ANDREW LEE MELLOR

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. ncbi Indoleamine 2,3 dioxygenase and regulation of T cell immunity
    Andrew Mellor
    Immunotherapy Center, Medical College of Georgia, 1120, 15th St, Augusta, GA 30912, USA
    Biochem Biophys Res Commun 338:20-4. 2005
  2. ncbi Creating immune privilege: active local suppression that benefits friends, but protects foes
    Andrew L Mellor
    Immunotherapy and Cancer Centers, Medical College of Georgia, Augusta, Georgia USA
    Nat Rev Immunol 8:74-80. 2008
  3. ncbi Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase
    Andrew L Mellor
    Department of Medicine, Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120, 15th Street, Augusta, GA 30912 2600, USA
    Int Immunol 16:1391-401. 2004
  4. ncbi Policing pregnancy: Tregs help keep the peace
    Andrew L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Trends Immunol 25:563-5. 2004
  5. pmc Targeting the immunoregulatory indoleamine 2,3 dioxygenase pathway in immunotherapy
    Burles A Johnson
    Immunotherapy Center and Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Immunotherapy 1:645-61. 2009
  6. ncbi A minor population of splenic dendritic cells expressing CD19 mediates IDO-dependent T cell suppression via type I IFN signaling following B7 ligation
    Babak Baban
    Immunotherapy Center, Medical College of Georgia, 1120, 15th Street, Augusta, GA 30912, USA
    Int Immunol 17:909-19. 2005
  7. pmc Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase
    Madhav D Sharma
    Department of Pediatrics, School of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Clin Invest 117:2570-82. 2007
  8. pmc Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division
    Geon Kook Lee
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Immunology 107:452-60. 2002
  9. pmc IDO activates regulatory T cells and blocks their conversion into Th17-like T cells
    Babak Baban
    Immunotherapy and Cancer Centers, Department of Pathology, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 183:2475-83. 2009
  10. pmc Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes
    Madhav D Sharma
    Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
    Blood 113:6102-11. 2009

Research Grants

Collaborators

Detail Information

Publications38

  1. ncbi Indoleamine 2,3 dioxygenase and regulation of T cell immunity
    Andrew Mellor
    Immunotherapy Center, Medical College of Georgia, 1120, 15th St, Augusta, GA 30912, USA
    Biochem Biophys Res Commun 338:20-4. 2005
    ..In this review, I focus on dendritic cells that can express IDO, and which acquire potent T cell regulatory functions as a consequence...
  2. ncbi Creating immune privilege: active local suppression that benefits friends, but protects foes
    Andrew L Mellor
    Immunotherapy and Cancer Centers, Medical College of Georgia, Augusta, Georgia USA
    Nat Rev Immunol 8:74-80. 2008
    ....
  3. ncbi Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase
    Andrew L Mellor
    Department of Medicine, Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120, 15th Street, Augusta, GA 30912 2600, USA
    Int Immunol 16:1391-401. 2004
    ..These findings suggest that IDO-competent DCs provide a regulatory bridge, mediated by CTLA4-B7 engagement, between certain regulatory T cell subsets and naive responder T cells...
  4. ncbi Policing pregnancy: Tregs help keep the peace
    Andrew L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Trends Immunol 25:563-5. 2004
  5. pmc Targeting the immunoregulatory indoleamine 2,3 dioxygenase pathway in immunotherapy
    Burles A Johnson
    Immunotherapy Center and Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Immunotherapy 1:645-61. 2009
    ..Thus, manipulating IDO is a promising strategy to treat a range of chronic inflammatory diseases...
  6. ncbi A minor population of splenic dendritic cells expressing CD19 mediates IDO-dependent T cell suppression via type I IFN signaling following B7 ligation
    Babak Baban
    Immunotherapy Center, Medical College of Georgia, 1120, 15th Street, Augusta, GA 30912, USA
    Int Immunol 17:909-19. 2005
    ..Thus, CD19+ DCs may be a target for regulatory T cells expressing surface CTLA4, and may suppress T cell responses via induction of IDO...
  7. pmc Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase
    Madhav D Sharma
    Department of Pediatrics, School of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Clin Invest 117:2570-82. 2007
    ..We hypothesize that IDO+ pDCs create a profoundly suppressive microenvironment within tumor-draining LNs via constitutive activation of Tregs...
  8. pmc Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division
    Geon Kook Lee
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Immunology 107:452-60. 2002
    ....
  9. pmc IDO activates regulatory T cells and blocks their conversion into Th17-like T cells
    Babak Baban
    Immunotherapy and Cancer Centers, Department of Pathology, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 183:2475-83. 2009
    ..These findings support the hypothesis that IDO dominantly controls the functional status of Tregs in response to inflammatory stimuli in physiological settings...
  10. pmc Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes
    Madhav D Sharma
    Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
    Blood 113:6102-11. 2009
    ..Thus, Tregs in TDLNs can be actively reprogrammed in situ into T-helper cells, without the need for physical depletion, and IDO serves as a key regulator of this critical conversion...
  11. pmc Role of CD28 in fatal autoimmune disorder in scurfy mice
    Nagendra Singh
    Immunotherapy Center, Medical College of Georgia, Augusta, USA
    Blood 110:1199-206. 2007
    ..These data support the hypothesis that CD28-B7 interactions play a critical role in the etiology of lethal autoimmune disease in scurfy mice by stimulating the differentiation of antigen-activated naive T cells into effector T cells...
  12. pmc Indoleamine 2,3-dioxygenase in lung dendritic cells promotes Th2 responses and allergic inflammation
    Hui Xu
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine and Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 105:6690-5. 2008
    ..Collectively, these data suggest that IDO is not required for the induction of immune tolerance in the airways but plays a role in promoting Th2-mediated allergic airway inflammation via unique effects on lung dendritic cells...
  13. pmc Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase
    Alexander J Muller
    Immunotherapy and Cancer Centers, Flow Cytometry Core Facility, and Departments of Pediatrics and Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Proc Natl Acad Sci U S A 105:17073-8. 2008
    ..Thus, IDO is a key immunosuppressive factor that facilitates tumor progression in this setting of chronic inflammation driven by repeated topical PMA exposure...
  14. ncbi Tryptophan catabolism and regulation of adaptive immunity
    Andrew L Mellor
    Department of Medicine, Medical College of Georgia, Augusta GA 30912, USA
    J Immunol 170:5809-13. 2003
  15. ncbi Cell-autonomous control of interferon type I expression by indoleamine 2,3-dioxygenase in regulatory CD19+ dendritic cells
    Anna K Manlapat
    Immunotherapy and Cancer Centers, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Eur J Immunol 37:1064-71. 2007
    ..In the case of B7 ligation, IDO activates cell-autonomous signals essential for IFN-alpha production, most likely by activating the GCN2-kinase-dependent stress response...
  16. doi CD4(+)CD25(+) regulatory T cells resist a novel form of CD28- and Fas-dependent p53-induced T cell apoptosis
    Nagendra Singh
    Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 184:94-104. 2010
    ..The data presented herein demonstrate a novel process of Ag-induced T cell death by sustained TCR and CD28 engagement and represent a simple and efficient procedure for the expansion of regulatory T cells in vitro...
  17. ncbi A high-affinity, tryptophan-selective amino acid transport system in human macrophages
    Robert L Seymour
    Immunotherapy Center, CN 4141, Medical College of Georgia, Augusta, GA 30912, USA
    J Leukoc Biol 80:1320-7. 2006
    ....
  18. pmc Indoleamine 2,3-dioxygenase and tumor-induced tolerance
    David H Munn
    Immunotherapy Program, Department of Pediatrics, MCG Cancer Center, Medical College of Georgia, Augusta, GA 30912, USA
    J Clin Invest 117:1147-54. 2007
    ..It can also function as an antagonist to other activators of antitumor immunity. Therefore, strategies to block IDO might enhance the effectiveness of tumor immunotherapy...
  19. ncbi Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses
    Andrew L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 168:3771-6. 2002
    ..These outcomes suggest that genetically enhanced IDO activity inhibited T cell proliferation in vitro and in vivo. Genetic manipulation of IDO activity may be of therapeutic utility in suppressing undesirable T cell responses...
  20. ncbi The tumor-draining lymph node as an immune-privileged site
    David H Munn
    Immunotherapy Center, Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
    Immunol Rev 213:146-58. 2006
    ..These mechanisms will need to be interrupted in order for clinical anti-tumor immunotherapy to be successful...
  21. pmc B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase
    Burles A Johnson
    Immunotherapy and Cancer Centers, Departments of Pathology and Medicine, and Flow Cytometry Core Facility, Medical College of Georgia, Augusta, GA 30912, USA
    Proc Natl Acad Sci U S A 107:10644-8. 2010
    ..Thus, IDO-competent cells constitute a distinctive B-lymphoid cell type with quintessential T-cell regulatory attributes and phenotypic features of both B cells and DCs...
  22. ncbi Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase
    David H Munn
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Science 297:1867-70. 2002
    ..IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans...
  23. ncbi Indoleamine 2,3-dioxygenase, immunosuppression and pregnancy
    Andrew L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    J Reprod Immunol 57:143-50. 2002
    ..Here we review evidence that cells expressing IDO contribute to immunosuppression by inhibiting T-cell responses to tumor antigens and tissue allografts, as well as fetal tissues...
  24. ncbi Macrophages and the regulation of self-reactive T cells
    David H Munn
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Curr Pharm Des 9:257-64. 2003
    ..This review examines the array of immunosuppressive mechanisms which may help macrophages suppress unwanted T cell responses, and considers the consequences of a breakdown in these negative-regulatory systems in autoimmunity...
  25. ncbi Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion
    Andrew L Mellor
    Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 171:1652-5. 2003
    ..Thus, IDO expression is an inducible feature of specific subsets of DCs, and provides a potential mechanistic explanation for their T cell regulatory properties...
  26. ncbi Pattern of recruitment of immunoregulatory antigen-presenting cells in malignant melanoma
    Jeffrey R Lee
    Institute of Molecular Medicine and Genetics, Augusta Veterans Affairs Medical Center, Department of Pathology, Medical College of Georgia, Augusta, Georgia, USA
    Lab Invest 83:1457-66. 2003
    ....
  27. ncbi IDO and tolerance to tumors
    David H Munn
    Department of Pediatrics, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Trends Mol Med 10:15-8. 2004
  28. ncbi Ligation of B7-1/B7-2 by human CD4+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells
    David H Munn
    Institute of Molecular Medicine and Genetics and Departments of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 172:4100-10. 2004
    ..We hypothesize that IDO activation via engagement of B7-1/B7-2 molecules on DCs, specifically, engagement by CTLA4 expressed on regulatory CD4(+) T cells, may function as a physiologic regulator of T cell responses in vivo...
  29. ncbi Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific
    Babak Baban
    Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia 1120, 15th Street, Augusta, GA 30912 2600, USA
    J Reprod Immunol 61:67-77. 2004
    ..Hence, IDO is a key immunosuppressive mechanism in normal murine pregnancies, and it is regulated entirely through maternally inherited fetal genes...
  30. ncbi Tryptophan catabolism and T cell responses
    Andrew L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Adv Exp Med Biol 527:27-35. 2003
    ....
  31. pmc Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes
    David H Munn
    Department of Pediatrics, Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Clin Invest 114:280-90. 2004
    ..We hypothesize that IDO-mediated suppression by pDCs in TDLNs creates a local microenvironment that is potently suppressive of host antitumor T cell responses...
  32. ncbi IDO expression by dendritic cells: tolerance and tryptophan catabolism
    Andrew L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    Nat Rev Immunol 4:762-74. 2004
    ..In this review, we summarize key recent developments and propose a unifying model for the role of IDO in tolerance induction...
  33. ncbi GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase
    David H Munn
    Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
    Immunity 22:633-42. 2005
    ..We hypothesize that GCN2 acts as a molecular sensor in T cells, allowing them to detect and respond to conditions created by IDO...
  34. ncbi Cutting edge: CpG oligonucleotides induce splenic CD19+ dendritic cells to acquire potent indoleamine 2,3-dioxygenase-dependent T cell regulatory functions via IFN Type 1 signaling
    Andrew L Mellor
    Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 175:5601-5. 2005
    ....
  35. ncbi Decreased protein nitration in macrophages that overexpress indoleamine 2, 3-dioxygenase
    Derin B Keskin
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, 30912, USA
    Cell Mol Biol Lett 12:82-102. 2007
    ..Our results are consistent with the concept that, besides degrading tryptophan, IDO activity may protect cells from oxidative damage...
  36. ncbi Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses
    De Yan Hou
    Immunotherapy Center and Departments of Pediatrics, Medicine, and Biostatistics, Medical College of Georgia, Augusta, Georgia
    Cancer Res 67:792-801. 2007
    ....
  37. pmc Chemotherapy rescues tumor-driven aberrant CD4+ T-cell differentiation and restores an activated polyfunctional helper phenotype
    Zhi Chun Ding
    Cancer Immunotherapy Program, MCG Cancer Center, Medical College of Georgia, Augusta, GA 30912, USA
    Blood 115:2397-406. 2010
    ..We hypothesize that prevention of tumor-induced effector cell dysfunction is a major mechanism contributing to the efficacy of combined chemoimmunotherapy...
  38. pmc Dendritic cells, indoleamine 2,3 dioxygenase and acquired immune privilege
    Lei Huang
    Immunotherapy Center and Department of Radiology, Medical College of Georgia, Augusta, GA, USA
    Int Rev Immunol 29:133-55. 2010
    ..Thus, IDO-expressing pDCs create immune privilege and provide novel opportunities to improve immunotherapy in multiple disease syndromes...

Research Grants15

  1. T cell regulation by IDO-competent plasmacytoid dendritic cells
    Andrew Mellor; Fiscal Year: 2009
    ..This observation provides a rationale for treating mice with donor allograft and self-antigens to induce tolerance that will protect skin grafts and pancreatic islet cells from T cell mediated destruction. 1 ..
  2. IDO dependent T cell suppression
    Andrew Mellor; Fiscal Year: 2009
    ..Studies in Aim 2 examine how minor subsets of IDO-competent DCs promote dominant T cell suppression and studies in Aim 3 examine the relationship between IDO expression and Treg development and function. ..
  3. Regulation of T cell immunity by indol 2,3 dioxygenase
    Andrew Mellor; Fiscal Year: 2006
    ....
  4. T CELL IMMUNOREGULATION BY TRYPTOPHAN DEPLETION
    Andrew Mellor; Fiscal Year: 2002
    ....
  5. T cell regulation by IDO-competent plasmacytoid dendritic cells
    ANDREW LEE MELLOR; Fiscal Year: 2010
    ..This observation provides a rationale for treating mice with donor allograft and self-antigens to induce tolerance that will protect skin grafts and pancreatic islet cells from T cell mediated destruction. 1 ..