Shi Jiang Li

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Cocaine administration decreases functional connectivity in human primary visual and motor cortex as detected by functional MRI
    S J Li
    Biophysics Research Institute, Medical College of Wisconsin, Milwaukee 53226, USA
    Magn Reson Med 43:45-51. 2000
  2. ncbi request reprint Alzheimer Disease: evaluation of a functional MR imaging index as a marker
    Shi Jiang Li
    Biophysics Research Institute, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Radiology 225:253-9. 2002
  3. ncbi request reprint Neural responses to acute cocaine administration in the human brain detected by fMRI
    Peter R Kufahl
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Neuroimage 28:904-14. 2005
  4. pmc Recovery of hippocampal network connectivity correlates with cognitive improvement in mild Alzheimer's disease patients treated with donepezil assessed by resting-state fMRI
    Joseph S Goveas
    Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Magn Reson Imaging 34:764-73. 2011
  5. pmc Changes in regional cerebral blood flow and functional connectivity in the cholinergic pathway associated with cognitive performance in subjects with mild Alzheimer's disease after 12-week donepezil treatment
    Wenjun Li
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Neuroimage 60:1083-91. 2012
  6. pmc Classification of Alzheimer disease, mild cognitive impairment, and normal cognitive status with large-scale network analysis based on resting-state functional MR imaging
    Gang Chen
    Department of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Radiology 259:213-21. 2011
  7. ncbi request reprint Transient relationships among BOLD, CBV, and CBF changes in rat brain as detected by functional MRI
    Gaohong Wu
    Biophysics Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
    Magn Reson Med 48:987-93. 2002
  8. pmc The co-existence of geriatric depression and amnestic mild cognitive impairment detrimentally affect gray matter volumes: voxel-based morphometry study
    Chunming Xie
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Behav Brain Res 235:244-50. 2012
  9. pmc Oral administration of levo-tetrahydropalmatine attenuates reinstatement of extinguished cocaine seeking by cocaine, stress or drug-associated cues in rats
    Yazmin Figueroa-Guzman
    Department of Biomedical Sciences, Marquette University, Milwaukee, WI 53201, USA
    Drug Alcohol Depend 116:72-9. 2011
  10. pmc Functional network endophenotypes unravel the effects of apolipoprotein E epsilon 4 in middle-aged adults
    Joseph S Goveas
    Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 8:e55902. 2013

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Cocaine administration decreases functional connectivity in human primary visual and motor cortex as detected by functional MRI
    S J Li
    Biophysics Research Institute, Medical College of Wisconsin, Milwaukee 53226, USA
    Magn Reson Med 43:45-51. 2000
    ....
  2. ncbi request reprint Alzheimer Disease: evaluation of a functional MR imaging index as a marker
    Shi Jiang Li
    Biophysics Research Institute, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Radiology 225:253-9. 2002
    ..To measure changes in functional synchrony in the hippocampus in patients with mild cognitive impairment (MCI) and Alzheimer disease (AD)...
  3. ncbi request reprint Neural responses to acute cocaine administration in the human brain detected by fMRI
    Peter R Kufahl
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Neuroimage 28:904-14. 2005
    ..It is suggested that the dopaminergic pathways and the hierarchical brain networks may participate in mediating cocaine reward processes, associative learning, motivation, and memory in cocaine addiction in the human brain...
  4. pmc Recovery of hippocampal network connectivity correlates with cognitive improvement in mild Alzheimer's disease patients treated with donepezil assessed by resting-state fMRI
    Joseph S Goveas
    Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Magn Reson Imaging 34:764-73. 2011
    ..To identify the neural correlates of cognitive improvement in mild Alzheimer's disease (AD) subjects following 12 weeks of donepezil treatment...
  5. pmc Changes in regional cerebral blood flow and functional connectivity in the cholinergic pathway associated with cognitive performance in subjects with mild Alzheimer's disease after 12-week donepezil treatment
    Wenjun Li
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Neuroimage 60:1083-91. 2012
    ..It also is suggested that the combined pCASL-MRI and R-fMRI methods could be used to detect regional CBF and FC changes when using drug treatments in mild AD subjects...
  6. pmc Classification of Alzheimer disease, mild cognitive impairment, and normal cognitive status with large-scale network analysis based on resting-state functional MR imaging
    Gang Chen
    Department of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Radiology 259:213-21. 2011
    ..To use large-scale network (LSN) analysis to classify subjects with Alzheimer disease (AD), those with amnestic mild cognitive impairment (aMCI), and cognitively normal (CN) subjects...
  7. ncbi request reprint Transient relationships among BOLD, CBV, and CBF changes in rat brain as detected by functional MRI
    Gaohong Wu
    Biophysics Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
    Magn Reson Med 48:987-93. 2002
    ..To avoid overestimation of the cerebral metabolic rate of oxygen changes seen using fMRI, caution should be taken to not include voxels with large veins and a large BOLD signal...
  8. pmc The co-existence of geriatric depression and amnestic mild cognitive impairment detrimentally affect gray matter volumes: voxel-based morphometry study
    Chunming Xie
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Behav Brain Res 235:244-50. 2012
    ..Our findings suggest that the co-existence of these clinical phenotypes is a potential marker for higher risk of AD...
  9. pmc Oral administration of levo-tetrahydropalmatine attenuates reinstatement of extinguished cocaine seeking by cocaine, stress or drug-associated cues in rats
    Yazmin Figueroa-Guzman
    Department of Biomedical Sciences, Marquette University, Milwaukee, WI 53201, USA
    Drug Alcohol Depend 116:72-9. 2011
    ..0mg/kg, l-THP dose, indicating that the effects of 3mg/kg l-THP on reinstatement were likely independent of non-specific motor impairment. These findings further suggest that l-THP may have utility for the treatment of cocaine addiction...
  10. pmc Functional network endophenotypes unravel the effects of apolipoprotein E epsilon 4 in middle-aged adults
    Joseph S Goveas
    Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 8:e55902. 2013
    ..Prospective studies are essential to elucidate the potential of R-fMRI technique as a biomarker for predicting conversion from normal to early AD in healthy APOE-ε4 carriers...
  11. pmc Functional connectivity of the cortical swallowing network in humans
    Arash Babaei
    Gastroenterology and Hepatology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Neuroimage 76:33-44. 2013
    ..Our aim was to systematically characterize FC of underlying neural network involved in swallowing, and to evaluate its reproducibility and modulation during rest or task performance...
  12. pmc A method to determine the necessity for global signal regression in resting-state fMRI studies
    Gang Chen
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Magn Reson Med 68:1828-35. 2012
    ..By using the criteria, one can determine whether to include or exclude the global signal regression in minimizing errors in functional connectivity measures...
  13. ncbi request reprint Multiecho segmented EPI with z-shimmed background gradient compensation (MESBAC) pulse sequence for fMRI
    Zhu Li
    Biophysics Research Institute, Medical College of Wisconsin, Milwaukee 53226, USA
    Magn Reson Med 48:312-21. 2002
    ..The MESBAC sequence will be particularly useful for pharmacological and affective fMRI studies in brain regions such as the OFC, nucleus accumbens, amygdala, parahippocampus, etc...
  14. ncbi request reprint Attenuation of brain response to heroin correlates with the reinstatement of heroin-seeking in rats by fMRI
    Feng Luo
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Neuroimage 22:1328-35. 2004
    ....
  15. pmc A clustering-based method to detect functional connectivity differences
    Gang Chen
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Neuroimage 61:56-61. 2012
    ..In conclusion, the new clustering method provides an advanced approach for studying functional brain organization changes associated with brain diseases...
  16. pmc Neural correlates of the interactive relationship between memory deficits and depressive symptoms in nondemented elderly: resting fMRI study
    Joseph Goveas
    Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    Behav Brain Res 219:205-12. 2011
    ..Our findings suggest that the R-fMRI technique can be used to examine the changes in functional neural networks where memory deficits and depressive symptoms coexist in the geriatric population...
  17. ncbi request reprint Peripheral blood pressure changes induced by dobutamine do not alter BOLD signals in the human brain
    Heng Liu
    Department of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neuroimage 30:745-52. 2006
    ....
  18. pmc Differential effects of deep sedation with propofol on the specific and nonspecific thalamocortical systems: a functional magnetic resonance imaging study
    Xiaolin Liu
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Anesthesiology 118:59-69. 2013
    ..The authors studied the effect of propofol on thalamocortical functional connectivity in the specific and nonspecific systems, using functional magnetic resonance imaging...
  19. pmc Reproducibility of swallow-induced cortical BOLD positive and negative fMRI activity
    Arash Babaei
    Department of Medicine, Medical College of Wisconsin, Milwaukee, USA
    Am J Physiol Gastrointest Liver Physiol 303:G600-9. 2012
    ..Group cortical activity maps, as well as extent and amplitude of activity induced by volitional swallowing in the cortical swallowing network, are reproducible between study sessions...
  20. ncbi request reprint Effects of the coexistence of late-life depression and mild cognitive impairment on white matter microstructure
    Wenjun Li
    Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, WI, USA Electronic address
    J Neurol Sci 338:46-56. 2014
    ..This work investigates the extent of these WM abnormalities in patients LLD and aMCI when these diseases occur alone and when they coexist...
  21. ncbi request reprint Characterization of effects of mean arterial blood pressure induced by cocaine and cocaine methiodide on BOLD signals in rat brain
    Feng Luo
    Biophysics Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Magn Reson Med 49:264-70. 2003
    ..These results confirm that the BOLD-weighted fMRI method can be extended to map drug-induced neuronal activity...
  22. pmc Levo-tetrahydropalmatine attenuates cocaine self-administration under a progressive-ratio schedule and cocaine discrimination in rats
    John R Mantsch
    Department of Biomedical Sciences, Marquette University, Milwaukee, WI 53201 1881, USA
    Pharmacol Biochem Behav 97:310-6. 2010
    ....
  23. ncbi request reprint Spatial correlations of laminar BOLD and CBV responses to rat whisker stimulation with neuronal activity localized by Fos expression
    Hanbing Lu
    Department of Biophysics, Medical College of Wisconsin, Milwaukee 53226, USA
    Magn Reson Med 52:1060-8. 2004
    ..We conclude that neuronal activity can be inferred from CBV fMRI data with high spatial accuracy. The data indicate that both intracolumn functional connectivity and neurovascular coupling can be studied using CBV fMRI...
  24. pmc Negative functional connectivity and its dependence on the shortest path length of positive network in the resting-state human brain
    Guangyu Chen
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Brain Connect 1:195-206. 2011
    ..It is suggested that our study can be extended to examine a variety of neurological diseases and psychiatric disorders by measuring the changes of SPL and functional reorganization in the brain...
  25. ncbi request reprint Task-modulation of functional synchrony between spontaneous low-frequency oscillations in the human brain detected by fMRI
    Guofan Xu
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Magn Reson Med 56:41-50. 2006
    ..It is suggested that the dynamic property of SLOs and the quantitative assessment of their functional synchrony could be utilized as a biomarker to noninvasively characterize localized pathophysiological functions in the human brain...
  26. pmc Differential effect of isoflurane, medetomidine, and urethane on BOLD responses to acute levo-tetrahydropalmatine in the rat
    Xiping Liu
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Magn Reson Med 68:552-9. 2012
    ..Medetomidine showed mixed positive and negative activations. Region-specific interactions were found between the l-THP-induced blood oxygen level-dependent responses and the anesthetic agents...
  27. ncbi request reprint Momentum-weighted conjugate gradient descent algorithm for gradient coil optimization
    Hanbing Lu
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Magn Reson Med 51:158-64. 2004
    ..The benefits of this design include improved gradient field uniformity and efficiency, with a shorter length than gradient coil designs using coaxial return paths...
  28. ncbi request reprint Levo-tetrahydropalmatine attenuates cocaine self-administration and cocaine-induced reinstatement in rats
    John R Mantsch
    Department of Biomedical Sciences, Marquette University, Schroeder Health Complex, P O Box 1881, Milwaukee, WI 53201 1881, USA
    Psychopharmacology (Berl) 192:581-91. 2007
    ..Accordingly, l-THP has been reported to reduce heroin craving and relapse in recovering addicts...
  29. ncbi request reprint Expectation modulates human brain responses to acute cocaine: a functional magnetic resonance imaging study
    Peter Kufahl
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Biol Psychiatry 63:222-30. 2008
    ..However, their neurophysiological mechanisms are not clear. This study investigates how cocaine expectation modulates human brain responses to acute cocaine administration...
  30. ncbi request reprint Two-dimensional excitation short echo time chemical shift imaging at 0.5 tesla
    Robert W Prost
    Biophysics Research Institute, Medical College of Wisconsin, WI 53226, USA
    J Comput Assist Tomogr 27:442-8. 2003
    ..44. Combined with the field strength-related improvements in glutamate and glx detection previously demonstrated at 0.5 T, EECSI offers further improvements for imaging glutamate and glx in vivo...
  31. pmc Scale-free functional connectivity of the brain is maintained in anesthetized healthy participants but not in patients with unresponsive wakefulness syndrome
    Xiaolin Liu
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 9:e92182. 2014
    ..The maintenance of scale-invariance across propofol sedation in healthy participants suggests the presence of persistent, on-going self-organizing processes to a critical state--a capacity that is compromised in patients with UWS...
  32. ncbi request reprint Theoretical noise model for oxygenation-sensitive magnetic resonance imaging
    Gaohong Wu
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, 53226, USA
    Magn Reson Med 53:1046-54. 2005
    ..Furthermore, the proposed theoretical models not only unified previously proposed BOLD CNR models, but also provided mechanisms for interpreting apparent controversies and limitations that exist in the literature...
  33. pmc The phase shift index for marking functional asynchrony in Alzheimer's disease patients using fMRI
    Yin Xu
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Magn Reson Imaging 26:379-92. 2008
    ..6+/-11.3 degrees ), followed by the MCI group (58.6+/-5.7 degrees ) and, finally, the control group (40.6+/-8.4 degrees ). These results suggest that the larger is the PSI value, the more asynchrony exists between SLF components...
  34. pmc Propofol disrupts functional interactions between sensory and high-order processing of auditory verbal memory
    Xiaolin Liu
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Hum Brain Mapp 33:2487-98. 2012
    ..Such findings contribute to our understanding of anesthetic mechanisms as related to information and integration in the brain...
  35. pmc Responses of dopaminergic, serotonergic and noradrenergic networks to acute levo-tetrahydropalmatine administration in naïve rats detected at 9.4 T
    Xiping Liu
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Magn Reson Imaging 30:261-70. 2012
    ..The aim of this study was to understand the neuropharmacological characteristics of levo-tetrahydropalmatine (l-THP), a recently found potential treatment for drug addiction, and discover its neural correlates and sites of action...
  36. pmc Increased precuneus connectivity during propofol sedation
    Xiaolin Liu
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA
    Neurosci Lett 561:18-23. 2014
    ....
  37. pmc Two-axis acceleration of functional connectivity magnetic resonance imaging by parallel excitation of phase-tagged slices and half k-space acceleration
    Andrzej Jesmanowicz
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Brain Connect 1:81-90. 2011
    ....
  38. pmc Repeated N-acetyl cysteine reduces cocaine seeking in rodents and craving in cocaine-dependent humans
    Shelley L Amen
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA
    Neuropsychopharmacology 36:871-8. 2011
    ..Collectively, these data demonstrate that N-acetyl cysteine diminishes the motivational qualities of a cocaine challenge injection possibly by altering pathogenic drug-induced plasticity...
  39. pmc Enhancing effects of flavored nutritive stimuli on cortical swallowing network activity
    Arash Babaei
    Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Gastrointest Liver Physiol 299:G422-9. 2010
    ..Concurrent gustatory, olfactory, and visual nutritive stimulation enhances the activity of the cortical swallowing network. This finding may have clinical implications in management of swallowing disorders due to cortical lesions...
  40. pmc Chronic stress selectively reduces hippocampal volume in rats: a longitudinal magnetic resonance imaging study
    Taekwan Lee
    Department of Psychology, Garland Hall, University of Wisconsin, Milwaukee, Wisconsin, USA
    Neuroreport 20:1554-8. 2009
    ..This longitudinal, within-subjects design study provides direct evidence that the hippocampus is differentially vulnerable and sensitive to chronic stress...
  41. ncbi request reprint Imbalanced hippocampal functional networks associated with remitted geriatric depression and apolipoprotein E ε4 allele in nondemented elderly: a preliminary study
    Hao Shu
    Neurologic Department of Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, Nanjing, China Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA
    J Affect Disord 164:5-13. 2014
    ..Coexistence of both factors could notably enhance the risk of cognitive impairment in nondemented elderly. However, neural basis of the association remains unclear...
  42. ncbi request reprint A statistical approach to SENSE regularization with arbitrary k-space trajectories
    Leslie Ying
    Department of Electrical Engineering and Computer Science, University of Wisconsin Milwaukee, Milwaukee, Wisconsin 53211, USA
    Magn Reson Med 60:414-21. 2008
    ..Phantom and in vivo experiments demonstrate improved image quality and convergence speed over both the unregularized conjugate gradient method and Tikhonov regularization method, at no increase in total computation time...
  43. ncbi request reprint GABAergic mechanisms of heroin-induced brain activation assessed with functional MRI
    Zheng Xiong Xi
    Biophysics Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Magn Reson Med 48:838-43. 2002
    ..Administration of GVG altered these mechanisms and further suggested that involvement of the opiate's pharmacological actions can, at least in part, be mediated by inhibiting brain GABA release...
  44. ncbi request reprint Digit tapping model of functional activation in the rat somatosensory cortex
    Marie L Schulte
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA
    J Neurosci Methods 157:48-53. 2006
    ....
  45. pmc COmplex-Model-Based Estimation of thermal noise for fMRI data in the presence of artifacts
    Yin Xu
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Magn Reson Imaging 25:1079-88. 2007
    ....
  46. ncbi request reprint In vivo diffusion tensor imaging of the rat spinal cord at 9.4T
    Benjamin M Ellingson
    Department of Biomedical Engineering, Marquette University, Milwaukee, WI 53201 1881, USA
    J Magn Reson Imaging 27:634-42. 2008
    ..To determine differences in diffusion measurements in white matter (WM) and gray matter (GM) regions of the rat cervical, thoracic, and cauda equina spinal cord using in vivo diffusion tensor imaging (DTI) with a 9.4T MR scanner...

Research Grants27

  1. Roles of Orbitofrontal Cortex in Cocaine Abuse by fMRI
    Shi Jiang Li; Fiscal Year: 2006
    ..Specific Aim 4 will test that the combination of cue- and cocaine-elicited cravings, similar to the actual context of cocaine experience, will greatly enhance OFC activations and induce intense drive to take the drug. ..
  2. An FMRI Index as a Risk Marker for Alzheimer's Disease
    Shi Jiang Li; Fiscal Year: 2006
    ..abstract_text> ..
  3. A Composite MR NeuroImaging Marker for Alzheimer's Disease
    Shi Jiang Li; Fiscal Year: 2010
    ..We will employ the MRN index to distinguish mild cognitive impaired subjects who are destined to develop AD from individuals evidencing the normal aging processes or converting to different types of dementia. ..
  4. Imaging Cocaine Valuations in the Human Brain by fMRI
    Shi Jiang Li; Fiscal Year: 2009
    ..The proposed study will greatly enhance our understanding of drugs of abuse and may potentially guide the development of new treatments for addiction. ..
  5. Development of fMRI Methods for Neurpharmacology
    Shi Jiang Li; Fiscal Year: 2006
    ..We will also conduct Laser Doppler Flowmetry and EEG experiments to validate this biophysical model. ..
  6. An FMRI Index as a Risk Marker for Alzheimer's Disease
    Shi Jiang Li; Fiscal Year: 2004
    ..abstract_text> ..
  7. Development of fMRI Methods for Neurpharmacology
    Shi Jiang Li; Fiscal Year: 2003
    ..We will also conduct Laser Doppler Flowmetry and EEG experiments to validate this biophysical model. ..
  8. Roles of Orbitofrontal Cortex in Cocaine Abuse by fMRI
    Shi Jiang Li; Fiscal Year: 2002
    ..Specific Aim 4 will test that the combination of cue- and cocaine-elicited cravings, similar to the actual context of cocaine experience, will greatly enhance OFC activations and induce intense drive to take the drug. ..
  9. An FMRI Index as a Risk Marker for Alzheimer's Disease
    Shi Jiang Li; Fiscal Year: 2003
    ..abstract_text> ..
  10. Imaging Cocaine Valuations in the Human Brain by fMRI
    Shi Jiang Li; Fiscal Year: 2010
    ..The proposed study will greatly enhance our understanding of drugs of abuse and may potentially guide the development of new treatments for addiction. ..
  11. A Composite MR NeuroImaging Marker for Alzheimer's Disease
    Shi Jiang Li; Fiscal Year: 2009
    ..We will employ the MRN index to distinguish mild cognitive impaired subjects who are destined to develop AD from individuals evidencing the normal aging processes or converting to different types of dementia. ..
  12. Development of fMRI Methods for Neuropharmacology
    Shi Jiang Li; Fiscal Year: 2007
    ..We will also conduct Laser Doppler Flowmetry and EEG experiments to validate this biophysical model. ..
  13. FUNCTIONAL MRI/MRS OF HUMAN COCAINE ABUSE
    Shi Jiang Li; Fiscal Year: 1999
    ..g., working memory, Stroop Interference, Levine) in individuals undergoing withdrawal from chronic cocaine use. ..
  14. Development of fMRI Methods for Neurpharmacology
    Shi Jiang Li; Fiscal Year: 2005
    ..We will also conduct Laser Doppler Flowmetry and EEG experiments to validate this biophysical model. ..
  15. An FMRI Index as a Risk Marker for Alzheimer's Disease
    Shi Jiang Li; Fiscal Year: 2005
    ..abstract_text> ..
  16. Roles of Orbitofrontal Cortex in Cocaine Abuse by fMRI
    Shi Jiang Li; Fiscal Year: 2005
    ..Specific Aim 4 will test that the combination of cue- and cocaine-elicited cravings, similar to the actual context of cocaine experience, will greatly enhance OFC activations and induce intense drive to take the drug. ..
  17. Development of fMRI Methods for Neurpharmacology
    Shi Jiang Li; Fiscal Year: 2004
    ..We will also conduct Laser Doppler Flowmetry and EEG experiments to validate this biophysical model. ..
  18. FUNCTIONAL MRI/MRS OF HUMAN COCAINE ABUSE
    Shi Jiang Li; Fiscal Year: 2000
    ..g., working memory, Stroop Interference, Levine) in individuals undergoing withdrawal from chronic cocaine use. ..
  19. Roles of Orbitofrontal Cortex in Cocaine Abuse by fMRI
    Shi Jiang Li; Fiscal Year: 2004
    ..Specific Aim 4 will test that the combination of cue- and cocaine-elicited cravings, similar to the actual context of cocaine experience, will greatly enhance OFC activations and induce intense drive to take the drug. ..
  20. Bruker Biospec 9.4T/40cm Bore MRI System
    Shi Jiang Li; Fiscal Year: 2002
    ..The purchase of this imaging system will also provide a resource for the state of Wisconsin as the only super-high field and large bore animal instrument available. ..
  21. Roles of Orbitofrontal Cortex in Cocaine Abuse by fMRI
    Shi Jiang Li; Fiscal Year: 2002
    ..Specific Aim 4 will test that the combination of cue- and cocaine-elicited cravings, similar to the actual context of cocaine experience, will greatly enhance OFC activations and induce intense drive to take the drug. ..
  22. An FMRI Index as a Risk Marker for Alzheimer's Disease
    Shi Jiang Li; Fiscal Year: 2002
    ..abstract_text> ..
  23. Roles of Orbitofrontal Cortex in Cocaine Abuse by fMRI
    Shi Jiang Li; Fiscal Year: 2003
    ..Specific Aim 4 will test that the combination of cue- and cocaine-elicited cravings, similar to the actual context of cocaine experience, will greatly enhance OFC activations and induce intense drive to take the drug. ..