Research Topics
Genomes and Genes
| Lin MeiSummaryAffiliation: Medical College of Georgia Country: USA Publications
Research Grants
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Detail Information
Publications
Beta-catenin regulates acetylcholine receptor clustering in muscle cells through interaction with rapsynBin Zhang
Program of Developmental Neurobiology and Department of Neurology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
J Neurosci 27:3968-73. 2007..These results suggest that beta-catenin may serve as a link between AChRs and alpha-catenin-associated cytoskeleton, revealing a novel function of beta-catenin in synaptogenesis...
Neuregulin 1 in neural development, synaptic plasticity and schizophreniaLin Mei
Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
Nat Rev Neurosci 9:437-52. 2008..An improved understanding of the mechanisms by which altered function of NRG1 and ErbB4 contributes to schizophrenia might eventually lead to the development of more effective therapeutics...- Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneuronsAnnie K Ting
Institute of Molecular Medicine and Genetics and Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
J Neurosci 31:15-25. 2011..In light of the association of the genes of both NRG1 and ErbB4 with schizophrenia and dysfunction of GABAergic system in this disorder, these results provide insight into its potential pathological mechanism... 
Retrograde regulation of motoneuron differentiation by muscle beta-cateninXiao Ming Li
Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, 1120 15th Street, Augusta, Georgia 30912, USA
Nat Neurosci 11:262-8. 2008..Taken together, these observations indicate a role for muscle beta-catenin in presynaptic differentiation and function, identifying a previously unknown retrograde signaling in the synapse formation and synaptic plasticity...- LRP4 serves as a coreceptor of agrinBin Zhang
Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
Neuron 60:285-97. 2008..These observations indicate that LRP4 is a coreceptor of agrin that is necessary for MuSK signaling and AChR clustering and identify a potential target protein whose mutation and/or autoimmunization may cause muscular dystrophies... - Differential regulation of myosin X movements by its cargos, DCC and neogeninYu Liu
Institute of Molecular Medicine and Genetics and Department of Neurology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA
J Cell Sci 125:751-62. 2012..These results thus demonstrate differential regulatory roles on Myo X activity by its cargo proteins, DCC and neogenin, revealing different cellular functions of DCC and neogenin... - HSP90 beta regulates rapsyn turnover and subsequent AChR cluster formation and maintenanceShiwen Luo
Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
Neuron 60:97-110. 2008..Together, these results indicate a role of HSP90beta in NMJ development by regulating rapsyn turnover and subsequent AChR cluster formation and maintenance... - Neuregulin-1 enhances depolarization-induced GABA releaseRan Sook Woo
Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
Neuron 54:599-610. 2007..Because both NRG1 and ErbB4 have emerged as susceptibility genes of schizophrenia, these observations may suggest a mechanism for abnormal GABAergic neurotransmission in this disorder... - Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasisDae Hoon Lee
Institute of Molecular Medicine and Genetics, and Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
Blood 115:3136-45. 2010..These results reveal a novel mechanism underlying neogenin regulation of HJV-BMP signaling... - Muscle-specific receptor tyrosine kinase endocytosis in acetylcholine receptor clustering in response to agrinDan Zhu
Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
J Neurosci 28:1688-96. 2008..Furthermore, suppression of NSF expression and NSF mutation attenuate MuSK downstream signaling. Our study reveals a potentially novel mechanism that regulates agrin/MuSK signaling cascade... - Neogenin regulation of BMP-induced canonical Smad signaling and endochondral bone formationZheng Zhou
Institute of Molecular Medicine and Genetics and Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
Dev Cell 19:90-102. 2010..Taken together, our results indicate that neogenin promotes chondrogenesis in vitro and in vivo, revealing an unexpected mechanism underlying neogenin regulation of BMP signaling... - The Ig1/2 domain of MuSK binds to muscle surface and is involved in acetylcholine receptor clusteringQiang Wang
Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
Neurosignals 16:246-53. 2008..These results suggest that the Ig1/2 domain of MuSK is involved in AChR clustering by binding to the muscle surface... - Distinct roles of muscle and motoneuron LRP4 in neuromuscular junction formationHaitao Wu
Institute of Molecular Medicine and Genetics and Department of Neurology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA
Neuron 75:94-107. 2012..These observations uncovered distinct roles of LRP4 in motoneurons and muscles in NMJ development... - Synaptic dysfunction in schizophreniaDong Min Yin
Department of Neurology, Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, GA 30912, USA
Adv Exp Med Biol 970:493-516. 2012..We propose that mouse models with precise temporal and spatial control of mutation or overexpression would be useful to delineate schizophrenia pathogenic mechanisms... - alpha-Actinin interacts with rapsyn in agrin-stimulated AChR clusteringG Clement Dobbins
Institute of Molecular Medicine and Genetics, Department of Neurobiology, Medical College of Georgia, Augusta, Georgia 30912, USA
Mol Brain 1:18. 2008..Furthermore, the rapsyn-α-actinin interaction can be disrupted by inhibiting Abl and by cholinergic stimulation. Together these results indicate a role for α-actinin in AChR clustering... - HMGB1 regulates RANKL-induced osteoclastogenesis in a manner dependent on RAGEZheng Zhou
Institute of Molecular Medicine and Genomics and Department of Neurology, Medical College of Georgia, Augusta, Georgia GA 30912, USA
J Bone Miner Res 23:1084-96. 2008..Taken together, these observations show a novel function of HMGB1 in osteoclastogenesis and provide a new link between inflammatory mechanisms and bone resorption... - PYK2 interacts with MyD88 and regulates MyD88-mediated NF-kappaB activation in macrophagesCai Xia Xi
Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
J Leukoc Biol 87:415-23. 2010..These results suggest that via interaction with MyD88, PYK2 is involved in modulating cytokine (e.g., LPS) stimulation of NF-kappaB activity and signaling, providing a mechanism underlying PYK2 regulation of an inflammatory response... - Receptor for advanced glycation end products (RAGE) prevents endothelial cell membrane resealing and regulates F-actin remodeling in a beta-catenin-dependent mannerFei Xiong
Institute of Molecular Medicine and Genetics and Department of Neurology, Georgia Health Sciences University, Augusta, Georgia 30912, USA
J Biol Chem 286:35061-70. 2011..These results thus suggest a negative function for RAGE in endothelial cell membrane repair and reveal a new mechanism underlying RAGE regulation of F-actin remodeling and membrane resealing... - To build a synapse: signaling pathways in neuromuscular junction assemblyHaitao Wu
Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
Development 137:1017-33. 2010.... - Erbin is required for myelination in regenerated axons after injuryChuan Liang
Institute of Molecular Medicine and Genetics and Department of Neurology, Georgia Health Science University, Augusta, Georgia 30912, USA
J Neurosci 32:15169-80. 2012..Together, these observations demonstrate that Erbin is required for remyelination of regenerated axons after injury, probably by regulating ErbB2 and NRG1 levels, identifying a novel player in regulating remyelination... - VPS35 haploinsufficiency increases Alzheimer's disease neuropathologyLei Wen
Institute of Molecular Medicine and Genetics, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA
J Cell Biol 195:765-79. 2011..These results demonstrate an essential role for VPS35 in suppression of AD neuropathology and in inhibition of BACE1 activation and Aβ production by promoting BACE1 endosome-to-Golgi retrieval... - Wnt proteins regulate acetylcholine receptor clustering in muscle cellsBin Zhang
Department of Neurology and Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, Georgia 30912, USA
Mol Brain 5:7. 2012..NMJ formation requires agrin and its coreceptors LRP4 and MuSK. Increasing evidence indicates that Wnt signaling regulates NMJ formation in Drosophila, C. elegans and zebrafish... - APPswe/Aβ regulation of osteoclast activation and RAGE expression in an age-dependent mannerShun Cui
Institute of Molecular Medicine and Genetics and Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
J Bone Miner Res 26:1084-98. 2011..These results suggest an unexpected function of APPswe/Aβ, reveal a mechanism underlying altered bone remodeling in AD patients, and implicate APP/Aβ and RAGE as common denominators for both AD and osteoporosis... - Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2Shi Wen Luo
Department of Neurology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
EMBO J 28:2568-82. 2009.... - Autoantibodies to lipoprotein-related protein 4 in patients with double-seronegative myasthenia gravisBin Zhang
Department of Neurology, Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, 1120 15th St, Augusta, GA 30912, USA
Arch Neurol 69:445-51. 2012.... - Beta-catenin interacts with MyoD and regulates its transcription activityChang Hoon Kim
Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th St, CB2803, Augusta, GA 30912, USA
Mol Cell Biol 28:2941-51. 2008..These results demonstrate that beta-catenin is necessary for MyoD function, identifying MyoD as an effector in the Wnt canonical pathway... - Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneuronsLei Wen
Institute of Molecular Medicine and Genetics and Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
Proc Natl Acad Sci U S A 107:1211-6. 2010.... - β-Catenin gain of function in muscles impairs neuromuscular junction formationHaitao Wu
Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, Georgia 30912, USA
Development 139:2392-404. 2012..These observations provide additional genetic evidence that pre- and postsynaptic development of the NMJ requires an intricate balance of β-catenin activity in muscles... - Get ready to Wnt: prepatterning in neuromuscular junction formationBin Zhang
Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
Dev Cell 16:325-7. 2009..Jing et al. now report in Neuron that this prepatterning of AChRs, via a novel MuSK-dependent Wnt pathway, may guide motor axons to the central region of muscle fibers for synapse formation in zebrafish... - Specific regulation of NRG1 isoform expression by neuronal activityXihui Liu
Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, Georgia 30912, USA
J Neurosci 31:8491-501. 2011..These results indicate that expression of NRG1 isoforms is regulated by distinct mechanisms, which may contribute to versatile functions of NRG1 and pathologic mechanisms of brain disorders such as schizophrenia... - FAK interaction with MBD2: A link from cell adhesion to nuclear chromatin remodeling?Lin Mei
Institute of Molecular Medicine and Genetics and Department of Neurology, Medical College of Georgia, Augusta, GA, USA
Cell Adh Migr 4:77-80. 2010..These results demonstrate a new mechanism underlying FAK regulation of gene expression, and suggest a potential link between cell adhesion and cell differentiation... - MuSK signaling at the neuromuscular junctionQiang Wang
Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, GA, USA
J Mol Neurosci 30:223-6. 2006..MuSK appears to be involved in every aspect of NMJ development and maintenance. The paper reviews agrin-MuSK cascades and its potential cross talk with Wnt signaling pathways... - Stimulated ErbB4 internalization is necessary for neuregulin signaling in neuronsYu Liu
Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
Biochem Biophys Res Commun 354:505-10. 2007..Remarkably, inhibition of ErbB endocytosis attenuates NRG1-induced activation of Erk and Akt in neurons. These observations indicate a role of ErbB endocytosis in NRG1 signaling in neurons... - Erbin regulates NRG1 signaling and myelinationYanmei Tao
Department of Neurology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
Proc Natl Acad Sci U S A 106:9477-82. 2009..Our results suggest that Erbin, via the PDZ domain, binds to and stabilizes ErbB2, which is necessary for NRG1 signaling that has been implicated in tumorigenesis, heart development, and neural function... - VPS35 regulates developing mouse hippocampal neuronal morphogenesis by promoting retrograde trafficking of BACE1Chun Lei Wang
Institute of Molecular Medicine and Genetics, and Department of Neurology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA
Biol Open 1:1248-57. 2012.... - Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitabilityY Eugene Yu
MCG Cancer Center, School of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
Hum Mol Genet 19:1702-11. 2010..This mouse model, therefore, provides novel insights into the mechanism behind ADPEAF and offers a new opportunity to study the mechanism behind the role of LGI1 in susceptibility to myoclonic seizures... - The role of the cytoskeleton in neuromuscular junction formationG Clement Dobbins
Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
J Mol Neurosci 30:115-8. 2006..1982; Connolly, 1984; Peng and Phelan, 1984; Bloch, 1986; Dai et al., 2000). How AChRs are tethered to the actin cytoskeleton remains unclear... - Welcome to molecular brainLin Mei
Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
Mol Brain 1:1. 2008..It will be a premier platform for neuroscientists to exchange their ideas with researchers from around the world to help improve our understanding of the molecular mechanisms of the brain and mind... - Myosin X regulates netrin receptors and functions in axonal path-findingXiao juan Zhu
Program of Developmental Neurobiology, IMMAG and Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
Nat Cell Biol 9:184-92. 2007..Taken together, these results identify a novel role for Myo X in regulating netrin-1 function... - Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusinsCraig Brooks
Department of Cellular Biology and Anatomy, Medical College of Georgia and Veterans Affairs Medical Center, Augusta, GA 30912, USA
Proc Natl Acad Sci U S A 104:11649-54. 2007..By this function, Bak may collaborate with Bax to permeabilize the outer membrane of mitochondria, unleashing the apoptotic cascade... - DCC-dependent phospholipase C signaling in netrin-1-induced neurite elongationYi Xie
Institute of Molecular Medicine and Genomics and Department of Neurology, Medical College of Georgia, Augusta, Georgia 30809, USA
J Biol Chem 281:2605-11. 2006..These results suggest that netrin-1 regulates phosphatidylinositol turnover and demonstrate a crucial role of PLC signaling in netrin-1-induced neurite elongation... - Regulation of osteoclast function and bone mass by RAGEZheng Zhou
Institute of Molecular Medicine and Genomics and Department of Neurology, Medical College of Georgia, Augusta, GA, 30912, USA
J Exp Med 203:1067-80. 2006.... - Lipid rafts serve as a signaling platform for nicotinic acetylcholine receptor clusteringDan Zhu
Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
J Neurosci 26:4841-51. 2006..These results provide insight into mechanisms of AChR cluster formation... - Shp2 is dispensable in the formation and maintenance of the neuromuscular junctionXian Ping Dong
Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
Neurosignals 15:53-63. 2006..Both the frequency and amplitude of mEPPs in CKO mice were similar to those in controls, suggesting normal neurotransmission when SHP2 was deficient. These results suggest that Shp2 is not required for NMJ formation and/or maintenance... - Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complexPenggao Dai
Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, 30912, USA
J Biol Chem 281:927-33. 2006..These results demonstrate a regulatory role of Erbin in the Ras-Raf-MEK pathway, suggesting that Erbin may inhibit ERK activation by disrupting the Sur-8-Ras/Raf interaction... - An unconventional role of neurotransmission in synapse formationWen C Xiong
Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta 30912, USA
Neuron 46:521-3. 2005..This dispersing activity, which requires the serine/threonine kinase Cdk5, cooperates with positive signals from motoneurons to ensure high concentration of AChRs at the neuromuscular junction... - The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticityBo Li
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Neuron 54:583-97. 2007..These findings link proposed effectors in schizophrenia: NRG1/erbB4 signaling perturbation, neurodevelopmental deficit, and glutamatergic hypofunction... - Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and functionYang Z Huang
Department of Neurobiology, Pathology, Physical Medicine and Rehabilitation, University of Alabama at Birmingham, 35294 0021, USA
Int J Dev Neurosci 20:173-85. 2002..Such mechanisms could be important for the maintenance and function of the synapse... - Erbin enhances voltage-dependent facilitation of Ca(v)1.3 Ca2+ channels through relief of an autoinhibitory domain in the Ca(v)1.3 alpha1 subunitIrina Calin-Jageman
Department of Pharmacology and Center for Neurodegenerative Disease, Emory University, Atlanta, Georgia 30322, USA
J Neurosci 27:1374-85. 2007..Our findings reveal a novel mechanism by which PDZ interactions and alternative splicing of alpha1 1.3 may influence activity-dependent regulation of Ca(v)1.3 channels at the synapse... - Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid raftsLi Ma
Department of Neurobiology, University of Alabama at Birmingham, Civitan International Research Center, Birmingham, Alabama 35294 0021, USA
J Neurosci 23:3164-75. 2003..Thus, our results indicate that NRG stimulation causes translocation of ErbB4 into lipid rafts and that lipid rafts are necessary for signaling by ErbB4... - Regulation of MuSK expression by a novel signaling pathwayChang Hoon Kim
Department of Neurobiology, University of Alabama at Birmingham, Civitan International Research Center, 35294, USA
J Biol Chem 278:38522-7. 2003..Rather, MuSK expression is increased in muscle cells stimulated with Wnt or at conditions when the Wnt signaling was activated. These results suggest a novel mechanism for the MuSK synapse-specific expression... - Hypertension alters GABA receptor-mediated inhibition of neurons in the nucleus of the solitary tractLin Mei
Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284-7764, USA
Am J Physiol Regul Integr Comp Physiol 285:R1276-86. 2003..The alterations are dependent on the subtype of GABA receptor being activated and whether the neuron receives a mono- or polysynaptic baroreceptor afferent input... - Neuregulin-induced expression of the acetylcholine receptor requires endocytosis of ErbB receptorsXiao-Li Yang
Department of Neurobiology, University of Alabama at Birmingham, Civitan International Research Center, Birmingham, AL 35294, USA
Mol Cell Neurosci 28:335-46. 2005..These results indicate that ErbB proteins undergo endocytosis in response to neuregulin, and this process is required for neuregulin signaling and induced AChR expression... - Signaling complexes for postsynaptic differentiationZhenge Luo
Departments of Neurobiology, Pathology, and Physical Medicine and Rehabilitation, Civitan International Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Neurocytol 32:697-708. 2003..These results suggest that MuSK may function as a scaffold tyrosine kinase that forms a multi-molecule complex for AChR clustering... - Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and EosJianxin Bao
Department of Otolaryngology, Washington University, St Louis, Missouri 63110, USA
Nat Neurosci 7:1250-8. 2004..This upregulation of PSD-95 expression by the Nrg-ICD-Eos complex provides a molecular basis for activity-dependent synaptic plasticity... - Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4Hahn Jun Lee
Department of Pathology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Biol Chem 277:6318-23. 2002..Our studies also support the idea that presenilins play a generic role in intramembrane cleavage of selected type I membrane proteins... - ErbB4 is a suppressor of long-term potentiation in the adult hippocampusGraham M Pitcher
Program in Neurosciences and Mental Health, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Neuroreport 19:139-43. 2008....
Research Grants
- REGULATION OF ACETYLCHOLINE RECEPTOR EXPRESSIONLin Mei; Fiscal Year: 2007..In addition to providing insight into mechanisms by which neuregulin mediates expression of neuronal AChR, the primary target of nicotine, the proposed studies will identify novel targets that may be altered during nicotine abuse. ..
- Neuromuscular Junction FormationLin Mei; Fiscal Year: 2009..These studies will contribute to a better understanding of pathophysiology of the neuromuscular disorders and to developing strategies of gene therapy and of diagnostic tools for these diseases. ..
- Neuromuscular Junction FormationLin Mei; Fiscal Year: 2010..These studies will contribute to a better understanding of pathophysiology of the neuromuscular disorders and to developing strategies of gene therapy and of diagnostic tools for these diseases. ..
- Neuregulin-1 regulation of neurotransmissionLin Mei; Fiscal Year: 2010..These studies will insight into potential mechanisms by which this trophic factor regulates synaptic plasticity. Such knowledge will contribute to a better understanding of pathogenesis of schizophrenia. ..
- Activation and regulation of MuSKLin Mei; Fiscal Year: 2010..They will also contribute to a better understanding of pathophysiology of muscular dystrophy and to developing strategies of gene therapy and of diagnostic tools. ..
- Neuromuscular Junction FormationLin Mei; Fiscal Year: 2009..These studies will contribute to a better understanding of pathophysiology of the neuromuscular disorders and to developing strategies of gene therapy and of diagnostic tools for these diseases. ..
- Netrin and Integrin Signalings in Axon PathfindingLin Mei; Fiscal Year: 2006..Such knowledge is essential for understating the mechanisms involved in axon path-finding in neural development and birth defects with malformation of the brain and spinal cord. ..
- SIGNALING MECHANISMS REGULATING ACHR SYNTHESIS AT NMJLin Mei; Fiscal Year: 2003..The results of proposed experiments should contribute not only to our understanding of signaling mechanisms in regulation of AChR synthesis, but also to a more general understanding of synapse formation. ..
- Erbin Regulation of AChR ExpressionLin Mei; Fiscal Year: 2005..The resulting data will provide a better understanding of how NRG signaling and NRG-induced AChR expression are regulated at cellular levels. Such knowledge will contribute to our understanding of neurological disorders at the NMJ. ..
- Neuregulin-1 regulation of neurotransmissionLin Mei; Fiscal Year: 2010..These studies will insight into potential mechanisms by which this trophic factor regulates synaptic plasticity. Such knowledge will contribute to a better understanding of pathogenesis of schizophrenia. ..