MEETHA M MEDHORA

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. pmc Dose-modifying factor for captopril for mitigation of radiation injury to normal lung
    Meetha Medhora
    Department of Radiation Oncology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Radiat Res 53:633-40. 2012
  2. pmc Radiation damage to the lung: mitigation by angiotensin-converting enzyme (ACE) inhibitors
    Meetha Medhora
    Department of Radiation Oncology, Medical College of Wisconsin, Wisconsin, USA
    Respirology 17:66-71. 2012
  3. ncbi request reprint Retinoic acid upregulates beta(1)-integrin in vascular smooth muscle cells and alters adhesion to fibronectin
    M M Medhora
    Department of Physiology, Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 279:H382-7. 2000
  4. pmc Role of JNK in network formation of human lung microvascular endothelial cells
    Meetha Medhora
    Division of Pulmonary and Critical Care, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Lung Cell Mol Physiol 294:L676-85. 2008
  5. ncbi request reprint Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids
    Meetha Medhora
    Division of Pulmonary and Critical Care, Department of Medicine, Medical College of Wisconsin, 8701, Watertown Plank Road, Milwaukee, WI 53226, USA
    Prostaglandins Other Lipid Mediat 82:19-29. 2007
  6. ncbi request reprint Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells
    Meetha Medhora
    Division of Pulmonary and Critical Care, Department of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Physiol Heart Circ Physiol 284:H215-24. 2003
  7. ncbi request reprint Identifying endothelium-derived hyperpolarizing factor: recent approaches to assay the role of epoxyeicosatrienoic acids
    M Medhora
    Cardiovascular Research Center, Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Jpn J Pharmacol 86:369-75. 2001
  8. pmc Mitigation of radiation induced pulmonary vascular injury by delayed treatment with captopril
    Robert C Molthen
    Division of Pulmonary and Critical Care, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Respirology 17:1261-8. 2012
  9. ncbi request reprint Nitric oxide contributes to 20-HETE-induced relaxation of pulmonary arteries
    Ming Yu
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Appl Physiol 93:1391-9. 2002
  10. ncbi request reprint CYP4A mRNA, protein, and product in rat lungs: novel localization in vascular endothelium
    Daling Zhu
    Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA
    J Appl Physiol 93:330-7. 2002

Research Grants

  1. Role of EETs in Growth of Human Endothelial Cells
    Meetha Medhora; Fiscal Year: 2003
  2. Role of EETs in Growth of Human Endothelial Cells
    Meetha Medhora; Fiscal Year: 2004
  3. Role of EETs in Growth of Human Endothelial Cells
    Meetha Medhora; Fiscal Year: 2005
  4. Role of EETs in Growth of Human Endothelial Cells
    Meetha Medhora; Fiscal Year: 2006

Collaborators

Detail Information

Publications29

  1. pmc Dose-modifying factor for captopril for mitigation of radiation injury to normal lung
    Meetha Medhora
    Department of Radiation Oncology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Radiat Res 53:633-40. 2012
    ..These encouraging results advance our goals, since DMF measurements are essential for drug labeling and comparison with other mitigators...
  2. pmc Radiation damage to the lung: mitigation by angiotensin-converting enzyme (ACE) inhibitors
    Meetha Medhora
    Department of Radiation Oncology, Medical College of Wisconsin, Wisconsin, USA
    Respirology 17:66-71. 2012
    ..These results offer hope that lung injury from radiation accidents may be mitigated, since the ACE inhibitor captopril was effective when started up to 1 week after irradiation...
  3. ncbi request reprint Retinoic acid upregulates beta(1)-integrin in vascular smooth muscle cells and alters adhesion to fibronectin
    M M Medhora
    Department of Physiology, Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 279:H382-7. 2000
    ..These results showed that modulation of vascular integrins by ATRA in adult rats contributes to functional changes that can cause remodeling of blood vessels...
  4. pmc Role of JNK in network formation of human lung microvascular endothelial cells
    Meetha Medhora
    Division of Pulmonary and Critical Care, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Lung Cell Mol Physiol 294:L676-85. 2008
    ..Our results demonstrate a specific role for the JNK pathway in network formation of human lung endothelial cells in vitro while confirming that it is essential for the formation of new vessels in vivo...
  5. ncbi request reprint Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids
    Meetha Medhora
    Division of Pulmonary and Critical Care, Department of Medicine, Medical College of Wisconsin, 8701, Watertown Plank Road, Milwaukee, WI 53226, USA
    Prostaglandins Other Lipid Mediat 82:19-29. 2007
    ..We also discuss current observations describing the protective effects of EETs for survival of the endothelium...
  6. ncbi request reprint Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells
    Meetha Medhora
    Division of Pulmonary and Critical Care, Department of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Physiol Heart Circ Physiol 284:H215-24. 2003
    ..These data support an important role for CYP2C9 in promoting angiogenesis...
  7. ncbi request reprint Identifying endothelium-derived hyperpolarizing factor: recent approaches to assay the role of epoxyeicosatrienoic acids
    M Medhora
    Cardiovascular Research Center, Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Jpn J Pharmacol 86:369-75. 2001
    ....
  8. pmc Mitigation of radiation induced pulmonary vascular injury by delayed treatment with captopril
    Robert C Molthen
    Division of Pulmonary and Critical Care, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Respirology 17:1261-8. 2012
    ..In this study, we evaluate the potential of a renin-angiotensin system (RAS) modulator, the ACE inhibitor captopril, to mitigate this pulmonary vascular damage...
  9. ncbi request reprint Nitric oxide contributes to 20-HETE-induced relaxation of pulmonary arteries
    Ming Yu
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Appl Physiol 93:1391-9. 2002
    ..20-HETE-induced NO release was blunted by removal of extracellular calcium, as well as NO synthase inhibitors (L-NAME). These results suggest that 20-HETE dilates PAs at least in part by increasing [Ca(2+)](i) and NO release in BPAECs...
  10. ncbi request reprint CYP4A mRNA, protein, and product in rat lungs: novel localization in vascular endothelium
    Daling Zhu
    Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA
    J Appl Physiol 93:330-7. 2002
    ..These data show that 20-HETE is an endogenous product of several pulmonary cell types and is localized to tissues that optimally position it to modulate physiological functions such as smooth muscle tone or electrolyte flux...
  11. pmc Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels
    Sreedhar Bodiga
    Pulmonary and Critical Care Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Mol Cell Cardiol 46:978-88. 2009
    ....
  12. pmc Renin-Angiotensin system suppression mitigates experimental radiation pneumonitis
    Swarajit N Ghosh
    Department of Medicine, Division of Pulmonary and Critical Care, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Radiat Oncol Biol Phys 75:1528-36. 2009
    ..To find the mitigators of pneumonitis induced by moderate doses of thoracic radiation (10-15 Gy)...
  13. pmc 8,9-Epoxyeicosatrienoic acid protects the glomerular filtration barrier
    Mukut Sharma
    Division of Nephrology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Prostaglandins Other Lipid Mediat 89:43-51. 2009
    ..These novel findings suggest a unique protective role for 8,9-EET in the glomerulus. Stable analogs of 8,9-EET may be valuable in developing effective management/treatment of glomerular dysfunction...
  14. ncbi request reprint Chronic hypoxia activates lung 15-lipoxygenase, which catalyzes production of 15-HETE and enhances constriction in neonatal rabbit pulmonary arteries
    Daling Zhu
    Department of Medicine, Medical College of Wisconsin, Milwaukee, Wis 53226, USA
    Circ Res 92:992-1000. 2003
    ..Although a clear causal relationship remains to be demonstrated, these data suggest a previously unrecognized role for 15-LO in hypoxic vasoconstriction in neonatal mammals...
  15. ncbi request reprint Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells
    Yuenmu Chen
    Pulmonary and Critical Care Division, Department of Medicine, Division of Pediatric Surgery and Childrens Research Institute, Cardiovascular Center Medical College of Wisconsin, 53226, USA
    Am J Physiol Lung Cell Mol Physiol 291:L378-85. 2006
    ..Unlike aortic endothelial cells, eNOS activation in BPAECs by either VEGF or 20-HETE does not appear to require increased association of Hsp90...
  16. ncbi request reprint VEGF-induced relaxation of pulmonary arteries is mediated by endothelial cytochrome P-450 hydroxylase
    Elizabeth R Jacobs
    Cardiovascular Center, Pulmonary and Critical Care Division, Department of Medicine, Medical College of Wisconsin, Milwaukee, 53226, USA
    Am J Physiol Lung Cell Mol Physiol 291:L369-77. 2006
    ..Given the unique expression of 20-HETE-forming CYP4 in BPAECs vs. systemic arterial endothelial cells, CYP4 may be an important mediator of endothelial-dependent vasoreactivity in PAs...
  17. ncbi request reprint Mechanisms regulating cerebral blood flow as therapeutic targets
    Phillip F Pratt
    Cardiovascular Center, Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Curr Opin Investig Drugs 5:952-6. 2004
    ..Finally, we discuss novel inhibitors of 20-HETE formation and actions as well as interventions to enhance EET production in cerebrovascular disease...
  18. pmc 20-HETE-induced nitric oxide production in pulmonary artery endothelial cells is mediated by NADPH oxidase, H2O2, and PI3-kinase/Akt
    Sreedhar Bodiga
    Division of Pulmonary and Critical Care Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Lung Cell Mol Physiol 298:L564-74. 2010
    ..Superoxide is rapidly dismutated to hydrogen peroxide, which then mediates activation of PI3-kinase/Akt, phosphorylation of eNOS, and enhanced release of NO from eNOS in response to 20-HETE in BPAECs...
  19. pmc Cellular inflammatory infiltrate in pneumonitis induced by a single moderate dose of thoracic x radiation in rats
    Sara Szabo
    Department of Pathology, Children s Hospital, Milwaukee, Wisconsin 53226, USA
    Radiat Res 173:545-56. 2010
    ....
  20. ncbi request reprint Upregulation of collagens detected by gene array in a model of flow-induced pulmonary vascular remodeling
    Meetha Medhora
    Department of Medicine and Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 282:H414-22. 2002
    ..Our observations expand the list of genes as putative candidates in pulmonary vascular remodeling and support the utility of cross-species microarray analysis in such applications...
  21. ncbi request reprint Protective effects of epoxyeicosatrienoic acids on human endothelial cells from the pulmonary and coronary vasculature
    Anuradha Dhanasekaran
    Division of Pulmonary and Critical Care, Department of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 291:H517-31. 2006
    ....
  22. pmc 20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells
    Anuradha Dhanasekaran
    Dept of Medicine, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee WI 53226, USA
    Am J Physiol Heart Circ Physiol 296:H777-86. 2009
    ..In summary, 20-HETE may afford a survival advantage to BPAECs through activation of prosurvival PI3-kinase and Akt pathways, NADPH oxidase activation, and NADPH oxidase-derived superoxide...
  23. pmc 20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells
    Meetha Medhora
    Pulmonary and Critical Care Medicine and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Lung Cell Mol Physiol 294:L902-11. 2008
    ..These observations suggest that 20-HETE stimulates ROS production in BPAECs at least in part through activation of NADPH oxidase within minutes of application of the lipid...
  24. pmc Animal models for medical countermeasures to radiation exposure
    Jacqueline P Williams
    Department of Radiation Oncology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 647, Rochester, NY 14642, USA
    Radiat Res 173:557-78. 2010
    ..Discussions covered the most appropriate species and strains available as well as other factors that may affect differential findings between groups and institutions. This report provides the workshop findings...
  25. doi request reprint Irradiation of varying volumes of rat lung to same mean lung dose: a little to a lot or a lot to a little?
    Vladimir A Semenenko
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Radiat Oncol Biol Phys 71:838-47. 2008
    ..To investigate whether irradiating small lung volumes with a large dose or irradiating large lung volumes with a small dose, given the same mean lung dose (MLD), has a different effect on pulmonary function in laboratory animals...
  26. ncbi request reprint Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs)
    Laurel K Dunn
    Cardiovascular Center, Pulmonary and Critical Care Division, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Anat Rec A Discov Mol Cell Evol Biol 285:771-80. 2005
    ..In conclusion, we report a novel vascular response to EETs using the CAM as an in vivo model. These lipids specifically distend a subset of capillaries in a dose- and development-dependent manner...
  27. pmc Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia
    Anuradha Dhanasekaran
    Division of Pulmonary and Critical Care Medicine, Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 294:H724-35. 2008
    ..Understanding the targets of action of EET-mediated protection will promote the development of these fatty acids as therapeutic agents against cardiac ischemia-reperfusion...
  28. pmc Near infrared light protects cardiomyocytes from hypoxia and reoxygenation injury by a nitric oxide dependent mechanism
    Rong Zhang
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53326, USA
    J Mol Cell Cardiol 46:4-14. 2009
    ..Taken together these data provide evidence for protection against hypoxia and reoxygenation injury in cardiomyocytes by NIR in a manner that is dependent upon NO derived from NOS and non-NOS sources...
  29. pmc Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes
    Irina A Ionova
    Department of Surgery Transplant Surgery, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 295:H2178-87. 2008
    ....

Research Grants5

  1. Role of EETs in Growth of Human Endothelial Cells
    Meetha Medhora; Fiscal Year: 2003
    ..It will impact on the potential for development of EETs as therapeutic agents during and after cardiac ischemia and acute lung injury. ..
  2. Role of EETs in Growth of Human Endothelial Cells
    Meetha Medhora; Fiscal Year: 2004
    ..It will impact on the potential for development of EETs as therapeutic agents during and after cardiac ischemia and acute lung injury. ..
  3. Role of EETs in Growth of Human Endothelial Cells
    Meetha Medhora; Fiscal Year: 2005
    ..It will impact on the potential for development of EETs as therapeutic agents during and after cardiac ischemia and acute lung injury. ..
  4. Role of EETs in Growth of Human Endothelial Cells
    Meetha Medhora; Fiscal Year: 2006
    ..It will impact on the potential for development of EETs as therapeutic agents during and after cardiac ischemia and acute lung injury. ..