Affiliation: Medical University of South Carolina
Ghatak S, Misra S, Moreno Rodrigue R, Hascall V, Leone G, Markwald R. Periostin/β1integrin interaction regulates p21-activated kinases in valvular interstitial cell survival and in actin cytoskeleton reorganization. Biochim Biophys Acta Gen Subj. 2019;1863:813-829 pubmed publisher
Misra S, Heldin P, Hascall V, Karamanos N, Skandalis S, Markwald R, et al
. Hyaluronan-CD44 interactions as potential targets for cancer therapy. FEBS J. 2011;278:1429-43 pubmed publisher
..This minireview summarizes how the interaction between hyaluronan and CD44v can serve as a potential target for cancer therapy, in particular how silencing CD44v can target multiple metastatic tumors. ..
Misra S, Ghatak S, Toole B. Regulation of MDR1 expression and drug resistance by a positive feedback loop involving hyaluronan, phosphoinositide 3-kinase, and ErbB2. J Biol Chem. 2005;280:20310-5 pubmed
..This pathway may also be important in progression of other malignant characteristics. These results illustrate the potential importance of hyaluronan as a therapeutic target in multidrug-resistant carcinomas. ..
Misra S, Obeid L, Hannun Y, Minamisawa S, Berger F, Markwald R, et al
. Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells. J Biol Chem. 2008;283:14335-44 pubmed publisher
..Defining hyaluronan-dependent cyclooxygenase-2/prostaglandin E(2)-associated signaling pathways will provide a platform for developing novel therapeutic approaches for colon cancer. ..
Misra S, Hascall V, Berger F, Markwald R, Ghatak S. Hyaluronan, CD44, and cyclooxygenase-2 in colon cancer. Connect Tissue Res. 2008;49:219-24 pubmed publisher
..This review includes a summary of the authors work over the past years as well as citations of specific reviews related to role of hyaluronan in the pathogenesis of colon cancer. ..
Misra S, Hascall V, De Giovanni C, Markwald R, Ghatak S. Delivery of CD44 shRNA/nanoparticles within cancer cells: perturbation of hyaluronan/CD44v6 interactions and reduction in adenoma growth in Apc Min/+ MICE. J Biol Chem. 2009;284:12432-46 pubmed publisher
..Together, these data provide insight into the novel therapeutic strategies of short hairpin RNA/nanoparticle technology and its potential for silencing genes associated with colon tumor cells. ..
Ghatak S, Hascall V, Markwald R, Feghali Bostwick C, Artlett C, Gooz M, et al
. Transforming growth factor ?1 (TGF?1)-induced CD44V6-NOX4 signaling in pathogenesis of idiopathic pulmonary fibrosis. J Biol Chem. 2017;292:10490-10519 pubmed publisher
..These studies support a function for CD44V6 in lung fibrosis and offer proof of concept for therapeutic targeting of CD44V6 in lung fibrosis disorders. ..
Ghatak S, Markwald R, Hascall V, Dowling W, Lottes R, Baatz J, et al
. Transforming growth factor ?1 (TGF?1) regulates CD44V6 expression and activity through extracellular signal-regulated kinase (ERK)-induced EGR1 in pulmonary fibrogenic fibroblasts. J Biol Chem. 2017;292:10465-10489 pubmed publisher
..These results demonstrate a novel positive-feedback loop that links the myofibroblast phenotype to TGF?1-stimulated CD44V6/ERK/EGR1 signaling. ..