Gregory Liou

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. pmc Mediation of cannabidiol anti-inflammation in the retina by equilibrative nucleoside transporter and A2A adenosine receptor
    Gregory I Liou
    Department of Ophthalmology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Invest Ophthalmol Vis Sci 49:5526-31. 2008
  2. pmc Retinal microglial activation and inflammation induced by amadori-glycated albumin in a rat model of diabetes
    Ahmed S Ibrahim
    epartment of Ophthalmology, Medical College of Georgia, Augusta, Georgia, USA
    Diabetes 60:1122-33. 2011
  3. pmc Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation
    A B El-Remessy
    Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Vis 14:2190-203. 2008
  4. pmc Genistein attenuates retinal inflammation associated with diabetes by targeting of microglial activation
    Ahmed S Ibrahim
    Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Vis 16:2033-42. 2010
  5. pmc Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes
    Azza B el-Remessy
    Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 15th St, Augusta, GA 30912, USA
    Am J Pathol 168:235-44. 2006
  6. ncbi request reprint VEGF-induced paracellular permeability in cultured endothelial cells involves urokinase and its receptor
    M Ali Behzadian
    Vascular Biology Center, Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 15th Street, Augusta, Georgia 30912, USA
    FASEB J 17:752-4. 2003
  7. ncbi request reprint Alternative splicing of the APC gene in the neural retina and retinal pigment epithelium
    Gregory I Liou
    Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Vis 10:383-91. 2004
  8. ncbi request reprint Vascular endothelial growth factor and diabetic retinopathy: role of oxidative stress
    Ruth B Caldwell
    Vascular Biology Center, The Medical College of Georgia, Augusta, 30912, USA
    Curr Drug Targets 6:511-24. 2005
  9. pmc Role of IL-6 in angiotensin II-induced retinal vascular inflammation
    Modesto Rojas
    VA Medical Center, Augusta, Georgia, USA
    Invest Ophthalmol Vis Sci 51:1709-18. 2010
  10. ncbi request reprint MAP kinase and beta-catenin signaling in HGF induced RPE migration
    Gregory I Liou
    Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Vis 8:483-93. 2002

Research Grants

  1. OCULAR CANNABINOID EFFECTS
    Gregory Liou; Fiscal Year: 2001

Collaborators

Detail Information

Publications17

  1. pmc Mediation of cannabidiol anti-inflammation in the retina by equilibrative nucleoside transporter and A2A adenosine receptor
    Gregory I Liou
    Department of Ophthalmology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Invest Ophthalmol Vis Sci 49:5526-31. 2008
    ..However, the protective mechanism of this anti-inflammatory cannabinoid is not completely understood. The goal of this study is to determine the role of adenosine signaling in retinal inflammation and its potential modulation by CBD...
  2. pmc Retinal microglial activation and inflammation induced by amadori-glycated albumin in a rat model of diabetes
    Ahmed S Ibrahim
    epartment of Ophthalmology, Medical College of Georgia, Augusta, Georgia, USA
    Diabetes 60:1122-33. 2011
    ..The mechanism by which diabetes activates microglia to release those inflammatory mediators is unclear and was therefore elucidated...
  3. pmc Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation
    A B El-Remessy
    Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Vis 14:2190-203. 2008
    ....
  4. pmc Genistein attenuates retinal inflammation associated with diabetes by targeting of microglial activation
    Ahmed S Ibrahim
    Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Vis 16:2033-42. 2010
    ....
  5. pmc Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes
    Azza B el-Remessy
    Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 15th St, Augusta, GA 30912, USA
    Am J Pathol 168:235-44. 2006
    ..These results demonstrate that CBD treatment reduces neurotoxicity, inflammation, and BRB breakdown in diabetic animals through activities that may involve inhibition of p38 MAP kinase...
  6. ncbi request reprint VEGF-induced paracellular permeability in cultured endothelial cells involves urokinase and its receptor
    M Ali Behzadian
    Vascular Biology Center, Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 15th Street, Augusta, Georgia 30912, USA
    FASEB J 17:752-4. 2003
    ..In conclusion, VEGF induces a sustained paracellular permeability in capillary endothelial cells that is mediated by activation of the uPA/uPAR system...
  7. ncbi request reprint Alternative splicing of the APC gene in the neural retina and retinal pigment epithelium
    Gregory I Liou
    Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Vis 10:383-91. 2004
    ..Distinctive APC isoforms exist in different cell types due to alternative splicing of the APC transcripts. We hypothesize that differences in expression patterns of APC protein isoforms are critical to RPE proliferation/differentiation...
  8. ncbi request reprint Vascular endothelial growth factor and diabetic retinopathy: role of oxidative stress
    Ruth B Caldwell
    Vascular Biology Center, The Medical College of Georgia, Augusta, 30912, USA
    Curr Drug Targets 6:511-24. 2005
    ..Potential therapeutic strategies for preventing VEGF overexpression or blocking its pathological actions in the diabetic retina are considered...
  9. pmc Role of IL-6 in angiotensin II-induced retinal vascular inflammation
    Modesto Rojas
    VA Medical Center, Augusta, Georgia, USA
    Invest Ophthalmol Vis Sci 51:1709-18. 2010
    ..The present study was an investigation of the role of interleukin (IL)-6 in angiotensin II-induced retinopathy...
  10. ncbi request reprint MAP kinase and beta-catenin signaling in HGF induced RPE migration
    Gregory I Liou
    Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Vis 8:483-93. 2002
    ..The aim of this study is to investigate HGF induced signaling pathways that lead to RPE cell migration...
  11. ncbi request reprint HGF regulation of RPE proliferation in an IL-1beta/retinal hole-induced rabbit model of PVR
    Gregory I Liou
    Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Vis 8:494-501. 2002
    ..To understand molecular events that lead to retinal pigment epithelial (RPE) cell proliferation and migration during the early phases of proliferative vitreoretinopathy (PVR) in a rabbit model...
  12. pmc NAD(P)H oxidase-dependent regulation of CCL2 production during retinal inflammation
    Wenbo Zhang
    VA Medical Center, Augusta, Georgia, USA
    Invest Ophthalmol Vis Sci 50:3033-40. 2009
    ..The authors had previously found that the blockade of NAD(P)H oxidase in turn blocks leukocyte adhesion to retinal vessels during diabetes and uveitis. In this study, the role of NAD(P)H oxidase in CCL2 production was assessed...
  13. pmc Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite
    Azza B el-Remessy
    Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
    Am J Pathol 163:1997-2008. 2003
    ..The effect of THC was in part mediated by the cannabinoid receptor CB1. These results suggest the potential use of CBD as a novel topical therapy for the treatment of glaucoma...
  14. pmc Role of NADPH oxidase in retinal vascular inflammation
    Mohamed Al-Shabrawey
    Oral Biology and Anatomy, School of Dentistry, Medical College of Georgia, Augusta, Georgia 30912, USA
    Invest Ophthalmol Vis Sci 49:3239-44. 2008
    ..The goal of this study was to evaluate the potential role of NOX2 and NADPH oxidase activity in the development of retinal vascular inflammation...
  15. ncbi request reprint Neuroprotective and intraocular pressure-lowering effects of (-)Delta9-tetrahydrocannabinol in a rat model of glaucoma
    James Crandall
    Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912, USA
    Ophthalmic Res 39:69-75. 2007
    ..The RGC loss in the operated eyes of the THC-treated animals was reduced to 10-20%. These results demonstrate that THC is a neuroprotectant that preserves RGCs in an experimental model of glaucoma, possibly through a reduction in IOP...
  16. doi request reprint Peroxynitrite mediates retinal neurodegeneration by inhibiting nerve growth factor survival signaling in experimental and human diabetes
    Tayyeba K Ali
    Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA
    Diabetes 57:889-98. 2008
    ..However, the causal role of peroxynitrite and the impact of tyrosine nitration on diabetes-induced retinal neurodegeneration and NGF survival signaling have not been elucidated...
  17. ncbi request reprint Sequence analysis of the mouse IRBP gene and cDNA
    R Keith Shuler
    Department of Ophthalmology, Emory University, Atlanta, GA 30322, USA
    Curr Eye Res 24:354-67. 2002
    ..To compare the levels of expression of IRBP RNA in normal and knockout mice...

Research Grants1

  1. OCULAR CANNABINOID EFFECTS
    Gregory Liou; Fiscal Year: 2001
    ..Those drug/vehicle combinations yielding the best and most consistent falls in IOP will be examined for their effects on aqueous humor dynamics. ..