Research Topics
Species | Louis LuttrellSummaryAffiliation: Medical University of South Carolina Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
β-arrestin-selective G protein-coupled receptor agonists engender unique biological efficacy in vivoDiane Gesty-Palmer
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Mol Endocrinol 27:296-314. 2013....- Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptorsLouis M Luttrell
Division of Endocrinology, Diabetes and Medical Genetics, Department of Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, 816 CSB, P O Box 250624, Charleston, SC 29425, USA
Mol Biotechnol 39:239-64. 2008..While the physiologic relevance of many of these novel mechanisms of GPCR signaling remains to be established, their existence suggests that the mechanisms of GPCR signaling are even more diverse than previously imagined... 
Composition and function of g protein-coupled receptor signalsomes controlling mitogen-activated protein kinase activityLouis M Luttrell
Departments of Medicine and Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
J Mol Neurosci 26:253-64. 2005..Together, these highly organized signaling complexes dictate the location, duration, and ultimate function of GPCR-stimulated MAP kinase activity...- Refining efficacy: allosterism and bias in G protein-coupled receptor signalingLouis M Luttrell
Department of Medicine, Medical University of South Carolina, Charleston, SC, USA
Methods Mol Biol 756:3-35. 2011..A more complete description of ligand-receptor interaction requires the use of multiplexed assays of receptor activation and screening assays may need to be tailored to detect specific efficacy profiles... 
Novel mechanisms in the regulation of G protein-coupled receptor trafficking to the plasma membraneBaby G Tholanikunnel
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Biol Chem 285:33816-25. 2010....- Beta-arrestin 2 negatively regulates sepsis-induced inflammationHongkuan Fan
Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA
Immunology 130:344-51. 2010..Our data demonstrate that beta-arrestin 2 functions to negatively regulate the inflammatory response in polymicrobial sepsis... - Angiotensin II-induced cyclooxygenase 2 expression in rat aorta vascular smooth muscle cells does not require heterotrimeric G protein activationThomas A Morinelli
Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
J Pharmacol Exp Ther 330:118-24. 2009..These data suggest that G protein activation results in increased COX-2 protein expression, but AngII-induced COX-2 expression seems to occur independently of G protein activation... - Connective tissue growth factor and susceptibility to renal and vascular disease risk in type 1 diabetesAyad A Jaffa
Department of Medicine, Endocrinology Diabetes Medical Genetics, Medical University of South Carolina, 114 Doughty Street, Charleston, SC 29425, USA
J Clin Endocrinol Metab 93:1893-900. 2008..We explored the relevance and significance of connective tissue growth factor (CTGF) as a determinant of renal and vascular complications among type 1 diabetic patients... - Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activationSudha K Shenoy
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 282:29549-62. 2007.... - Transmembrane signaling by G protein-coupled receptorsLouis M Luttrell
Department of Medicine and Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, USA
Methods Mol Biol 332:3-49. 2006..In some cases, these processes appear to generate signals in conjunction with, or even independent of, G protein activation... - Constitutive ERK1/2 activation by a chimeric neurokinin 1 receptor-beta-arrestin1 fusion protein. Probing the composition and function of the G protein-coupled receptor "signalsome"Farahdiba Jafri
Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Biol Chem 281:19346-57. 2006..These data suggest that beta-arrestin binding to GPCRs nucleates the formation of a stable "signalsome" that functions as a passive scaffold for the ERK1/2 cascade while confining ERK1/2 activity to an extranuclear compartment... - Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivoLiza Barki-Harrington
Department of Medicine, Duke University Medical Center, Durham, NC, 27710, USA
Circulation 108:1611-8. 2003..CONCLUSIONS: We show that direct interactions between betaARs and AT1Rs may have profound consequences on the overall response to drugs that antagonize these receptors... - Role of beta-arrestin-mediated desensitization and signaling in the control of angiotensin AT1a receptor-stimulated transcriptionMi Hye Lee
Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Biol Chem 283:2088-97. 2008.... - Not so strange bedfellows: G-protein-coupled receptors and Src family kinasesDeirdre K Luttrell
Department of Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA
Oncogene 23:7969-78. 2004..It is now clear that GPCRs and Src family kinases do not belong to separate, exclusive clubs. Rather, these strange bedfellows are intimately involved in multilayered forms of crosstalk that influence a host of cellular processes... - Bradykinin decreases podocyte permeability through ADAM17-dependent epidermal growth factor receptor activation and zonula occludens-1 rearrangementMamon Dey
Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Pharmacol Exp Ther 334:775-83. 2010..Our data indicate that ADAM17 and the EGFR may be potential novel therapeutic targets in diabetic nephropathy and other chronic kidney diseases... - Genetic variant in the promoter of connective tissue growth factor gene confers susceptibility to nephropathy in type 1 diabetesBing Wang
Department of Medicine, Medical University of South Carolina, 114 Doughty Street, P O Box 250776 Charleston, SC 29425, USA
J Med Genet 47:391-7. 2010.... - Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminusDavid S Feldman
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 277:28631-40. 2002..ERK activation by the G(q/11)-coupled alpha(1B)AR was unaffected by GsCT. These findings suggest that peptide G protein inhibitors can provide insights into the complex interplay between G protein pools in cellular regulation... - Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblastsIntekhab Ahmed
Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Mol Endocrinol 17:1607-21. 2003..These data suggest that autocrine/paracrine cross-talk between EGF receptors and Gi- or Gq/11-coupled GPCRs represents the predominant mechanism of GPCR-mediated activation of ERK1/2 in cultured TMOb osteoblasts... - Identification of a putative nuclear localization sequence within ANG II AT(1A) receptor associated with nuclear activationThomas A Morinelli
Division of Nephrology, Department of Medicine, Medical University of South Carolina, 829 Clinical Sciences Bldg, 96 Jonathan Lucas St, Charleston, SC 29425, USA
Am J Physiol Cell Physiol 292:C1398-408. 2007.... - Beta-arrestins 1 and 2 differentially regulate LPS-induced signaling and pro-inflammatory gene expressionHongkuan Fan
Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, United States
Mol Immunol 44:3092-9. 2007..Understanding the role of beta-arrestins in regulation of TLR signaling pathways may provide novel insights into control mechanisms for inflammatory gene expression... - Activation and targeting of mitogen-activated protein kinases by G-protein-coupled receptorsLouis M Luttrell
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Can J Physiol Pharmacol 80:375-82. 2002..By controlling the spatial and temporal distribution of MAP kinase activity within the cell, the consequences of GPCR-stimulated MAP kinase activation may be determined by the mechanism by which they are activated... - Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificityRobert J Lefkowitz
Department of Medicine, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
Mol Pharmacol 62:971-4. 2002 - Diversity in arrestin functionRyan T Kendall
Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
Cell Mol Life Sci 66:2953-73. 2009..Growing evidence suggests that signalsomes regulate such diverse processes as endocytosis and exocytosis, cell migration, survival, and contractility... - A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activationDiane Gesty-Palmer
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Sci Transl Med 1:1ra1. 2009..Ligands with these properties may form the basis for improved 7TMR-directed pharmacologic agents with enhanced therapeutic specificity... - The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activationAkira Tohgo
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 278:6258-67. 2003.... - Beyond desensitization: physiological relevance of arrestin-dependent signalingLouis M Luttrell
Department of Medicine, Medical University of South Carolina, USA
Pharmacol Rev 62:305-30. 2010..Understanding the signaling roles of arrestins may foster the development of pathway-selective drugs that exploit these pathways for therapeutic benefit... - Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptorsRany T Abdallah
Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Biol Chem 285:35206-15. 2010..These results suggest a novel mechanism of bradykinin-independent kallikrein action that may contribute to the regulation of vascular responses in pathophysiologic states, such as diabetes mellitus... - beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblastsDiane Gesty-Palmer
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 280:32157-67. 2005..These data indicate that beta-arrestin 2 functions both to attenuate EGF receptor transactivation-dependent signaling and to promote a distinct subset of ERK1/2-mediated responses to LPA receptor activation... - Essential role of c-Cbl in amphiregulin-induced recycling and signaling of the endogenous epidermal growth factor receptorAleksander Baldys
Nephrology Division, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Biochemistry 48:1462-73. 2009..These data support novel functions of c-Cbl in mediating recycling of EGF receptors to the plasma membrane, as well as in mediating the duration of activation (transient vs sustained) of ERK1/2 MAPK phosphorylation... - The adiponectin receptors AdipoR1 and AdipoR2 activate ERK1/2 through a Src/Ras-dependent pathway and stimulate cell growthMi Hye Lee
Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Biochemistry 47:11682-92. 2008..These results suggest that adiponectin can exert proliferative effects by activating Ras signaling pathways... - Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activationDiane Gesty-Palmer
Department of Medicine, Howard Hughes Medical Institute, Duke University, Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 281:10856-64. 2006..These findings imply the existence of distinct active conformations of the hPTH1R responsible for the two pathways, which can be stimulated by unique ligands. Such ligands may have distinct and valuable therapeutic properties... - The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cellsHesham M El-Shewy
Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Biol Chem 282:26150-7. 2007..These data indicate that endogenous IGF-1 and IGF-2 receptors can independently initiate ERK1/2 signaling and point to a potential physiologic role for IGF-2 receptors in the cellular response to IGF-2... - Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptorsHesham M El-Shewy
Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Biol Chem 281:31399-407. 2006..Given the ubiquity of SK and S1P receptor expression, S1P receptor transactivation may represent a general mechanism for G protein-dependent signaling by non-G protein-coupled receptors... - 5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-alpha-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cellsMonika Gooz
Nephrology, Rheumatology and Endocrinology Divisions, Department of Medicine of the Medical University of South Carolina, Charleston, 29425, USA
J Biol Chem 281:21004-12. 2006..To our knowledge, this is the first time that TACE has been implicated in 5-HT-induced EGFR transactivation or in proliferation induced by a G protein-coupled receptor in native cells in culture... - Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptorSeungkirl Ahn
Howard Hughes Medical Institute, Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 277:26642-51. 2002..Thus, c-Src-mediated tyrosine phosphorylation is required for the function of dynamin in ligand-induced signaling receptor internalization... - Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2Huijun Wei
Howard Hughes Medical Institute and Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 100:10782-7. 2003.... - beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulationAkira Tohgo
Howard Hughes Medical Institute and the Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 277:9429-36. 2002..These data demonstrate that beta-arrestins facilitate GPCR-mediated ERK activation but inhibit ERK-dependent transcription by binding to phospho-ERK1/2, leading to its retention in the cytosol... - Signaling in time and space: G protein-coupled receptors and mitogen-activated protein kinasesDeirdre K Luttrell
Department of High Throughput Biology, GlaxoSmithKline, Research Triangle Park, North Carolina, USA
Assay Drug Dev Technol 1:327-38. 2003.... - Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted systemA Musa Zamah
Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
J Biol Chem 277:31249-56. 2002..These results provide strong experimental support for the idea that PKA-mediated phosphorylation of the beta(2)-adrenergic receptor switches its predominant coupling from G(s) to G(i)... - The origins of diversity and specificity in g protein-coupled receptor signalingStuart Maudsley
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Gerontology Research Center, 5600 Nathan Shock Drive, Johns Hopkins Medical Center, Baltimore, MD, USA
J Pharmacol Exp Ther 314:485-94. 2005..As a more comprehensive understanding of the complexity of GPCR signaling is developed, the rational design of ligands possessing increased specific efficacy and attenuated side effects may become the standard mode of drug development... - Arrestin-mediated ERK activation by gonadotropin-releasing hormone receptors: receptor-specific activation mechanisms and compartmentalizationChristopher J Caunt
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Whitson Street, Bristol BS1 3NY, United Kingdom
J Biol Chem 281:2701-10. 2006.... - Signal switching, crosstalk, and arrestin scaffolds: novel G protein-coupled receptor signaling in cardiovascular diseaseNicola J Smith
Molecular Endocrinology Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
Hypertension 48:173-9. 2006 - G protein-coupled receptor signaling complexity in neuronal tissue: implications for novel therapeuticsStuart Maudsley
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Gerontology Research Center, Johns Hopkins Medical Center, Baltimore, MD 21224, USA
Curr Alzheimer Res 4:3-19. 2007..As a more comprehensive understanding of the complexity of GPCR signaling is developed, the rational design of ligands possessing increased specific efficacy and attenuated side effects may become the standard mode of drug development... - Heptahelical terpsichory. Who calls the tune?Diane Gesty-Palmer
Department of Medicine Duke University Medical Center, Durham, North Carolina, USA
J Recept Signal Transduct Res 28:39-58. 2008.... - The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signalsLouis M Luttrell
The Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
J Cell Sci 115:455-65. 2002..Thus, their binding to GPCRs might initiate a second wave of signaling and represent a novel mechanism of GPCR signal transduction...
Research Grants
- Parathyroid Hormone and Osteoblast MitogenesisLouis Luttrell; Fiscal Year: 2005..By increasing our understanding of the mechanisms of GPCR signaling in bone, these studies may permit the rational development of safe strategies for employing PTH analogues to modulate osteoblast number and/or function. ..
- Tyrosine kinases in G protein mediated signaling.Louis Luttrell; Fiscal Year: 2006....
- TYROSINE KINASES IN G PROTEIN MEDIATED SIGNALINGLouis Luttrell; Fiscal Year: 2009..These studies address fundamental gaps in our understanding of how GPCRs work and may provide insights into novel therapeutic applications of GPCR ligands with pathway-selective agonist or antagonist properties. ..
- TYROSINE KINASES IN G PROTEIN MEDIATED SIGNALINGLouis M Luttrell; Fiscal Year: 2010..These studies address fundamental gaps in our understanding of how GPCRs work and may provide insights into novel therapeutic applications of GPCR ligands with pathway-selective agonist or antagonist properties. ..
- Receptor 'transactivation' in insulin signaling.Louis Luttrell; Fiscal Year: 2004..Understanding these mechanisms may lead to pharmacologic approaches to dissociate the potentially harmful proliferative effects of insulin family receptors from their anti-apoptotic and metabolic effects. ..
- TYROSINE KINASES IN G PROTEIN MEDIATED SIGNALINGLouis Luttrell; Fiscal Year: 2002....
- TYROSINE KINASES IN G PROTEIN MEDIATED SIGNALINGLouis M Luttrell; Fiscal Year: 2010..These studies address fundamental gaps in our understanding of how GPCRs work and may provide insights into novel therapeutic applications of GPCR ligands with pathway-selective agonist or antagonist properties. ..