Robert Malcolm

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. pmc A comparison of missing data methods for hypothesis tests of the treatment effect in substance abuse clinical trials: a Monte-Carlo simulation study
    Sarra L Hedden
    Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, 135 Cannon Place, Charleston, SC 29425, USA
    Subst Abuse Treat Prev Policy 3:13. 2008
  2. pmc Randomization in substance abuse clinical trials
    Sarra L Hedden
    Department of Biostatistics, Bioinformatics and Epidemiology DB2E, Medical University of South Carolina, Cannon Place, Cannon Street, Charleston, SC 29425, USA
    Subst Abuse Treat Prev Policy 1:6. 2006
  3. ncbi request reprint Recurrent detoxification may elevate alcohol craving as measured by the Obsessive Compulsive Drinking scale
    R Malcolm
    Medical University of South Carolina, Alcohol Research Center, Charleston 29425, USA
    Alcohol 20:181-5. 2000
  4. ncbi request reprint Modafinil and cocaine interactions
    Robert Malcolm
    Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Drug Alcohol Abuse 32:577-87. 2006
  5. ncbi request reprint The safety of disulfiram for the treatment of alcohol and cocaine dependence in randomized clinical trials: guidance for clinical practice
    Robert Malcolm
    Medical University of South Carolina, Institute of Psychiatry, 67 President Street, MSC 861, Charleston, SC 29425, USA
    Expert Opin Drug Saf 7:459-72. 2008
  6. ncbi request reprint A controlled trial of amlodipine for cocaine dependence: a negative report
    Robert Malcolm
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    J Subst Abuse Treat 28:197-204. 2005
  7. ncbi request reprint Self-reported sleep, sleepiness, and repeated alcohol withdrawals: a randomized, double blind, controlled comparison of lorazepam vs gabapentin
    Robert Malcolm
    Charleston Alcohol Research Center, Medical University of South Carolina, Charleston, USA
    J Clin Sleep Med 3:24-32. 2007
  8. ncbi request reprint Amlodipine reduces blood pressure and headache frequency in cocaine-dependent outpatients
    Robert Malcolm
    Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Psychoactive Drugs 34:415-9. 2002
  9. pmc The effects of carbamazepine and lorazepam on single versus multiple previous alcohol withdrawals in an outpatient randomized trial
    R Malcolm
    Alcohol Research Center, Medical University of South Carolina, Charleston 29425, USA
    J Gen Intern Med 17:349-55. 2002
  10. ncbi request reprint A double-blind, placebo-controlled outpatient trial of pergolide for cocaine dependence
    R Malcolm
    Department of Psychiatry and Behavioral Sciences, Center for Drug and Alcohol Programs, Medical University of South Carolina, 171 Ashley Ave, Charleston, SC 29425, USA
    Drug Alcohol Depend 60:161-8. 2000

Research Grants

  1. A Controlled Trial of NAC for Cocaine Dependence
    Robert Malcolm; Fiscal Year: 2009
  2. CBT and Modafinil for Cocaine Addiction
    Robert Malcolm; Fiscal Year: 2006
  3. AMLODIPINE TREATMENT FOR COCAINE DEPENDENCE
    Robert Malcolm; Fiscal Year: 2001
  4. CBT and Modafinil for Cocaine Addiction
    Robert Malcolm; Fiscal Year: 2009

Detail Information

Publications45

  1. pmc A comparison of missing data methods for hypothesis tests of the treatment effect in substance abuse clinical trials: a Monte-Carlo simulation study
    Sarra L Hedden
    Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, 135 Cannon Place, Charleston, SC 29425, USA
    Subst Abuse Treat Prev Policy 3:13. 2008
    ..However, missing data are often ignored in the presentation of substance abuse clinical trials. This paper demonstrates missing data methods which may be used for hypothesis testing...
  2. pmc Randomization in substance abuse clinical trials
    Sarra L Hedden
    Department of Biostatistics, Bioinformatics and Epidemiology DB2E, Medical University of South Carolina, Cannon Place, Cannon Street, Charleston, SC 29425, USA
    Subst Abuse Treat Prev Policy 1:6. 2006
    ....
  3. ncbi request reprint Recurrent detoxification may elevate alcohol craving as measured by the Obsessive Compulsive Drinking scale
    R Malcolm
    Medical University of South Carolina, Alcohol Research Center, Charleston 29425, USA
    Alcohol 20:181-5. 2000
    ..Findings emphasize the need to address craving and other psychological variables with respect to treatment of AWS...
  4. ncbi request reprint Modafinil and cocaine interactions
    Robert Malcolm
    Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Drug Alcohol Abuse 32:577-87. 2006
    ..Modafinil significantly dampened scores on Visual Analog Scale measures as compared to baseline cocaine conditions. No significant alterations in labs occurred. Further outpatient trials of modafinil appear to be warranted...
  5. ncbi request reprint The safety of disulfiram for the treatment of alcohol and cocaine dependence in randomized clinical trials: guidance for clinical practice
    Robert Malcolm
    Medical University of South Carolina, Institute of Psychiatry, 67 President Street, MSC 861, Charleston, SC 29425, USA
    Expert Opin Drug Saf 7:459-72. 2008
    ..Disulfiram has demonstrated efficacy in six randomized clinical trials for the treatment of cocaine dependence, but is rarely used in clinical settings because of safety concerns...
  6. ncbi request reprint A controlled trial of amlodipine for cocaine dependence: a negative report
    Robert Malcolm
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    J Subst Abuse Treat 28:197-204. 2005
    ..Both groups showed comparable levels of medication compliance and therapy attendance. In the end, amlodipine was no more effective than placebo in reducing craving or measured levels of cocaine use...
  7. ncbi request reprint Self-reported sleep, sleepiness, and repeated alcohol withdrawals: a randomized, double blind, controlled comparison of lorazepam vs gabapentin
    Robert Malcolm
    Charleston Alcohol Research Center, Medical University of South Carolina, Charleston, USA
    J Clin Sleep Med 3:24-32. 2007
    ..The secondary objective of this study was to determine if drug treatment efficacy differed by the patient history of previous treatments for alcohol withdrawal...
  8. ncbi request reprint Amlodipine reduces blood pressure and headache frequency in cocaine-dependent outpatients
    Robert Malcolm
    Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Psychoactive Drugs 34:415-9. 2002
    ..004). The high frequency of headaches reported by cocaine-dependent individuals was significantly reduced by amlodipine and may reflect improved cerebrovascular tone...
  9. pmc The effects of carbamazepine and lorazepam on single versus multiple previous alcohol withdrawals in an outpatient randomized trial
    R Malcolm
    Alcohol Research Center, Medical University of South Carolina, Charleston 29425, USA
    J Gen Intern Med 17:349-55. 2002
    ....
  10. ncbi request reprint A double-blind, placebo-controlled outpatient trial of pergolide for cocaine dependence
    R Malcolm
    Department of Psychiatry and Behavioral Sciences, Center for Drug and Alcohol Programs, Medical University of South Carolina, 171 Ashley Ave, Charleston, SC 29425, USA
    Drug Alcohol Depend 60:161-8. 2000
    ..Pergolide does not appear to have clinical value in the treatment of cocaine dependence or in decreasing alcohol use in cocaine-dependent individuals at the presently studied doses...
  11. ncbi request reprint Multiple previous detoxifications are associated with less responsive treatment and heavier drinking during an index outpatient detoxification
    R Malcolm
    Alcohol Research Center, Medical University of South Carolina, P O BOX 67, President Street, Charleston, SC 29425, USA
    Alcohol 22:159-64. 2000
    ..0002). In the present study, intensity of AW symptoms and early heavy drinking were independent of treatment medications and were more common in patients who had previously undergone multiple treatments for AW...
  12. ncbi request reprint Is cocaine desire reduced by N-acetylcysteine?
    Steven D LaRowe
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Psychiatry 164:1115-7. 2007
    ..Animal models suggest that N-acetylcysteine inhibits cocaine-seeking. The present pilot study evaluated whether N-acetylcysteine would suppress reactivity to cocaine-related cues in cocaine-dependent humans...
  13. doi request reprint Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms
    Raymond F Anton
    Medical University of South Carolina, Charleston, SC, USA
    J Clin Psychopharmacol 29:334-42. 2009
    ..These results suggest a differential response to FMZ/GBP treatment, depending on pretreatment AW status that should be taken into account during future treatment trials...
  14. pmc A double-blind trial of gabapentin versus lorazepam in the treatment of alcohol withdrawal
    Hugh Myrick
    Ralph H Johnson Department of Veterans Affairs Medical Center, Research and Development Service, Charleston, SC, USA
    Alcohol Clin Exp Res 33:1582-8. 2009
    ..The aim of this study was to evaluate alcohol use and symptom reduction of gabapentin when compared with lorazepam in the treatment of alcohol withdrawal in a double-blinded randomized clinical trial...
  15. ncbi request reprint The differential effects of medication on mood, sleep disturbance, and work ability in outpatient alcohol detoxification
    Robert Malcolm
    Alcohol Research Center, Medical University of South Carolina, Charleston 29425, USA
    Am J Addict 11:141-50. 2002
    ..025). In this study of outpatients with mild to moderate alcohol withdrawal, carbamazepine was superior to lorazepam in reducing anxiety and improving sleep...
  16. ncbi request reprint A retrospective chart review comparing tiagabine and benzodiazepines for the treatment of alcohol withdrawal
    Hugh Myrick
    Institute of Psychiatry, MUSC, Charleston, South Carolina 29425, USA
    J Psychoactive Drugs 37:409-14. 2005
    ..12). The reduction in alcohol withdrawal symptoms and decreased tendency to relapse observed in patients treated with the anticonvulsant tiagabine suggests that a double-blind, placebo controlled trial may be warranted...
  17. pmc Safety and tolerability of N-acetylcysteine in cocaine-dependent individuals
    Steven D LaRowe
    Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Addict 15:105-10. 2006
    ..These preliminary results suggest that NAC is well tolerated in healthy, cocaine-dependent individuals and may reduce cocaine-related withdrawal symptoms and craving...
  18. doi request reprint Measures of cognitive functioning as predictors of treatment outcome for cocaine dependence
    Travis H Turner
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425 6060, USA
    J Subst Abuse Treat 37:328-34. 2009
    ..Notably, no other cognitive measures predicted treatment outcome. The observed relationship implicates the relevance of executive functioning to treatment outcome for cocaine dependence...
  19. pmc The role of cystine-glutamate exchange in nicotine dependence in rats and humans
    Lori A Knackstedt
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Biol Psychiatry 65:841-5. 2009
    ....
  20. ncbi request reprint Modafinil: preclinical, clinical, and post-marketing surveillance--a review of abuse liability issues
    Hugh Myrick
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann Clin Psychiatry 16:101-9. 2004
    ..Initial evidence suggests that modafinil has limited potential for large-scale abuse...
  21. pmc Depressive Symptoms, Pain, and Quality of Life among Patients with Nonalcohol-Related Chronic Pancreatitis
    Wendy E Balliet
    Division of Biobehavioral Medicine, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Pain Res Treat 2012:978646. 2012
    ..Thus, routine screening for depressive symptomology among patients with nonalcoholic pancreatitis may be warranted...
  22. ncbi request reprint Impact of lifetime alcohol quit attempts and medicated detoxifications on time to relapse during an index alcohol detoxification
    Tara M Wright
    From the Center for Drug and Alcohol Program TMW, hm, RM, PR, EB, SH, RA, Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, Charleston, SC and Ralph H Johnson Department of Veteran Affairs Medical Center HM, Research and Development Service, Charleston, SC
    J Addict Med 1:15-20. 2007
    ....
  23. ncbi request reprint Clinical applications of modafinil in stimulant abusers: low abuse potential
    Robert Malcolm
    Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Addict 11:247-9. 2002
  24. ncbi request reprint New anticonvulsants: a review of applications for the management of substance abuse disorders
    John R Gentry
    Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina, USA
    Ann Clin Psychiatry 14:233-45. 2002
    ..Each medication appears to have potential advantages for these uses, and further study of these medications in treatment of substance abuse disorders is recommended...
  25. ncbi request reprint Risk factors for delirium tremens: a retrospective chart review
    Tara Wright
    Department of Psychiatry and Behavioral Sciences, Alcohol Research Center, Medical University of South Carolina, Charleston, South Carolina, USA
    Am J Addict 15:213-9. 2006
    ..While not reaching statistical significance, there were differences in reason for admission and relapse rate upon follow-up between the groups...
  26. doi request reprint Excess health care service utilization and costs associated with underrecognition of psychiatric comorbidity in a medical/surgical inpatient setting
    Jeffrey J Borckardt
    Medical University of South Carolina Charleston, USA
    Qual Manag Health Care 20:98-102. 2011
    ..Thus, the criteria used to determine whether or not a psychiatry consultation is triggered, and the timing of the consultation request need further study...
  27. pmc Characteristics of cocaine- and marijuana-dependent subjects presenting for medication treatment trials
    Aimee L McRae
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Addict Behav 32:1433-40. 2007
    ..Past and current other drug use was similar between the two groups. These results highlight the significant impairments associated with marijuana and cocaine dependence...
  28. ncbi request reprint Carbamazepine in the treatment of cocaine dependence: subtyping by affective disorder
    Kathleen T Brady
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Carolina 29401, USA
    Exp Clin Psychopharmacol 10:276-85. 2002
    ..08) and a significantly longer time to first cocaine use (p = .06). CBZ treatment did not have any impact on cocaine use in individuals without affective disorders...
  29. ncbi request reprint An open-label trial of N-acetylcysteine for the treatment of cocaine dependence: a pilot study
    Pascale N Mardikian
    Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:389-94. 2007
    ..Overall the findings suggest that it is feasible to treat cocaine-dependent treatment seekers with N-acetylcysteine on an outpatient basis...
  30. ncbi request reprint Disulfiram: an old therapeutic with new applications
    Kelly S Barth
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    CNS Neurol Disord Drug Targets 9:5-12. 2010
    ..We will also review recent literature on newer potential applications for disulfiram use via its unique action on dopamine beta-hydroxylase...
  31. doi request reprint Adolescents with insomnia and substance abuse: consequences and comorbidities
    Heather L Shibley
    Medical University of South Carolina, Charleston, SC, USA
    J Psychiatr Pract 14:146-53. 2008
    ..At the very least, the presence of insomnia should alert clinicians to the need for further evaluation for drug and alcohol abuse...
  32. ncbi request reprint Topiramate reduces ethanol consumption by C57BL/6 mice
    Shaun A Nguyen
    Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29482, USA
    Synapse 61:150-6. 2007
    ..In the present study, a C57BL/6 (B6) murine model (n = 40) was used to evaluate the effect of TPM on the consumption of 12% alcohol over a 21-h period...
  33. pmc Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis
    Hao Jie Zhu
    Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Hum Genet 82:1241-8. 2008
    ..Asp260fs, respectively, compared to the wild-type enzyme. These findings indicate that specific CES1 gene variants can lead to clinically significant alterations in pharmacokinetics and drug response of carboxylesterase 1 substrates...
  34. ncbi request reprint GABA systems, benzodiazepines, and substance dependence
    Robert J Malcolm
    Medical University of South Carolina, Center for Drug and Alcohol Programs, Charleston 29425, USA
    J Clin Psychiatry 64:36-40. 2003
    ..The GABA(A) and GABA(B) pump reuptake inhibitor tiagabine has potential for managing alcohol and sedative-hypnotic withdrawal and also possibly a role in relapse prevention...
  35. doi request reprint Pharmacotherapy of obesity: clinical treatments and considerations
    Kelly Anne Holes-Lewis
    Department of Medicine, Division of Endocrinology, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Med Sci 345:284-8. 2013
    ..Although unique to each individual, the benefits of weight loss are substantial and can improve well-being and physical health...
  36. pmc Depression and Anxiety Symptoms Relate to Distinct Components of Pain Experience among Patients with Breast Cancer
    Sarah K Galloway
    Division of Biobehavioral Medicine, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, 1 South, Charleston, SC 29425, USA
    Pain Res Treat 2012:851276. 2012
    ..State anxiety serves as a predictor of the sensory dimension of the pain experience, whereas depression serves as a predictor of the affective dimension of the pain experience...
  37. ncbi request reprint Chronic pain among liver transplant candidates
    Alok Madan
    Medical University of South Carolina, Charleston, SC, USA
    Prog Transplant 22:379-84. 2012
    ..Appropriate pain assessment and management are important areas of consideration as treatment options are limited...
  38. ncbi request reprint Modafinil influences the pharmacokinetics of intravenous cocaine in healthy cocaine-dependent volunteers
    Jennifer L Donovan
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina MUSC, Charleston, South Carolina, USA
    Clin Pharmacokinet 44:753-65. 2005
    ..To determine if modafinil, a putative treatment for cocaine dependence, influences the pharmacokinetics of intravenous cocaine in otherwise healthy cocaine-dependent volunteers...
  39. ncbi request reprint Tiagabine reduces ethanol reward in C57BL/6 mice under acute and chronic administration regimens
    Shaun A Nguyen
    Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Synapse 56:135-46. 2005
    ..The results of the experiments suggest that in addition to reducing alcohol withdrawal symptoms, tiagabine might also reduce the potency of ethanol-conditioned cues that drive appetitive behavior for ethanol...
  40. pmc The impact of loss to follow-up on hypothesis tests of the treatment effect for several statistical methods in substance abuse clinical trials
    Sarra L Hedden
    Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Subst Abuse Treat 37:54-63. 2009
    ..e., "ignorable"). If the missing data are presumed to be nonignorable, a sensitivity analysis is recommended...
  41. ncbi request reprint Chiral analysis of d- and l-modafinil in human serum: application to human pharmacokinetic studies
    Jennifer L Donovan
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ther Drug Monit 25:197-202. 2003
    ..The validation data support the use of this method for human pharmacokinetic studies of modafinil in patients with known or suspected use of common antidepressants, psychostimulants, and drugs of abuse...
  42. ncbi request reprint Nicotine, cotinine, withdrawal, and craving patterns during smoking and nicotine nasal spray use: results from a pilot study with African American men
    Patricia L Mabry
    SAIC Frederick, Inc, support to Tobacco Control Research Branch TCRB, Behavioral Research Program BRP, Division of Cancer Control and Population Sciences DCCPS, National Cancer Institute Bethesda, MD
    Nicotine Tob Res 9:65-82. 2007
    ..When predicting nicotine, cotinine, withdrawal, and cravings, we observed significant interactions between route of nicotine intake and a variety of independent variables...
  43. ncbi request reprint An overview of medications for the treatment of alcohol withdrawal and alcohol dependence with an emphasis on the use of older and newer anticonvulsants
    Nassima Ait-Daoud
    Department of Psychiatric Medicine, University of Virginia, P O Box 800623, Charlottesville, VA 22908 0623, USA
    Addict Behav 31:1628-49. 2006
    ..Furthermore, as a class of medication, there appears to be a growing interest in investigating the utility of novel anticonvulsants such as topiramate for the treatment of alcohol dependence...
  44. doi request reprint Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trial
    Bankole A Johnson
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
    Arch Intern Med 168:1188-99. 2008
    ..We sought to determine whether topiramate's antidrinking effects are bolstered by improvements in physical and psychosocial well-being...
  45. ncbi request reprint Development of novel pharmacotherapies for the treatment of alcohol dependence: focus on antiepileptics
    Bankole A Johnson
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Alcohol Clin Exp Res 28:295-301. 2004
    ..DiClemente; (5) Synopsis of promising medications to treat alcoholism, by Robert M. Swift; and (6) New knowledge on the development of antiepileptic medications for the treatment of alcoholism, by Robert J. Malcolm, Jr...

Research Grants15

  1. A Controlled Trial of NAC for Cocaine Dependence
    Robert Malcolm; Fiscal Year: 2009
    ..placebo; and 3) to study cocaine craving/cue reactivity and withdrawal symptoms in subjects taking NAC or placebo. ..
  2. CBT and Modafinil for Cocaine Addiction
    Robert Malcolm; Fiscal Year: 2006
    ..Safety will be assessed by a combination of self-report and repeated physical examinations, laboratory studies, ECGs, and monitoring by an independent data safety monitoring board. ..
  3. AMLODIPINE TREATMENT FOR COCAINE DEPENDENCE
    Robert Malcolm; Fiscal Year: 2001
    ....
  4. CBT and Modafinil for Cocaine Addiction
    Robert Malcolm; Fiscal Year: 2009
    ....