Research Topics
| Robert MalcolmSummaryAffiliation: Medical University of South Carolina Country: USA Publications
Research Grants
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Publications
A comparison of missing data methods for hypothesis tests of the treatment effect in substance abuse clinical trials: a Monte-Carlo simulation studySarra L Hedden
Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, 135 Cannon Place, Charleston, SC 29425, USA
Subst Abuse Treat Prev Policy 3:13. 2008..However, missing data are often ignored in the presentation of substance abuse clinical trials. This paper demonstrates missing data methods which may be used for hypothesis testing...- Randomization in substance abuse clinical trialsSarra L Hedden
Department of Biostatistics, Bioinformatics and Epidemiology DB2E, Medical University of South Carolina, Cannon Place, Cannon Street, Charleston, SC 29425, USA
Subst Abuse Treat Prev Policy 1:6. 2006.... 
Recurrent detoxification may elevate alcohol craving as measured by the Obsessive Compulsive Drinking scaleR Malcolm
Medical University of South Carolina, Alcohol Research Center, Charleston 29425, USA
Alcohol 20:181-5. 2000..Findings emphasize the need to address craving and other psychological variables with respect to treatment of AWS...- Modafinil and cocaine interactionsRobert Malcolm
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Am J Drug Alcohol Abuse 32:577-87. 2006..Modafinil significantly dampened scores on Visual Analog Scale measures as compared to baseline cocaine conditions. No significant alterations in labs occurred. Further outpatient trials of modafinil appear to be warranted... - The safety of disulfiram for the treatment of alcohol and cocaine dependence in randomized clinical trials: guidance for clinical practiceRobert Malcolm
Medical University of South Carolina, Institute of Psychiatry, 67 President Street, MSC 861, Charleston, SC 29425, USA
Expert Opin Drug Saf 7:459-72. 2008..Disulfiram has demonstrated efficacy in six randomized clinical trials for the treatment of cocaine dependence, but is rarely used in clinical settings because of safety concerns... - A controlled trial of amlodipine for cocaine dependence: a negative reportRobert Malcolm
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
J Subst Abuse Treat 28:197-204. 2005..Both groups showed comparable levels of medication compliance and therapy attendance. In the end, amlodipine was no more effective than placebo in reducing craving or measured levels of cocaine use... - Self-reported sleep, sleepiness, and repeated alcohol withdrawals: a randomized, double blind, controlled comparison of lorazepam vs gabapentinRobert Malcolm
Charleston Alcohol Research Center, Medical University of South Carolina, Charleston, USA
J Clin Sleep Med 3:24-32. 2007..The secondary objective of this study was to determine if drug treatment efficacy differed by the patient history of previous treatments for alcohol withdrawal... - Amlodipine reduces blood pressure and headache frequency in cocaine-dependent outpatientsRobert Malcolm
Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Psychoactive Drugs 34:415-9. 2002..004). The high frequency of headaches reported by cocaine-dependent individuals was significantly reduced by amlodipine and may reflect improved cerebrovascular tone... - The effects of carbamazepine and lorazepam on single versus multiple previous alcohol withdrawals in an outpatient randomized trialR Malcolm
Alcohol Research Center, Medical University of South Carolina, Charleston 29425, USA
J Gen Intern Med 17:349-55. 2002.... - A double-blind, placebo-controlled outpatient trial of pergolide for cocaine dependenceR Malcolm
Department of Psychiatry and Behavioral Sciences, Center for Drug and Alcohol Programs, Medical University of South Carolina, 171 Ashley Ave, Charleston, SC 29425, USA
Drug Alcohol Depend 60:161-8. 2000..Pergolide does not appear to have clinical value in the treatment of cocaine dependence or in decreasing alcohol use in cocaine-dependent individuals at the presently studied doses... - Multiple previous detoxifications are associated with less responsive treatment and heavier drinking during an index outpatient detoxificationR Malcolm
Alcohol Research Center, Medical University of South Carolina, P O BOX 67, President Street, Charleston, SC 29425, USA
Alcohol 22:159-64. 2000..0002). In the present study, intensity of AW symptoms and early heavy drinking were independent of treatment medications and were more common in patients who had previously undergone multiple treatments for AW... - Is cocaine desire reduced by N-acetylcysteine?Steven D LaRowe
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
Am J Psychiatry 164:1115-7. 2007..Animal models suggest that N-acetylcysteine inhibits cocaine-seeking. The present pilot study evaluated whether N-acetylcysteine would suppress reactivity to cocaine-related cues in cocaine-dependent humans... 
Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptomsRaymond F Anton
Medical University of South Carolina, Charleston, SC, USA
J Clin Psychopharmacol 29:334-42. 2009..These results suggest a differential response to FMZ/GBP treatment, depending on pretreatment AW status that should be taken into account during future treatment trials...- A double-blind trial of gabapentin versus lorazepam in the treatment of alcohol withdrawalHugh Myrick
Ralph H Johnson Department of Veterans Affairs Medical Center, Research and Development Service, Charleston, SC, USA
Alcohol Clin Exp Res 33:1582-8. 2009..The aim of this study was to evaluate alcohol use and symptom reduction of gabapentin when compared with lorazepam in the treatment of alcohol withdrawal in a double-blinded randomized clinical trial... - The differential effects of medication on mood, sleep disturbance, and work ability in outpatient alcohol detoxificationRobert Malcolm
Alcohol Research Center, Medical University of South Carolina, Charleston 29425, USA
Am J Addict 11:141-50. 2002..025). In this study of outpatients with mild to moderate alcohol withdrawal, carbamazepine was superior to lorazepam in reducing anxiety and improving sleep... - A retrospective chart review comparing tiagabine and benzodiazepines for the treatment of alcohol withdrawalHugh Myrick
Institute of Psychiatry, MUSC, Charleston, South Carolina 29425, USA
J Psychoactive Drugs 37:409-14. 2005..12). The reduction in alcohol withdrawal symptoms and decreased tendency to relapse observed in patients treated with the anticonvulsant tiagabine suggests that a double-blind, placebo controlled trial may be warranted... - Safety and tolerability of N-acetylcysteine in cocaine-dependent individualsSteven D LaRowe
Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Am J Addict 15:105-10. 2006..These preliminary results suggest that NAC is well tolerated in healthy, cocaine-dependent individuals and may reduce cocaine-related withdrawal symptoms and craving... - Measures of cognitive functioning as predictors of treatment outcome for cocaine dependenceTravis H Turner
Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425 6060, USA
J Subst Abuse Treat 37:328-34. 2009..Notably, no other cognitive measures predicted treatment outcome. The observed relationship implicates the relevance of executive functioning to treatment outcome for cocaine dependence... - The role of cystine-glutamate exchange in nicotine dependence in rats and humansLori A Knackstedt
Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Biol Psychiatry 65:841-5. 2009.... - Modafinil: preclinical, clinical, and post-marketing surveillance--a review of abuse liability issuesHugh Myrick
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Ann Clin Psychiatry 16:101-9. 2004..Initial evidence suggests that modafinil has limited potential for large-scale abuse... - Depressive Symptoms, Pain, and Quality of Life among Patients with Nonalcohol-Related Chronic PancreatitisWendy E Balliet
Division of Biobehavioral Medicine, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
Pain Res Treat 2012:978646. 2012..Thus, routine screening for depressive symptomology among patients with nonalcoholic pancreatitis may be warranted... - Impact of lifetime alcohol quit attempts and medicated detoxifications on time to relapse during an index alcohol detoxificationTara M Wright
From the Center for Drug and Alcohol Program TMW, hm, RM, PR, EB, SH, RA, Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, Charleston, SC and Ralph H Johnson Department of Veteran Affairs Medical Center HM, Research and Development Service, Charleston, SC
J Addict Med 1:15-20. 2007.... - Clinical applications of modafinil in stimulant abusers: low abuse potentialRobert Malcolm
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
Am J Addict 11:247-9. 2002 - New anticonvulsants: a review of applications for the management of substance abuse disordersJohn R Gentry
Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina, USA
Ann Clin Psychiatry 14:233-45. 2002..Each medication appears to have potential advantages for these uses, and further study of these medications in treatment of substance abuse disorders is recommended... - Risk factors for delirium tremens: a retrospective chart reviewTara Wright
Department of Psychiatry and Behavioral Sciences, Alcohol Research Center, Medical University of South Carolina, Charleston, South Carolina, USA
Am J Addict 15:213-9. 2006..While not reaching statistical significance, there were differences in reason for admission and relapse rate upon follow-up between the groups... - Excess health care service utilization and costs associated with underrecognition of psychiatric comorbidity in a medical/surgical inpatient settingJeffrey J Borckardt
Medical University of South Carolina Charleston, USA
Qual Manag Health Care 20:98-102. 2011..Thus, the criteria used to determine whether or not a psychiatry consultation is triggered, and the timing of the consultation request need further study... - Carbamazepine in the treatment of cocaine dependence: subtyping by affective disorderKathleen T Brady
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Carolina 29401, USA
Exp Clin Psychopharmacol 10:276-85. 2002..08) and a significantly longer time to first cocaine use (p = .06). CBZ treatment did not have any impact on cocaine use in individuals without affective disorders... - An open-label trial of N-acetylcysteine for the treatment of cocaine dependence: a pilot studyPascale N Mardikian
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
Prog Neuropsychopharmacol Biol Psychiatry 31:389-94. 2007..Overall the findings suggest that it is feasible to treat cocaine-dependent treatment seekers with N-acetylcysteine on an outpatient basis... - Disulfiram: an old therapeutic with new applicationsKelly S Barth
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
CNS Neurol Disord Drug Targets 9:5-12. 2010..We will also review recent literature on newer potential applications for disulfiram use via its unique action on dopamine beta-hydroxylase... - Adolescents with insomnia and substance abuse: consequences and comorbiditiesHeather L Shibley
Medical University of South Carolina, Charleston, SC, USA
J Psychiatr Pract 14:146-53. 2008..At the very least, the presence of insomnia should alert clinicians to the need for further evaluation for drug and alcohol abuse... - Characteristics of cocaine- and marijuana-dependent subjects presenting for medication treatment trialsAimee L McRae
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
Addict Behav 32:1433-40. 2007..Past and current other drug use was similar between the two groups. These results highlight the significant impairments associated with marijuana and cocaine dependence... - Topiramate reduces ethanol consumption by C57BL/6 miceShaun A Nguyen
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29482, USA
Synapse 61:150-6. 2007..In the present study, a C57BL/6 (B6) murine model (n = 40) was used to evaluate the effect of TPM on the consumption of 12% alcohol over a 21-h period... - Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basisHao Jie Zhu
Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
Am J Hum Genet 82:1241-8. 2008..Asp260fs, respectively, compared to the wild-type enzyme. These findings indicate that specific CES1 gene variants can lead to clinically significant alterations in pharmacokinetics and drug response of carboxylesterase 1 substrates... - GABA systems, benzodiazepines, and substance dependenceRobert J Malcolm
Medical University of South Carolina, Center for Drug and Alcohol Programs, Charleston 29425, USA
J Clin Psychiatry 64:36-40. 2003..The GABA(A) and GABA(B) pump reuptake inhibitor tiagabine has potential for managing alcohol and sedative-hypnotic withdrawal and also possibly a role in relapse prevention... - Chronic pain among liver transplant candidatesAlok Madan
Medical University of South Carolina, Charleston, SC, USA
Prog Transplant 22:379-84. 2012..Appropriate pain assessment and management are important areas of consideration as treatment options are limited... - Depression and Anxiety Symptoms Relate to Distinct Components of Pain Experience among Patients with Breast CancerSarah K Galloway
Division of Biobehavioral Medicine, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, 1 South, Charleston, SC 29425, USA
Pain Res Treat 2012:851276. 2012..State anxiety serves as a predictor of the sensory dimension of the pain experience, whereas depression serves as a predictor of the affective dimension of the pain experience... - Modafinil influences the pharmacokinetics of intravenous cocaine in healthy cocaine-dependent volunteersJennifer L Donovan
Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina (MUSC, Charleston, South Carolina, USA
Clin Pharmacokinet 44:753-65. 2005..In contrast, long-term administration of modafinil significantly decreased systemic exposure to cocaine during the first 180 minutes following intravenous cocaine administration... - Chiral analysis of d- and l-modafinil in human serum: application to human pharmacokinetic studiesJennifer L Donovan
Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Ther Drug Monit 25:197-202. 2003..The validation data support the use of this method for human pharmacokinetic studies of modafinil in patients with known or suspected use of common antidepressants, psychostimulants, and drugs of abuse... - Tiagabine reduces ethanol reward in C57BL/6 mice under acute and chronic administration regimensShaun A Nguyen
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Synapse 56:135-46. 2005..The results of the experiments suggest that in addition to reducing alcohol withdrawal symptoms, tiagabine might also reduce the potency of ethanol-conditioned cues that drive appetitive behavior for ethanol... - The impact of loss to follow-up on hypothesis tests of the treatment effect for several statistical methods in substance abuse clinical trialsSarra L Hedden
Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
J Subst Abuse Treat 37:54-63. 2009..e., "ignorable"). If the missing data are presumed to be nonignorable, a sensitivity analysis is recommended... - An overview of medications for the treatment of alcohol withdrawal and alcohol dependence with an emphasis on the use of older and newer anticonvulsantsNassima Ait-Daoud
Department of Psychiatric Medicine, University of Virginia, P O Box 800623, Charlottesville, VA 22908 0623, USA
Addict Behav 31:1628-49. 2006..Furthermore, as a class of medication, there appears to be a growing interest in investigating the utility of novel anticonvulsants such as topiramate for the treatment of alcohol dependence... - Nicotine, cotinine, withdrawal, and craving patterns during smoking and nicotine nasal spray use: results from a pilot study with African American menPatricia L Mabry
SAIC Frederick, Inc, support to Tobacco Control Research Branch TCRB, Behavioral Research Program BRP, Division of Cancer Control and Population Sciences DCCPS, National Cancer Institute Bethesda, MD
Nicotine Tob Res 9:65-82. 2007..When predicting nicotine, cotinine, withdrawal, and cravings, we observed significant interactions between route of nicotine intake and a variety of independent variables... - Development of novel pharmacotherapies for the treatment of alcohol dependence: focus on antiepilepticsBankole A Johnson
Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
Alcohol Clin Exp Res 28:295-301. 2004..DiClemente; (5) Synopsis of promising medications to treat alcoholism, by Robert M. Swift; and (6) New knowledge on the development of antiepileptic medications for the treatment of alcoholism, by Robert J. Malcolm, Jr... - Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trialBankole A Johnson
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
Arch Intern Med 168:1188-99. 2008..We sought to determine whether topiramate's antidrinking effects are bolstered by improvements in physical and psychosocial well-being...
Research Grants
- A Controlled Trial of NAC for Cocaine DependenceRobert Malcolm; Fiscal Year: 2009..placebo; and 3) to study cocaine craving/cue reactivity and withdrawal symptoms in subjects taking NAC or placebo. ..
- CBT and Modafinil for Cocaine AddictionRobert Malcolm; Fiscal Year: 2006..Safety will be assessed by a combination of self-report and repeated physical examinations, laboratory studies, ECGs, and monitoring by an independent data safety monitoring board. ..
- AMLODIPINE TREATMENT FOR COCAINE DEPENDENCERobert Malcolm; Fiscal Year: 2001....
- CBT and Modafinil for Cocaine AddictionRobert Malcolm; Fiscal Year: 2009....