Research Topics
| A L MellorSummaryAffiliation: Medical College of Georgia Country: USA Publications
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Publications
Indoleamine 2,3-dioxygenase expression promotes renal ischemia-reperfusion injuryKanishka Mohib
Department of Medicine, University of Western Ontario, London, Ontario, Canada
Am J Physiol Renal Physiol 295:F226-34. 2008..008). Our data suggest that attenuation of IDO expression within the kidney may represent a novel strategy to reduce renal injury as a result of ischemia reperfusion...
Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responsesAndrew L Mellor
Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
J Immunol 168:3771-6. 2002..These outcomes suggest that genetically enhanced IDO activity inhibited T cell proliferation in vitro and in vivo. Genetic manipulation of IDO activity may be of therapeutic utility in suppressing undesirable T cell responses...- IDO expression by dendritic cells: tolerance and tryptophan catabolismAndrew L Mellor
Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
Nat Rev Immunol 4:762-74. 2004..In this review, we summarize key recent developments and propose a unifying model for the role of IDO in tolerance induction... - Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansionAndrew L Mellor
Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
J Immunol 171:1652-5. 2003..Thus, IDO expression is an inducible feature of specific subsets of DCs, and provides a potential mechanistic explanation for their T cell regulatory properties... - Tryptophan catabolism and T cell responsesAndrew L Mellor
Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
Adv Exp Med Biol 527:27-35. 2003.... - Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancyA L Mellor
Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, 1120 15th St, Augusta, GA 30912, USA
Nat Immunol 2:64-8. 2001..These data show that IDO activity protects the fetus by suppressing T cell-driven local inflammatory responses to fetal alloantigens... - Extinguishing maternal immune responses during pregnancy: implications for immunosuppressionA L Mellor
Medical College of Georgia, Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
Semin Immunol 13:213-8. 2001.... - Indoleamine 2,3-dioxygenase, immunosuppression and pregnancyAndrew L Mellor
Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
J Reprod Immunol 57:143-50. 2002..Here we review evidence that cells expressing IDO contribute to immunosuppression by inhibiting T-cell responses to tumor antigens and tissue allografts, as well as fetal tissues... - Maturation of antigen-presenting cells is compromised in HLA-G transgenic miceA Horuzsko
Program in Molecular Immunology, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
Int Immunol 13:385-94. 2001..We hypothesize that HLA-G inhibits maturation of DC via receptor-mediated interactions with myelomonocytic precursors, which render immature DC precursors unable to receive signals from activated T cells... - Inhibition of T cell proliferation by macrophage tryptophan catabolismD H Munn
Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
J Exp Med 189:1363-72. 1999..We speculate that expression of IDO by certain antigen presenting cells in vivo allows them to suppress unwanted T cell responses... - Prevention of allogeneic fetal rejection by tryptophan catabolismD H Munn
Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
Science 281:1191-3. 1998..Thus, by catabolizing tryptophan, the mammalian conceptus suppresses T cell activity and defends itself against rejection... - Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?A L Mellor
Molecular Immunology Program, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
Immunol Today 20:469-73. 1999..Here, Andrew Mellor and David Munn discuss evidence that cells that synthesize IDO protect the mammalian fetus from maternal T-cell attack and argue that this mechanism might have wider implications for the control of T-cell responses... - Regulation of prostaglandin synthesis and cell adhesion by a tryptophan catabolizing enzymeB Marshall
Program in Molecular Immunology, Institute for Molecular Medicine and Genetics, Medical College of Georgia, CB 2803, 1120 15th Street, Augusta, GA 30912 3175, USA
BMC Biochem 2:5. 2001..Therefore, we investigated the circumstances under which IDO is expressed in vitro together with the effects of overexpression of IDO on the growth and morphology of cells... - Tryptophan catabolism prevents maternal T cells from activating lethal anti-fetal immune responsesA L Mellor
Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, CA 2006, Augusta, GA 30912 2000, USA
J Reprod Immunol 52:5-13. 2001.... - Immunology at the maternal-fetal interface: lessons for T cell tolerance and suppressionA L Mellor
Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Departments of Medicine and Pediatrics, Medical College of Georgia 30912, USA mcg edu
Annu Rev Immunol 18:367-91. 2000.... - Cutting edge: CpG oligonucleotides induce splenic CD19+ dendritic cells to acquire potent indoleamine 2,3-dioxygenase-dependent T cell regulatory functions via IFN Type 1 signalingAndrew L Mellor
Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912, USA
J Immunol 175:5601-5. 2005.... - Decreased protein nitration in macrophages that overexpress indoleamine 2, 3-dioxygenaseDerin B Keskin
Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, 30912, USA
Cell Mol Biol Lett 12:82-102. 2007..Our results are consistent with the concept that, besides degrading tryptophan, IDO activity may protect cells from oxidative damage... - A high-affinity, tryptophan-selective amino acid transport system in human macrophagesRobert L Seymour
Immunotherapy Center, CN-4141, Medical College of Georgia, Augusta, GA 30912, USA
J Leukoc Biol 80:1320-7. 2006.... - The tumor-draining lymph node as an immune-privileged siteDavid H Munn
Immunotherapy Center, Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
Immunol Rev 213:146-58. 2006..These mechanisms will need to be interrupted in order for clinical anti-tumor immunotherapy to be successful... - Influenza-induced expression of indoleamine 2,3-dioxygenase enhances interleukin-10 production and bacterial outgrowth during secondary pneumococcal pneumoniaKoenraad F Van Der Sluijs
Department of Pulmonology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Infect Dis 193:214-22. 2006.... - Cell-autonomous control of interferon type I expression by indoleamine 2,3-dioxygenase in regulatory CD19+ dendritic cellsAnna K Manlapat
Immunotherapy and Cancer Centers, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
Eur J Immunol 37:1064-71. 2007..In the case of B7 ligation, IDO activates cell-autonomous signals essential for IFN-alpha production, most likely by activating the GCN2-kinase-dependent stress response... - Role of CD28 in fatal autoimmune disorder in scurfy miceNagendra Singh
Immunotherapy Center, Medical College of Georgia, Augusta, USA
Blood 110:1199-206. 2007..These data support the hypothesis that CD28-B7 interactions play a critical role in the etiology of lethal autoimmune disease in scurfy mice by stimulating the differentiation of antigen-activated naive T cells into effector T cells... - Indoleamine 2,3-dioxygenase and tumor-induced toleranceDavid H Munn
Immunotherapy Program, Department of Pediatrics, MCG Cancer Center, Medical College of Georgia, Augusta, GA 30912, USA
J Clin Invest 117:1147-54. 2007..It can also function as an antagonist to other activators of antitumor immunity. Therefore, strategies to block IDO might enhance the effectiveness of tumor immunotherapy... - Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenaseMadhav D Sharma
Department of Pediatrics, School of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
J Clin Invest 117:2570-82. 2007..We hypothesize that IDO+ pDCs create a profoundly suppressive microenvironment within tumor-draining LNs via constitutive activation of Tregs... - Creating immune privilege: active local suppression that benefits friends, but protects foesAndrew L Mellor
Immunotherapy and Cancer Centers, Medical College of Georgia, Augusta, Georgia USA
Nat Rev Immunol 8:74-80. 2008.... - Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethalityLisa K Jasperson
University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, Minneapolis, MN 55455, USA
Blood 111:3257-65. 2008..These studies are the first to identify a function for IDO in GVHD lethality and indicate that modulation of the IDO pathway may be an effective strategy for treatment of this disease... - Deficiency of indoleamine 2,3-dioxygenase enhances commensal-induced antibody responses and protects against Citrobacter rodentium-induced colitisLynne Harrington
Mucosal Immunology Laboratory, Pediatric Gastroenterology Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Infect Immun 76:3045-53. 2008..Our observations point to an important role for IDO in the regulation of immunity to the gut commensal microbiota that has a significant impact on the response to intestinal pathogens... - Indoleamine 2,3-dioxygenase in lung dendritic cells promotes Th2 responses and allergic inflammationHui Xu
Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine and Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA
Proc Natl Acad Sci U S A 105:6690-5. 2008..Collectively, these data suggest that IDO is not required for the induction of immune tolerance in the airways but plays a role in promoting Th2-mediated allergic airway inflammation via unique effects on lung dendritic cells... - A critical role for the programmed death ligand 1 in fetomaternal toleranceIndira Guleria
Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 202:231-7. 2005..These results provide the first evidence that PDL1 is involved in fetomaternal tolerance... - A minor population of splenic dendritic cells expressing CD19 mediates IDO-dependent T cell suppression via type I IFN signaling following B7 ligationBabak Baban
Immunotherapy Center, Medical College of Georgia, 1120, 15th Street, Augusta, GA 30912, USA
Int Immunol 17:909-19. 2005..Thus, CD19+ DCs may be a target for regulatory T cells expressing surface CTLA4, and may suppress T cell responses via induction of IDO... - GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenaseDavid H Munn
Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
Immunity 22:633-42. 2005..We hypothesize that GCN2 acts as a molecular sensor in T cells, allowing them to detect and respond to conditions created by IDO... - Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejectionMaria Friberg
Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, Tampa, FL 33612, USA
Int J Cancer 101:151-5. 2002..Our study provides evidence for a novel mechanism whereby tumors evade rejection by the immune system, and suggests the possibility that inhibiting IDO may be developed as an anti-cancer immunotherapeutic strategy... - Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenaseDavid H Munn
Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
Science 297:1867-70. 2002..IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans... - Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell divisionGeon Kook Lee
Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
Immunology 107:452-60. 2002.... - Macrophages and the regulation of self-reactive T cellsDavid H Munn
Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
Curr Pharm Des 9:257-64. 2003..This review examines the array of immunosuppressive mechanisms which may help macrophages suppress unwanted T cell responses, and considers the consequences of a breakdown in these negative-regulatory systems in autoimmunity... - Tryptophan catabolism and regulation of adaptive immunityAndrew L Mellor
Department of Medicine, Medical College of Georgia, Augusta GA 30912, USA
J Immunol 170:5809-13. 2003 - Pattern of recruitment of immunoregulatory antigen-presenting cells in malignant melanomaJeffrey R Lee
Institute of Molecular Medicine and Genetics, Augusta Veterans Affairs Medical Center, Department of Pathology, Medical College of Georgia, Augusta, Georgia, USA
Lab Invest 83:1457-66. 2003.... - IDO and tolerance to tumorsDavid H Munn
Department of Pediatrics, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
Trends Mol Med 10:15-8. 2004 - Ligation of B7-1/B7-2 by human CD4+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cellsDavid H Munn
Institute of Molecular Medicine and Genetics and Departments of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
J Immunol 172:4100-10. 2004..We hypothesize that IDO activation via engagement of B7-1/B7-2 molecules on DCs, specifically, engagement by CTLA4 expressed on regulatory CD4(+) T cells, may function as a physiologic regulator of T cell responses in vivo... - Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specificBabak Baban
Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia 1120, 15th Street, Augusta, GA 30912 2600, USA
J Reprod Immunol 61:67-77. 2004..Hence, IDO is a key immunosuppressive mechanism in normal murine pregnancies, and it is regulated entirely through maternally inherited fetal genes... - Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodesDavid H Munn
Department of Pediatrics, Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
J Clin Invest 114:280-90. 2004..We hypothesize that IDO-mediated suppression by pDCs in TDLNs creates a local microenvironment that is potently suppressive of host antitumor T cell responses... - Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenaseAndrew L Mellor
Department of Medicine, Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120, 15th Street, Augusta, GA 30912 2600, USA
Int Immunol 16:1391-401. 2004..These findings suggest that IDO-competent DCs provide a regulatory bridge, mediated by CTLA4-B7 engagement, between certain regulatory T cell subsets and naive responder T cells... - Policing pregnancy: Tregs help keep the peaceAndrew L Mellor
Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
Trends Immunol 25:563-5. 2004 - Dendritic cells have the option to express IDO-mediated suppression or notDavid H Munn
Blood 105:2618. 2005 - Functional expression of indoleamine 2,3-dioxygenase by murine CD8 alpha(+) dendritic cellsFrancesca Fallarino
Department of Experimental Medicine, University of Perugia, Via del Giochetto, Perugia 06122, Italy
Int Immunol 14:65-8. 2002..Therefore, in the mouse, CD8 alpha(+) DC may be unique APC capable of fully expressing the IDO mechanism functionally... - Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responsesDe Yan Hou
Immunotherapy Center and Departments of Pediatrics, Medicine, and Biostatistics, Medical College of Georgia, Augusta, Georgia
Cancer Res 67:792-801. 2007....