Yanping Liu

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi request reprint High glucose impairs voltage-gated K(+) channel current in rat small coronary arteries
    Y Liu
    Department of Internal Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Circ Res 89:146-52. 2001
  2. ncbi request reprint Peroxynitrite reduces the endothelium-derived hyperpolarizing factor component of coronary flow-mediated dilation in PECAM-1-knockout mice
    Yanping Liu
    Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Regul Integr Comp Physiol 290:R57-65. 2006
  3. ncbi request reprint Nitration and functional loss of voltage-gated K+ channels in rat coronary microvessels exposed to high glucose
    Hongwei Li
    Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Diabetes 53:2436-42. 2004
  4. ncbi request reprint Mitochondrial sources of H2O2 generation play a key role in flow-mediated dilation in human coronary resistance arteries
    Yanping Liu
    Department of Internal Medicine, Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, Wis 53226, USA
    Circ Res 93:573-80. 2003
  5. ncbi request reprint Peroxynitrite inhibits Ca2+-activated K+ channel activity in smooth muscle of human coronary arterioles
    Yanping Liu
    Department of Internal Medicine, Medical College of Wisconsin, and Zablocki VA Medical Center, Milwaukee, Wis 53226, USA
    Circ Res 91:1070-6. 2002
  6. ncbi request reprint Oxidative stress and potassium channel function
    Yanping Liu
    Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Clin Exp Pharmacol Physiol 29:305-11. 2002
  7. ncbi request reprint The coronary circulation in diabetes: influence of reactive oxygen species on K+ channel-mediated vasodilation
    Yanping Liu
    Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Vascul Pharmacol 38:43-9. 2002
  8. ncbi request reprint Enhanced oxidative stress impairs cAMP-mediated dilation by reducing Kv channel function in small coronary arteries of diabetic rats
    Aaron H Bubolz
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    Am J Physiol Heart Circ Physiol 289:H1873-80. 2005
  9. ncbi request reprint Ebselen reduces nitration and restores voltage-gated potassium channel function in small coronary arteries of diabetic rats
    Aaron H Bubolz
    Department of Medicine, The Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Physiol Heart Circ Physiol 293:H2231-7. 2007
  10. ncbi request reprint Elevated glucose impairs cAMP-mediated dilation by reducing Kv channel activity in rat small coronary smooth muscle cells
    Hongwei Li
    Department of Internal Medicine, Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 285:H1213-9. 2003

Research Grants

  1. High glucose and arteriolar Kv channels
    Yanping Liu; Fiscal Year: 2004

Collaborators

Detail Information

Publications17

  1. ncbi request reprint High glucose impairs voltage-gated K(+) channel current in rat small coronary arteries
    Y Liu
    Department of Internal Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Circ Res 89:146-52. 2001
    ..We speculate that this O(2)(.-)-induced impairment may reduce vasodilator responsiveness in the coronary circulation of subjects with coronary disease or its risk factors...
  2. ncbi request reprint Peroxynitrite reduces the endothelium-derived hyperpolarizing factor component of coronary flow-mediated dilation in PECAM-1-knockout mice
    Yanping Liu
    Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Regul Integr Comp Physiol 290:R57-65. 2006
    ..In the absence of this adhesion and signaling molecule, ONOO- production is increased concomitant with a reduction in both the EDHF and INDO-sensitive components of FMD...
  3. ncbi request reprint Nitration and functional loss of voltage-gated K+ channels in rat coronary microvessels exposed to high glucose
    Hongwei Li
    Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Diabetes 53:2436-42. 2004
    ..We conclude that ONOO(-) generated by HG impairs K(v) channel function in coronary microvessels, possibly by nitrating tyrosine residues in the pore-forming region of the K(v) channel protein...
  4. ncbi request reprint Mitochondrial sources of H2O2 generation play a key role in flow-mediated dilation in human coronary resistance arteries
    Yanping Liu
    Department of Internal Medicine, Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, Wis 53226, USA
    Circ Res 93:573-80. 2003
    ..05). Neither cyanide nor apocynin altered flow-induced dilation. These results suggest that shear stress induced H2O2 formation, and flow-induced dilation is derived from O2*- originating from mitochondrial respiration...
  5. ncbi request reprint Peroxynitrite inhibits Ca2+-activated K+ channel activity in smooth muscle of human coronary arterioles
    Yanping Liu
    Department of Internal Medicine, Medical College of Wisconsin, and Zablocki VA Medical Center, Milwaukee, Wis 53226, USA
    Circ Res 91:1070-6. 2002
    ..This mechanism may contribute to impaired EDHF-mediated dilation in conditions such as ischemia/reperfusion where increased activity of NO synthase occurs in the presence of excess of O2*-...
  6. ncbi request reprint Oxidative stress and potassium channel function
    Yanping Liu
    Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Clin Exp Pharmacol Physiol 29:305-11. 2002
    ..5. Thus, redox modulation of potassium channel activity is an important mechanism regulating cell vascular smooth muscle membrane potential...
  7. ncbi request reprint The coronary circulation in diabetes: influence of reactive oxygen species on K+ channel-mediated vasodilation
    Yanping Liu
    Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Vascul Pharmacol 38:43-9. 2002
    ..In summary, determining the effect of ROS on K+ channel-mediated dilation will be important for understanding the pathophysiology of diabetic vascular dysfunction and for developing therapies to improve tissue perfusion in this disease...
  8. ncbi request reprint Enhanced oxidative stress impairs cAMP-mediated dilation by reducing Kv channel function in small coronary arteries of diabetic rats
    Aaron H Bubolz
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    Am J Physiol Heart Circ Physiol 289:H1873-80. 2005
    ..Forskolin-induced cAMP production was unaltered in DM. We conclude that in diabetes, enhanced O2-* formation by activation of NADPH oxidase impairs cAMP-medicated dilation in RSCAs by inhibiting Kv channel activity...
  9. ncbi request reprint Ebselen reduces nitration and restores voltage-gated potassium channel function in small coronary arteries of diabetic rats
    Aaron H Bubolz
    Department of Medicine, The Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Physiol Heart Circ Physiol 293:H2231-7. 2007
    ..Eb may be beneficial for the therapeutic treatment of vascular complications in diabetes mellitus...
  10. ncbi request reprint Elevated glucose impairs cAMP-mediated dilation by reducing Kv channel activity in rat small coronary smooth muscle cells
    Hongwei Li
    Department of Internal Medicine, Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 285:H1213-9. 2003
    ..We speculate that in addition to the endothelial dysfunction, altered smooth muscle function may also contribute to the reduced coronary vasodilation in diabetes...
  11. pmc H2O2 is the transferrable factor mediating flow-induced dilation in human coronary arterioles
    Yanping Liu
    Office of Research, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Circ Res 108:566-73. 2011
    ..However, H(2)O(2) has never been shown to be the endothelium-dependent transferrable hyperpolarization factor (EDHF) in response to shear stress...
  12. ncbi request reprint Redox modulation of vascular tone: focus of potassium channel mechanisms of dilation
    David D Gutterman
    Cardiovascular Center, Department of Medicine, General Clinical Research Center, VA Medical Center, Medical College of Wisconsin, Milwaukee 53226, USA
    Arterioscler Thromb Vasc Biol 25:671-8. 2005
    ..Therefore, discerning the activity of enzymes regulating production or degradation of ROS is important when assessing tissue perfusion in health and disease...
  13. ncbi request reprint Effect of gender on endothelium-dependent dilation to bradykinin in human adipose microvessels
    Atsushi Sato
    Department of Internal Medicine, Cardiovascular Research Center, and Veterans Administration Medical Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 283:H845-52. 2002
    ..Functional vascular differences in visceral and subcutaneous fat may underlie the proposed differential influence of these tissues on cardiovascular risk...
  14. ncbi request reprint Interaction of myogenic mechanisms and hypoxic dilation in rat middle cerebral arteries
    Yanping Liu
    Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Physiol Heart Circ Physiol 283:H2276-81. 2002
    ....
  15. pmc Redox signaling at reperfusion is required for protection from ischemic preconditioning but not from a direct PKC activator
    Yanping Liu
    Department of Physiology, MSB 3074, University of South Alabama College of Medicine, Mobile, AL 36688, USA
    Basic Res Cardiol 103:54-9. 2008
    ..We conclude that while redox signaling during the first few minutes of reperfusion is an essential component of preconditioning's protective mechanism, this step occurs upstream of PKC activation...
  16. pmc Endothelial cytoskeletal elements are critical for flow-mediated dilation in human coronary arterioles
    Yanping Liu
    The National Center for Research Resources, National Institutes of Health, Bethesda, MD, USA
    Med Biol Eng Comput 46:469-78. 2008
    ..58 +/- 7%). These results suggest that cytoskeletal elements are a critical component of the signaling mechanism linking endothelial shear stress and mitochondrial release of ROS in the human coronary microcirculation...
  17. pmc Infarct limitation by a protein kinase G activator at reperfusion in rabbit hearts is dependent on sensitizing the heart to A2b agonists by protein kinase C
    Atsushi Kuno
    Department of Physiology, University of South Alabama, College of Medicine, Mobile, AL 36688, USA
    Am J Physiol Heart Circ Physiol 295:H1288-H1295. 2008
    ..Activated PKC then augments sensitivity of normally low-affinity cardiac adenosine A2b receptors so endogenous adenosine can protect by activating Akt and ERK...

Research Grants2

  1. High glucose and arteriolar Kv channels
    Yanping Liu; Fiscal Year: 2004
    ..The results may suggest new therapeutic approaches for the treatment of microvascular dysfunction in patients with diabetes. ..