Research Topics
| Yanping LiuSummaryAffiliation: Medical College of Wisconsin Country: USA Publications
Research Grants
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Detail Information
Publications
High glucose impairs voltage-gated K(+) channel current in rat small coronary arteriesY Liu
Department of Internal Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Circ Res 89:146-52. 2001..We speculate that this O(2)(.-)-induced impairment may reduce vasodilator responsiveness in the coronary circulation of subjects with coronary disease or its risk factors...- Peroxynitrite reduces the endothelium-derived hyperpolarizing factor component of coronary flow-mediated dilation in PECAM-1-knockout miceYanping Liu
Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Am J Physiol Regul Integr Comp Physiol 290:R57-65. 2006..In the absence of this adhesion and signaling molecule, ONOO- production is increased concomitant with a reduction in both the EDHF and INDO-sensitive components of FMD... - Nitration and functional loss of voltage-gated K+ channels in rat coronary microvessels exposed to high glucoseHongwei Li
Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Diabetes 53:2436-42. 2004..We conclude that ONOO(-) generated by HG impairs K(v) channel function in coronary microvessels, possibly by nitrating tyrosine residues in the pore-forming region of the K(v) channel protein... - Mitochondrial sources of H2O2 generation play a key role in flow-mediated dilation in human coronary resistance arteriesYanping Liu
Department of Internal Medicine, Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, Wis 53226, USA
Circ Res 93:573-80. 2003..05). Neither cyanide nor apocynin altered flow-induced dilation. These results suggest that shear stress induced H2O2 formation, and flow-induced dilation is derived from O2*- originating from mitochondrial respiration... - Peroxynitrite inhibits Ca2+-activated K+ channel activity in smooth muscle of human coronary arteriolesYanping Liu
Department of Internal Medicine, Medical College of Wisconsin, and Zablocki VA Medical Center, Milwaukee, Wis 53226, USA
Circ Res 91:1070-6. 2002..This mechanism may contribute to impaired EDHF-mediated dilation in conditions such as ischemia/reperfusion where increased activity of NO synthase occurs in the presence of excess of O2*-... - Oxidative stress and potassium channel functionYanping Liu
Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Clin Exp Pharmacol Physiol 29:305-11. 2002..5. Thus, redox modulation of potassium channel activity is an important mechanism regulating cell vascular smooth muscle membrane potential... - The coronary circulation in diabetes: influence of reactive oxygen species on K+ channel-mediated vasodilationYanping Liu
Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Vascul Pharmacol 38:43-9. 2002..In summary, determining the effect of ROS on K+ channel-mediated dilation will be important for understanding the pathophysiology of diabetic vascular dysfunction and for developing therapies to improve tissue perfusion in this disease... - Enhanced oxidative stress impairs cAMP-mediated dilation by reducing Kv channel function in small coronary arteries of diabetic ratsAaron H Bubolz
Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
Am J Physiol Heart Circ Physiol 289:H1873-80. 2005..Forskolin-induced cAMP production was unaltered in DM. We conclude that in diabetes, enhanced O2-* formation by activation of NADPH oxidase impairs cAMP-medicated dilation in RSCAs by inhibiting Kv channel activity... - Ebselen reduces nitration and restores voltage-gated potassium channel function in small coronary arteries of diabetic ratsAaron H Bubolz
Department of Medicine, The Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Am J Physiol Heart Circ Physiol 293:H2231-7. 2007..Eb may be beneficial for the therapeutic treatment of vascular complications in diabetes mellitus... - Elevated glucose impairs cAMP-mediated dilation by reducing Kv channel activity in rat small coronary smooth muscle cellsHongwei Li
Department of Internal Medicine, Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Am J Physiol Heart Circ Physiol 285:H1213-9. 2003..We speculate that in addition to the endothelial dysfunction, altered smooth muscle function may also contribute to the reduced coronary vasodilation in diabetes... 
H2O2 is the transferrable factor mediating flow-induced dilation in human coronary arteriolesYanping Liu
Office of Research, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Circ Res 108:566-73. 2011..However, H(2)O(2) has never been shown to be the endothelium-dependent transferrable hyperpolarization factor (EDHF) in response to shear stress...- Redox modulation of vascular tone: focus of potassium channel mechanisms of dilationDavid D Gutterman
Cardiovascular Center, Department of Medicine, General Clinical Research Center, VA Medical Center, Medical College of Wisconsin, Milwaukee 53226, USA
Arterioscler Thromb Vasc Biol 25:671-8. 2005..Therefore, discerning the activity of enzymes regulating production or degradation of ROS is important when assessing tissue perfusion in health and disease... - Effect of gender on endothelium-dependent dilation to bradykinin in human adipose microvesselsAtsushi Sato
Department of Internal Medicine, Cardiovascular Research Center, and Veterans Administration Medical Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Am J Physiol Heart Circ Physiol 283:H845-52. 2002..Functional vascular differences in visceral and subcutaneous fat may underlie the proposed differential influence of these tissues on cardiovascular risk... - Interaction of myogenic mechanisms and hypoxic dilation in rat middle cerebral arteriesYanping Liu
Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
Am J Physiol Heart Circ Physiol 283:H2276-81. 2002.... - Redox signaling at reperfusion is required for protection from ischemic preconditioning but not from a direct PKC activatorYanping Liu
Department of Physiology, MSB 3074, University of South Alabama College of Medicine, Mobile, AL 36688, USA
Basic Res Cardiol 103:54-9. 2008..We conclude that while redox signaling during the first few minutes of reperfusion is an essential component of preconditioning's protective mechanism, this step occurs upstream of PKC activation... - Endothelial cytoskeletal elements are critical for flow-mediated dilation in human coronary arteriolesYanping Liu
The National Center for Research Resources, National Institutes of Health, Bethesda, MD, USA
Med Biol Eng Comput 46:469-78. 2008..58 +/- 7%). These results suggest that cytoskeletal elements are a critical component of the signaling mechanism linking endothelial shear stress and mitochondrial release of ROS in the human coronary microcirculation... - Infarct limitation by a protein kinase G activator at reperfusion in rabbit hearts is dependent on sensitizing the heart to A2b agonists by protein kinase CAtsushi Kuno
Department of Physiology, University of South Alabama, College of Medicine, Mobile, AL 36688, USA
Am J Physiol Heart Circ Physiol 295:H1288-H1295. 2008..Activated PKC then augments sensitivity of normally low-affinity cardiac adenosine A2b receptors so endogenous adenosine can protect by activating Akt and ERK...
Research Grants
- High glucose and arteriolar Kv channelsYanping Liu; Fiscal Year: 2004..The results may suggest new therapeutic approaches for the treatment of microvascular dysfunction in patients with diabetes. ..