A L Mellor

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. pmc Indoleamine 2,3-dioxygenase expression promotes renal ischemia-reperfusion injury
    Kanishka Mohib
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Am J Physiol Renal Physiol 295:F226-34. 2008
  2. ncbi Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses
    Andrew L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 168:3771-6. 2002
  3. ncbi IDO expression by dendritic cells: tolerance and tryptophan catabolism
    Andrew L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    Nat Rev Immunol 4:762-74. 2004
  4. ncbi Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion
    Andrew L Mellor
    Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 171:1652-5. 2003
  5. ncbi Tryptophan catabolism and T cell responses
    Andrew L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Adv Exp Med Biol 527:27-35. 2003
  6. ncbi Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy
    A L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, 1120 15th St, Augusta, GA 30912, USA
    Nat Immunol 2:64-8. 2001
  7. ncbi Extinguishing maternal immune responses during pregnancy: implications for immunosuppression
    A L Mellor
    Medical College of Georgia, Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
    Semin Immunol 13:213-8. 2001
  8. ncbi Indoleamine 2,3-dioxygenase, immunosuppression and pregnancy
    Andrew L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    J Reprod Immunol 57:143-50. 2002
  9. ncbi Maturation of antigen-presenting cells is compromised in HLA-G transgenic mice
    A Horuzsko
    Program in Molecular Immunology, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Int Immunol 13:385-94. 2001
  10. pmc Inhibition of T cell proliferation by macrophage tryptophan catabolism
    D H Munn
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Exp Med 189:1363-72. 1999

Collaborators

Detail Information

Publications46

  1. pmc Indoleamine 2,3-dioxygenase expression promotes renal ischemia-reperfusion injury
    Kanishka Mohib
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Am J Physiol Renal Physiol 295:F226-34. 2008
    ..008). Our data suggest that attenuation of IDO expression within the kidney may represent a novel strategy to reduce renal injury as a result of ischemia reperfusion...
  2. ncbi Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses
    Andrew L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 168:3771-6. 2002
    ..These outcomes suggest that genetically enhanced IDO activity inhibited T cell proliferation in vitro and in vivo. Genetic manipulation of IDO activity may be of therapeutic utility in suppressing undesirable T cell responses...
  3. ncbi IDO expression by dendritic cells: tolerance and tryptophan catabolism
    Andrew L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    Nat Rev Immunol 4:762-74. 2004
    ..In this review, we summarize key recent developments and propose a unifying model for the role of IDO in tolerance induction...
  4. ncbi Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion
    Andrew L Mellor
    Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 171:1652-5. 2003
    ..Thus, IDO expression is an inducible feature of specific subsets of DCs, and provides a potential mechanistic explanation for their T cell regulatory properties...
  5. ncbi Tryptophan catabolism and T cell responses
    Andrew L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Adv Exp Med Biol 527:27-35. 2003
    ....
  6. ncbi Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy
    A L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, 1120 15th St, Augusta, GA 30912, USA
    Nat Immunol 2:64-8. 2001
    ..These data show that IDO activity protects the fetus by suppressing T cell-driven local inflammatory responses to fetal alloantigens...
  7. ncbi Extinguishing maternal immune responses during pregnancy: implications for immunosuppression
    A L Mellor
    Medical College of Georgia, Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
    Semin Immunol 13:213-8. 2001
    ....
  8. ncbi Indoleamine 2,3-dioxygenase, immunosuppression and pregnancy
    Andrew L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    J Reprod Immunol 57:143-50. 2002
    ..Here we review evidence that cells expressing IDO contribute to immunosuppression by inhibiting T-cell responses to tumor antigens and tissue allografts, as well as fetal tissues...
  9. ncbi Maturation of antigen-presenting cells is compromised in HLA-G transgenic mice
    A Horuzsko
    Program in Molecular Immunology, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Int Immunol 13:385-94. 2001
    ..We hypothesize that HLA-G inhibits maturation of DC via receptor-mediated interactions with myelomonocytic precursors, which render immature DC precursors unable to receive signals from activated T cells...
  10. pmc Inhibition of T cell proliferation by macrophage tryptophan catabolism
    D H Munn
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Exp Med 189:1363-72. 1999
    ..We speculate that expression of IDO by certain antigen presenting cells in vivo allows them to suppress unwanted T cell responses...
  11. ncbi Prevention of allogeneic fetal rejection by tryptophan catabolism
    D H Munn
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Science 281:1191-3. 1998
    ..Thus, by catabolizing tryptophan, the mammalian conceptus suppresses T cell activity and defends itself against rejection...
  12. ncbi Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?
    A L Mellor
    Molecular Immunology Program, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Immunol Today 20:469-73. 1999
    ..Here, Andrew Mellor and David Munn discuss evidence that cells that synthesize IDO protect the mammalian fetus from maternal T-cell attack and argue that this mechanism might have wider implications for the control of T-cell responses...
  13. pmc Regulation of prostaglandin synthesis and cell adhesion by a tryptophan catabolizing enzyme
    B Marshall
    Program in Molecular Immunology, Institute for Molecular Medicine and Genetics, Medical College of Georgia, CB 2803, 1120 15th Street, Augusta, GA 30912 3175, USA
    BMC Biochem 2:5. 2001
    ..Therefore, we investigated the circumstances under which IDO is expressed in vitro together with the effects of overexpression of IDO on the growth and morphology of cells...
  14. ncbi Tryptophan catabolism prevents maternal T cells from activating lethal anti-fetal immune responses
    A L Mellor
    Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, CA 2006, Augusta, GA 30912 2000, USA
    J Reprod Immunol 52:5-13. 2001
    ....
  15. ncbi Immunology at the maternal-fetal interface: lessons for T cell tolerance and suppression
    A L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Departments of Medicine and Pediatrics, Medical College of Georgia 30912, USA mcg edu
    Annu Rev Immunol 18:367-91. 2000
    ....
  16. ncbi Cutting edge: CpG oligonucleotides induce splenic CD19+ dendritic cells to acquire potent indoleamine 2,3-dioxygenase-dependent T cell regulatory functions via IFN Type 1 signaling
    Andrew L Mellor
    Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 175:5601-5. 2005
    ....
  17. ncbi Decreased protein nitration in macrophages that overexpress indoleamine 2, 3-dioxygenase
    Derin B Keskin
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, 30912, USA
    Cell Mol Biol Lett 12:82-102. 2007
    ..Our results are consistent with the concept that, besides degrading tryptophan, IDO activity may protect cells from oxidative damage...
  18. ncbi A high-affinity, tryptophan-selective amino acid transport system in human macrophages
    Robert L Seymour
    Immunotherapy Center, CN 4141, Medical College of Georgia, Augusta, GA 30912, USA
    J Leukoc Biol 80:1320-7. 2006
    ....
  19. ncbi The tumor-draining lymph node as an immune-privileged site
    David H Munn
    Immunotherapy Center, Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
    Immunol Rev 213:146-58. 2006
    ..These mechanisms will need to be interrupted in order for clinical anti-tumor immunotherapy to be successful...
  20. ncbi Influenza-induced expression of indoleamine 2,3-dioxygenase enhances interleukin-10 production and bacterial outgrowth during secondary pneumococcal pneumonia
    Koenraad F Van Der Sluijs
    Department of Pulmonology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Infect Dis 193:214-22. 2006
    ....
  21. ncbi Cell-autonomous control of interferon type I expression by indoleamine 2,3-dioxygenase in regulatory CD19+ dendritic cells
    Anna K Manlapat
    Immunotherapy and Cancer Centers, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Eur J Immunol 37:1064-71. 2007
    ..In the case of B7 ligation, IDO activates cell-autonomous signals essential for IFN-alpha production, most likely by activating the GCN2-kinase-dependent stress response...
  22. pmc Role of CD28 in fatal autoimmune disorder in scurfy mice
    Nagendra Singh
    Immunotherapy Center, Medical College of Georgia, Augusta, USA
    Blood 110:1199-206. 2007
    ..These data support the hypothesis that CD28-B7 interactions play a critical role in the etiology of lethal autoimmune disease in scurfy mice by stimulating the differentiation of antigen-activated naive T cells into effector T cells...
  23. pmc Indoleamine 2,3-dioxygenase and tumor-induced tolerance
    David H Munn
    Immunotherapy Program, Department of Pediatrics, MCG Cancer Center, Medical College of Georgia, Augusta, GA 30912, USA
    J Clin Invest 117:1147-54. 2007
    ..It can also function as an antagonist to other activators of antitumor immunity. Therefore, strategies to block IDO might enhance the effectiveness of tumor immunotherapy...
  24. pmc Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase
    Madhav D Sharma
    Department of Pediatrics, School of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Clin Invest 117:2570-82. 2007
    ..We hypothesize that IDO+ pDCs create a profoundly suppressive microenvironment within tumor-draining LNs via constitutive activation of Tregs...
  25. ncbi Creating immune privilege: active local suppression that benefits friends, but protects foes
    Andrew L Mellor
    Immunotherapy and Cancer Centers, Medical College of Georgia, Augusta, Georgia USA
    Nat Rev Immunol 8:74-80. 2008
    ....
  26. pmc Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality
    Lisa K Jasperson
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, Minneapolis, MN 55455, USA
    Blood 111:3257-65. 2008
    ..These studies are the first to identify a function for IDO in GVHD lethality and indicate that modulation of the IDO pathway may be an effective strategy for treatment of this disease...
  27. pmc Deficiency of indoleamine 2,3-dioxygenase enhances commensal-induced antibody responses and protects against Citrobacter rodentium-induced colitis
    Lynne Harrington
    Mucosal Immunology Laboratory, Pediatric Gastroenterology Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Infect Immun 76:3045-53. 2008
    ..Our observations point to an important role for IDO in the regulation of immunity to the gut commensal microbiota that has a significant impact on the response to intestinal pathogens...
  28. pmc Indoleamine 2,3-dioxygenase in lung dendritic cells promotes Th2 responses and allergic inflammation
    Hui Xu
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine and Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 105:6690-5. 2008
    ..Collectively, these data suggest that IDO is not required for the induction of immune tolerance in the airways but plays a role in promoting Th2-mediated allergic airway inflammation via unique effects on lung dendritic cells...
  29. pmc A critical role for the programmed death ligand 1 in fetomaternal tolerance
    Indira Guleria
    Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 202:231-7. 2005
    ..These results provide the first evidence that PDL1 is involved in fetomaternal tolerance...
  30. ncbi A minor population of splenic dendritic cells expressing CD19 mediates IDO-dependent T cell suppression via type I IFN signaling following B7 ligation
    Babak Baban
    Immunotherapy Center, Medical College of Georgia, 1120, 15th Street, Augusta, GA 30912, USA
    Int Immunol 17:909-19. 2005
    ..Thus, CD19+ DCs may be a target for regulatory T cells expressing surface CTLA4, and may suppress T cell responses via induction of IDO...
  31. ncbi GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase
    David H Munn
    Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
    Immunity 22:633-42. 2005
    ..We hypothesize that GCN2 acts as a molecular sensor in T cells, allowing them to detect and respond to conditions created by IDO...
  32. ncbi Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection
    Maria Friberg
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, Tampa, FL 33612, USA
    Int J Cancer 101:151-5. 2002
    ..Our study provides evidence for a novel mechanism whereby tumors evade rejection by the immune system, and suggests the possibility that inhibiting IDO may be developed as an anti-cancer immunotherapeutic strategy...
  33. ncbi Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase
    David H Munn
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Science 297:1867-70. 2002
    ..IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans...
  34. pmc Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division
    Geon Kook Lee
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Immunology 107:452-60. 2002
    ....
  35. ncbi Macrophages and the regulation of self-reactive T cells
    David H Munn
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Curr Pharm Des 9:257-64. 2003
    ..This review examines the array of immunosuppressive mechanisms which may help macrophages suppress unwanted T cell responses, and considers the consequences of a breakdown in these negative-regulatory systems in autoimmunity...
  36. ncbi Tryptophan catabolism and regulation of adaptive immunity
    Andrew L Mellor
    Department of Medicine, Medical College of Georgia, Augusta GA 30912, USA
    J Immunol 170:5809-13. 2003
  37. ncbi Pattern of recruitment of immunoregulatory antigen-presenting cells in malignant melanoma
    Jeffrey R Lee
    Institute of Molecular Medicine and Genetics, Augusta Veterans Affairs Medical Center, Department of Pathology, Medical College of Georgia, Augusta, Georgia, USA
    Lab Invest 83:1457-66. 2003
    ....
  38. ncbi IDO and tolerance to tumors
    David H Munn
    Department of Pediatrics, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Trends Mol Med 10:15-8. 2004
  39. ncbi Ligation of B7-1/B7-2 by human CD4+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells
    David H Munn
    Institute of Molecular Medicine and Genetics and Departments of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 172:4100-10. 2004
    ..We hypothesize that IDO activation via engagement of B7-1/B7-2 molecules on DCs, specifically, engagement by CTLA4 expressed on regulatory CD4(+) T cells, may function as a physiologic regulator of T cell responses in vivo...
  40. ncbi Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific
    Babak Baban
    Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia 1120, 15th Street, Augusta, GA 30912 2600, USA
    J Reprod Immunol 61:67-77. 2004
    ..Hence, IDO is a key immunosuppressive mechanism in normal murine pregnancies, and it is regulated entirely through maternally inherited fetal genes...
  41. pmc Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes
    David H Munn
    Department of Pediatrics, Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Clin Invest 114:280-90. 2004
    ..We hypothesize that IDO-mediated suppression by pDCs in TDLNs creates a local microenvironment that is potently suppressive of host antitumor T cell responses...
  42. ncbi Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase
    Andrew L Mellor
    Department of Medicine, Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120, 15th Street, Augusta, GA 30912 2600, USA
    Int Immunol 16:1391-401. 2004
    ..These findings suggest that IDO-competent DCs provide a regulatory bridge, mediated by CTLA4-B7 engagement, between certain regulatory T cell subsets and naive responder T cells...
  43. ncbi Policing pregnancy: Tregs help keep the peace
    Andrew L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Trends Immunol 25:563-5. 2004
  44. ncbi Dendritic cells have the option to express IDO-mediated suppression or not
    David H Munn
    Blood 105:2618. 2005
  45. ncbi Functional expression of indoleamine 2,3-dioxygenase by murine CD8 alpha(+) dendritic cells
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, Via del Giochetto, Perugia 06122, Italy
    Int Immunol 14:65-8. 2002
    ..Therefore, in the mouse, CD8 alpha(+) DC may be unique APC capable of fully expressing the IDO mechanism functionally...
  46. ncbi Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses
    De Yan Hou
    Immunotherapy Center and Departments of Pediatrics, Medicine, and Biostatistics, Medical College of Georgia, Augusta, Georgia
    Cancer Res 67:792-801. 2007
    ....