Paul L McNeil

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. ncbi request reprint Repairing a torn cell surface: make way, lysosomes to the rescue
    Paul L McNeil
    Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30904, USA
    J Cell Sci 115:873-9. 2002
  2. ncbi request reprint An emergency response team for membrane repair
    Paul L McNeil
    Department of Anatomy and Cellular Biology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30921, USA
    Nat Rev Mol Cell Biol 6:499-505. 2005
  3. ncbi request reprint Plasma membrane disruption: repair, prevention, adaptation
    Paul L McNeil
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912, USA
    Annu Rev Cell Dev Biol 19:697-731. 2003
  4. pmc The endomembrane requirement for cell surface repair
    Paul L McNeil
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912, USA
    Proc Natl Acad Sci U S A 100:4592-7. 2003
  5. ncbi request reprint Cell surface events during resealing visualized by scanning-electron microscopy
    P L McNeil
    Department of Cellular Biology and Anatomy, and Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta 30912, USA
    Cell Tissue Res 304:141-6. 2001
  6. ncbi request reprint Coping with the inevitable: how cells repair a torn surface membrane
    P L McNeil
    Department of Cellular Biology and Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    Nat Cell Biol 3:E124-9. 2001
  7. ncbi request reprint Patching plasma membrane disruptions with cytoplasmic membrane
    P L McNeil
    Department of Cellular Biology and Anatomy, and Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, USA
    J Cell Sci 113:1891-902. 2000
  8. ncbi request reprint Mechanical injury and repair of cells
    Katsuya Miyake
    Department of Cellular Biology and Anatomy and the Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, 30912, USA
    Crit Care Med 31:S496-501. 2003
  9. pmc Promotion of plasma membrane repair by vitamin E
    Amber C Howard
    Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Nat Commun 2:597. 2011
  10. pmc Lectin-based food poisoning: a new mechanism of protein toxicity
    Katsuya Miyake
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia, United States of America
    PLoS ONE 2:e687. 2007

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Repairing a torn cell surface: make way, lysosomes to the rescue
    Paul L McNeil
    Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30904, USA
    J Cell Sci 115:873-9. 2002
    ..A myosin powered contraction occurring within this newly formed zone of F-actin then drives closure of the defect in a purse-string fashion...
  2. ncbi request reprint An emergency response team for membrane repair
    Paul L McNeil
    Department of Anatomy and Cellular Biology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30921, USA
    Nat Rev Mol Cell Biol 6:499-505. 2005
    ....
  3. ncbi request reprint Plasma membrane disruption: repair, prevention, adaptation
    Paul L McNeil
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912, USA
    Annu Rev Cell Dev Biol 19:697-731. 2003
    ..Prevention of disruption also can be a dynamic cell or tissue level adaptation triggered when a damaging level of mechanical stress is imposed. Disease results from failure of either the preventive or resealing mechanisms...
  4. pmc The endomembrane requirement for cell surface repair
    Paul L McNeil
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912, USA
    Proc Natl Acad Sci U S A 100:4592-7. 2003
    ..We conclude that rapid resealing is not mediated by simple physiochemical mechanisms; endomembrane is required...
  5. ncbi request reprint Cell surface events during resealing visualized by scanning-electron microscopy
    P L McNeil
    Department of Cellular Biology and Anatomy, and Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta 30912, USA
    Cell Tissue Res 304:141-6. 2001
    ..These observations provide strong confirmation that "patching" of large disruptions mediates their resealing...
  6. ncbi request reprint Coping with the inevitable: how cells repair a torn surface membrane
    P L McNeil
    Department of Cellular Biology and Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    Nat Cell Biol 3:E124-9. 2001
    ..Resealing is clearly a complex and dynamic cell adaptation, and, as we emphasize here, may be an evolutionarily primitive one that arose shortly after the ancestral eukaryote lost its protective cell wall...
  7. ncbi request reprint Patching plasma membrane disruptions with cytoplasmic membrane
    P L McNeil
    Department of Cellular Biology and Anatomy, and Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, USA
    J Cell Sci 113:1891-902. 2000
    ....
  8. ncbi request reprint Mechanical injury and repair of cells
    Katsuya Miyake
    Department of Cellular Biology and Anatomy and the Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, 30912, USA
    Crit Care Med 31:S496-501. 2003
    ..To concisely review the field of cell plasma membrane disruption (torn cell surface) and repair...
  9. pmc Promotion of plasma membrane repair by vitamin E
    Amber C Howard
    Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Nat Commun 2:597. 2011
    ..Our work suggests a novel biological function for vitamin E in promoting myocyte plasma membrane repair. We propose that this function is essential for maintenance of skeletal muscle homeostasis...
  10. pmc Lectin-based food poisoning: a new mechanism of protein toxicity
    Katsuya Miyake
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia, United States of America
    PLoS ONE 2:e687. 2007
    ..Lectins are known to inhibit exocytosis. We therefore tested the novel hypothesis that lectin toxicity is due to an inhibitory effect on plasma membrane repair...
  11. pmc A novel cellular defect in diabetes: membrane repair failure
    Amber C Howard
    Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, Georgia, USA
    Diabetes 60:3034-43. 2011
    ..One possible cause of myopathy is myocyte failure to repair contraction-generated plasma membrane injuries. Here, we test the hypothesis that diabetes induces a repair defect in skeletal muscle myocytes...
  12. ncbi request reprint Requirement for annexin A1 in plasma membrane repair
    Anna K McNeil
    Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Biol Chem 281:35202-7. 2006
    ..We propose that Ca2+ entering through a disruption locally induces annexin A1 binding to membranes, initiating emergency fusion events whenever and wherever required...
  13. ncbi request reprint Age-related loss of muscle mass and bone strength in mice is associated with a decline in physical activity and serum leptin
    Mark W Hamrick
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912, USA
    Bone 39:845-53. 2006
    ..Our data show that mice lose a significant amount of muscle and bone tissue with age, and this loss of musculoskeletal tissue is accompanied by a drop in serum leptin and preceded by a significant decrease in physical activity...
  14. ncbi request reprint Noise-induced transient microlesions in the cell membranes of auditory hair cells
    M J Mulroy
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta 30912 2000, USA
    Hear Res 115:93-100. 1998
    ..We propose that the Lucifer yellow entered the hair cells via noise-induced lesions in their cell membranes, and that the cells were able to survive and recover functionally...
  15. ncbi request reprint Antibody neutralization of vascular endothelial growth factor inhibits wound granulation tissue formation
    T R Howdieshell
    Department of Surgery, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Surg Res 96:173-82. 2001
    ....
  16. pmc Role of muscle-derived growth factors in bone formation
    M W Hamrick
    Department of Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, GA, USA
    J Musculoskelet Neuronal Interact 10:64-70. 2010
    ..Hence, the integrated growth and development of bone and muscle is likely to be regulated in part by paracrine mechanisms at the muscle-bone interface involving growth factor signaling...
  17. ncbi request reprint Cell wound assays
    P L McNeil
    Medical College of Georgia, Augusta, Georgia, USA
    Curr Protoc Cell Biol . 2001
    ..This unit describes methods for identifying "wounded" cells, often present as a minority in culture or tissues. The use of these methods can provide information about the frequency and extent of cellular wounding...
  18. ncbi request reprint An actin barrier to resealing
    K Miyake
    Second Department of Anatomy, School of Medicine, Fukushima Medical University, Fukushima 960 1295, Japan
    J Cell Sci 114:3487-94. 2001
    ..We conclude that localized filamentous actin disassembly removes a cortical barrier standing in the way of membrane-membrane contacts leading to resealing-requisite homotypic and exocytotic fusion events...
  19. ncbi request reprint Increased osteogenic response to exercise in metaphyseal versus diaphyseal cortical bone
    M W Hamrick
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912, USA
    J Musculoskelet Neuronal Interact 6:258-63. 2006
    ....
  20. ncbi request reprint Yolk granule tethering: a role in cell resealing and identification of several protein components
    Anna McNeil
    Department of Cellular Biology and Anatomy, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
    J Cell Sci 118:4701-8. 2005
    ..We have, moreover, identified several proteins that may be critical to this tethering mechanism...
  21. pmc Cell wounding activates phospholipase D in primary mouse keratinocytes
    Senthil N Arun
    Charlie Norwood VA Medical Center, Augusta, GA 30904, USA
    J Lipid Res 54:581-91. 2013
    ..In an in vivo full-thickness mouse skin wound model, PG accelerated wound healing. These results suggest that PLD and the PLD2/AQP3 signaling module may be involved in membrane repair and wound healing...
  22. ncbi request reprint Breaking biological barriers with a toothbrush
    K Amano
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912 2000, USA
    J Dent Res 86:769-74. 2007
    ..We concluded that brushing disrupts cell plasma membrane barriers in the oral cavity and activates gene expression events that may lead to local adaptive changes in tissue architecture beneficial to gingival health...
  23. pmc Disruption-induced mucus secretion: repair and protection
    K Miyake
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia, United States of America
    PLoS Biol 4:e276. 2006
    ..This mode of mechanotransduction can, we propose, explain how lubrication in the gastrointestinal tract is rapidly and precisely adjusted to widely fluctuating, diet-dependent levels of mechanical stress...
  24. pmc The role of N-methyl-D-aspartate receptor activation in homocysteine-induced death of retinal ganglion cells
    Preethi S Ganapathy
    Department of Cellular Biology and Anatomy, Georgia Health Sciences, University, Medical College of Georgia, Augusta, GA, USA
    Invest Ophthalmol Vis Sci 52:5515-24. 2011
    ..This study examined the role of the NMDA receptor in homocysteine-mediated ganglion cell death...
  25. ncbi request reprint Direct introduction of molecules into cells
    P L McNeil
    Medical College of Georgia, Augusta, Georgia, USA
    Curr Protoc Cell Biol . 2001
    ....
  26. ncbi request reprint Defective membrane repair in dysferlin-deficient muscular dystrophy
    Dimple Bansal
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    Nature 423:168-72. 2003
    ..Our findings show that disruption of the muscle membrane repair machinery is responsible for dysferlin-deficient muscle degeneration, and highlight the importance of this basic cellular mechanism of membrane resealing in human disease...
  27. pmc The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing
    Jan Cerny
    Department of Cell Biology and The CBR Institute for Biomedical Research, Harvard Medical School, Boston, Massachusetts 02115, USA
    EMBO Rep 5:883-8. 2004
    ..Because cells heal normally in the presence of vacuolin-1, we suggest that lysosomes are dispensable for resealing...
  28. ncbi request reprint Calpain is required for the rapid, calcium-dependent repair of wounded plasma membrane
    Ronald L Mellgren
    Department of Physiology, Pharmacology, Metabolism, and Cardiovascular Sciences, University of Toledo College of Medicine, Toledo, Ohio 43614, USA
    J Biol Chem 282:2567-75. 2007
    ..The results indicate that conventional calpains are required for calcium-facilitated survival after plasma membrane damage and may act by localized remodeling of the cortical cytoskeleton at the injury site...
  29. ncbi request reprint Patients with a non-dysferlin Miyoshi myopathy have a novel membrane repair defect
    Jyoti K Jaiswal
    The Rockefeller University, Box 304, 1230 York Avenue, New York, NY 10021, USA
    Traffic 8:77-88. 2007
    ....
  30. ncbi request reprint Cell suffering and its prevention in lung
    Paul L McNeil
    Am J Respir Crit Care Med 167:1046-7. 2003
  31. ncbi request reprint Acinar cell membrane disruption is an early event in experimental acute pancreatitis in rats
    Michael W Müller
    Department of Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Pancreas 35:e30-40. 2007
    ..To test the hypothesis that disruption of acinar cell membranes is the earliest event that takes place after the onset of acute pancreatitis...
  32. ncbi request reprint Local arginine supplementation results in sustained wound nitric oxide production and reductions in vascular endothelial growth factor expression and granulation tissue formation
    Daithi Heffernan
    Department of Surgery, University of New Mexico HSC, Albuquerque, New Mexico 87131 0001, USA
    J Surg Res 133:46-54. 2006
    ..The goal of this work was to test the functional role of L-arginine in promotion of nitric oxide (NO) production and the vigorous granulation tissue formation characteristic of this wound model...
  33. pmc Dysferlin-mediated membrane repair protects the heart from stress-induced left ventricular injury
    Renzhi Han
    Howard Hughes Medical Institute, The University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    J Clin Invest 117:1805-13. 2007
    ..Thus, our study establishes what we believe is a novel mechanism underlying the cardiomyopathy that results from a defective membrane repair in the absence of dysferlin...