dependent signaling
    Aleksandar Francki
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104, USA
    J Cell Biochem 88:802-11. 2003
    ....
  5. ncbi request reprint Inhibition of PDGF-stimulated and matrix-mediated proliferation of human vascular smooth muscle cells by SPARC is independent of changes in cell shape or cyclin-dependent kinase inhibitors
    Kouros Motamed
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104, USA
    J Cell Biochem 84:759-71. 2002
    ....
  6. pmc SPARC inhibits LPA-mediated mesothelial-ovarian cancer cell crosstalk
    Neveen A Said
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    Neoplasia 9:23-35. 2007
    ..Taken together, our findings underscore the use of SPARC as a potential therapeutic candidate in peritoneal ovarian carcinomatosis...
  7. pmc Secreted protein acidic and rich in cysteine (SPARC) inhibits integrin-mediated adhesion and growth factor-dependent survival signaling in ovarian cancer
    Neveen Said
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    Am J Pathol 170:1054-63. 2007
    ..In summary, we have identified a novel role of SPARC as a negative regulator of both integrin-mediated adhesion and growth factor-stimulated survival signaling pathways in ovarian cancer...
  8. ncbi request reprint Protein kinase C and downstream signaling pathways in a three-dimensional model of phorbol ester-induced angiogenesis
    Caroline J Taylor
    Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912, USA
    Angiogenesis 9:39-51. 2006
    ..These findings illustrate the complexities of blood vessel formation, and suggest that activators utilize multiple independent pathways to invoke a complete angiogenic response...
  9. pmc Absence of host-secreted protein acidic and rich in cysteine (SPARC) augments peritoneal ovarian carcinomatosis
    Neveen Said
    Department of Pathology, Medical College of Georgia, Augusta, 30912, USA
    Am J Pathol 167:1739-52. 2005
    ..Thus, SPARC represents an important therapeutic candidate in ovarian cancer...
  10. ncbi request reprint Cell-based and direct gene transfer-induced angiogenesis via a secreted chimeric fibroblast growth factor-1 (sp-FGF-1) in the chick chorioallantoic membrane (CAM)
    Reza Forough
    Department of Medical Physiology and Cardiovascular Research Institute, College of Medicine, The Texas A and M University System Health Science Center, College Station, TX 77843, USA
    Angiogenesis 6:47-54. 2003
    ..These CAM models are useful both for studying molecular mechanisms of angiogenesis and for developing better gene therapy strategies...
  11. ncbi request reprint Normalization of the ovarian cancer microenvironment by SPARC
    Neveen Said
    Vascular Biology Center, Medical College of Georgia, Augusta, Georgea 30912, USA
    Mol Cancer Res 5:1015-30. 2007
    ....