Research Topics
| MARILYN MERKERSummaryAffiliation: Medical College of Wisconsin Country: USA Publications
Research Grants
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Detail Information
Publications
Coenzyme Q(1) as a probe for mitochondrial complex I activity in the intact perfused hyperoxia-exposed wild-type and Nqo1-null mouse lungRobert D Bongard
Medical College of Wisconsin, Zablocki VAMC, Milwaukee, WI 53295, USA
Am J Physiol Lung Cell Mol Physiol 302:L949-58. 2012..This study provides new evidence for the potential utility of CoQ(1) as a nondestructive indicator of the impact of pharmacological or pathological exposures on complex I activity in the intact perfused mouse lung...
Influence of pulmonary arterial endothelial cells on quinone redox status: effect of hyperoxia-induced NAD(P)H:quinone oxidoreductase 1Marilyn P Merker
Department of Anesthesiology, Medical College of Wisconsin, VA Medical Center, Research Service 151, Milwaukee, WI 53295, USA
Am J Physiol Lung Cell Mol Physiol 290:L607-19. 2006..This study demonstrates that exposure to chronic hyperoxia increases the capacity of pulmonary arterial endothelial cells to reduce DQ to DQH2 via a hyperoxia-induced increase in NQO1 protein and total activity...- Impact of pulmonary arterial endothelial cells on duroquinone redox statusMarilyn P Merker
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA
Free Radic Biol Med 37:86-103. 2004..These endothelial redox functions and their apposition to the vessel lumen are consistent with the pulmonary endothelium being an important site of DQ reduction to DQH2 observed in the lungs... - Lung redox homeostasis: emerging conceptsM P Merker
Departments of Anesthesiology, Pharmacology Toxicology, and Physiology, Medical College of Wisconsin and Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295, USA
Am J Physiol Lung Cell Mol Physiol 279:L413-7. 2000..Although the lung endothelium was the predominant cell type under consideration, at least some of the proposed mechanisms operate in or affect other cell types and organs as well... - Intracellular redox status affects transplasma membrane electron transport in pulmonary arterial endothelial cellsMarilyn P Merker
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53295, USA
Am J Physiol Lung Cell Mol Physiol 282:L36-43. 2002..The results suggest that cellular redox status is a determinant of pulmonary arterial endothelial cell TPMET activity, with TPMET activity more highly correlated with the poise of the NADH/NAD(+) redox pair... - Preferential utilization of NADPH as the endogenous electron donor for NAD(P)H:quinone oxidoreductase 1 (NQO1) in intact pulmonary arterial endothelial cellsRobert D Bongard
Department of Pulmonary Medicine, Medical College of Wisconsin, Milwaukee, USA
Free Radic Biol Med 46:25-32. 2009.... - Role of mitochondrial electron transport complex I in coenzyme Q1 reduction by intact pulmonary arterial endothelial cells and the effect of hyperoxiaMarilyn P Merker
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Am J Physiol Lung Cell Mol Physiol 293:L809-19. 2007.... - Duroquinone reduction during passage through the pulmonary circulationSaid H Audi
Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin 53201, USA
Am J Physiol Lung Cell Mol Physiol 285:L1116-31. 2003..For DQ, the effect is conversion of a redox-cycling, oxygen-activating quinone into a stable hydroquinone... - Effect of chronic hyperoxic exposure on duroquinone reduction in adult rat lungsSaid H Audi
Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin, USA
Am J Physiol Lung Cell Mol Physiol 289:L788-97. 2005..The increase in Kma could be accounted for by approximately 40% increase in vascular transit time heterogeneity in 21-day hyperoxic lungs... - Pulmonary arterial endothelial cells affect the redox status of coenzyme Q0Said H Audi
Department of Biomedical Engineering, Marquette University, Milwaukee, WI, USA
Free Radic Biol Med 34:892-907. 2003..In addition, once formed the QH2 undergoes a cyanide-sensitive oxidation by the cells. Thus, the actual rate of Q reduction by the cells is greater than the net QH2 output from the cells... - Coenzyme Q1 redox metabolism during passage through the rat pulmonary circulation and the effect of hyperoxiaSaid H Audi
Research Service 151, Zablocki VAMC, 5000 W National Avenue, Milwaukee, WI 53295, USA
J Appl Physiol 105:1114-26. 2008.... - Quantifying mitochondrial and plasma membrane potentials in intact pulmonary arterial endothelial cells based on extracellular disposition of rhodamine dyesZhuohui Gan
Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin, USA
Am J Physiol Lung Cell Mol Physiol 300:L762-72. 2011.... - Genetic evidence for NAD(P)H:quinone oxidoreductase 1-catalyzed quinone reduction on passage through the mouse pulmonary circulationBrian J Lindemer
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Am J Physiol Lung Cell Mol Physiol 300:L773-80. 2011..The data provide genetic evidence implicating DQ as a specific NQO1 probe in the perfused rodent lung...
Research Grants
- REDOX ACTIVITY OF THE PULMONARY ENDOTHELIAL SURFACEMARILYN MERKER; Fiscal Year: 2003..abstract_text> ..
- REDOX ACTIVITY OF THE PULMONARY ENDOTHELIAL SURFACEMARILYN MERKER; Fiscal Year: 2007....