A L Mellor

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. ncbi request reprint Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?
    A L Mellor
    Molecular Immunology Program, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Immunol Today 20:469-73. 1999
  2. ncbi request reprint Immunology at the maternal-fetal interface: lessons for T cell tolerance and suppression
    A L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Departments of Medicine and Pediatrics, Medical College of Georgia 30912, USA mcg edu
    Annu Rev Immunol 18:367-91. 2000
  3. ncbi request reprint Tryptophan catabolism prevents maternal T cells from activating lethal anti-fetal immune responses
    A L Mellor
    Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, CA 2006, Augusta, GA 30912 2000, USA
    J Reprod Immunol 52:5-13. 2001
  4. ncbi request reprint Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy
    A L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, 1120 15th St, Augusta, GA 30912, USA
    Nat Immunol 2:64-8. 2001
  5. pmc Inhibition of T cell proliferation by macrophage tryptophan catabolism
    D H Munn
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Exp Med 189:1363-72. 1999
  6. ncbi request reprint Extinguishing maternal immune responses during pregnancy: implications for immunosuppression
    A L Mellor
    Medical College of Georgia, Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
    Semin Immunol 13:213-8. 2001
  7. ncbi request reprint Prevention of allogeneic fetal rejection by tryptophan catabolism
    D H Munn
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Science 281:1191-3. 1998
  8. ncbi request reprint Maturation of antigen-presenting cells is compromised in HLA-G transgenic mice
    A Horuzsko
    Program in Molecular Immunology, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Int Immunol 13:385-94. 2001
  9. pmc Regulation of prostaglandin synthesis and cell adhesion by a tryptophan catabolizing enzyme
    B Marshall
    Program in Molecular Immunology, Institute for Molecular Medicine and Genetics, Medical College of Georgia, CB 2803, 1120 15th Street, Augusta, GA 30912 3175, USA
    BMC Biochem 2:5. 2001

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?
    A L Mellor
    Molecular Immunology Program, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Immunol Today 20:469-73. 1999
    ..Here, Andrew Mellor and David Munn discuss evidence that cells that synthesize IDO protect the mammalian fetus from maternal T-cell attack and argue that this mechanism might have wider implications for the control of T-cell responses...
  2. ncbi request reprint Immunology at the maternal-fetal interface: lessons for T cell tolerance and suppression
    A L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Departments of Medicine and Pediatrics, Medical College of Georgia 30912, USA mcg edu
    Annu Rev Immunol 18:367-91. 2000
    ....
  3. ncbi request reprint Tryptophan catabolism prevents maternal T cells from activating lethal anti-fetal immune responses
    A L Mellor
    Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, CA 2006, Augusta, GA 30912 2000, USA
    J Reprod Immunol 52:5-13. 2001
    ....
  4. ncbi request reprint Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy
    A L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, 1120 15th St, Augusta, GA 30912, USA
    Nat Immunol 2:64-8. 2001
    ..These data show that IDO activity protects the fetus by suppressing T cell-driven local inflammatory responses to fetal alloantigens...
  5. pmc Inhibition of T cell proliferation by macrophage tryptophan catabolism
    D H Munn
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Exp Med 189:1363-72. 1999
    ..We speculate that expression of IDO by certain antigen presenting cells in vivo allows them to suppress unwanted T cell responses...
  6. ncbi request reprint Extinguishing maternal immune responses during pregnancy: implications for immunosuppression
    A L Mellor
    Medical College of Georgia, Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
    Semin Immunol 13:213-8. 2001
    ....
  7. ncbi request reprint Prevention of allogeneic fetal rejection by tryptophan catabolism
    D H Munn
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Science 281:1191-3. 1998
    ..Thus, by catabolizing tryptophan, the mammalian conceptus suppresses T cell activity and defends itself against rejection...
  8. ncbi request reprint Maturation of antigen-presenting cells is compromised in HLA-G transgenic mice
    A Horuzsko
    Program in Molecular Immunology, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Int Immunol 13:385-94. 2001
    ..We hypothesize that HLA-G inhibits maturation of DC via receptor-mediated interactions with myelomonocytic precursors, which render immature DC precursors unable to receive signals from activated T cells...
  9. pmc Regulation of prostaglandin synthesis and cell adhesion by a tryptophan catabolizing enzyme
    B Marshall
    Program in Molecular Immunology, Institute for Molecular Medicine and Genetics, Medical College of Georgia, CB 2803, 1120 15th Street, Augusta, GA 30912 3175, USA
    BMC Biochem 2:5. 2001
    ..Therefore, we investigated the circumstances under which IDO is expressed in vitro together with the effects of overexpression of IDO on the growth and morphology of cells...