MARILYN MERKER

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. pmc Coenzyme Q(1) as a probe for mitochondrial complex I activity in the intact perfused hyperoxia-exposed wild-type and Nqo1-null mouse lung
    Robert D Bongard
    Medical College of Wisconsin, Zablocki VAMC, Milwaukee, WI 53295, USA
    Am J Physiol Lung Cell Mol Physiol 302:L949-58. 2012
  2. ncbi request reprint Influence of pulmonary arterial endothelial cells on quinone redox status: effect of hyperoxia-induced NAD(P)H:quinone oxidoreductase 1
    Marilyn P Merker
    Department of Anesthesiology, Medical College of Wisconsin, VA Medical Center, Research Service 151, Milwaukee, WI 53295, USA
    Am J Physiol Lung Cell Mol Physiol 290:L607-19. 2006
  3. ncbi request reprint Impact of pulmonary arterial endothelial cells on duroquinone redox status
    Marilyn P Merker
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA
    Free Radic Biol Med 37:86-103. 2004
  4. ncbi request reprint Lung redox homeostasis: emerging concepts
    M P Merker
    Departments of Anesthesiology, Pharmacology Toxicology, and Physiology, Medical College of Wisconsin and Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295, USA
    Am J Physiol Lung Cell Mol Physiol 279:L413-7. 2000
  5. ncbi request reprint Intracellular redox status affects transplasma membrane electron transport in pulmonary arterial endothelial cells
    Marilyn P Merker
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53295, USA
    Am J Physiol Lung Cell Mol Physiol 282:L36-43. 2002
  6. pmc Preferential utilization of NADPH as the endogenous electron donor for NAD(P)H:quinone oxidoreductase 1 (NQO1) in intact pulmonary arterial endothelial cells
    Robert D Bongard
    Department of Pulmonary Medicine, Medical College of Wisconsin, Milwaukee, USA
    Free Radic Biol Med 46:25-32. 2009
  7. ncbi request reprint Role of mitochondrial electron transport complex I in coenzyme Q1 reduction by intact pulmonary arterial endothelial cells and the effect of hyperoxia
    Marilyn P Merker
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Physiol Lung Cell Mol Physiol 293:L809-19. 2007
  8. ncbi request reprint Duroquinone reduction during passage through the pulmonary circulation
    Said H Audi
    Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin 53201, USA
    Am J Physiol Lung Cell Mol Physiol 285:L1116-31. 2003
  9. ncbi request reprint Effect of chronic hyperoxic exposure on duroquinone reduction in adult rat lungs
    Said H Audi
    Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin, USA
    Am J Physiol Lung Cell Mol Physiol 289:L788-97. 2005
  10. ncbi request reprint Pulmonary arterial endothelial cells affect the redox status of coenzyme Q0
    Said H Audi
    Department of Biomedical Engineering, Marquette University, Milwaukee, WI, USA
    Free Radic Biol Med 34:892-907. 2003

Research Grants

Collaborators

Detail Information

Publications13

  1. pmc Coenzyme Q(1) as a probe for mitochondrial complex I activity in the intact perfused hyperoxia-exposed wild-type and Nqo1-null mouse lung
    Robert D Bongard
    Medical College of Wisconsin, Zablocki VAMC, Milwaukee, WI 53295, USA
    Am J Physiol Lung Cell Mol Physiol 302:L949-58. 2012
    ..This study provides new evidence for the potential utility of CoQ(1) as a nondestructive indicator of the impact of pharmacological or pathological exposures on complex I activity in the intact perfused mouse lung...
  2. ncbi request reprint Influence of pulmonary arterial endothelial cells on quinone redox status: effect of hyperoxia-induced NAD(P)H:quinone oxidoreductase 1
    Marilyn P Merker
    Department of Anesthesiology, Medical College of Wisconsin, VA Medical Center, Research Service 151, Milwaukee, WI 53295, USA
    Am J Physiol Lung Cell Mol Physiol 290:L607-19. 2006
    ..This study demonstrates that exposure to chronic hyperoxia increases the capacity of pulmonary arterial endothelial cells to reduce DQ to DQH2 via a hyperoxia-induced increase in NQO1 protein and total activity...
  3. ncbi request reprint Impact of pulmonary arterial endothelial cells on duroquinone redox status
    Marilyn P Merker
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA
    Free Radic Biol Med 37:86-103. 2004
    ..These endothelial redox functions and their apposition to the vessel lumen are consistent with the pulmonary endothelium being an important site of DQ reduction to DQH2 observed in the lungs...
  4. ncbi request reprint Lung redox homeostasis: emerging concepts
    M P Merker
    Departments of Anesthesiology, Pharmacology Toxicology, and Physiology, Medical College of Wisconsin and Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295, USA
    Am J Physiol Lung Cell Mol Physiol 279:L413-7. 2000
    ..Although the lung endothelium was the predominant cell type under consideration, at least some of the proposed mechanisms operate in or affect other cell types and organs as well...
  5. ncbi request reprint Intracellular redox status affects transplasma membrane electron transport in pulmonary arterial endothelial cells
    Marilyn P Merker
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53295, USA
    Am J Physiol Lung Cell Mol Physiol 282:L36-43. 2002
    ..The results suggest that cellular redox status is a determinant of pulmonary arterial endothelial cell TPMET activity, with TPMET activity more highly correlated with the poise of the NADH/NAD(+) redox pair...
  6. pmc Preferential utilization of NADPH as the endogenous electron donor for NAD(P)H:quinone oxidoreductase 1 (NQO1) in intact pulmonary arterial endothelial cells
    Robert D Bongard
    Department of Pulmonary Medicine, Medical College of Wisconsin, Milwaukee, USA
    Free Radic Biol Med 46:25-32. 2009
    ....
  7. ncbi request reprint Role of mitochondrial electron transport complex I in coenzyme Q1 reduction by intact pulmonary arterial endothelial cells and the effect of hyperoxia
    Marilyn P Merker
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Physiol Lung Cell Mol Physiol 293:L809-19. 2007
    ....
  8. ncbi request reprint Duroquinone reduction during passage through the pulmonary circulation
    Said H Audi
    Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin 53201, USA
    Am J Physiol Lung Cell Mol Physiol 285:L1116-31. 2003
    ..For DQ, the effect is conversion of a redox-cycling, oxygen-activating quinone into a stable hydroquinone...
  9. ncbi request reprint Effect of chronic hyperoxic exposure on duroquinone reduction in adult rat lungs
    Said H Audi
    Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin, USA
    Am J Physiol Lung Cell Mol Physiol 289:L788-97. 2005
    ..The increase in Kma could be accounted for by approximately 40% increase in vascular transit time heterogeneity in 21-day hyperoxic lungs...
  10. ncbi request reprint Pulmonary arterial endothelial cells affect the redox status of coenzyme Q0
    Said H Audi
    Department of Biomedical Engineering, Marquette University, Milwaukee, WI, USA
    Free Radic Biol Med 34:892-907. 2003
    ..In addition, once formed the QH2 undergoes a cyanide-sensitive oxidation by the cells. Thus, the actual rate of Q reduction by the cells is greater than the net QH2 output from the cells...
  11. pmc Coenzyme Q1 redox metabolism during passage through the rat pulmonary circulation and the effect of hyperoxia
    Said H Audi
    Research Service 151, Zablocki VAMC, 5000 W National Avenue, Milwaukee, WI 53295, USA
    J Appl Physiol 105:1114-26. 2008
    ....
  12. pmc Quantifying mitochondrial and plasma membrane potentials in intact pulmonary arterial endothelial cells based on extracellular disposition of rhodamine dyes
    Zhuohui Gan
    Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin, USA
    Am J Physiol Lung Cell Mol Physiol 300:L762-72. 2011
    ....
  13. pmc Genetic evidence for NAD(P)H:quinone oxidoreductase 1-catalyzed quinone reduction on passage through the mouse pulmonary circulation
    Brian J Lindemer
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Physiol Lung Cell Mol Physiol 300:L773-80. 2011
    ..The data provide genetic evidence implicating DQ as a specific NQO1 probe in the perfused rodent lung...

Research Grants7

  1. REDOX ACTIVITY OF THE PULMONARY ENDOTHELIAL SURFACE
    MARILYN MERKER; Fiscal Year: 2003
    ..abstract_text> ..
  2. REDOX ACTIVITY OF THE PULMONARY ENDOTHELIAL SURFACE
    MARILYN MERKER; Fiscal Year: 2007
    ....