Lin Mei

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. ncbi Beta-catenin regulates acetylcholine receptor clustering in muscle cells through interaction with rapsyn
    Bin Zhang
    Program of Developmental Neurobiology and Department of Neurology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Neurosci 27:3968-73. 2007
  2. pmc Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
    Lin Mei
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Nat Rev Neurosci 9:437-52. 2008
  3. ncbi Erbin interacts with TARP γ-2 for surface expression of AMPA receptors in cortical interneurons
    Yanmei Tao
    Institute of Developmental and Regenerative Biology, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China
    Nat Neurosci 16:290-9. 2013
  4. pmc LRP4 serves as a coreceptor of agrin
    Bin Zhang
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Neuron 60:285-97. 2008
  5. pmc Regulation of spine formation by ErbB4 in PV-positive interneurons
    Dong Min Yin
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Georgia Regents University, Augusta, Georgia 30912, Department of Neurobiology, Southern Medical University, Guangzhou, Guangdong, China, Department of Neurology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia 30912, and Charlie Norwood Veterans Administration Medical Center, Augusta, Georgia 30912
    J Neurosci 33:19295-303. 2013
  6. doi Reversal of behavioral deficits and synaptic dysfunction in mice overexpressing neuregulin 1
    Dong Min Yin
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA
    Neuron 78:644-57. 2013
  7. pmc Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons
    Annie K Ting
    Institute of Molecular Medicine and Genetics and Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Neurosci 31:15-25. 2011
  8. doi Retrograde regulation of motoneuron differentiation by muscle beta-catenin
    Xiao Ming Li
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, 1120 15th Street, Augusta, Georgia 30912, USA
    Nat Neurosci 11:262-8. 2008
  9. pmc Vps35 loss promotes hyperresorptive osteoclastogenesis and osteoporosis via sustained RANKL signaling
    Wen Fang Xia
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA
    J Cell Biol 200:821-37. 2013
  10. ncbi Swedish mutant APP suppresses osteoblast differentiation and causes osteoporotic deficit, which are ameliorated by N-acetyl-L-cysteine
    Wen Fang Xia
    Institute of Molecular Medicine and Genetics and Department of Neurology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA Charlie Norwood VA Medical Center, Augusta, GA, USA Department of Rheumatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P R, China
    J Bone Miner Res 28:2122-35. 2013

Collaborators

Detail Information

Publications65

  1. ncbi Beta-catenin regulates acetylcholine receptor clustering in muscle cells through interaction with rapsyn
    Bin Zhang
    Program of Developmental Neurobiology and Department of Neurology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Neurosci 27:3968-73. 2007
    ..These results suggest that beta-catenin may serve as a link between AChRs and alpha-catenin-associated cytoskeleton, revealing a novel function of beta-catenin in synaptogenesis...
  2. pmc Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
    Lin Mei
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Nat Rev Neurosci 9:437-52. 2008
    ..An improved understanding of the mechanisms by which altered function of NRG1 and ErbB4 contributes to schizophrenia might eventually lead to the development of more effective therapeutics...
  3. ncbi Erbin interacts with TARP γ-2 for surface expression of AMPA receptors in cortical interneurons
    Yanmei Tao
    Institute of Developmental and Regenerative Biology, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China
    Nat Neurosci 16:290-9. 2013
    ..These observations demonstrate a crucial function for Erbin in AMPAR surface expression in cortical PV-positive interneurons and may contribute to a better understanding of psychiatric disorders...
  4. pmc LRP4 serves as a coreceptor of agrin
    Bin Zhang
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Neuron 60:285-97. 2008
    ..These observations indicate that LRP4 is a coreceptor of agrin that is necessary for MuSK signaling and AChR clustering and identify a potential target protein whose mutation and/or autoimmunization may cause muscular dystrophies...
  5. pmc Regulation of spine formation by ErbB4 in PV-positive interneurons
    Dong Min Yin
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Georgia Regents University, Augusta, Georgia 30912, Department of Neurobiology, Southern Medical University, Guangzhou, Guangdong, China, Department of Neurology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia 30912, and Charlie Norwood Veterans Administration Medical Center, Augusta, Georgia 30912
    J Neurosci 33:19295-303. 2013
    ..Our results demonstrate a role of ErbB4 in PV-positive interneurons for spine formation in excitatory neurons. ..
  6. doi Reversal of behavioral deficits and synaptic dysfunction in mice overexpressing neuregulin 1
    Dong Min Yin
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA
    Neuron 78:644-57. 2013
    ....
  7. pmc Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons
    Annie K Ting
    Institute of Molecular Medicine and Genetics and Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Neurosci 31:15-25. 2011
    ..In light of the association of the genes of both NRG1 and ErbB4 with schizophrenia and dysfunction of GABAergic system in this disorder, these results provide insight into its potential pathological mechanism...
  8. doi Retrograde regulation of motoneuron differentiation by muscle beta-catenin
    Xiao Ming Li
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, 1120 15th Street, Augusta, Georgia 30912, USA
    Nat Neurosci 11:262-8. 2008
    ..Taken together, these observations indicate a role for muscle beta-catenin in presynaptic differentiation and function, identifying a previously unknown retrograde signaling in the synapse formation and synaptic plasticity...
  9. pmc Vps35 loss promotes hyperresorptive osteoclastogenesis and osteoporosis via sustained RANKL signaling
    Wen Fang Xia
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA
    J Cell Biol 200:821-37. 2013
    ..These results indicate that VPS35 critically deregulates RANK signaling, thus restraining increased formation of hyperresorptive OCs and preventing osteoporotic deficits...
  10. ncbi Swedish mutant APP suppresses osteoblast differentiation and causes osteoporotic deficit, which are ameliorated by N-acetyl-L-cysteine
    Wen Fang Xia
    Institute of Molecular Medicine and Genetics and Department of Neurology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA Charlie Norwood VA Medical Center, Augusta, GA, USA Department of Rheumatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P R, China
    J Bone Miner Res 28:2122-35. 2013
    ..2013 American Society for Bone and Mineral Research. ..
  11. pmc HSP90 beta regulates rapsyn turnover and subsequent AChR cluster formation and maintenance
    Shiwen Luo
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Neuron 60:97-110. 2008
    ..Together, these results indicate a role of HSP90beta in NMJ development by regulating rapsyn turnover and subsequent AChR cluster formation and maintenance...
  12. pmc Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis
    Dae Hoon Lee
    Institute of Molecular Medicine and Genetics, and Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Blood 115:3136-45. 2010
    ..These results reveal a novel mechanism underlying neogenin regulation of HJV-BMP signaling...
  13. pmc Differential regulation of myosin X movements by its cargos, DCC and neogenin
    Yu Liu
    Institute of Molecular Medicine and Genetics and Department of Neurology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA
    J Cell Sci 125:751-62. 2012
    ..These results thus demonstrate differential regulatory roles on Myo X activity by its cargo proteins, DCC and neogenin, revealing different cellular functions of DCC and neogenin...
  14. pmc VPS35 haploinsufficiency increases Alzheimer's disease neuropathology
    Lei Wen
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA
    J Cell Biol 195:765-79. 2011
    ..These results demonstrate an essential role for VPS35 in suppression of AD neuropathology and in inhibition of BACE1 activation and Aβ production by promoting BACE1 endosome-to-Golgi retrieval...
  15. pmc Erbin is required for myelination in regenerated axons after injury
    Chuan Liang
    Institute of Molecular Medicine and Genetics and Department of Neurology, Georgia Health Science University, Augusta, Georgia 30912, USA
    J Neurosci 32:15169-80. 2012
    ..Together, these observations demonstrate that Erbin is required for remyelination of regenerated axons after injury, probably by regulating ErbB2 and NRG1 levels, identifying a novel player in regulating remyelination...
  16. pmc Distinct roles of muscle and motoneuron LRP4 in neuromuscular junction formation
    Haitao Wu
    Institute of Molecular Medicine and Genetics and Department of Neurology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA
    Neuron 75:94-107. 2012
    ..These observations uncovered distinct roles of LRP4 in motoneurons and muscles in NMJ development...
  17. doi Synaptic dysfunction in schizophrenia
    Dong Min Yin
    Department of Neurology, Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, GA 30912, USA
    Adv Exp Med Biol 970:493-516. 2012
    ..We propose that mouse models with precise temporal and spatial control of mutation or overexpression would be useful to delineate schizophrenia pathogenic mechanisms...
  18. pmc To build a synapse: signaling pathways in neuromuscular junction assembly
    Haitao Wu
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Development 137:1017-33. 2010
    ....
  19. pmc PYK2 interacts with MyD88 and regulates MyD88-mediated NF-kappaB activation in macrophages
    Cai Xia Xi
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    J Leukoc Biol 87:415-23. 2010
    ..These results suggest that via interaction with MyD88, PYK2 is involved in modulating cytokine (e.g., LPS) stimulation of NF-kappaB activity and signaling, providing a mechanism underlying PYK2 regulation of an inflammatory response...
  20. pmc Autoantibodies to agrin in myasthenia gravis patients
    Bin Zhang
    Department of Neuroscience and Regenerative Medicine and Department of Neurology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia, United States of America Department of Physiology, Basic Medical School, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, P R China
    PLoS ONE 9:e91816. 2014
    ..Together, these observations indicate that agrin is another autoantigen in patients with MG and agrin autoantibodies may be pathogenic through inhibition of agrin/LRP4/MuSK signaling at the NMJ. ..
  21. pmc Neogenin regulation of BMP-induced canonical Smad signaling and endochondral bone formation
    Zheng Zhou
    Institute of Molecular Medicine and Genetics and Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Dev Cell 19:90-102. 2010
    ..Taken together, our results indicate that neogenin promotes chondrogenesis in vitro and in vivo, revealing an unexpected mechanism underlying neogenin regulation of BMP signaling...
  22. pmc Beta-catenin interacts with MyoD and regulates its transcription activity
    Chang Hoon Kim
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th St, CB2803, Augusta, GA 30912, USA
    Mol Cell Biol 28:2941-51. 2008
    ..These results demonstrate that beta-catenin is necessary for MyoD function, identifying MyoD as an effector in the Wnt canonical pathway...
  23. doi Muscle-specific receptor tyrosine kinase endocytosis in acetylcholine receptor clustering in response to agrin
    Dan Zhu
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Neurosci 28:1688-96. 2008
    ..Furthermore, suppression of NSF expression and NSF mutation attenuate MuSK downstream signaling. Our study reveals a potentially novel mechanism that regulates agrin/MuSK signaling cascade...
  24. pmc Receptor for advanced glycation end products (RAGE) prevents endothelial cell membrane resealing and regulates F-actin remodeling in a beta-catenin-dependent manner
    Fei Xiong
    Institute of Molecular Medicine and Genetics and Department of Neurology, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    J Biol Chem 286:35061-70. 2011
    ..These results thus suggest a negative function for RAGE in endothelial cell membrane repair and reveal a new mechanism underlying RAGE regulation of F-actin remodeling and membrane resealing...
  25. pmc alpha-Actinin interacts with rapsyn in agrin-stimulated AChR clustering
    G Clement Dobbins
    Institute of Molecular Medicine and Genetics, Department of Neurobiology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Mol Brain 1:18. 2008
    ..Furthermore, the rapsyn-α-actinin interaction can be disrupted by inhibiting Abl and by cholinergic stimulation. Together these results indicate a role for α-actinin in AChR clustering...
  26. pmc Wnt proteins regulate acetylcholine receptor clustering in muscle cells
    Bin Zhang
    Department of Neurology and Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Mol Brain 5:7. 2012
    ..NMJ formation requires agrin and its coreceptors LRP4 and MuSK. Increasing evidence indicates that Wnt signaling regulates NMJ formation in Drosophila, C. elegans and zebrafish...
  27. pmc Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2
    Shi Wen Luo
    Department of Neurology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    EMBO J 28:2568-82. 2009
    ....
  28. pmc Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons
    Lei Wen
    Institute of Molecular Medicine and Genetics and Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Proc Natl Acad Sci U S A 107:1211-6. 2010
    ....
  29. doi Culture of dissociated hippocampal neurons
    Yun Peng
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA
    Methods Mol Biol 1018:39-47. 2013
    ..Here, we describe a general procedure of dissociated hippocampal neuron culture...
  30. ncbi Neuregulin-1 enhances depolarization-induced GABA release
    Ran Sook Woo
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Neuron 54:599-610. 2007
    ..Because both NRG1 and ErbB4 have emerged as susceptibility genes of schizophrenia, these observations may suggest a mechanism for abnormal GABAergic neurotransmission in this disorder...
  31. doi Autoantibodies to lipoprotein-related protein 4 in patients with double-seronegative myasthenia gravis
    Bin Zhang
    Department of Neurology, Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, 1120 15th St, Augusta, GA 30912, USA
    Arch Neurol 69:445-51. 2012
    ....
  32. pmc VPS35 regulates developing mouse hippocampal neuronal morphogenesis by promoting retrograde trafficking of BACE1
    Chun Lei Wang
    Institute of Molecular Medicine and Genetics, and Department of Neurology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA
    Biol Open 1:1248-57. 2012
    ....
  33. ncbi MuSK signaling at the neuromuscular junction
    Qiang Wang
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, GA, USA
    J Mol Neurosci 30:223-6. 2006
    ..MuSK appears to be involved in every aspect of NMJ development and maintenance. The paper reviews agrin-MuSK cascades and its potential cross talk with Wnt signaling pathways...
  34. pmc Specific regulation of NRG1 isoform expression by neuronal activity
    Xihui Liu
    Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    J Neurosci 31:8491-501. 2011
    ..These results indicate that expression of NRG1 isoforms is regulated by distinct mechanisms, which may contribute to versatile functions of NRG1 and pathologic mechanisms of brain disorders such as schizophrenia...
  35. doi Get ready to Wnt: prepatterning in neuromuscular junction formation
    Bin Zhang
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Dev Cell 16:325-7. 2009
    ..Jing et al. now report in Neuron that this prepatterning of AChRs, via a novel MuSK-dependent Wnt pathway, may guide motor axons to the central region of muscle fibers for synapse formation in zebrafish...
  36. ncbi Caspase-3, shears for synapse pruning
    Chengyong Shen
    Department of Neuroscience and Regenerative Medicine and Department of Neurology, Medical College of Georgia, Georgia Regents University, 1120 15 th Street, Augusta, GA 30912, USA Charlie Norwood VA Medical Center, Augusta, GA 30904, USA
    Dev Cell 28:604-6. 2014
    ..Wang et al. (2014) now report in this issue of Developmental Cell a critical role for caspase-3 in intracellular mechanisms of acetylcholine-induced dispersal...
  37. pmc Erbin regulates NRG1 signaling and myelination
    Yanmei Tao
    Department of Neurology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Proc Natl Acad Sci U S A 106:9477-82. 2009
    ..Our results suggest that Erbin, via the PDZ domain, binds to and stabilizes ErbB2, which is necessary for NRG1 signaling that has been implicated in tumorigenesis, heart development, and neural function...
  38. pmc FAK interaction with MBD2: A link from cell adhesion to nuclear chromatin remodeling?
    Lin Mei
    Institute of Molecular Medicine and Genetics and Department of Neurology, Medical College of Georgia, Augusta, GA, USA
    Cell Adh Migr 4:77-80. 2010
    ..These results demonstrate a new mechanism underlying FAK regulation of gene expression, and suggest a potential link between cell adhesion and cell differentiation...
  39. pmc β-Catenin gain of function in muscles impairs neuromuscular junction formation
    Haitao Wu
    Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Development 139:2392-404. 2012
    ..These observations provide additional genetic evidence that pre- and postsynaptic development of the NMJ requires an intricate balance of β-catenin activity in muscles...
  40. pmc APPswe/Aβ regulation of osteoclast activation and RAGE expression in an age-dependent manner
    Shun Cui
    Institute of Molecular Medicine and Genetics and Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    J Bone Miner Res 26:1084-98. 2011
    ..These results suggest an unexpected function of APPswe/Aβ, reveal a mechanism underlying altered bone remodeling in AD patients, and implicate APP/Aβ and RAGE as common denominators for both AD and osteoporosis...
  41. doi The Ig1/2 domain of MuSK binds to muscle surface and is involved in acetylcholine receptor clustering
    Qiang Wang
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Neurosignals 16:246-53. 2008
    ..These results suggest that the Ig1/2 domain of MuSK is involved in AChR clustering by binding to the muscle surface...
  42. pmc Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability
    Y Eugene Yu
    MCG Cancer Center, School of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Hum Mol Genet 19:1702-11. 2010
    ..This mouse model, therefore, provides novel insights into the mechanism behind ADPEAF and offers a new opportunity to study the mechanism behind the role of LGI1 in susceptibility to myoclonic seizures...
  43. ncbi The role of the cytoskeleton in neuromuscular junction formation
    G Clement Dobbins
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    J Mol Neurosci 30:115-8. 2006
    ..1982; Connolly, 1984; Peng and Phelan, 1984; Bloch, 1986; Dai et al., 2000). How AChRs are tethered to the actin cytoskeleton remains unclear...
  44. pmc Welcome to molecular brain
    Lin Mei
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Brain 1:1. 2008
    ..It will be a premier platform for neuroscientists to exchange their ideas with researchers from around the world to help improve our understanding of the molecular mechanisms of the brain and mind...
  45. ncbi Myosin X regulates netrin receptors and functions in axonal path-finding
    Xiao juan Zhu
    Program of Developmental Neurobiology, IMMAG and Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Nat Cell Biol 9:184-92. 2007
    ..Taken together, these results identify a novel role for Myo X in regulating netrin-1 function...
  46. pmc HMGB1 regulates RANKL-induced osteoclastogenesis in a manner dependent on RAGE
    Zheng Zhou
    Institute of Molecular Medicine and Genomics and Department of Neurology, Medical College of Georgia, Augusta, Georgia GA 30912, USA
    J Bone Miner Res 23:1084-96. 2008
    ..Taken together, these observations show a novel function of HMGB1 in osteoclastogenesis and provide a new link between inflammatory mechanisms and bone resorption...
  47. pmc Stimulated ErbB4 internalization is necessary for neuregulin signaling in neurons
    Yu Liu
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Biochem Biophys Res Commun 354:505-10. 2007
    ..Remarkably, inhibition of ErbB endocytosis attenuates NRG1-induced activation of Erk and Akt in neurons. These observations indicate a role of ErbB endocytosis in NRG1 signaling in neurons...
  48. pmc Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins
    Craig Brooks
    Department of Cellular Biology and Anatomy, Medical College of Georgia and Veterans Affairs Medical Center, Augusta, GA 30912, USA
    Proc Natl Acad Sci U S A 104:11649-54. 2007
    ..By this function, Bak may collaborate with Bax to permeabilize the outer membrane of mitochondria, unleashing the apoptotic cascade...
  49. ncbi DCC-dependent phospholipase C signaling in netrin-1-induced neurite elongation
    Yi Xie
    Institute of Molecular Medicine and Genomics and Department of Neurology, Medical College of Georgia, Augusta, Georgia 30809, USA
    J Biol Chem 281:2605-11. 2006
    ..These results suggest that netrin-1 regulates phosphatidylinositol turnover and demonstrate a crucial role of PLC signaling in netrin-1-induced neurite elongation...
  50. pmc Regulation of osteoclast function and bone mass by RAGE
    Zheng Zhou
    Institute of Molecular Medicine and Genomics and Department of Neurology, Medical College of Georgia, Augusta, GA, 30912, USA
    J Exp Med 203:1067-80. 2006
    ....
  51. ncbi Lipid rafts serve as a signaling platform for nicotinic acetylcholine receptor clustering
    Dan Zhu
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Neurosci 26:4841-51. 2006
    ..These results provide insight into mechanisms of AChR cluster formation...
  52. ncbi Shp2 is dispensable in the formation and maintenance of the neuromuscular junction
    Xian Ping Dong
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Neurosignals 15:53-63. 2006
    ..Both the frequency and amplitude of mEPPs in CKO mice were similar to those in controls, suggesting normal neurotransmission when SHP2 was deficient. These results suggest that Shp2 is not required for NMJ formation and/or maintenance...
  53. ncbi Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex
    Penggao Dai
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, 30912, USA
    J Biol Chem 281:927-33. 2006
    ..These results demonstrate a regulatory role of Erbin in the Ras-Raf-MEK pathway, suggesting that Erbin may inhibit ERK activation by disrupting the Sur-8-Ras/Raf interaction...
  54. ncbi An unconventional role of neurotransmission in synapse formation
    Wen C Xiong
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta 30912, USA
    Neuron 46:521-3. 2005
    ..This dispersing activity, which requires the serine/threonine kinase Cdk5, cooperates with positive signals from motoneurons to ensure high concentration of AChRs at the neuromuscular junction...
  55. pmc The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity
    Bo Li
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuron 54:583-97. 2007
    ..These findings link proposed effectors in schizophrenia: NRG1/erbB4 signaling perturbation, neurodevelopmental deficit, and glutamatergic hypofunction...
  56. ncbi Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function
    Yang Z Huang
    Department of Neurobiology, Pathology, Physical Medicine and Rehabilitation, University of Alabama at Birmingham, 35294 0021, USA
    Int J Dev Neurosci 20:173-85. 2002
    ..Such mechanisms could be important for the maintenance and function of the synapse...
  57. ncbi Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts
    Li Ma
    Department of Neurobiology, University of Alabama at Birmingham, Civitan International Research Center, Birmingham, Alabama 35294 0021, USA
    J Neurosci 23:3164-75. 2003
    ..Thus, our results indicate that NRG stimulation causes translocation of ErbB4 into lipid rafts and that lipid rafts are necessary for signaling by ErbB4...
  58. ncbi Regulation of MuSK expression by a novel signaling pathway
    Chang Hoon Kim
    Department of Neurobiology, University of Alabama at Birmingham, Civitan International Research Center, 35294, USA
    J Biol Chem 278:38522-7. 2003
    ..Rather, MuSK expression is increased in muscle cells stimulated with Wnt or at conditions when the Wnt signaling was activated. These results suggest a novel mechanism for the MuSK synapse-specific expression...
  59. ncbi Hypertension alters GABA receptor-mediated inhibition of neurons in the nucleus of the solitary tract
    Lin Mei
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284 7764, USA
    Am J Physiol Regul Integr Comp Physiol 285:R1276-86. 2003
    ..The alterations are dependent on the subtype of GABA receptor being activated and whether the neuron receives a mono- or polysynaptic baroreceptor afferent input...
  60. ncbi Signaling complexes for postsynaptic differentiation
    Zhenge Luo
    Departments of Neurobiology, Pathology, and Physical Medicine and Rehabilitation, Civitan International Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Neurocytol 32:697-708. 2003
    ..These results suggest that MuSK may function as a scaffold tyrosine kinase that forms a multi-molecule complex for AChR clustering...
  61. ncbi Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos
    Jianxin Bao
    Department of Otolaryngology, Washington University, St Louis, Missouri 63110, USA
    Nat Neurosci 7:1250-8. 2004
    ..This upregulation of PSD-95 expression by the Nrg-ICD-Eos complex provides a molecular basis for activity-dependent synaptic plasticity...
  62. ncbi Neuregulin-induced expression of the acetylcholine receptor requires endocytosis of ErbB receptors
    Xiao li Yang
    Department of Neurobiology, University of Alabama at Birmingham, Civitan International Research Center, Birmingham, AL 35294, USA
    Mol Cell Neurosci 28:335-46. 2005
    ..These results indicate that ErbB proteins undergo endocytosis in response to neuregulin, and this process is required for neuregulin signaling and induced AChR expression...
  63. ncbi Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4
    Hahn Jun Lee
    Department of Pathology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 277:6318-23. 2002
    ..Our studies also support the idea that presenilins play a generic role in intramembrane cleavage of selected type I membrane proteins...
  64. pmc ErbB4 is a suppressor of long-term potentiation in the adult hippocampus
    Graham M Pitcher
    Program in Neurosciences and Mental Health, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Neuroreport 19:139-43. 2008
    ....
  65. ncbi Erbin enhances voltage-dependent facilitation of Ca(v)1.3 Ca2+ channels through relief of an autoinhibitory domain in the Ca(v)1.3 alpha1 subunit
    Irina Calin-Jageman
    Department of Pharmacology and Center for Neurodegenerative Disease, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 27:1374-85. 2007
    ..Our findings reveal a novel mechanism by which PDZ interactions and alternative splicing of alpha1 1.3 may influence activity-dependent regulation of Ca(v)1.3 channels at the synapse...

Research Grants25

  1. SIGNALING MECHANISMS REGULATING ACHR SYNTHESIS AT NMJ
    Lin Mei; Fiscal Year: 2000
    ..The results of proposed experiments should contribute not only to our understanding of signaling mechanisms in regulation of AChR synthesis, but also to a more general understanding of synapse formation. ..
  2. REGULATION OF ACETYLCHOLINE RECEPTOR EXPRESSION
    Lin Mei; Fiscal Year: 2007
    ..In addition to providing insight into mechanisms by which neuregulin mediates expression of neuronal AChR, the primary target of nicotine, the proposed studies will identify novel targets that may be altered during nicotine abuse. ..
  3. Neuromuscular Junction Formation
    Lin Mei; Fiscal Year: 2009
    ..These studies will contribute to a better understanding of pathophysiology of the neuromuscular disorders and to developing strategies of gene therapy and of diagnostic tools for these diseases. ..
  4. Neuregulin-1 regulation of neurotransmission
    Lin Mei; Fiscal Year: 2009
    ..These studies will insight into potential mechanisms by which this trophic factor regulates synaptic plasticity. Such knowledge will contribute to a better understanding of pathogenesis of schizophrenia. ..
  5. Neuromuscular Junction Formation
    Lin Mei; Fiscal Year: 2010
    ..These studies will contribute to a better understanding of pathophysiology of the neuromuscular disorders and to developing strategies of gene therapy and of diagnostic tools for these diseases. ..
  6. Neuregulin-1 regulation of neurotransmission
    Lin Mei; Fiscal Year: 2010
    ..These studies will insight into potential mechanisms by which this trophic factor regulates synaptic plasticity. Such knowledge will contribute to a better understanding of pathogenesis of schizophrenia. ..
  7. Activation and regulation of MuSK
    Lin Mei; Fiscal Year: 2010
    ..They will also contribute to a better understanding of pathophysiology of muscular dystrophy and to developing strategies of gene therapy and of diagnostic tools. ..
  8. Neuromuscular Junction Formation
    Lin Mei; Fiscal Year: 2009
    ..These studies will contribute to a better understanding of pathophysiology of the neuromuscular disorders and to developing strategies of gene therapy and of diagnostic tools for these diseases. ..
  9. REGULATION OF ACETYLCHOLINE RECEPTOR EXPRESSION
    Lin Mei; Fiscal Year: 2006
    ..In addition to providing insight into mechanisms by which neuregulin mediates expression of neuronal AChR, the primary target of nicotine, the proposed studies will identify novel targets that may be altered during nicotine abuse. ..
  10. Netrin and Integrin Signalings in Axon Pathfinding
    Lin Mei; Fiscal Year: 2006
    ..Such knowledge is essential for understating the mechanisms involved in axon path-finding in neural development and birth defects with malformation of the brain and spinal cord. ..
  11. REGULATION OF ACETYLCHOLINE RECEPTOR EXPRESSION
    Lin Mei; Fiscal Year: 2005
    ..In addition to providing insight into mechanisms by which neuregulin mediates expression of neuronal AChR, the primary target of nicotine, the proposed studies will identify novel targets that may be altered during nicotine abuse. ..
  12. SIGNALING MECHANISMS REGULATING ACHR SYNTHESIS AT NMJ
    Lin Mei; Fiscal Year: 2001
    ..The results of proposed experiments should contribute not only to our understanding of signaling mechanisms in regulation of AChR synthesis, but also to a more general understanding of synapse formation. ..
  13. SIGNALING MECHANISMS REGULATING ACHR SYNTHESIS AT NMJ
    Lin Mei; Fiscal Year: 2002
    ..The results of proposed experiments should contribute not only to our understanding of signaling mechanisms in regulation of AChR synthesis, but also to a more general understanding of synapse formation. ..
  14. Netrin and Integrin Signalings in Axon Pathfinding
    Lin Mei; Fiscal Year: 2003
    ..Such knowledge is essential for understating the mechanisms involved in axon path-finding in neural development and birth defects with malformation of the brain and spinal cord. ..
  15. SIGNALING MECHANISMS REGULATING ACHR SYNTHESIS AT NMJ
    Lin Mei; Fiscal Year: 2003
    ..The results of proposed experiments should contribute not only to our understanding of signaling mechanisms in regulation of AChR synthesis, but also to a more general understanding of synapse formation. ..
  16. Erbin Regulation of AChR Expression
    Lin Mei; Fiscal Year: 2003
    ..The resulting data will provide a better understanding of how NRG signaling and NRG-induced AChR expression are regulated at cellular levels. Such knowledge will contribute to our understanding of neurological disorders at the NMJ. ..
  17. Netrin and Integrin Signalings in Axon Pathfinding
    Lin Mei; Fiscal Year: 2004
    ..Such knowledge is essential for understating the mechanisms involved in axon path-finding in neural development and birth defects with malformation of the brain and spinal cord. ..
  18. Erbin Regulation of AChR Expression
    Lin Mei; Fiscal Year: 2004
    ..The resulting data will provide a better understanding of how NRG signaling and NRG-induced AChR expression are regulated at cellular levels. Such knowledge will contribute to our understanding of neurological disorders at the NMJ. ..
  19. REGULATION OF ACETYLCHOLINE RECEPTOR EXPRESSION
    Lin Mei; Fiscal Year: 2004
    ..In addition to providing insight into mechanisms by which neuregulin mediates expression of neuronal AChR, the primary target of nicotine, the proposed studies will identify novel targets that may be altered during nicotine abuse. ..
  20. Netrin and Integrin Signalings in Axon Pathfinding
    Lin Mei; Fiscal Year: 2004
    ..Such knowledge is essential for understating the mechanisms involved in axon path-finding in neural development and birth defects with malformation of the brain and spinal cord. ..
  21. Erbin Regulation of AChR Expression
    Lin Mei; Fiscal Year: 2005
    ..The resulting data will provide a better understanding of how NRG signaling and NRG-induced AChR expression are regulated at cellular levels. Such knowledge will contribute to our understanding of neurological disorders at the NMJ. ..
  22. Neuregulin-1 regulation of neurotransmission
    Lin Mei; Fiscal Year: 2010
    ..These studies will insight into potential mechanisms by which this trophic factor regulates synaptic plasticity. Such knowledge will contribute to a better understanding of pathogenesis of schizophrenia. ..