J S Markowitz

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. ncbi Advances in the pharmacotherapy of attention-deficit-hyperactivity disorder: focus on methylphenidate formulations
    John S Markowitz
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425 0742, USA
    Pharmacotherapy 23:1281-99. 2003
  2. ncbi Drug interactions with psychostimulants
    J S Markowitz
    The Institute of Psychiatry, Medical University of South Carolina, Charleston 29425 0742, USA
    Int Clin Psychopharmacol 14:1-18. 1999
  3. doi Predicting interactions between conventional medications and botanical products on the basis of in vitro investigations
    John S Markowitz
    Department of Psychiatry and Behavioral Sciences, Center for Medication Safety, Charles P Darby Children s Research Institute, Medical University of South Carolina, Charleston, SC 29425, USA
    Mol Nutr Food Res 52:747-54. 2008
  4. ncbi The effects of probenecid on the disposition of risperidone and olanzapine in healthy volunteers
    John S Markowitz
    Department of Pharmaceutical Sciences, Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, Charleston, SC 29425, USA
    Clin Pharmacol Ther 71:30-8. 2002
  5. doi Given the multifaceted nature of ADHD, namely its physiologic, cognitive, psychological, and behavioral manifestations, multimodal approaches to treatment are advocated. Introduction
    John S Markowitz
    Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Psychopharmacol 28:S37-8. 2008
  6. ncbi Effect of Ginkgo biloba extract on plasma steroid concentrations in healthy volunteers: a pilot study
    John S Markowitz
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Children s Research Institute, Charleston, South Carolina 29425, USA
    Pharmacotherapy 25:1337-40. 2005
  7. ncbi Pharmacokinetics of methylphenidate after oral administration of two modified-release formulations in healthy adults
    John S Markowitz
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425 0742, USA
    Clin Pharmacokinet 42:393-401. 2003
  8. ncbi Multiple doses of saw palmetto (Serenoa repens) did not alter cytochrome P450 2D6 and 3A4 activity in normal volunteers
    John S Markowitz
    Medical University of South Carolina, Institute of Psychiatry, RM 246 North, Laboratory of Drug Disposition and Pharmacogenetics, 67 President St, Charleston, SC 29425, USA
    Clin Pharmacol Ther 74:536-42. 2003
  9. ncbi Multiple-dose administration of Ginkgo biloba did not affect cytochrome P-450 2D6 or 3A4 activity in normal volunteers
    John S Markowitz
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Rm 246, North Laboratory of Drug Disposition and Pharmacogenetics, 67 President Street, Charleston, SC 29425, USA
    J Clin Psychopharmacol 23:576-81. 2003
  10. ncbi Intranasal sumatriptan in post-ECT headache: results of an open-label trial
    J S Markowitz
    The Institute of Psychiatry, Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425 0742, USA
    J ECT 17:280-3. 2001

Research Grants

  1. Screening Herbs for Drug Interactions
    JOHN MARKOWITZ; Fiscal Year: 2002
  2. Ginkgo biloba for ECT-induced Memory Deficits
    JOHN MARKOWITZ; Fiscal Year: 2003
  3. P-Glycoprotein and Disposition of Psychostimulants
    JOHN MARKOWITZ; Fiscal Year: 2005
  4. Drug Transporters and the Disposition of ADHD Therapeutic Agents
    JOHN MARKOWITZ; Fiscal Year: 2007

Collaborators

Detail Information

Publications69

  1. ncbi Advances in the pharmacotherapy of attention-deficit-hyperactivity disorder: focus on methylphenidate formulations
    John S Markowitz
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425 0742, USA
    Pharmacotherapy 23:1281-99. 2003
    ..This notwithstanding, a single-isomer d-MPH immediate-release product is now available for dosing recommended at one-half that of dl-MPH...
  2. ncbi Drug interactions with psychostimulants
    J S Markowitz
    The Institute of Psychiatry, Medical University of South Carolina, Charleston 29425 0742, USA
    Int Clin Psychopharmacol 14:1-18. 1999
    ..The published data support the safe use of psychostimulants with most classes of medications with few absolute contraindications...
  3. doi Predicting interactions between conventional medications and botanical products on the basis of in vitro investigations
    John S Markowitz
    Department of Psychiatry and Behavioral Sciences, Center for Medication Safety, Charles P Darby Children s Research Institute, Medical University of South Carolina, Charleston, SC 29425, USA
    Mol Nutr Food Res 52:747-54. 2008
    ..This mini-review is intended to address the particular problems and challenges in evaluating botanical supplements using in vitro methods, and review what can and cannot be learned from such investigations...
  4. ncbi The effects of probenecid on the disposition of risperidone and olanzapine in healthy volunteers
    John S Markowitz
    Department of Pharmaceutical Sciences, Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, Charleston, SC 29425, USA
    Clin Pharmacol Ther 71:30-8. 2002
    ..We hypothesized that olanzapine disposition would be altered as a result of decreased glucuronidation, whereas risperidone disposition would be relatively unaffected...
  5. doi Given the multifaceted nature of ADHD, namely its physiologic, cognitive, psychological, and behavioral manifestations, multimodal approaches to treatment are advocated. Introduction
    John S Markowitz
    Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Psychopharmacol 28:S37-8. 2008
  6. ncbi Effect of Ginkgo biloba extract on plasma steroid concentrations in healthy volunteers: a pilot study
    John S Markowitz
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Children s Research Institute, Charleston, South Carolina 29425, USA
    Pharmacotherapy 25:1337-40. 2005
    ..To determine if a standardized ginkgo supplement significantly alters concentrations of circulating androgenic steroids in humans...
  7. ncbi Pharmacokinetics of methylphenidate after oral administration of two modified-release formulations in healthy adults
    John S Markowitz
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425 0742, USA
    Clin Pharmacokinet 42:393-401. 2003
    ..To compare the rate and extent of absorption of DL-threo-methylphenidate (MPH) from two modified-release MPH formulations at their respective recommended starting doses in healthy adult volunteers...
  8. ncbi Multiple doses of saw palmetto (Serenoa repens) did not alter cytochrome P450 2D6 and 3A4 activity in normal volunteers
    John S Markowitz
    Medical University of South Carolina, Institute of Psychiatry, RM 246 North, Laboratory of Drug Disposition and Pharmacogenetics, 67 President St, Charleston, SC 29425, USA
    Clin Pharmacol Ther 74:536-42. 2003
    ..These conclusions must be weighed in the context of the study's limited assessments and regarded as only the initial investigation into the drug interaction potential of saw palmetto...
  9. ncbi Multiple-dose administration of Ginkgo biloba did not affect cytochrome P-450 2D6 or 3A4 activity in normal volunteers
    John S Markowitz
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Rm 246, North Laboratory of Drug Disposition and Pharmacogenetics, 67 President Street, Charleston, SC 29425, USA
    J Clin Psychopharmacol 23:576-81. 2003
    ..We conclude that standardized extracts of GB at recommended doses are unlikely to significantly alter the disposition of co-administered medications primarily dependent on the CYP2D6 or CYP3A4 pathways for elimination...
  10. ncbi Intranasal sumatriptan in post-ECT headache: results of an open-label trial
    J S Markowitz
    The Institute of Psychiatry, Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425 0742, USA
    J ECT 17:280-3. 2001
    ..The aim of the present open-label study was to assess the efficacy and tolerability of intranasal sumatriptan for post-ECT headache...
  11. ncbi Pharmacokinetic and pharmacodynamic drug interactions in the treatment of attention-deficit hyperactivity disorder
    J S Markowitz
    Institute of Psychiatry, Medical University of South Carolina, Department of Pharmaceutical Sciences, Charleston 29425 0742, USA
    Clin Pharmacokinet 40:753-72. 2001
    ..The interactions of monoamine oxidase inhibitors with psychostimulants represent one of the few strict contraindications...
  12. ncbi Effect of St. John's wort (Hypericum perforatum) on cytochrome P-450 2D6 and 3A4 activity in healthy volunteers
    J S Markowitz
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston 29425, USA
    Life Sci 66:PL133-9. 2000
    ..These results suggest that St. John's wort, when taken at recommended doses for depression, is unlikely to inhibit CYP 2D6 or CYP 3A4 activity...
  13. ncbi Ethylphenidate formation in human subjects after the administration of a single dose of methylphenidate and ethanol
    J S Markowitz
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina, USA
    Drug Metab Dispos 28:620-4. 2000
    ..g., in the abuse of methylphenidate and ethanol, the metabolite ethylphenidate may contribute to drug effects...
  14. ncbi Oral nutritional supplementation for the alcoholic patient: a brief overview
    J S Markowitz
    Department of Pharmaceutical Sciences, Institute of Psychiatry, Medical University of South Carolina, Charleston 29425, USA
    Ann Clin Psychiatry 12:153-8. 2000
    ..The present paper reviews basic nutrient deficits commonly encountered in alcoholic individuals and describes the rationale and basic guidelines for oral replacement therapy...
  15. ncbi The psychostimulant d-threo-(R,R)-methylphenidate binds as an agonist to the 5HT(1A) receptor
    J S Markowitz
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Pharmaceutical and Biomedical Sciences, Charles P Darby Children s Research Institute, Rm 412, Medical University of South Carolina, Charleston, SC 29425, USA
    Pharmazie 64:123-5. 2009
    ..It is speculated that the activation of 5-HT(1A) receptor might play a partial role in d-threo-(R,R)-MPH mediated dopamine (DA) release in the brain...
  16. ncbi Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme
    John S Markowitz
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Institute of Psychiatry, Charleston 29425, USA
    JAMA 290:1500-4. 2003
    ..St John's wort is a popular herbal product used to treat depression but it has been implicated in drug interactions...
  17. doi Differential pharmacokinetics and pharmacodynamics of methylphenidate enantiomers: does chirality matter?
    John S Markowitz
    Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Psychopharmacol 28:S54-61. 2008
    ..Taken together, data from in vitro, animal, and human studies support the premise that the d-enantiomer of MPH mediates the neurophysiological actions of MPH and therefore likely mediates its clinical efficacy...
  18. ncbi Single-dose pharmacokinetics of methylphenidate in CYP2D6 extensive and poor metabolizers
    C L DeVane
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425, USA
    J Clin Psychopharmacol 20:347-9. 2000
    ..These data suggest a lack of involvement of CYP2D6 in the metabolism of MPH. Drugs that are inhibitors of CYP2D6 when taken concurrently with MPH should not affect its plasma concentration...
  19. ncbi Effects of St John's wort (Hypericum perforatum L.) extract on plasma androgen concentrations in healthy men and women: a pilot study
    Jennifer L Donovan
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, North Charleston, SC 29425, USA
    Phytother Res 19:901-6. 2005
    ....
  20. ncbi A double-blind placebo-controlled case study of the use of donepezil to improve cognition in a schizoaffective disorder patient: functional MRI correlates
    S C Risch
    Institute of Psychiatry, Medical University of South Carolina, 67 President Street, Room 502N, PO Box 250861, Charleston, SC 29425, USA
    Neurocase 7:105-10. 2001
    ..Further studies of donepezil augmentation of neuroleptics in schizophrenia are warranted...
  21. pmc Interactions of attention-deficit/hyperactivity disorder therapeutic agents with the efflux transporter P-glycoprotein
    Hao Jie Zhu
    Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, USA
    Eur J Pharmacol 578:148-58. 2008
    ..Furthermore, P-glycoprotein may play a minor role in the transport of d-methylphenidate, d-modafinil, and l-modafinil...
  22. pmc Influence of ethanol and gender on methylphenidate pharmacokinetics and pharmacodynamics
    K S Patrick
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina, USA
    Clin Pharmacol Ther 81:346-53. 2007
    ..The more pronounced stimulant effects experienced by women have sex-based abuse liability implications...
  23. ncbi Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers
    Jennifer L Donovan
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Drug Metab Dispos 32:1333-6. 2004
    ....
  24. ncbi Green tea (Camellia sinensis) extract does not alter cytochrome p450 3A4 or 2D6 activity in healthy volunteers
    Jennifer L Donovan
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425, USA
    Drug Metab Dispos 32:906-8. 2004
    ..3 +/- 1.8 microM 2 h after DGT treatment. Our results indicate that DGT is unlikely to alter the disposition of medications primarily dependent on the CYP2D6 or CYP3A4 pathways of metabolism...
  25. ncbi Drug glucuronidation in clinical psychopharmacology
    H L Liston
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, USA
    J Clin Psychopharmacol 21:500-15. 2001
    ..This review summarizes the relevant literature pertaining to drug glucuronidation and its implications for clinical psychopharmacology...
  26. ncbi Risperidone and paliperidone inhibit p-glycoprotein activity in vitro
    Hao Jie Zhu
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, SC, USA
    Neuropsychopharmacology 32:757-64. 2007
    ..In particular, RSP may interact with its own active metabolite PALI by promoting its brain concentration through inhibiting P-gp-mediated efflux of PALI across endothelial cells of the BBB...
  27. ncbi Siberian ginseng (Eleutheroccus senticosus) effects on CYP2D6 and CYP3A4 activity in normal volunteers
    Jennifer L Donovan
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Drug Metab Dispos 31:519-22. 2003
    ....
  28. ncbi A high-performance liquid chromatography assay with ultraviolet detection for olanzapine in human plasma and urine
    D W Boulton
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425, USA
    J Chromatogr B Biomed Sci Appl 759:319-23. 2001
    ..This method is suitable for studying olanzapine disposition in single or multiple-dose pharmacokinetic studies...
  29. pmc Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis
    Hao Jie Zhu
    Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Hum Genet 82:1241-8. 2008
    ..Asp260fs, respectively, compared to the wild-type enzyme. These findings indicate that specific CES1 gene variants can lead to clinically significant alterations in pharmacokinetics and drug response of carboxylesterase 1 substrates...
  30. ncbi Effects of garlic (Allium sativum L.) supplementation on cytochrome P450 2D6 and 3A4 activity in healthy volunteers
    John S Markowitz
    Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, Charleston, SC 29425, USA
    Clin Pharmacol Ther 74:170-7. 2003
    ..7 +/- 4.4 h versus 14.5 +/- 4.3 h). Our results indicate that garlic extracts are unlikely to alter the disposition of coadministered medications primarily dependent on the CYP2D6 or CYP3A4 pathway of metabolism...
  31. ncbi In vitro P-glycoprotein affinity for atypical and conventional antipsychotics
    David W Boulton
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, PO Box 250861, Charleston, SC 29425, USA
    Life Sci 71:163-9. 2002
    ..These results suggest that P-gp is likely to influence the access to the brain of all of the atypical antipsychotics studied to various degrees. In vivo studies are needed to confirm these findings...
  32. ncbi Population pharmacokinetic analysis of drug-drug interactions among risperidone, bupropion, and sertraline in CF1 mice
    Jun Sheng Wang
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 183:490-9. 2006
    ..Accumulating evidence indicates that modulation of the activity of cytochrome P450 (CYP) enzymes and the multidrug resistance transporter P-glycoprotein (P-gp) is responsible for many drug-drug interactions...
  33. ncbi Charleston Antidepressant Drug Interactions Surveillance Program (CADISP)
    C L DeVane
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425 0742, USA
    Psychopharmacol Bull 35:50-61. 2001
    ..These data do not eliminate the need for caution when prescribing antidepressants with the potential for causing metabolic interactions, but do help allay the fear that such interactions are highly prevalent and routinely hazardous...
  34. ncbi The emerging recognition of herb-drug interactions with a focus on St. John's wort (Hypericum perforatum)
    J S Markowitz
    Department of Pharmaceutical Sciences, College of Pharmacy, Medical University of South Carolina, Charleston, SC, USA
    Psychopharmacol Bull 35:53-64. 2001
    ..Concomitant use of herbal agents and conventional medications should generally be discouraged until further information is available. Additional research is urgently needed in this area...
  35. ncbi Pharmacokinetics of olanzapine after single-dose oral administration of standard tablet versus normal and sublingual administration of an orally disintegrating tablet in normal volunteers
    John S Markowitz
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, USA
    J Clin Pharmacol 46:164-71. 2006
    ..The homozygous TT genotype for P-gp resulted in an increased AUC of OLZ for SOT administration but not for either condition where sublingual absorption could occur...
  36. ncbi New methylphenidate formulations for the treatment of attention-deficit/hyperactivity disorder
    Kennerly S Patrick
    Medical University of South Carolina, Department of Pharmaceutical Sciences, 280 Calhoun St, QF221A, Charleston, SC 29425 0742, USA
    Expert Opin Drug Deliv 2:121-43. 2005
    ..A long-acting formulation of d-MPH, which employs the SODAS technology, is in the advanced stages of clinical development...
  37. ncbi Psychoactive drug interactions with pharmacotherapy for diabetes
    C Lindsay Devane
    Department of Psychiatry and Behavioral Sciences, 67 President Street, Medical University of South Carolina, Charleston, SC 29425, USA
    Psychopharmacol Bull 36:40-52. 2002
    ..The newer drugs for treatment of type 2 diabetes are discussed, and considerations are given for avoiding or minimizing drug interactions when prescribing psychoactive drugs to patients with diabetes...
  38. ncbi Differential time course of cytochrome P450 2D6 enzyme inhibition by fluoxetine, sertraline, and paroxetine in healthy volunteers
    Heidi L Liston
    Department of Psychiatry, Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Clin Psychopharmacol 22:169-73. 2002
    ..These data define the time course of a persistent effect that fluoxetine, sertraline, and paroxetine have on CYP2D6 following drug discontinuation and should be considered when initiating therapy with a CYP2D6 substrate...
  39. doi Age- and sex-related expression and activity of carboxylesterase 1 and 2 in mouse and human liver
    Hao Jie Zhu
    Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, 73 Ashley Avenue, Charleston, SC 29425, USA
    Drug Metab Dispos 37:1819-25. 2009
    ..In conclusion, the expression and activity of CES1 and CES2 are age-related but independent of growth hormone level. Sex seems to be an unlikely factor contributing to the regulation of CES1 and CES2...
  40. ncbi Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein
    Jun Sheng Wang
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 187:415-23. 2006
    ..The multidrug resistance transporter, P-glycoprotein (P-gp), is involved in efflux transport of several antipsychotics in the blood-brain barrier (BBB)...
  41. doi Activation of the antiviral prodrug oseltamivir is impaired by two newly identified carboxylesterase 1 variants
    Hao Jie Zhu
    Department of Pharmaceutical and Biomedical Sciences, Laboratory of Drug Disposition and Pharmacogenetics, Charles P Darby Children s Research Institute, Room 405B, Medical University of South Carolina, Charleston, SC 29425, USA
    Drug Metab Dispos 37:264-7. 2009
    ..Furthermore, the potential for increased adverse effects or toxicity as a result of exposure to high concentrations of the nonhydrolyzed prodrug should be considered...
  42. ncbi Augmenting atypical antipsychotics with a cognitive enhancer (donepezil) improves regional brain activity in schizophrenia patients: a pilot double-blind placebo controlled BOLD fMRI study
    Ziad Nahas
    Brain Stimulation Laboratory, Center for Advanced Imaging Research, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA
    Neurocase 9:274-82. 2003
    ..This pilot study supports the cingulate's role in modulating cognition and neuronal connectivity in schizophrenia...
  43. ncbi Comparative CYP3A4 inhibitory effects of venlafaxine, fluoxetine, sertraline, and nefazodone in healthy volunteers
    C Lindsay Devane
    Department of Psychiatry, Medical University of South Carolina MUSC, Charleston, SC 29425, USA
    J Clin Psychopharmacol 24:4-10. 2004
    ..These results demonstrate in vivo that, unlike nefazodone, venlafaxine, sertraline, and fluoxetine do not possess significant metabolic inductive or inhibitory effects on CYP3A4...
  44. ncbi Clinical pharmacokinetics of sertraline
    C Lindsay Devane
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425 0742, USA
    Clin Pharmacokinet 41:1247-66. 2002
    ..Like other selective serotonin reuptake inhibitors, sertraline is well tolerated in therapeutic dosages and relatively safe in overdosage...
  45. ncbi A comprehensive in vitro screening of d-, l-, and dl-threo-methylphenidate: an exploratory study
    John S Markowitz
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Child Adolesc Psychopharmacol 16:687-98. 2006
    ..However, the present exploratory studies reflect receptor binding affinities only. The specific pharmacological activities (i.e., agonism vs. antagonism) of these compounds await further exploration...
  46. ncbi Atomoxetine, a novel treatment for attention-deficit-hyperactivity disorder
    Alisa K Christman
    Department of Pharmacy Practice, Medical University of South Carolina, Charleston 29425, USA
    Pharmacotherapy 24:1020-36. 2004
    ..Additional long-term studies are needed to determine its continued efficacy for those who require lifelong treatment, and comparative trials against other stimulant and nonstimulant agents...
  47. ncbi The brain entry of risperidone and 9-hydroxyrisperidone is greatly limited by P-glycoprotein
    Jun Sheng Wang
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Int J Neuropsychopharmacol 7:415-9. 2004
    ..These results indicate that P-gp in the blood-brain barrier significantly influences the brain concentrations of risperidone and 9-OH-risperidone by limiting their CNS access...
  48. pmc Antipsychotic drugs inhibit the function of breast cancer resistance protein
    Jun Sheng Wang
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA
    Basic Clin Pharmacol Toxicol 103:336-41. 2008
    ..The present results suggest that a potential source of pharmacokinetic interactions exists between BCRP substrates and several antipsychotics...
  49. ncbi Hypotension and bradycardia in a healthy volunteer following a single 5 mg dose of olanzapine
    John S Markowitz
    Institute of Psychiatry, Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston 29425, USA
    J Clin Pharmacol 42:104-6. 2002
    ..This case suggests that atypical antipsychotics, although generally better tolerated than conventional agents, may still result in untoward reactions that may be partially due to individual differences in drug absorption and metabolism...
  50. ncbi Oral administration of a decaffeinated green tea (Camellia sinensis) extract did not alter urinary 8-epi-prostaglandin F(2 alpha), a biomarker for in-vivo lipid peroxidation
    Jennifer L Donovan
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    J Pharm Pharmacol 57:1365-9. 2005
    ..There were no significant differences in the excretion of urinary 8-epi-PGF(2 alpha) after treatment with green tea. We conclude that 14 days of green tea supplementation did not significantly alter in-vivo lipid peroxidation...
  51. ncbi Brain penetration of methadone (R)- and (S)-enantiomers is greatly increased by P-glycoprotein deficiency in the blood-brain barrier of Abcb1a gene knockout mice
    Jun Sheng Wang
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 173:132-8. 2004
    ..Therefore, the function of P-gp in blood-brain barrier (BBB) may affect the concentration of methadone at its site(s) of action in the central nervous system, thereby contributing to its therapeutic efficacy and/or adverse events...
  52. ncbi The role of the polymorphic efflux transporter P-glycoprotein on the brain accumulation of d-methylphenidate and d-amphetamine
    Hao Jie Zhu
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Drug Metab Dispos 34:1116-21. 2006
    ..In addition, d-MPH is a relatively weak P-gp substrate, and its entry into the brain may be limited by P-gp. Furthermore, the mechanism by which d-MPH-induced locomotor activity was attenuated in P-gp KO mice remains to be elucidated...
  53. ncbi Olanzapine penetration into brain is greater in transgenic Abcb1a P-glycoprotein-deficient mice than FVB1 (wild-type) animals
    Jun Sheng Wang
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 49425, USA
    Neuropsychopharmacology 29:551-7. 2004
    ....
  54. ncbi Chiral analysis of d- and l-modafinil in human serum: application to human pharmacokinetic studies
    Jennifer L Donovan
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ther Drug Monit 25:197-202. 2003
    ..The validation data support the use of this method for human pharmacokinetic studies of modafinil in patients with known or suspected use of common antidepressants, psychostimulants, and drugs of abuse...
  55. ncbi Dietary levels of quinine in tonic water do not inhibit CYP2D6 in vivo
    Jennifer L Donovan
    Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, 67 President St suite 246 N, Charleston, SC 29425, USA
    Food Chem Toxicol 41:1199-201. 2003
    ..05). We conclude that quinine as consumed in tonic water does not inhibit CYP2D6 activity in vivo. Thus, quinine should not alter the metabolism of CYP2D6 substrates taken concomitantly with tonic water...
  56. doi Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril
    Hao Jie Zhu
    Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, 29425, USA
    Biochem Pharmacol 77:1266-72. 2009
    ..CES1 mutations p.Gly143Glu and p.Asp260fs are essentially dysfunctional enzymes with regard to the conversion of trandolapril to its more active metabolite trandolaprilat...
  57. doi Aripiprazole brain concentration is altered in P-glycoprotein deficient mice
    Jun Sheng Wang
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Schizophr Res 110:90-4. 2009
    ..Thus, factors influencing P-gp activity within the blood brain barrier in humans may have implications for the therapeutic effects and tolerability of aripiprazole...
  58. ncbi New onset diabetes and atypical antipsychotics
    K A Liebzeit
    College of Pharmacy, Medical University of South Carolina, Charleston, SC 29425, USA
    Eur Neuropsychopharmacol 11:25-32. 2001
    ..In multiple cases, diabetic ketoacidosis has been the presenting symptom; daily atypical antipsychotic doses have been within acceptable ranges and were not considered to be excessive...
  59. pmc Enantiospecific gas chromatographic-mass spectrometric analysis of urinary methylphenidate: implications for phenotyping
    Natalie L LeVasseur
    Department of Chemistry and Biochemistry, College of Charleston, Charleston, SC, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 862:140-9. 2008
    ..Clinical implications concerning rational drug selection for an identified or suspected MPH PM are discussed...
  60. ncbi P-glycoprotein does not actively transport nicotine and cotinine
    Jun Sheng Wang
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina 49425, USA
    Addict Biol 10:127-9. 2005
    ..The observed carrier-mediated nicotine transport in various cell lines may be mediated by other transporter proteins but not P-gp...
  61. ncbi Characterization of P-glycoprotein inhibition by major cannabinoids from marijuana
    Hao Jie Zhu
    Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 317:850-7. 2006
    ..These findings indicate that CBD significantly inhibits P-gp-mediated drug transport, suggesting CBD could potentially influence the absorption and disposition of other coadministered compounds that are P-gp substrates...
  62. ncbi Selective serotonin reuptake inhibitor-induced rash: case report and review of the literature
    Tracie J Sannicandro
    Institute of Psychiatry, Medical University of South Carolina, Charleston 29425, USA
    Pharmacotherapy 22:516-8. 2002
    ..The rash resolved within 2 days of drug discontinuation and treatment with oral diphenhydramine and topical hydrocortisone cream...
  63. ncbi Short-term administration of (-)-epigallocatechin gallate reduces hepatic steatosis and protects against warm hepatic ischemia/reperfusion injury in steatotic mice
    Ryan N Fiorini
    Department of Surgery, Division of Transplant Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
    Liver Transpl 11:298-308. 2005
    ....
  64. pmc A novel HPLC fluorescence method for the quantification of methylphenidate in human plasma
    Hao Jie Zhu
    Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 858:91-5. 2007
    ..This method is the first HPLC assay with non-MS detection providing sufficient reliability and sensitivity for both pre-clinical and clinical studies of MPH...
  65. ncbi Sex differences in the response of children with ADHD to once-daily formulations of methylphenidate
    Edmund J S Sonuga-Barke
    Developmental Brain Behaviour Unit, University of Southampton, Southampton, UK
    J Am Acad Child Adolesc Psychiatry 46:701-10. 2007
    ..This paper reports an examination of sex differences based on further analysis of data from a comparison of two once-daily methylphenidate formulations (the COMACS study), which addresses these shortcomings...
  66. ncbi Donepezil effects on mood in patients with schizophrenia and schizoaffective disorder
    S Craig Risch
    Department of Psychiatry, University of California, San Francisco, CA 94143 0984, USA
    Int J Neuropsychopharmacol 9:603-5. 2006
    ..Thus, in this study, donepezil did not induce or worsen depressive symptoms in schizophrenic and schizoaffective disorder patients...
  67. ncbi Double-blind donepezil-placebo crossover augmentation study of atypical antipsychotics in chronic, stable schizophrenia: a pilot study
    S Craig Risch
    Langley Porter Psychiatric Institute, University of California San Francisco 94143 0984, USA
    Schizophr Res 93:131-5. 2007
    ..018, n=13). These results are discussed with respect to other studies using cholinesterase inhibitors as an augmentation strategy in schizophrenia...
  68. ncbi Common herbal supplements did not produce false-positive results on urine drug screens analyzed by enzyme immunoassay
    John S Markowitz
    J Anal Toxicol 28:272-3. 2004
  69. ncbi Agave (Agave americana): an evidence-based systematic review by the natural standard research collaboration
    Dana A Hackman
    Northeastern University, USA
    J Herb Pharmacother 6:101-22. 2006
    ..An evidence-based systematic review including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing...

Research Grants4

  1. Screening Herbs for Drug Interactions
    JOHN MARKOWITZ; Fiscal Year: 2002
    ..Further, the proposed studies will complement existing and future NCCAM studies of agents such as St. John's wort and Gingko biloba. ..
  2. Ginkgo biloba for ECT-induced Memory Deficits
    JOHN MARKOWITZ; Fiscal Year: 2003
    ..will utilize larger groups and additional cognitive tests will be incorporated to provide more definitive conclusions regarding efficacy, optimal dose and duration, persistence of effects, and safety and tolerability ..
  3. P-Glycoprotein and Disposition of Psychostimulants
    JOHN MARKOWITZ; Fiscal Year: 2005
    ....
  4. Drug Transporters and the Disposition of ADHD Therapeutic Agents
    JOHN MARKOWITZ; Fiscal Year: 2007
    ....