Research Topics
Genomes and Genes | Mingyu LiangSummaryAffiliation: Medical College of Wisconsin Country: USA Publications
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Publications
Novel role of fumarate metabolism in dahl-salt sensitive hypertensionZhongmin Tian
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Hypertension 54:255-60. 2009..These data suggest a novel role for fumarate metabolism in salt-induced hypertension and renal medullary oxidative stress...
Renal medullary genes in salt-sensitive hypertension: a chromosomal substitution and cDNA microarray studyMingyu Liang
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Physiol Genomics 8:139-49. 2002..These results should provide an informative source for designing future functional studies in salt-sensitive hypertension...- MicroRNA: a new entrance to the broad paradigm of systems molecular medicineMingyu Liang
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Physiol Genomics 38:113-5. 2009..Physiological genomics is a powerful approach for addressing these open questions... - MicroRNA: a new frontier in kidney and blood pressure researchMingyu Liang
Dept of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Am J Physiol Renal Physiol 297:F553-8. 2009..Further progress in the understanding of miRNA biogenesis and action and technical improvements for target identification and miRNA manipulation will be important for studying miRNAs in renal function and blood pressure regulation... 
Molecular networks in Dahl salt-sensitive hypertension based on transcriptome analysis of a panel of consomic ratsMingyu Liang
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Physiol Genomics 34:54-64. 2008....- Integrative pathway knowledge bases as a tool for systems molecular medicineMingyu Liang
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Physiol Genomics 30:209-12. 2007..A potentially powerful approach is to build integrative pathway knowledge bases that link organ systems function with molecules... - Thiol-related genes in diabetic complications: a novel protective role for endogenous thioredoxin 2Mingyu Liang
Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Arterioscler Thromb Vasc Biol 27:77-83. 2007..Our laboratory and others have found that deficiencies in cellular thiols may be importantly involved in the development of diabetic complications. However, the role for specific thiol-related genes in diabetic complications is unclear... - High throughput gene expression profiling: a molecular approach to integrative physiologyMingyu Liang
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
J Physiol 554:22-30. 2004..With a keen sense of homeostasis, global regulation, and quantitative analysis, integrative physiologists are uniquely positioned to apply these techniques to enhance the understanding of complex physiological functions... - Insights into Dahl salt-sensitive hypertension revealed by temporal patterns of renal medullary gene expressionMingyu Liang
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Physiol Genomics 12:229-37. 2003.... - Quantitative assessment of the importance of dye switching and biological replication in cDNA microarray studiesMingyu Liang
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Physiol Genomics 14:199-207. 2003..Recommendations regarding the use of these procedures were proposed... - Renal medullary microRNAs in Dahl salt-sensitive rats: miR-29b regulates several collagens and related genesYong Liu
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wis, USA
Hypertension 55:974-82. 2010..The result demonstrated broad effects of miR-29b on a large number of collagens and genes related to the extracellular matrix and suggested involvement of miR-29b in the protection from renal medullary injury in SS-13(BN) rats... - MicroRNA-target pairs in human renal epithelial cells treated with transforming growth factor beta 1: a novel role of miR-382Alison J Kriegel
Department of Physiology, Biotechnology and Biomedical Engineering Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Nucleic Acids Res 38:8338-47. 2010.... - Dynamic convergence and divergence of renal genomic and biological pathways in protection from Dahl salt-sensitive hypertensionLimin Lu
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Physiol Genomics 41:63-70. 2010.... - Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertensionDi Feng
Physiology Department, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Cell Metab 15:201-8. 2012..These rats exhibited a significant reduction of salt-sensitive hypertension and renal medullary oxidative stress and injury. p67(phox) could represent a target for salt-sensitive hypertension therapy... - Renal medullary 11 beta-hydroxysteroid dehydrogenase type 1 in Dahl salt-sensitive hypertensionYong Liu
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Physiol Genomics 36:52-8. 2008..In summary, we have demonstrated that suppression of 11 beta-hydroxysteroid dehydrogenase type 1 expression in the renal medulla attenuates salt-induced hypertension in Dahl salt-sensitive rats... - A novel amiloride-sensitive h+ transport pathway mediates enhanced superoxide production in thick ascending limb of salt-sensitive rats, not na+/h+ exchangePaul M O'Connor
Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53202, USA
Hypertension 54:248-54. 2009..We concluded that only H(+) efflux through a specific, as-yet-unidentified, amiloride-sensitive H(+) channel promotes O(2)(.-) production in the medullary thick ascending limb and that this channel is upregulated in SS rats... - Renal regional proteomes in young Dahl salt-sensitive ratsZhongmin Tian
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Hypertension 51:899-904. 2008.... - High perfusion pressure accelerates renal injury in salt-sensitive hypertensionTakefumi Mori
Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
J Am Soc Nephrol 19:1472-82. 2008..We conclude that elevations of RPP contribute significantly to the fibrosis and epithelial-to-mesenchymal transition found in the early phases of hypertension in the salt-sensitive rat... - MicroRNA-target pairs in the rat kidney identified by microRNA microarray, proteomic, and bioinformatic analysisZhongmin Tian
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Genome Res 18:404-11. 2008..In addition, this study establishes a differential profile of microRNA expression between the renal cortex and the renal medulla and greatly expands the known differential proteome profiles between the two kidney regions... - Glucocorticoid response elements and 11 beta-hydroxysteroid dehydrogenases in the regulation of endothelial nitric oxide synthase expressionYong Liu
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Cardiovasc Res 81:140-7. 2009..We studied the transcriptional and biochemical mechanisms that mediate or modulate the suppression of eNOS expression by glucocorticoids... - Tissue-specific transcriptome responses in rats with early streptozotocin-induced diabetesKristen E Knoll
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Physiol Genomics 21:222-9. 2005..It appears that both common pathways and, perhaps more importantly, tissue-specific mechanisms are involved in the adaptation to diabetes or the initiation of diabetic complications... - Increased proliferative cells in the medullary thick ascending limb of the loop of Henle in the Dahl salt-sensitive ratChun Yang
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA
Hypertension 61:208-15. 2013.... - Transcriptome analysis and kidney research: toward systems biologyMingyu Liang
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Kidney Int 67:2114-22. 2005.... - NADPH oxidase in the renal medulla causes oxidative stress and contributes to salt-sensitive hypertension in Dahl S ratsNorman E Taylor
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Hypertension 47:692-8. 2006..We conclude that excess renal medullary superoxide production in SS rats contributes to salt-induced hypertension, and NADPH oxidase is the major source of the excess superoxide... - Effect of sodium delivery on superoxide and nitric oxide in the medullary thick ascending limbMichiaki Abe
Dept. of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Am J Physiol Renal Physiol 291:F350-7. 2006..This may lead to reduction in medullary blood flow and promote hypoxia and tubular necrosis within the renal medulla during in hypertension... - Renal interstitial corticosterone and 11-dehydrocorticosterone in conscious ratsKristie Usa
Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Am J Physiol Renal Physiol 293:F186-92. 2007..8-fold. These results demonstrated that corticosterone excess in the renal medulla might be sufficient to cause hypertension and provided the first characterization of renal interstitial glucocorticoids... - Narrowing a region on rat chromosome 13 that protects against hypertension in Dahl SS-13BN congenic strainsCarol Moreno
Department of Physiology, Medical College of Wisconsin, Milwaukee, USA
Am J Physiol Heart Circ Physiol 300:H1530-5. 2011..4 Mb (159 genes) to a 1.9-Mb segment containing only 13 genes, of which 4 are differentially expressed in strains partially protected from the development of hypertension... - Delayed ischemic preconditioning contributes to renal protection by upregulation of miR-21Xialian Xu
Division of Nephrology, Shanghai Medical College, Fudan University, Zhongshan Hospital, Shanghai, PR China
Kidney Int 82:1167-75. 2012..Thus, upregulation of miR-21 contributes to the protective effect of delayed ischemic preconditioning against subsequent renal ischemia-reperfusion injury... - The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injuryAlison J Kriegel
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Physiol Genomics 44:237-44. 2012..It remains to be explored how various cellular effects of miR-29s determine functional relevance of miR-29s to specific diseases and how the miR-29 family members may function cooperatively or separately... - Translational study of microRNAs and its application in kidney disease and hypertension researchAlison J Kriegel
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Clin Sci (Lond) 122:439-47. 2012..Translational research of microRNAs in the kidney faces unique challenges, but provides many opportunities to develop and apply new methods, and to merge complementary basic and clinical approaches... - Suppression of 11beta-hydroxysteroid dehydrogenase type 1 with RNA interference substantially attenuates 3T3-L1 adipogenesisYong Liu
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Physiol Genomics 32:343-51. 2008..These results indicate that 11beta-HSD1 plays a significant functional role in the initiation of 3T3-L1 adipogenesis and provide new mechanistic insights into the role of 11beta-HSD1 in the development of obesity and related diseases... - Gene expression reveals vulnerability to oxidative stress and interstitial fibrosis of renal outer medulla to nonhypertensive elevations of ANG IIBaozhi Yuan
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Am J Physiol Regul Integr Comp Physiol 284:R1219-30. 2003.... - MicroRNAs contribute to the maintenance of cell-type-specific physiological characteristics: miR-192 targets Na+/K+-ATPase β1Domagoj Mladinov
Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Nucleic Acids Res 41:1273-83. 2013..It supports an important role of miRNAs in determining cellular characteristics that may appear subtle yet are physiologically critical... - MiR-382 targeting of kallikrein 5 contributes to renal inner medullary interstitial fibrosisAlison J Kriegel
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Physiol Genomics 44:259-67. 2012..The study provided the first demonstration of an in vivo functional role of miR-382 in any species and any organ system... - Mitochondrial proteomic analysis reveals deficiencies in oxygen utilization in medullary thick ascending limb of Henle in the Dahl salt-sensitive ratNadezhda N Zheleznova
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Physiol Genomics 44:829-42. 2012..The results reveal the importance of a largely unexplored role for deficiencies of mTAL mitochondrial metabolism and oxygen utilization in salt-induced hypertension and renal medullary oxidative stress... - Effect of high glucose on gene expression in mesangial cells: upregulation of the thiol pathway is an adaptational responseJolean Morrison
Department of Physiology, Milwaukee, Wisconsin 53226, USA
Physiol Genomics 17:271-82. 2004.... - Identification of persistently altered gene expression in the kidney after functional recovery from ischemic acute renal failureDavid P Basile
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Am J Physiol Renal Physiol 288:F953-63. 2005..In summary, genes with known inflammatory, remodeling, and vasoactive activities were identified in rat kidneys after recovery from ARF, some of which may play a role in altering long-term renal function after recovery from ARF... - Hypertension as a mitochondrial and metabolic diseaseMingyu Liang
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Kidney Int 80:15-6. 2011..Mitochondrial and metabolic abnormalities could be crucial pieces of this puzzle... - The application of microarray analysis to pediatric diseasesMartin J Hessner
The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Pediatr Clin North Am 53:579-90. 2006..This article reviews the basics of array technology and analysis, and highlights its application to pediatric diseases... - Physiology and genomics: toward systems biologyAllen W Cowley
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Sheng Li Xue Bao 58:1-4. 2006....
Research Grants
- Renal 11b-Hydroxysteroid Dehydrogenases and HypertensionMingyu Liang; Fiscal Year: 2007..The results are expected to elucidate a novel aspect of the pathophysiology of salt- sensitive hypertension and to provide potential new targets for prevention and treatment of hypertension. ..