Aimee L McRae

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. pmc Effect of oxytocin on craving and stress response in marijuana-dependent individuals: a pilot study
    Aimee L McRae-Clark
    Clinical Neuroscience Division, Department of Psychiatry, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 228:623-31. 2013
  2. pmc Stress- and cue-elicited craving and reactivity in marijuana-dependent individuals
    Aimee L McRae-Clark
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA
    Psychopharmacology (Berl) 218:49-58. 2011
  3. pmc A placebo-controlled trial of atomoxetine in marijuana-dependent individuals with attention deficit hyperactivity disorder
    Aimee L McRae-Clark
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Addict 19:481-9. 2010
  4. pmc Methylphenidate transdermal system in adults with past stimulant misuse: an open-label trial
    Aimee L McRae-Clark
    Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    J Atten Disord 15:539-44. 2011
  5. pmc A placebo-controlled trial of buspirone for the treatment of marijuana dependence
    Aimee L McRae-Clark
    Department of Psychiatry, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Drug Alcohol Depend 105:132-8. 2009
  6. ncbi request reprint Review of sertraline and its clinical applications in psychiatric disorders
    A L McRae
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, PO Box 250861, Charleston, SC 29425, USA
    Expert Opin Pharmacother 2:883-92. 2001
  7. pmc Characteristics of cocaine- and marijuana-dependent subjects presenting for medication treatment trials
    Aimee L McRae
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Addict Behav 32:1433-40. 2007
  8. ncbi request reprint Stress reactivity: biological and subjective responses to the cold pressor and Trier Social stressors
    Aimee L McRae
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Hum Psychopharmacol 21:377-85. 2006
  9. ncbi request reprint Alcohol and substance abuse
    A L McRae
    Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA
    Med Clin North Am 85:779-801. 2001
  10. ncbi request reprint Escitalopram H Lundbeck
    Aimee L McRae
    Ralph H Johnson VA Medical Center, MUSC Clinical Trials Network, Charleston, SC 29401 5799, USA
    Curr Opin Investig Drugs 3:1225-9. 2002

Research Grants

  1. Career Training in Marijuana Dependence
    Aimee McRae; Fiscal Year: 2006
  2. Atomoxetine Treatment for ADHD and Marijuana Dependence
    Aimee McRae Clark; Fiscal Year: 2006
  3. Stress and Marijuana Cue-Elicited Craving and Reactivity
    Aimee McRae; Fiscal Year: 2007
  4. Buspirone Treatment for Marijuana Dependence
    Aimee McRae Clark; Fiscal Year: 2009
  5. Buspirone Treatment for Marijuana Dependence
    Aimee L McRae Clark; Fiscal Year: 2010

Detail Information

Publications31

  1. pmc Effect of oxytocin on craving and stress response in marijuana-dependent individuals: a pilot study
    Aimee L McRae-Clark
    Clinical Neuroscience Division, Department of Psychiatry, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 228:623-31. 2013
    ..Oxytocin is a hypothalamic neuropeptide that has been shown to moderate behavioral responding to stress as well as play a role in the neuroadaptations that occur as a consequence of long-term drug use...
  2. pmc Stress- and cue-elicited craving and reactivity in marijuana-dependent individuals
    Aimee L McRae-Clark
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA
    Psychopharmacology (Berl) 218:49-58. 2011
    ..Cue-elicited craving and stress responses have been identified as predictors of relapse in drug dependence, but little research exists on the contribution of these factors to marijuana use specifically...
  3. pmc A placebo-controlled trial of atomoxetine in marijuana-dependent individuals with attention deficit hyperactivity disorder
    Aimee L McRae-Clark
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Addict 19:481-9. 2010
    ..These results suggest that atomoxetine may improve some ADHD symptoms but does not reduce marijuana use in this population. ..
  4. pmc Methylphenidate transdermal system in adults with past stimulant misuse: an open-label trial
    Aimee L McRae-Clark
    Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    J Atten Disord 15:539-44. 2011
    ..This 8-week, open-label trial assessed the efficacy of methylphenidate transdermal system (MTS) in 14 adult individuals diagnosed with ADHD and with a history of stimulant misuse, abuse, or dependence...
  5. pmc A placebo-controlled trial of buspirone for the treatment of marijuana dependence
    Aimee L McRae-Clark
    Department of Psychiatry, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Drug Alcohol Depend 105:132-8. 2009
    ..054). Further study with buspirone in this population may be warranted; however, strategies to enhance study retention and improve outcome measurement should be considered in future trials...
  6. ncbi request reprint Review of sertraline and its clinical applications in psychiatric disorders
    A L McRae
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, PO Box 250861, Charleston, SC 29425, USA
    Expert Opin Pharmacother 2:883-92. 2001
    ..As a result of its proven efficacy, good tolerability and lack of pharmacokinetic interactions, sertraline should be considered first-line in the treatment of anxiety and depressive disorders...
  7. pmc Characteristics of cocaine- and marijuana-dependent subjects presenting for medication treatment trials
    Aimee L McRae
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Addict Behav 32:1433-40. 2007
    ..Past and current other drug use was similar between the two groups. These results highlight the significant impairments associated with marijuana and cocaine dependence...
  8. ncbi request reprint Stress reactivity: biological and subjective responses to the cold pressor and Trier Social stressors
    Aimee L McRae
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Hum Psychopharmacol 21:377-85. 2006
    ..The results suggest that the TSST results in a greater HPA response than the CPT; however, the CPT may have utility in diagnostically heterogeneous patients...
  9. ncbi request reprint Alcohol and substance abuse
    A L McRae
    Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA
    Med Clin North Am 85:779-801. 2001
    ..A growing body of evidence indicates that the treatment of substance use disorders can be effective, making early diagnosis and treatment or referral increasingly important...
  10. ncbi request reprint Escitalopram H Lundbeck
    Aimee L McRae
    Ralph H Johnson VA Medical Center, MUSC Clinical Trials Network, Charleston, SC 29401 5799, USA
    Curr Opin Investig Drugs 3:1225-9. 2002
    ..By March 2002, Lundbeck had started to supply escitalopram to Forest [442326]. Lundbeck and Morchida entered a Japanese development and marketing agreement in May 2002, replacing a collaboration with Mitsui [453377]...
  11. ncbi request reprint Treatment of marijuana dependence: a review of the literature
    Aimee L McRae
    Ralph H Johnson VAMC, 109 Bee Street, MUSC CTN, 29401, Charleston, SC, USA
    J Subst Abuse Treat 24:369-76. 2003
    ....
  12. ncbi request reprint A randomized, placebo-controlled trial of buspirone for the treatment of anxiety in opioid-dependent individuals
    Aimee L McRae
    Clinical Neuroscience Division, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 61 President Street, Charleston, SC 29425, USA
    Am J Addict 13:53-63. 2004
    ..Buspirone treatment did not significantly reduce anxiety symptoms in opioid-dependent patients. However, buspirone treatment was associated with trends toward reduction in depression scale scores and a slower return to substance use...
  13. ncbi request reprint Comparison of nefazodone and sertraline for the treatment of posttraumatic stress disorder
    Aimee L McRae
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Depress Anxiety 19:190-6. 2004
    ..This study did not find significant differences in the effectiveness of nefazodone and sertraline for the treatment of PTSD. Larger trials are warranted...
  14. pmc Response to corticotropin-releasing hormone infusion in cocaine-dependent individuals
    Kathleen T Brady
    Department of Psychiatry and Behavioral Sciences, Clinical Neurosciences Division, Medical University of South Carolina, 67 President St, PO Box 250861, Charleston, SC 29425, USA
    Arch Gen Psychiatry 66:422-30. 2009
    ..Little is known about the response of cocaine-dependent individuals to CRH administration...
  15. ncbi request reprint The impact of alcohol dependence and posttraumatic stress disorder on cold pressor task response
    Kathleen T Brady
    Division of Clinical Neuroscience, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Box 250861, Charleston, South Carolina 29425, USA
    J Stud Alcohol 67:700-6. 2006
    ..The objective of this study was to investigate HPA axis reactivity to the cold pressor task (CPT) among individuals with alcohol dependence, PTSD, and comorbid alcohol dependence and PTSD...
  16. pmc Community-dwelling cocaine-dependent men and women respond differently to social stressors versus cocaine cues
    Angela E Waldrop
    Medical University of South Carolina, 67 President St, Charleston, SC 29403, United States
    Psychoneuroendocrinology 35:798-806. 2010
    ..11]). No gender differences were found in ACTH responses to the CUE. The results are reviewed in the context of the existing literature on gender differences in cocaine dependence and potential implications for treatment are discussed...
  17. pmc Effects of gender and cigarette smoking on reactivity to psychological and pharmacological stress provocation
    Sudie E Back
    Department of Psychiatry, Clinical Neuroscience Division, Medical University of South Carolina, 67 President Street, PO Box 250861, Charleston, SC, USA
    Psychoneuroendocrinology 33:560-8. 2008
    ..In addition, there is some evidence for a more robust neuroendocrine and physiologic response to acute laboratory stress in women as compared to men...
  18. ncbi request reprint PTSD and the HPA axis: differences in response to the cold pressor task among individuals with child vs. adult trauma
    Elizabeth J Santa Ana
    Division of Clinical Neuroscience, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, P O Box 250861, Charleston, SC 29425, USA
    Psychoneuroendocrinology 31:501-9. 2006
    ..The findings reveal differences in the neuroendocrine response to the CPT in individuals with PTSD compared to control subjects, and differences in PTSD subjects when examined by age of index trauma...
  19. ncbi request reprint Assessment of club drug use in a treatment-seeking sample of individuals with marijuana dependence
    Marcia L Verduin
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, USA
    Am J Addict 16:484-7. 2007
    ..This appears to be the first study to report on club drug use in treatment-seeking marijuana-dependent individuals. Clinical implications and directions for future research are discussed...
  20. pmc Early life trauma and sensitivity to current life stressors in individuals with and without cocaine dependence
    Sudie E Back
    Division of Clinical Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Drug Alcohol Abuse 34:389-96. 2008
    ..Adverse childhood events may lead to an altered view of the environment that contributes to increased irritability with daily life events among cocaine-dependent individuals...
  21. ncbi request reprint Cold pressor task reactivity: predictors of alcohol use among alcohol-dependent individuals with and without comorbid posttraumatic stress disorder
    Kathleen T Brady
    Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Alcohol Clin Exp Res 30:938-46. 2006
    ..This study investigated the relationship between subjective and neuroendocrine stress reactivity to the cold pressor task (CPT) and prospective alcohol use among individuals with alcohol dependence, with and without comorbid PTSD...
  22. ncbi request reprint Differences in early onset alcohol use and heavy drinking among persons with childhood and adulthood trauma
    Angela E Waldrop
    Clinical Neuroscience Division, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425, USA
    Am J Addict 16:439-42. 2007
    ....
  23. pmc Daily stressor sensitivity, abuse effects, and cocaine use in cocaine dependence
    Angela E Waldrop
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Box 250861, Charleston, SC 29425, USA
    Addict Behav 32:3015-25. 2007
    ..Reactivity to cocaine cues was related to daily hassle sensitivity among women only. Limitations and implications of the findings are discussed...
  24. pmc Psychoticism and neuroticism predict cocaine dependence and future cocaine use via different mechanisms
    James J Prisciandaro
    Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, Clinical Neuroscience Division, Charleston, SC 29425, USA
    Drug Alcohol Depend 116:80-5. 2011
    ..e., impulsivity, neuroticism) and problematic cocaine use. Reactivity to a pharmacological stressor as a potential mediator of the relationship between neuroticism and future cocaine use was also examined...
  25. pmc Influence of cocaine dependence and early life stress on pituitary-adrenal axis responses to CRH and the Trier social stressor
    Megan M Moran-Santa Maria
    Department of Psychiatry and Behavioral Sciences, Clinical Neuroscience Division, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, United States
    Psychoneuroendocrinology 35:1492-500. 2010
    ....
  26. pmc Extinction of drug cue reactivity in methamphetamine-dependent individuals
    Kimber L Price
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, 29425, USA
    Behav Res Ther 48:860-5. 2010
    ..These results indicate that extinction of drug cue conditioned responding occurs in methamphetamine-dependent individuals, offering promise for the development of extinction- based treatment strategies...
  27. doi request reprint Determinants of cue-elicited craving and physiologic reactivity in methamphetamine-dependent subjects in the laboratory
    Bryan K Tolliver
    Division of Clinical Neuroscience, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Drug Alcohol Abuse 36:106-13. 2010
    ..In this study, clinical and demographic correlates of methamphetamine craving and the optimal conditions for its measurement in the laboratory are explored...
  28. pmc D-cycloserine and cocaine cue reactivity: preliminary findings
    Kimber L Price
    Medical University of South Carolina, Department of Psychiatry, Clinical Neuroscience Division, 67 President Street, Charleston, SC 29425, USA
    Am J Drug Alcohol Abuse 35:434-8. 2009
    ..D-cycloserine (DCS), a partial glutamate N-methyl-D-aspartic acid (NMDA) receptor agonist, enhances extinction of conditioned fear responding in rodents and facilitates exposure-based learning in humans with anxiety disorders...
  29. pmc Reactivity to laboratory stress provocation predicts relapse to cocaine
    Sudie E Back
    Medical University of South Carolina, Department of Psychiatry, Clinical Neuroscience Division, 67 President Street, MSC861, Charleston, SC 29425, United States
    Drug Alcohol Depend 106:21-7. 2010
    ..Elevated levels of stress have been associated with relapse to cocaine; however, the nature of this association is not well understood...
  30. pmc Relationship between child abuse and adult smoking
    Eve G Spratt
    Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Int J Psychiatry Med 39:417-26. 2009
    ..In this study, the relationship between severe childhood abuse and smoking were examined in a group of adults without significant psychopathology...
  31. ncbi request reprint Buspirone for treatment of marijuana dependence: a pilot study
    Aimee L McRae
    Am J Addict 15:404. 2006

Research Grants6

  1. Career Training in Marijuana Dependence
    Aimee McRae; Fiscal Year: 2006
    ..The primary outcome measure will be marijuana use as assessed by self-report and weekly urine drug screens. The results of this study will help guide future directions for research in the area of marijuana dependence. ..
  2. Atomoxetine Treatment for ADHD and Marijuana Dependence
    Aimee McRae Clark; Fiscal Year: 2006
    ..The project is designed to increase our knowledge of treatment options for patients with marijuana dependence, an area which has been under investigated. ..
  3. Stress and Marijuana Cue-Elicited Craving and Reactivity
    Aimee McRae; Fiscal Year: 2007
    ....
  4. Buspirone Treatment for Marijuana Dependence
    Aimee McRae Clark; Fiscal Year: 2009
    ....
  5. Buspirone Treatment for Marijuana Dependence
    Aimee L McRae Clark; Fiscal Year: 2010
    ....