Affiliation: Medical College of Georgia
- Porous-wall hollow glass microspheres as novel potential nanocarriers for biomedical applicationsShuyi Li
Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
Nanomedicine 6:127-36. 2010..PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anti-cancer drugs...
- Intranuclear delivery of a novel antibody-derived radiosensitizer targeting the DNA-dependent protein kinase catalytic subunitHairong Xiong
Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, GA 30912, USA
Int J Radiat Oncol Biol Phys 83:1023-30. 2012..Development as a radiosensitizer has been limited by the lack of a method for intranuclear delivery to target cells. We investigated a delivery method based on folate receptor-mediated endocytosis...
- Estrogen receptor alpha mediates acute potassium channel stimulation in human coronary artery smooth muscle cellsGuichun Han
Dept Pharmacology and Toxicology, 1120 15th Street, Augusta, GA, USA
J Pharmacol Exp Ther 316:1025-30. 2006....
- Modifying the function of DNA repair nanomachines for therapeutic benefitWilliam S Dynan
Institute of Molecular Medicine and Genetics, Cancer Biology and Regulation Program, Medical College of Georgia, Augusta, GA 30912, USA
Nanomedicine 2:74-81. 2006..Third, we discuss similarities in the overall size, shape, and design of different nanomachines that manipulate DNA and RNA, and the possibility of developing nanomachines with new specificities not found in nature...
- Involvement of p54(nrb), a PSF partner protein, in DNA double-strand break repair and radioresistanceShuyi Li
Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia, USA
Nucleic Acids Res 37:6746-53. 2009..Together, results indicate that p54(nrb) contributes to rapid and accurate repair of DSBs in vivo in human cells and that the PSF.p54(nrb) complex may thus be a potential target for radiosensitizer development...
- E. coli expression of a soluble, active single-chain antibody variable fragment containing a nuclear localization signalHairong Xiong
Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
Protein Expr Purif 66:172-80. 2009..Following lipid-mediated uptake into cultured cells, NLS-tagged ScFv 18-2, unlike the parental ScFv 18-2, localized predominantly in the cell nucleus...
- Modification of the ionizing radiation response in living cells by an scFv against the DNA-dependent protein kinaseShuyi Li
Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
Nucleic Acids Res 31:5848-57. 2003..The ability to modify the radiation response in situ in living cells provides a link between biochemical, genetic and cytologic approaches to the study of double-strand break repair intermediates...