Michael Michalkiewicz

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi Hypotension and reduced catecholamines in neuropeptide Y transgenic rats
    Mieczyslaw Michalkiewicz
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, PO Box 26509, Milwaukee, WI 53226 050, USA
    Hypertension 41:1056-62. 2003
  2. ncbi Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat
    Mieczyslaw Michalkiewicz
    Department of Physiology, Human Molecular and Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
    Physiol Genomics 19:228-32. 2004
  3. ncbi Central neuropeptide Y signaling ameliorates N(omega)-nitro-L-arginine methyl ester hypertension in the rat through a Y1 receptor mechanism
    Mieczyslaw Michalkiewicz
    Department of Physiology, Human Molecular and Genetic Center, Medical College of Wisconsin, Milwaukee 53226 0509, USA
    Hypertension 45:780-5. 2005
  4. ncbi Efficient transgenic rat production by a lentiviral vector
    Mieczyslaw Michalkiewicz
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 293:H881-94. 2007
  5. ncbi Aged neuropeptide Y transgenic rats are resistant to acute stress but maintain spatial and non-spatial learning
    Cristina C Carvajal
    Department of Neurology and Neurosurgery, Douglas Hospital Research Centre, McGill University, 6875 Boulevard LaSalle, , Que, H4H 1R3, Canada
    Behav Brain Res 153:471-80. 2004

Research Grants

  1. TRANSGENIC STUDY VASCULAR ROLE OF NEUROPEPTIDE Y
    Michael Michalkiewicz; Fiscal Year: 2002

Collaborators

Detail Information

Publications5

  1. ncbi Hypotension and reduced catecholamines in neuropeptide Y transgenic rats
    Mieczyslaw Michalkiewicz
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, PO Box 26509, Milwaukee, WI 53226 050, USA
    Hypertension 41:1056-62. 2003
    ..As indicated by the increased longevity of these rats, in long-term regulation, these buffering actions of neuropeptide Y may have important cardiovascular protective effects against sympathetic hyperexcitation...
  2. ncbi Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat
    Mieczyslaw Michalkiewicz
    Department of Physiology, Human Molecular and Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
    Physiol Genomics 19:228-32. 2004
    ..It also demonstrates that transgenic rescue in the rat is a practical and definitive method for revealing the function of a novel gene...
  3. ncbi Central neuropeptide Y signaling ameliorates N(omega)-nitro-L-arginine methyl ester hypertension in the rat through a Y1 receptor mechanism
    Mieczyslaw Michalkiewicz
    Department of Physiology, Human Molecular and Genetic Center, Medical College of Wisconsin, Milwaukee 53226 0509, USA
    Hypertension 45:780-5. 2005
    ....
  4. ncbi Efficient transgenic rat production by a lentiviral vector
    Mieczyslaw Michalkiewicz
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 293:H881-94. 2007
    ..Thus lentiviral transgenesis provides a powerful tool for the production of transgenic inbred rats and will enhance the usefulness of this species in gene discovery and target validation studies...
  5. ncbi Aged neuropeptide Y transgenic rats are resistant to acute stress but maintain spatial and non-spatial learning
    Cristina C Carvajal
    Department of Neurology and Neurosurgery, Douglas Hospital Research Centre, McGill University, 6875 Boulevard LaSalle, , Que, H4H 1R3, Canada
    Behav Brain Res 153:471-80. 2004
    ..These results also provide additional evidence for the mechanistic dissociation between anxiety and cognition-related behaviors modulated by NPY...

Research Grants5

  1. TRANSGENIC STUDY VASCULAR ROLE OF NEUROPEPTIDE Y
    Michael Michalkiewicz; Fiscal Year: 2002
    ..The NPY overexpressing rats with well defined mutation of the NPY gene will provide a new transgenic animal model of hypertension; such a model should also be very useful for development of new therapies for treating this diseases. ..