Louis Luttrell

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. pmc β-arrestin-selective G protein-coupled receptor agonists engender unique biological efficacy in vivo
    Diane Gesty-Palmer
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Endocrinol 27:296-314. 2013
  2. doi request reprint Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors
    Louis M Luttrell
    Division of Endocrinology, Diabetes and Medical Genetics, Department of Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, 816 CSB, P O Box 250624, Charleston, SC 29425, USA
    Mol Biotechnol 39:239-64. 2008
  3. ncbi request reprint Composition and function of g protein-coupled receptor signalsomes controlling mitogen-activated protein kinase activity
    Louis M Luttrell
    Departments of Medicine and Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Mol Neurosci 26:253-64. 2005
  4. doi request reprint Refining efficacy: allosterism and bias in G protein-coupled receptor signaling
    Louis M Luttrell
    Department of Medicine, Medical University of South Carolina, Charleston, SC, USA
    Methods Mol Biol 756:3-35. 2011
  5. pmc Novel mechanisms in the regulation of G protein-coupled receptor trafficking to the plasma membrane
    Baby G Tholanikunnel
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 285:33816-25. 2010
  6. pmc Beta-arrestin 2 negatively regulates sepsis-induced inflammation
    Hongkuan Fan
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA
    Immunology 130:344-51. 2010
  7. doi request reprint Angiotensin II-induced cyclooxygenase 2 expression in rat aorta vascular smooth muscle cells does not require heterotrimeric G protein activation
    Thomas A Morinelli
    Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 330:118-24. 2009
  8. pmc Connective tissue growth factor and susceptibility to renal and vascular disease risk in type 1 diabetes
    Ayad A Jaffa
    Department of Medicine, Endocrinology Diabetes Medical Genetics, Medical University of South Carolina, 114 Doughty Street, Charleston, SC 29425, USA
    J Clin Endocrinol Metab 93:1893-900. 2008
  9. pmc Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation
    Sudha K Shenoy
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 282:29549-62. 2007
  10. ncbi request reprint Transmembrane signaling by G protein-coupled receptors
    Louis M Luttrell
    Department of Medicine and Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, USA
    Methods Mol Biol 332:3-49. 2006

Research Grants

  1. Parathyroid Hormone and Osteoblast Mitogenesis
    Louis Luttrell; Fiscal Year: 2005
  2. Tyrosine kinases in G protein mediated signaling.
    Louis Luttrell; Fiscal Year: 2006
  3. TYROSINE KINASES IN G PROTEIN MEDIATED SIGNALING
    Louis Luttrell; Fiscal Year: 2009
  4. TYROSINE KINASES IN G PROTEIN MEDIATED SIGNALING
    Louis M Luttrell; Fiscal Year: 2010
  5. Receptor 'transactivation' in insulin signaling.
    Louis Luttrell; Fiscal Year: 2004
  6. TYROSINE KINASES IN G PROTEIN MEDIATED SIGNALING
    Louis Luttrell; Fiscal Year: 2002
  7. TYROSINE KINASES IN G PROTEIN MEDIATED SIGNALING
    Louis M Luttrell; Fiscal Year: 2010

Collaborators

Detail Information

Publications45

  1. pmc β-arrestin-selective G protein-coupled receptor agonists engender unique biological efficacy in vivo
    Diane Gesty-Palmer
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Endocrinol 27:296-314. 2013
    ....
  2. doi request reprint Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors
    Louis M Luttrell
    Division of Endocrinology, Diabetes and Medical Genetics, Department of Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, 816 CSB, P O Box 250624, Charleston, SC 29425, USA
    Mol Biotechnol 39:239-64. 2008
    ..While the physiologic relevance of many of these novel mechanisms of GPCR signaling remains to be established, their existence suggests that the mechanisms of GPCR signaling are even more diverse than previously imagined...
  3. ncbi request reprint Composition and function of g protein-coupled receptor signalsomes controlling mitogen-activated protein kinase activity
    Louis M Luttrell
    Departments of Medicine and Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Mol Neurosci 26:253-64. 2005
    ..Together, these highly organized signaling complexes dictate the location, duration, and ultimate function of GPCR-stimulated MAP kinase activity...
  4. doi request reprint Refining efficacy: allosterism and bias in G protein-coupled receptor signaling
    Louis M Luttrell
    Department of Medicine, Medical University of South Carolina, Charleston, SC, USA
    Methods Mol Biol 756:3-35. 2011
    ..A more complete description of ligand-receptor interaction requires the use of multiplexed assays of receptor activation and screening assays may need to be tailored to detect specific efficacy profiles...
  5. pmc Novel mechanisms in the regulation of G protein-coupled receptor trafficking to the plasma membrane
    Baby G Tholanikunnel
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 285:33816-25. 2010
    ....
  6. pmc Beta-arrestin 2 negatively regulates sepsis-induced inflammation
    Hongkuan Fan
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA
    Immunology 130:344-51. 2010
    ..Our data demonstrate that beta-arrestin 2 functions to negatively regulate the inflammatory response in polymicrobial sepsis...
  7. doi request reprint Angiotensin II-induced cyclooxygenase 2 expression in rat aorta vascular smooth muscle cells does not require heterotrimeric G protein activation
    Thomas A Morinelli
    Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 330:118-24. 2009
    ..These data suggest that G protein activation results in increased COX-2 protein expression, but AngII-induced COX-2 expression seems to occur independently of G protein activation...
  8. pmc Connective tissue growth factor and susceptibility to renal and vascular disease risk in type 1 diabetes
    Ayad A Jaffa
    Department of Medicine, Endocrinology Diabetes Medical Genetics, Medical University of South Carolina, 114 Doughty Street, Charleston, SC 29425, USA
    J Clin Endocrinol Metab 93:1893-900. 2008
    ..We explored the relevance and significance of connective tissue growth factor (CTGF) as a determinant of renal and vascular complications among type 1 diabetic patients...
  9. pmc Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation
    Sudha K Shenoy
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 282:29549-62. 2007
    ....
  10. ncbi request reprint Transmembrane signaling by G protein-coupled receptors
    Louis M Luttrell
    Department of Medicine and Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, USA
    Methods Mol Biol 332:3-49. 2006
    ..In some cases, these processes appear to generate signals in conjunction with, or even independent of, G protein activation...
  11. ncbi request reprint Constitutive ERK1/2 activation by a chimeric neurokinin 1 receptor-beta-arrestin1 fusion protein. Probing the composition and function of the G protein-coupled receptor "signalsome"
    Farahdiba Jafri
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 281:19346-57. 2006
    ..These data suggest that beta-arrestin binding to GPCRs nucleates the formation of a stable "signalsome" that functions as a passive scaffold for the ERK1/2 cascade while confining ERK1/2 activity to an extranuclear compartment...
  12. ncbi request reprint Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo
    Liza Barki-Harrington
    Department of Medicine, Duke University Medical Center, Durham, NC, 27710, USA
    Circulation 108:1611-8. 2003
    ..Although the renin-angiotensin and the beta-adrenergic systems are interrelated, a direct interaction between beta-adrenergic receptors (betaARs) and angiotensin II type 1 receptors (AT1Rs) has not been identified...
  13. ncbi request reprint Role of beta-arrestin-mediated desensitization and signaling in the control of angiotensin AT1a receptor-stimulated transcription
    Mi Hye Lee
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 283:2088-97. 2008
    ....
  14. ncbi request reprint Not so strange bedfellows: G-protein-coupled receptors and Src family kinases
    Deirdre K Luttrell
    Department of Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA
    Oncogene 23:7969-78. 2004
    ..It is now clear that GPCRs and Src family kinases do not belong to separate, exclusive clubs. Rather, these strange bedfellows are intimately involved in multilayered forms of crosstalk that influence a host of cellular processes...
  15. pmc Bradykinin decreases podocyte permeability through ADAM17-dependent epidermal growth factor receptor activation and zonula occludens-1 rearrangement
    Mamon Dey
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Pharmacol Exp Ther 334:775-83. 2010
    ..Our data indicate that ADAM17 and the EGFR may be potential novel therapeutic targets in diabetic nephropathy and other chronic kidney diseases...
  16. doi request reprint Genetic variant in the promoter of connective tissue growth factor gene confers susceptibility to nephropathy in type 1 diabetes
    Bing Wang
    Department of Medicine, Medical University of South Carolina, 114 Doughty Street, P O Box 250776 Charleston, SC 29425, USA
    J Med Genet 47:391-7. 2010
    ....
  17. ncbi request reprint Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus
    David S Feldman
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:28631-40. 2002
    ..ERK activation by the G(q/11)-coupled alpha(1B)AR was unaffected by GsCT. These findings suggest that peptide G protein inhibitors can provide insights into the complex interplay between G protein pools in cellular regulation...
  18. ncbi request reprint Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts
    Intekhab Ahmed
    Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Mol Endocrinol 17:1607-21. 2003
    ..These data suggest that autocrine/paracrine cross-talk between EGF receptors and Gi- or Gq/11-coupled GPCRs represents the predominant mechanism of GPCR-mediated activation of ERK1/2 in cultured TMOb osteoblasts...
  19. ncbi request reprint Identification of a putative nuclear localization sequence within ANG II AT(1A) receptor associated with nuclear activation
    Thomas A Morinelli
    Division of Nephrology, Department of Medicine, Medical University of South Carolina, 829 Clinical Sciences Bldg, 96 Jonathan Lucas St, Charleston, SC 29425, USA
    Am J Physiol Cell Physiol 292:C1398-408. 2007
    ....
  20. pmc Beta-arrestins 1 and 2 differentially regulate LPS-induced signaling and pro-inflammatory gene expression
    Hongkuan Fan
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, United States
    Mol Immunol 44:3092-9. 2007
    ..Understanding the role of beta-arrestins in regulation of TLR signaling pathways may provide novel insights into control mechanisms for inflammatory gene expression...
  21. ncbi request reprint Activation and targeting of mitogen-activated protein kinases by G-protein-coupled receptors
    Louis M Luttrell
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Can J Physiol Pharmacol 80:375-82. 2002
    ..By controlling the spatial and temporal distribution of MAP kinase activity within the cell, the consequences of GPCR-stimulated MAP kinase activation may be determined by the mechanism by which they are activated...
  22. ncbi request reprint Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity
    Robert J Lefkowitz
    Department of Medicine, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Pharmacol 62:971-4. 2002
  23. doi request reprint Diversity in arrestin function
    Ryan T Kendall
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Cell Mol Life Sci 66:2953-73. 2009
    ..Growing evidence suggests that signalsomes regulate such diverse processes as endocytosis and exocytosis, cell migration, survival, and contractility...
  24. pmc A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation
    Diane Gesty-Palmer
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Sci Transl Med 1:1ra1. 2009
    ..Ligands with these properties may form the basis for improved 7TMR-directed pharmacologic agents with enhanced therapeutic specificity...
  25. ncbi request reprint The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation
    Akira Tohgo
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 278:6258-67. 2003
    ....
  26. pmc Beyond desensitization: physiological relevance of arrestin-dependent signaling
    Louis M Luttrell
    Department of Medicine, Medical University of South Carolina, USA
    Pharmacol Rev 62:305-30. 2010
    ..Understanding the signaling roles of arrestins may foster the development of pathway-selective drugs that exploit these pathways for therapeutic benefit...
  27. pmc Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors
    Rany T Abdallah
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 285:35206-15. 2010
    ..These results suggest a novel mechanism of bradykinin-independent kallikrein action that may contribute to the regulation of vascular responses in pathophysiologic states, such as diabetes mellitus...
  28. ncbi request reprint beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts
    Diane Gesty-Palmer
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:32157-67. 2005
    ..These data indicate that beta-arrestin 2 functions both to attenuate EGF receptor transactivation-dependent signaling and to promote a distinct subset of ERK1/2-mediated responses to LPA receptor activation...
  29. pmc Essential role of c-Cbl in amphiregulin-induced recycling and signaling of the endogenous epidermal growth factor receptor
    Aleksander Baldys
    Nephrology Division, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Biochemistry 48:1462-73. 2009
    ..These data support novel functions of c-Cbl in mediating recycling of EGF receptors to the plasma membrane, as well as in mediating the duration of activation (transient vs sustained) of ERK1/2 MAPK phosphorylation...
  30. pmc The adiponectin receptors AdipoR1 and AdipoR2 activate ERK1/2 through a Src/Ras-dependent pathway and stimulate cell growth
    Mi Hye Lee
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Biochemistry 47:11682-92. 2008
    ..These results suggest that adiponectin can exert proliferative effects by activating Ras signaling pathways...
  31. ncbi request reprint Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation
    Diane Gesty-Palmer
    Department of Medicine, Howard Hughes Medical Institute, Duke University, Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 281:10856-64. 2006
    ..These findings imply the existence of distinct active conformations of the hPTH1R responsible for the two pathways, which can be stimulated by unique ligands. Such ligands may have distinct and valuable therapeutic properties...
  32. ncbi request reprint The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells
    Hesham M El-Shewy
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 282:26150-7. 2007
    ..These data indicate that endogenous IGF-1 and IGF-2 receptors can independently initiate ERK1/2 signaling and point to a potential physiologic role for IGF-2 receptors in the cellular response to IGF-2...
  33. ncbi request reprint Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors
    Hesham M El-Shewy
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 281:31399-407. 2006
    ..Given the ubiquity of SK and S1P receptor expression, S1P receptor transactivation may represent a general mechanism for G protein-dependent signaling by non-G protein-coupled receptors...
  34. ncbi request reprint 5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-alpha-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cells
    Monika Gooz
    Nephrology, Rheumatology and Endocrinology Divisions, Department of Medicine of the Medical University of South Carolina, Charleston, 29425, USA
    J Biol Chem 281:21004-12. 2006
    ..To our knowledge, this is the first time that TACE has been implicated in 5-HT-induced EGFR transactivation or in proliferation induced by a G protein-coupled receptor in native cells in culture...
  35. ncbi request reprint Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor
    Seungkirl Ahn
    Howard Hughes Medical Institute, Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:26642-51. 2002
    ..Thus, c-Src-mediated tyrosine phosphorylation is required for the function of dynamin in ligand-induced signaling receptor internalization...
  36. pmc Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2
    Huijun Wei
    Howard Hughes Medical Institute and Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 100:10782-7. 2003
    ....
  37. ncbi request reprint beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation
    Akira Tohgo
    Howard Hughes Medical Institute and the Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:9429-36. 2002
    ..These data demonstrate that beta-arrestins facilitate GPCR-mediated ERK activation but inhibit ERK-dependent transcription by binding to phospho-ERK1/2, leading to its retention in the cytosol...
  38. ncbi request reprint Signaling in time and space: G protein-coupled receptors and mitogen-activated protein kinases
    Deirdre K Luttrell
    Department of High Throughput Biology, GlaxoSmithKline, Research Triangle Park, North Carolina, USA
    Assay Drug Dev Technol 1:327-38. 2003
    ....
  39. ncbi request reprint Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system
    A Musa Zamah
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    J Biol Chem 277:31249-56. 2002
    ..These results provide strong experimental support for the idea that PKA-mediated phosphorylation of the beta(2)-adrenergic receptor switches its predominant coupling from G(s) to G(i)...
  40. pmc The origins of diversity and specificity in g protein-coupled receptor signaling
    Stuart Maudsley
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Gerontology Research Center, 5600 Nathan Shock Drive, Johns Hopkins Medical Center, Baltimore, MD, USA
    J Pharmacol Exp Ther 314:485-94. 2005
    ..As a more comprehensive understanding of the complexity of GPCR signaling is developed, the rational design of ligands possessing increased specific efficacy and attenuated side effects may become the standard mode of drug development...
  41. ncbi request reprint Arrestin-mediated ERK activation by gonadotropin-releasing hormone receptors: receptor-specific activation mechanisms and compartmentalization
    Christopher J Caunt
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Whitson Street, Bristol BS1 3NY, United Kingdom
    J Biol Chem 281:2701-10. 2006
    ....
  42. ncbi request reprint Signal switching, crosstalk, and arrestin scaffolds: novel G protein-coupled receptor signaling in cardiovascular disease
    Nicola J Smith
    Molecular Endocrinology Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Hypertension 48:173-9. 2006
  43. ncbi request reprint G protein-coupled receptor signaling complexity in neuronal tissue: implications for novel therapeutics
    Stuart Maudsley
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Gerontology Research Center, Johns Hopkins Medical Center, Baltimore, MD 21224, USA
    Curr Alzheimer Res 4:3-19. 2007
    ..As a more comprehensive understanding of the complexity of GPCR signaling is developed, the rational design of ligands possessing increased specific efficacy and attenuated side effects may become the standard mode of drug development...
  44. ncbi request reprint Heptahelical terpsichory. Who calls the tune?
    Diane Gesty-Palmer
    Department of Medicine Duke University Medical Center, Durham, North Carolina, USA
    J Recept Signal Transduct Res 28:39-58. 2008
    ....
  45. ncbi request reprint The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals
    Louis M Luttrell
    The Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Sci 115:455-65. 2002
    ..Thus, their binding to GPCRs might initiate a second wave of signaling and represent a novel mechanism of GPCR signal transduction...

Research Grants24

  1. Parathyroid Hormone and Osteoblast Mitogenesis
    Louis Luttrell; Fiscal Year: 2005
    ..By increasing our understanding of the mechanisms of GPCR signaling in bone, these studies may permit the rational development of safe strategies for employing PTH analogues to modulate osteoblast number and/or function. ..
  2. Tyrosine kinases in G protein mediated signaling.
    Louis Luttrell; Fiscal Year: 2006
    ....
  3. TYROSINE KINASES IN G PROTEIN MEDIATED SIGNALING
    Louis Luttrell; Fiscal Year: 2009
    ..These studies address fundamental gaps in our understanding of how GPCRs work and may provide insights into novel therapeutic applications of GPCR ligands with pathway-selective agonist or antagonist properties. ..
  4. TYROSINE KINASES IN G PROTEIN MEDIATED SIGNALING
    Louis M Luttrell; Fiscal Year: 2010
    ..These studies address fundamental gaps in our understanding of how GPCRs work and may provide insights into novel therapeutic applications of GPCR ligands with pathway-selective agonist or antagonist properties. ..
  5. Receptor 'transactivation' in insulin signaling.
    Louis Luttrell; Fiscal Year: 2004
    ..Understanding these mechanisms may lead to pharmacologic approaches to dissociate the potentially harmful proliferative effects of insulin family receptors from their anti-apoptotic and metabolic effects. ..
  6. TYROSINE KINASES IN G PROTEIN MEDIATED SIGNALING
    Louis Luttrell; Fiscal Year: 2002
    ....
  7. TYROSINE KINASES IN G PROTEIN MEDIATED SIGNALING
    Louis M Luttrell; Fiscal Year: 2010
    ..These studies address fundamental gaps in our understanding of how GPCRs work and may provide insights into novel therapeutic applications of GPCR ligands with pathway-selective agonist or antagonist properties. ..