Mingyu Liang

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. pmc Novel role of fumarate metabolism in dahl-salt sensitive hypertension
    Zhongmin Tian
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 54:255-60. 2009
  2. pmc MicroRNA-target pairs in human renal epithelial cells treated with transforming growth factor beta 1: a novel role of miR-382
    Alison J Kriegel
    Department of Physiology, Biotechnology and Biomedical Engineering Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Nucleic Acids Res 38:8338-47. 2010
  3. pmc MicroRNAs contribute to the maintenance of cell-type-specific physiological characteristics: miR-192 targets Na+/K+-ATPase β1
    Domagoj Mladinov
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Nucleic Acids Res 41:1273-83. 2013
  4. ncbi request reprint Base-resolution maps of 5-methylcytosine and 5-hydroxymethylcytosine in Dahl S rats: effect of salt and genomic sequence
    Yong Liu
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226 or
    Hypertension 63:827-38. 2014
  5. pmc Epigenomics of hypertension
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI Electronic address
    Semin Nephrol 33:392-9. 2013
  6. ncbi request reprint Thiol-related genes in diabetic complications: a novel protective role for endogenous thioredoxin 2
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Arterioscler Thromb Vasc Biol 27:77-83. 2007
  7. ncbi request reprint Integrative pathway knowledge bases as a tool for systems molecular medicine
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 30:209-12. 2007
  8. pmc MicroRNA: a new entrance to the broad paradigm of systems molecular medicine
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 38:113-5. 2009
  9. ncbi request reprint Molecular networks in Dahl salt-sensitive hypertension based on transcriptome analysis of a panel of consomic rats
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 34:54-64. 2008
  10. pmc MicroRNA: a new frontier in kidney and blood pressure research
    Mingyu Liang
    Dept of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 297:F553-8. 2009

Collaborators

Detail Information

Publications48

  1. pmc Novel role of fumarate metabolism in dahl-salt sensitive hypertension
    Zhongmin Tian
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 54:255-60. 2009
    ..These data suggest a novel role for fumarate metabolism in salt-induced hypertension and renal medullary oxidative stress...
  2. pmc MicroRNA-target pairs in human renal epithelial cells treated with transforming growth factor beta 1: a novel role of miR-382
    Alison J Kriegel
    Department of Physiology, Biotechnology and Biomedical Engineering Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Nucleic Acids Res 38:8338-47. 2010
    ....
  3. pmc MicroRNAs contribute to the maintenance of cell-type-specific physiological characteristics: miR-192 targets Na+/K+-ATPase β1
    Domagoj Mladinov
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Nucleic Acids Res 41:1273-83. 2013
    ..It supports an important role of miRNAs in determining cellular characteristics that may appear subtle yet are physiologically critical...
  4. ncbi request reprint Base-resolution maps of 5-methylcytosine and 5-hydroxymethylcytosine in Dahl S rats: effect of salt and genomic sequence
    Yong Liu
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226 or
    Hypertension 63:827-38. 2014
    ....
  5. pmc Epigenomics of hypertension
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI Electronic address
    Semin Nephrol 33:392-9. 2013
    ....
  6. ncbi request reprint Thiol-related genes in diabetic complications: a novel protective role for endogenous thioredoxin 2
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Arterioscler Thromb Vasc Biol 27:77-83. 2007
    ..Our laboratory and others have found that deficiencies in cellular thiols may be importantly involved in the development of diabetic complications. However, the role for specific thiol-related genes in diabetic complications is unclear...
  7. ncbi request reprint Integrative pathway knowledge bases as a tool for systems molecular medicine
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 30:209-12. 2007
    ..A potentially powerful approach is to build integrative pathway knowledge bases that link organ systems function with molecules...
  8. pmc MicroRNA: a new entrance to the broad paradigm of systems molecular medicine
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 38:113-5. 2009
    ..Physiological genomics is a powerful approach for addressing these open questions...
  9. ncbi request reprint Molecular networks in Dahl salt-sensitive hypertension based on transcriptome analysis of a panel of consomic rats
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 34:54-64. 2008
    ....
  10. pmc MicroRNA: a new frontier in kidney and blood pressure research
    Mingyu Liang
    Dept of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 297:F553-8. 2009
    ..Further progress in the understanding of miRNA biogenesis and action and technical improvements for target identification and miRNA manipulation will be important for studying miRNAs in renal function and blood pressure regulation...
  11. ncbi request reprint Renal medullary genes in salt-sensitive hypertension: a chromosomal substitution and cDNA microarray study
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 8:139-49. 2002
    ..These results should provide an informative source for designing future functional studies in salt-sensitive hypertension...
  12. pmc High throughput gene expression profiling: a molecular approach to integrative physiology
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Physiol 554:22-30. 2004
    ..With a keen sense of homeostasis, global regulation, and quantitative analysis, integrative physiologists are uniquely positioned to apply these techniques to enhance the understanding of complex physiological functions...
  13. ncbi request reprint Quantitative assessment of the importance of dye switching and biological replication in cDNA microarray studies
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 14:199-207. 2003
    ..Recommendations regarding the use of these procedures were proposed...
  14. ncbi request reprint Insights into Dahl salt-sensitive hypertension revealed by temporal patterns of renal medullary gene expression
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 12:229-37. 2003
    ....
  15. pmc Dynamic convergence and divergence of renal genomic and biological pathways in protection from Dahl salt-sensitive hypertension
    Limin Lu
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Physiol Genomics 41:63-70. 2010
    ....
  16. pmc Renal medullary microRNAs in Dahl salt-sensitive rats: miR-29b regulates several collagens and related genes
    Yong Liu
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wis, USA
    Hypertension 55:974-82. 2010
    ..The result demonstrated broad effects of miR-29b on a large number of collagens and genes related to the extracellular matrix and suggested involvement of miR-29b in the protection from renal medullary injury in SS-13(BN) rats...
  17. doi request reprint Renal regional proteomes in young Dahl salt-sensitive rats
    Zhongmin Tian
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 51:899-904. 2008
    ....
  18. pmc Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension
    Di Feng
    Physiology Department, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Cell Metab 15:201-8. 2012
    ..These rats exhibited a significant reduction of salt-sensitive hypertension and renal medullary oxidative stress and injury. p67(phox) could represent a target for salt-sensitive hypertension therapy...
  19. pmc MicroRNA-target pairs in the rat kidney identified by microRNA microarray, proteomic, and bioinformatic analysis
    Zhongmin Tian
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Genome Res 18:404-11. 2008
    ..In addition, this study establishes a differential profile of microRNA expression between the renal cortex and the renal medulla and greatly expands the known differential proteome profiles between the two kidney regions...
  20. pmc A novel amiloride-sensitive h+ transport pathway mediates enhanced superoxide production in thick ascending limb of salt-sensitive rats, not na+/h+ exchange
    Paul M O'Connor
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53202, USA
    Hypertension 54:248-54. 2009
    ..We concluded that only H(+) efflux through a specific, as-yet-unidentified, amiloride-sensitive H(+) channel promotes O(2)(.-) production in the medullary thick ascending limb and that this channel is upregulated in SS rats...
  21. pmc High perfusion pressure accelerates renal injury in salt-sensitive hypertension
    Takefumi Mori
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Am Soc Nephrol 19:1472-82. 2008
    ..We conclude that elevations of RPP contribute significantly to the fibrosis and epithelial-to-mesenchymal transition found in the early phases of hypertension in the salt-sensitive rat...
  22. pmc Renal medullary 11 beta-hydroxysteroid dehydrogenase type 1 in Dahl salt-sensitive hypertension
    Yong Liu
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 36:52-8. 2008
    ..In summary, we have demonstrated that suppression of 11 beta-hydroxysteroid dehydrogenase type 1 expression in the renal medulla attenuates salt-induced hypertension in Dahl salt-sensitive rats...
  23. pmc Increased proliferative cells in the medullary thick ascending limb of the loop of Henle in the Dahl salt-sensitive rat
    Chun Yang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA
    Hypertension 61:208-15. 2013
    ....
  24. pmc Glucocorticoid response elements and 11 beta-hydroxysteroid dehydrogenases in the regulation of endothelial nitric oxide synthase expression
    Yong Liu
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Cardiovasc Res 81:140-7. 2009
    ..We studied the transcriptional and biochemical mechanisms that mediate or modulate the suppression of eNOS expression by glucocorticoids...
  25. ncbi request reprint NADPH oxidase in the renal medulla causes oxidative stress and contributes to salt-sensitive hypertension in Dahl S rats
    Norman E Taylor
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 47:692-8. 2006
    ..We conclude that excess renal medullary superoxide production in SS rats contributes to salt-induced hypertension, and NADPH oxidase is the major source of the excess superoxide...
  26. ncbi request reprint Effect of sodium delivery on superoxide and nitric oxide in the medullary thick ascending limb
    Michiaki Abe
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 291:F350-7. 2006
    ..This may lead to reduction in medullary blood flow and promote hypoxia and tubular necrosis within the renal medulla during in hypertension...
  27. ncbi request reprint Tissue-specific transcriptome responses in rats with early streptozotocin-induced diabetes
    Kristen E Knoll
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 21:222-9. 2005
    ..It appears that both common pathways and, perhaps more importantly, tissue-specific mechanisms are involved in the adaptation to diabetes or the initiation of diabetic complications...
  28. pmc Characteristics of microRNAs enriched in specific cell types and primary tissue types in solid organs
    Alison J Kriegel
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin
    Physiol Genomics 45:1144-56. 2013
    ..These data indicate that the role of miRNAs in determining characteristics of primary tissue types may be different than their role in regulating cell type-specific functions in solid organs. ..
  29. ncbi request reprint Renal interstitial corticosterone and 11-dehydrocorticosterone in conscious rats
    Kristie Usa
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 293:F186-92. 2007
    ..8-fold. These results demonstrated that corticosterone excess in the renal medulla might be sufficient to cause hypertension and provided the first characterization of renal interstitial glucocorticoids...
  30. ncbi request reprint Transcriptome analysis and kidney research: toward systems biology
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Kidney Int 67:2114-22. 2005
    ....
  31. pmc Narrowing a region on rat chromosome 13 that protects against hypertension in Dahl SS-13BN congenic strains
    Carol Moreno
    Department of Physiology, Medical College of Wisconsin, Milwaukee, USA
    Am J Physiol Heart Circ Physiol 300:H1530-5. 2011
    ..4 Mb (159 genes) to a 1.9-Mb segment containing only 13 genes, of which 4 are differentially expressed in strains partially protected from the development of hypertension...
  32. pmc Characterization of biological pathways associated with a 1.37 Mbp genomic region protective of hypertension in Dahl S rats
    Allen W Cowley
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin
    Physiol Genomics 46:398-410. 2014
    ....
  33. pmc Delayed ischemic preconditioning contributes to renal protection by upregulation of miR-21
    Xialian Xu
    Division of Nephrology, Shanghai Medical College, Fudan University, Zhongshan Hospital, Shanghai, PR China
    Kidney Int 82:1167-75. 2012
    ..Thus, upregulation of miR-21 contributes to the protective effect of delayed ischemic preconditioning against subsequent renal ischemia-reperfusion injury...
  34. pmc The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury
    Alison J Kriegel
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Physiol Genomics 44:237-44. 2012
    ..It remains to be explored how various cellular effects of miR-29s determine functional relevance of miR-29s to specific diseases and how the miR-29 family members may function cooperatively or separately...
  35. doi request reprint Translational study of microRNAs and its application in kidney disease and hypertension research
    Alison J Kriegel
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Clin Sci (Lond) 122:439-47. 2012
    ..Translational research of microRNAs in the kidney faces unique challenges, but provides many opportunities to develop and apply new methods, and to merge complementary basic and clinical approaches...
  36. ncbi request reprint Gene expression reveals vulnerability to oxidative stress and interstitial fibrosis of renal outer medulla to nonhypertensive elevations of ANG II
    Baozhi Yuan
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1219-30. 2003
    ....
  37. ncbi request reprint Suppression of 11beta-hydroxysteroid dehydrogenase type 1 with RNA interference substantially attenuates 3T3-L1 adipogenesis
    Yong Liu
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 32:343-51. 2008
    ..These results indicate that 11beta-HSD1 plays a significant functional role in the initiation of 3T3-L1 adipogenesis and provide new mechanistic insights into the role of 11beta-HSD1 in the development of obesity and related diseases...
  38. pmc MiR-382 targeting of kallikrein 5 contributes to renal inner medullary interstitial fibrosis
    Alison J Kriegel
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Physiol Genomics 44:259-67. 2012
    ..The study provided the first demonstration of an in vivo functional role of miR-382 in any species and any organ system...
  39. pmc Targeting the endothelial progenitor cell surface proteome to identify novel mechanisms that mediate angiogenic efficacy in a rodent model of vascular disease
    Catherine C Kaczorowski
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin
    Physiol Genomics 45:999-1011. 2013
    ..Overall, novel methods to identify putative targets for repair of EPCs using discovery-based technologies will likely provide a major advance in the field of regenerative medicine. ..
  40. ncbi request reprint Identification of persistently altered gene expression in the kidney after functional recovery from ischemic acute renal failure
    David P Basile
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Physiol Renal Physiol 288:F953-63. 2005
    ..In summary, genes with known inflammatory, remodeling, and vasoactive activities were identified in rat kidneys after recovery from ARF, some of which may play a role in altering long-term renal function after recovery from ARF...
  41. pmc Mitochondrial proteomic analysis reveals deficiencies in oxygen utilization in medullary thick ascending limb of Henle in the Dahl salt-sensitive rat
    Nadezhda N Zheleznova
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 44:829-42. 2012
    ..The results reveal the importance of a largely unexplored role for deficiencies of mTAL mitochondrial metabolism and oxygen utilization in salt-induced hypertension and renal medullary oxidative stress...
  42. ncbi request reprint Effect of high glucose on gene expression in mesangial cells: upregulation of the thiol pathway is an adaptational response
    Jolean Morrison
    Department of Physiology, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 17:271-82. 2004
    ....
  43. pmc Ultrastructure of mitochondria and the endoplasmic reticulum in renal tubules of Dahl salt-sensitive rats
    Xiaofeng He
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin Department of Nephrology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China and
    Am J Physiol Renal Physiol 306:F1190-7. 2014
    ....
  44. ncbi request reprint Physiology and genomics: toward systems biology
    Allen W Cowley
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Sheng Li Xue Bao 58:1-4. 2006
    ....
  45. pmc Characterization of human plasma-derived exosomal RNAs by deep sequencing
    Xiaoyi Huang
    Department of Pathology and Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    BMC Genomics 14:319. 2013
    ..In all we evaluated 14 libraries (7 replicates)...
  46. doi request reprint miR-21 contributes to xenon-conferred amelioration of renal ischemia-reperfusion injury in mice
    Ping Jia
    Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China
    Anesthesiology 119:621-30. 2013
    ..MicroRNAs participate in the regulation of numerous physiological and disease processes. The in vivo role of microRNAs in anesthetics-conferred organoprotection is unknown...
  47. ncbi request reprint The application of microarray analysis to pediatric diseases
    Martin J Hessner
    The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Pediatr Clin North Am 53:579-90. 2006
    ..This article reviews the basics of array technology and analysis, and highlights its application to pediatric diseases...
  48. doi request reprint Hypertension as a mitochondrial and metabolic disease
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Kidney Int 80:15-6. 2011
    ..Mitochondrial and metabolic abnormalities could be crucial pieces of this puzzle...

Research Grants4

  1. Renal 11b-Hydroxysteroid Dehydrogenases and Hypertension
    Mingyu Liang; Fiscal Year: 2007
    ..The results are expected to elucidate a novel aspect of the pathophysiology of salt- sensitive hypertension and to provide potential new targets for prevention and treatment of hypertension. ..
  2. Renal 11b-Hydroxysteroid Dehydrogenases and Hypertension
    Mingyu Liang; Fiscal Year: 2005
    ..The results are expected to elucidate a novel aspect of the pathophysiology of salt- sensitive hypertension and to provide potential new targets for prevention and treatment of hypertension. ..
  3. Renal 11b-Hydoxysteroid Dehydrogenases and Hypertension
    Mingyu Liang; Fiscal Year: 2006
    ..The results are expected to elucidate a novel aspect of the pathophysiology of salt- sensitive hypertension and to provide potential new targets for prevention and treatment of hypertension. ..