David Mattson

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Substitution of chromosome 1 ameliorates L-NAME hypertension and renal disease in the fawn-hooded hypertensive rat
    David L Mattson
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 288:F1015-22. 2005
  2. ncbi request reprint Dietary protein source determines the degree of hypertension and renal disease in the Dahl salt-sensitive rat
    David L Mattson
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 45:736-41. 2005
  3. doi request reprint Immune suppression blocks sodium-sensitive hypertension following recovery from ischemic acute renal failure
    Kimberly R Pechman
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1234-9. 2008
  4. pmc Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease
    David L Mattson
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 295:F837-42. 2008
  5. pmc CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney
    Nathan Rudemiller
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226
    Hypertension 63:559-64. 2014
  6. pmc Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damage
    David L Mattson
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Regul Integr Comp Physiol 304:R407-14. 2013
  7. ncbi request reprint Renal cortical and medullary blood flow responses to L-NAME and ANG II in wild-type, nNOS null mutant, and eNOS null mutant mice
    David L Mattson
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Regul Integr Comp Physiol 289:R991-7. 2005
  8. ncbi request reprint Sodium sensitivity of arterial blood pressure in L-NAME hypertensive but not eNOS knockout mice
    David L Mattson
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Hypertens 19:327-9. 2006
  9. ncbi request reprint Immune suppression attenuates hypertension and renal disease in the Dahl salt-sensitive rat
    David L Mattson
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 48:149-56. 2006
  10. ncbi request reprint Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats
    David L Mattson
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 293:F1905-14. 2007

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Substitution of chromosome 1 ameliorates L-NAME hypertension and renal disease in the fawn-hooded hypertensive rat
    David L Mattson
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 288:F1015-22. 2005
    ..Qualitatively similar results were obtained from female FHH, FHH-1BN, and BN rats. The present results indicate that genes contributing to l-NAME-induced hypertension and renal disease are found on chromosome 1 of the FHH rat...
  2. ncbi request reprint Dietary protein source determines the degree of hypertension and renal disease in the Dahl salt-sensitive rat
    David L Mattson
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 45:736-41. 2005
    ..The results of the present study indicate that dietary components other than sodium play an important role in the development of hypertension and renal disease in the Dahl SS/Mcw rat...
  3. doi request reprint Immune suppression blocks sodium-sensitive hypertension following recovery from ischemic acute renal failure
    Kimberly R Pechman
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1234-9. 2008
    ..The present data indicate that infiltrating immune cells mediate or participate in the development of sodium-sensitive hypertension and renal damage in rats apparently recovered from renal I/R injury...
  4. pmc Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease
    David L Mattson
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 295:F837-42. 2008
    ..Furthermore, this consomic rat panel provides a stable genetic platform that can facilitate further gene mapping by either linkage studies or the breeding of congenic and subcongenic rats...
  5. pmc CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney
    Nathan Rudemiller
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226
    Hypertension 63:559-64. 2014
    ....
  6. pmc Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damage
    David L Mattson
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Regul Integr Comp Physiol 304:R407-14. 2013
    ..These studies demonstrate the importance of renal infiltration of immune cells in the pathogenesis of hypertension and renal damage in Dahl SS rats...
  7. ncbi request reprint Renal cortical and medullary blood flow responses to L-NAME and ANG II in wild-type, nNOS null mutant, and eNOS null mutant mice
    David L Mattson
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Regul Integr Comp Physiol 289:R991-7. 2005
    ..These data demonstrate that NO from eNOS regulates baseline blood flow in the mouse renal cortex and medulla, while NO produced by nNOS mediates an increase in medullary blood flow in response to ANG II...
  8. ncbi request reprint Sodium sensitivity of arterial blood pressure in L-NAME hypertensive but not eNOS knockout mice
    David L Mattson
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Hypertens 19:327-9. 2006
    ..Therefore, nitric oxide produced by eNOS does not appear to be important in the physiologic adaptation to elevated sodium chloride intake...
  9. ncbi request reprint Immune suppression attenuates hypertension and renal disease in the Dahl salt-sensitive rat
    David L Mattson
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 48:149-56. 2006
    ..These experiments indicate that the activation of the immune system or renal infiltration of immune cells plays an important role in the development of hypertension and renal disease in Dahl SS/Mcw rats consuming an elevated NaCl diet...
  10. ncbi request reprint Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats
    David L Mattson
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 293:F1905-14. 2007
    ..The present data indicate that genes that can modify l-NAME-induced hypertension and proteinuria are on chromosomes 1, 15, 16, 18, and 20...
  11. pmc High dietary protein exacerbates hypertension and renal damage in Dahl SS rats by increasing infiltrating immune cells in the kidney
    Carmen De Miguel
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 57:269-74. 2011
    ..Moreover, the results show that hypertension in Dahl SS rats is sensitive to both NaCl and protein intake...
  12. ncbi request reprint Influence of diet and genetics on hypertension and renal disease in Dahl salt-sensitive rats
    David L Mattson
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 16:194-203. 2004
    ..These data demonstrate a significant influence of diet composition on salt-induced hypertension and renal disease in the Dahl SS/Mcw rat...
  13. ncbi request reprint Chronic sodium balance and blood pressure response to captopril in conscious mice
    D L Mattson
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 32:923-8. 1998
    ..The experiments also indicate that converting enzyme inhibition has a potent influence to lower blood pressure in normal mice; the hypotensive response appears to be due in part to increased urinary sodium excretion...
  14. ncbi request reprint Nitric oxide synthase activity and isoforms in rat renal vasculature
    D L Mattson
    Department of Physiology, Medical College of Wisconsin, MI 53226, USA
    Hypertension 35:337-41. 2000
    ..The present experiments indicate that the vasa recta, glomeruli, and afferent arterioles contain large amounts of calcium-dependent NOS enzymatic activity and that neuronal NOS and endothelial NOS mRNA are present in these segments...
  15. ncbi request reprint Comparison of arterial blood pressure in different strains of mice
    D L Mattson
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226 0509, USA
    Am J Hypertens 14:405-8. 2001
    ..These studies demonstrate similar levels of resting arterial pressure in different mouse strains under baseline conditions...
  16. ncbi request reprint Importance of the renal medullary circulation in the control of sodium excretion and blood pressure
    David L Mattson
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 284:R13-27. 2003
    ....
  17. ncbi request reprint Recovery from acute renal failure predisposes hypertension and secondary renal disease in response to elevated sodium
    Kimberly R Spurgeon-Pechman
    Dept of Physiology, Medical College of Wisconsin, Milwaukee, USA
    Am J Physiol Renal Physiol 293:F269-78. 2007
    ..These data suggest that the recovery from acute I/R injury is not complete, compromises Na homeostasis, and predisposes hypertension and secondary renal disease...
  18. pmc Recovery from renal ischemia-reperfusion injury is associated with altered renal hemodynamics, blunted pressure natriuresis, and sodium-sensitive hypertension
    Kimberly R Pechman
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1358-63. 2009
    ..The present data indicate that the pressure-natriuretic-diuretic response in I/R rats is blunted because of a decrease in GFR and RBF and the depressed pressure-dependent increase in medullary blood flow and interstitial pressure...
  19. pmc T lymphocytes mediate hypertension and kidney damage in Dahl salt-sensitive rats
    Carmen De Miguel
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1136-42. 2010
    ..The suppression of T-cell infiltration decreased intrarenal ANG II and prevented Dahl SS hypertension and kidney damage. As such, infiltrating cells are capable of participating in the established phase of Dahl SS hypertension...
  20. pmc Exogenous L-arginine ameliorates angiotensin II-induced hypertension and renal damage in rats
    Niwanthi W Rajapakse
    Department of Physiology, Medical College of Wisconsin, Milwaukee, USA
    Hypertension 52:1084-90. 2008
    ..This latter observation is most exciting because it indicates that increasing NO bioavailability, in addition to lowering arterial pressure, can greatly reduce hypertension-induced renal damage...
  21. ncbi request reprint Influence of elevated renin substrate on angiotensin II and arterial blood pressure in conscious mice
    Brian C Cholewa
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, PO Box 26509, Milwaukee, WI 53226 0509, USA
    Exp Physiol 90:607-12. 2005
    ..These results demonstrate that modulation of the circulating level of angiotensinogen can alter the plasma angiotensin II level and arterial blood pressure in normal animals...
  22. ncbi request reprint Chronic renal hypoxia after acute ischemic injury: effects of L-arginine on hypoxia and secondary damage
    David P Basile
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Renal Physiol 284:F338-48. 2003
    ..These data suggest that a reduction in the peritubular capillary density after ARF results in a persistent reduction in renal Po(2) and that hypoxia may play an important role in progression of chronic renal disease after ARF...
  23. ncbi request reprint Influence of dietary NaCl on L-arginine transport in the renal medulla
    Tewabech Zewde
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Regul Integr Comp Physiol 286:R89-93. 2004
    ..The decrease in l-arginine uptake capacity, however, does not alter the blood pressure response to l-arginine uptake inhibition in the renal medulla...
  24. ncbi request reprint BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat
    Anne E Kwitek
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 25:303-13. 2006
    ..These data provide a baseline for physiological comparison of traits related to cardiovascular, lung, blood, and renal function in the sequenced BN rats relative to the major strains of rats studied in biomedical research...
  25. ncbi request reprint Role of renal NO production in the regulation of medullary blood flow
    Allen W Cowley
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1355-69. 2003
    ..It is concluded that NO production in the renal medulla plays a very important role in sodium and water homeostasis and the long-term control of arterial pressure...
  26. ncbi request reprint Inhibition of cyclooxygenase-2 in the rat renal medulla leads to sodium-sensitive hypertension
    Tewabech Zewde
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Hypertension 44:424-8. 2004
    ..These results demonstrate the importance of cyclooxygenase-2 in the renal medulla in maintaining blood pressure during high-salt intake...
  27. ncbi request reprint Cationic amino acid transport in the renal medulla and blood pressure regulation
    Masao Kakoki
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Hypertension 39:287-92. 2002
    ..These results suggest that uptake of L-arginine by cationic amino acid transport systems in the renal medulla plays an important role in the regulation of medullary NO and MAP in rats...
  28. pmc Infiltrating T lymphocytes in the kidney increase oxidative stress and participate in the development of hypertension and renal disease
    Carmen De Miguel
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Physiol Renal Physiol 300:F734-42. 2011
    ..These experiments indicate that blockade of infiltrating immune cells is associated with decreased oxidative stress, an attenuation of hypertension, and a reduction of renal damage in Dahl SS rats fed high salt...
  29. pmc The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans
    Kazuyoshi Toyama
    Department of Medicine and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Clin Invest 118:3025-37. 2008
    ..These data suggest that KCa3.1 blockers represent a promising therapeutic strategy for atherosclerosis...
  30. ncbi request reprint Endothelial cell PECAM-1 confers protection against endotoxic shock
    Matthias Maas
    Blood Research Institute, Blood Center of Southeastern Wisconsin, PO Box 2178, 638 N 18th St, Milwaukee, WI 53201, USA
    Am J Physiol Heart Circ Physiol 288:H159-64. 2005
    ..The diverse functional roles played by PECAM-1 in thrombosis, inflammation, apoptosis, and the immune response may make this molecule an attractive target for the development of novel therapeutics to manage and treat endotoxic shock...
  31. doi request reprint Measuring kidney function in conscious mice
    David L Mattson
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA
    Methods Mol Biol 573:75-94. 2009
    ..As such, this in vivo preparation provides an assessment of physiological function in mice in their native state...
  32. ncbi request reprint L-Arginine uptake affects nitric oxide production and blood flow in the renal medulla
    Masao Kakoki
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, USA
    Am J Physiol Regul Integr Comp Physiol 287:R1478-85. 2004
    ..These results suggest that L-arginine transport by cationic amino acid transport mechanisms is important in the production of NO and maintenance of blood flow in the renal medulla...
  33. ncbi request reprint Amino acids as modulators of endothelium-derived nitric oxide
    Masao Kakoki
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, USA
    Am J Physiol Renal Physiol 291:F297-304. 2006
    ..Thus the present experiments demonstrate that cationic and neutral amino acids can modulate NO production in endothelial cells by altering cellular l-arginine transport through y(+) and y(+)L transport mechanisms...
  34. ncbi request reprint Renal medullary nitric oxide deficit of Dahl S rats enhances hypertensive actions of angiotensin II
    Mátyás Szentiványi
    Clinical Research Department, 2nd Institute of Physiology, Semmelweis University of Medicine, H 1088 Budapest, Hungary
    Am J Physiol Regul Integr Comp Physiol 283:R266-72. 2002
    ..These results indicate that an impaired NO counterregulatory system in the outer medulla of Dahl S rats makes them more susceptible to the hypertensive actions of small elevations of ANG II...
  35. ncbi request reprint Role of nitric oxide in regulation of the renal medulla in normal and hypertensive kidneys
    Thomas L Pallone
    Department of Medicine, Nephrology Division, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Curr Opin Nephrol Hypertens 11:93-8. 2002
    ..The likelihood that some forms of hypertension result directly from pathological alteration of transporters, channels, regulatory elements or enzymes that affect medullary nitric oxide seems high...

Research Grants13

  1. Arginine Uptake Mechanisms Regulate Nitric Oxide in the Renal Vasculature
    David Mattson; Fiscal Year: 2009
    ..The results of these studies may provide important insight into the causes of hypertension and vascular-related complications that are a leading cause of death and morbidity in the US. ..
  2. Arginine Uptake Mechanisms Regulate Nitric Oxide in the Renal Vasculature
    David Mattson; Fiscal Year: 2007
    ..The results of these studies may provide important insight into the causes of hypertension and vascular-related complications that are a leading cause of death and morbidity in the US. ..
  3. Arterial Blood Pressure in eNOS Knockout Mice
    David Mattson; Fiscal Year: 2006
    ..Moreover, the results of these studies may also provide important insight into the causes of hypertension and hypertension-related complications that are a leading cause of death and morbidity in the US. ..
  4. Arterial Blood Pressure in eNOS Knockout Mice
    David Mattson; Fiscal Year: 2005
    ..Moreover, the results of these studies may also provide important insight into the causes of hypertension and hypertension-related complications that are a leading cause of death and morbidity in the US. ..
  5. Arterial Blood Pressure in eNOS Knockout Mice
    David Mattson; Fiscal Year: 2004
    ..Moreover, the results of these studies may also provide important insight into the causes of hypertension and hypertension-related complications that are a leading cause of death and morbidity in the US. ..
  6. Arterial Blood Pressure in eNOS Knockout Mice
    David Mattson; Fiscal Year: 2003
    ..Moreover, the results of these studies may also provide important insight into the causes of hypertension and hypertension-related complications that are a leading cause of death and morbidity in the US. ..
  7. RENAL MEDULLARY NITRIC OXIDE AND BLOOD PRESSURE
    David Mattson; Fiscal Year: 2001
    ....
  8. RENAL MEDULLARY NITRIC OXIDE AND BLOOD PRESSURE
    David Mattson; Fiscal Year: 2000
    ....
  9. RENAL MEDULLARY NITRIC OXIDE AND BLOOD PRESSURE
    David Mattson; Fiscal Year: 1999
    ....
  10. Arginine Uptake Mechanisms Regulate Nitric Oxide in the Renal Vasculature
    David L Mattson; Fiscal Year: 2010
    ..The results of these studies may provide important insight into the causes of hypertension and vascular-related complications that are a leading cause of death and morbidity in the US. ..