J A Madden

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. doi request reprint Precursors and inhibitors of hydrogen sulfide synthesis affect acute hypoxic pulmonary vasoconstriction in the intact lung
    Jane A Madden
    Department of Neurology, The Medical College of Wisconsin and Research Service, Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295, USA
    J Appl Physiol 112:411-8. 2012
  2. doi request reprint Telokin expression and the effect of hypoxia on its phosphorylation status in smooth muscle cells from small and large pulmonary arteries
    Jane A Madden
    Department of Neurology, Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295, USA
    Am J Physiol Lung Cell Mol Physiol 294:L1166-73. 2008
  3. ncbi request reprint Integrin signaling, free radicals, and tyrosine kinase mediate flow constriction in isolated cerebral arteries
    J A Madden
    Department of Neurology, The Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol 277:H2264-71. 1999
  4. ncbi request reprint Changes in smooth muscle cell pH during hypoxic pulmonary vasoconstriction: a possible role for ion transporters
    J A Madden
    Department of Neurology, The Medical College of Wisconsin, Milwaukee, USA
    Physiol Res 49:561-6. 2000
  5. ncbi request reprint Ion exchange activity in pulmonary artery smooth muscle cells: the response to hypoxia
    J A Madden
    Department of Neurology, The Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Lung Cell Mol Physiol 280:L264-71. 2001
  6. ncbi request reprint Absence of flow-mediated vasodilation in the rabbit femoral artery
    P S Clifford
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, USA
    Physiol Res 59:331-8. 2010
  7. ncbi request reprint Cyclooxygenase contracting factors and altered pulmonary vascular responses in chronically hypoxic newborn pigs
    Candice D Fike
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Appl Physiol 92:67-74. 2002
  8. ncbi request reprint What leads to different mediators of alkalosis-induced vasodilation in isolated and in situ pulmonary vessels?
    John B Gordon
    Department of Pediatrics Critical Care, Medical College of Wisconsin and Zablocki Veterans Administration Medical Center, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Lung Cell Mol Physiol 284:L799-807. 2003
  9. ncbi request reprint Voltage-gated K+ channels at an early stage of chronic hypoxia-induced pulmonary hypertension in newborn piglets
    Candice D Fike
    Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Physiol Lung Cell Mol Physiol 291:L1169-76. 2006
  10. pmc Voltage-gated K+ channels in rat small cerebral arteries: molecular identity of the functional channels
    Sulayma Albarwani
    Department of Physiology, College of Medicine, Sultan Qaboos University, Al Khod, Sultanate of Oman
    J Physiol 551:751-63. 2003

Collaborators

Detail Information

Publications12

  1. doi request reprint Precursors and inhibitors of hydrogen sulfide synthesis affect acute hypoxic pulmonary vasoconstriction in the intact lung
    Jane A Madden
    Department of Neurology, The Medical College of Wisconsin and Research Service, Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295, USA
    J Appl Physiol 112:411-8. 2012
    ..The results of this study provide evidence that the rate of H(2)S synthesis plays a role in the magnitude of acute HPV in the isolated perfused rat lung...
  2. doi request reprint Telokin expression and the effect of hypoxia on its phosphorylation status in smooth muscle cells from small and large pulmonary arteries
    Jane A Madden
    Department of Neurology, Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295, USA
    Am J Physiol Lung Cell Mol Physiol 294:L1166-73. 2008
    ..These results suggest that in SPA, phosphorylated telokin may help maintain relaxation under unstimulated conditions, whereas in LPA, telokin's function remains undetermined...
  3. ncbi request reprint Integrin signaling, free radicals, and tyrosine kinase mediate flow constriction in isolated cerebral arteries
    J A Madden
    Department of Neurology, The Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol 277:H2264-71. 1999
    ..These data suggest that, in vitro, middle cerebral arteries constrict to flow through a mechanism involving free radicals and tyrosine kinase and that flow shear stresses resulting in constriction are transduced by integrin signaling...
  4. ncbi request reprint Changes in smooth muscle cell pH during hypoxic pulmonary vasoconstriction: a possible role for ion transporters
    J A Madden
    Department of Neurology, The Medical College of Wisconsin, Milwaukee, USA
    Physiol Res 49:561-6. 2000
    ..Future studies to determine the interaction between pHi, [Ca2+]i and HPV should ascertain whether pHi and [Ca2+]i changes are linked and how they may interact to promote or inhibit SMC contraction...
  5. ncbi request reprint Ion exchange activity in pulmonary artery smooth muscle cells: the response to hypoxia
    J A Madden
    Department of Neurology, The Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Lung Cell Mol Physiol 280:L264-71. 2001
    ..The absence of Na+ prevented hypoxia-induced alkalinization in SPA cells; in both cell types, inhibiting the Cl-/HCO3- exchange activities reversed the normal direction of pH(c) changes during hypoxia...
  6. ncbi request reprint Absence of flow-mediated vasodilation in the rabbit femoral artery
    P S Clifford
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, USA
    Physiol Res 59:331-8. 2010
    ..Based on these results, it seems unlikely that flow-mediated vasodilation in the rabbit femoral artery contributes to exercise hyperemia...
  7. ncbi request reprint Cyclooxygenase contracting factors and altered pulmonary vascular responses in chronically hypoxic newborn pigs
    Candice D Fike
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Appl Physiol 92:67-74. 2002
    ..The early development of thromboxane-mediated constriction may contribute to the pathogenesis of chronic hypoxia-induced pulmonary hypertension in newborns...
  8. ncbi request reprint What leads to different mediators of alkalosis-induced vasodilation in isolated and in situ pulmonary vessels?
    John B Gordon
    Department of Pediatrics Critical Care, Medical College of Wisconsin and Zablocki Veterans Administration Medical Center, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Lung Cell Mol Physiol 284:L799-807. 2003
    ..g., adventitia and parenchyma) and remote signaling pathways, will need to be carried out to reconcile this discordance between isolated and in situ arteries...
  9. ncbi request reprint Voltage-gated K+ channels at an early stage of chronic hypoxia-induced pulmonary hypertension in newborn piglets
    Candice D Fike
    Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Physiol Lung Cell Mol Physiol 291:L1169-76. 2006
    ..2, smooth muscle cell membrane properties are altered such that E(m) is depolarized and K(V) channel family function is impaired in SPA of piglets at an early stage of chronic hypoxia-induced pulmonary hypertension...
  10. pmc Voltage-gated K+ channels in rat small cerebral arteries: molecular identity of the functional channels
    Sulayma Albarwani
    Department of Physiology, College of Medicine, Sultan Qaboos University, Al Khod, Sultanate of Oman
    J Physiol 551:751-63. 2003
    ..The findings of this study suggest that KV1.2/1.5 heterotetramers are preferentially expressed in rat cerebral VSMCs, and that these channels contribute to the resting membrane potential and diameter of rat small cerebral arteries...
  11. ncbi request reprint Hydrogen sulfide as an oxygen sensor/transducer in vertebrate hypoxic vasoconstriction and hypoxic vasodilation
    Kenneth R Olson
    Indiana University School of Medicine South Bend, 1234 Notre Dame Avenue, South Bend, IN 46617, USA
    J Exp Biol 209:4011-23. 2006
    ..In this model, the concentration of vasoactive H2S in the vessel is governed by the balance between endogenous H2S production and its oxidation by available O2...
  12. ncbi request reprint Point:Counterpoint: "Release of an endothelium-derived vasoconstrictor and RhoA/Rho kinase-mediated calcium sensitization of smooth muscle cell contraction are/are not the main effectors for full and sustained hypoxic pulmonary vasoconstriction"
    Jane A Madden
    Medical College of Wisconsin, Zablocki Veterans Affairs Medical Center, USA
    J Appl Physiol 102:2077; discussion 2080. 2007