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Genomes and Genes | Jeffrey R LeeSummaryAffiliation: Medical College of Georgia Country: USA Publications
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Publications
Gastrointestinal autonomic nerve tumor: immunohistochemical and molecular identity with gastrointestinal stromal tumorJ R Lee
Veterans Affairs Medical Center, Department of Pathology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30904, USA
Am J Surg Pathol 25:979-87. 2001..The clinicopathologic, histologic, immunohistologic, and molecular features of GANT are similar to GIST, indicating that GANT merely represents a phenotypic variant of GIST...- Gastrointestinal stromal tumor of the posterior mediastinumJeffrey R Lee
Veterans Affairs Medical Center, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, USA
Eur J Cardiothorac Surg 22:1014-6. 2002..Accurate diagnosis of gastrointestinal stromal tumor is imperative, as specific medical therapy is now available for potential control of recurrent or metastatic disease... - Pattern of recruitment of immunoregulatory antigen-presenting cells in malignant melanomaJeffrey R Lee
Institute of Molecular Medicine and Genetics, Augusta Veterans Affairs Medical Center, Department of Pathology, Medical College of Georgia, Augusta, Georgia, USA
Lab Invest 83:1457-66. 2003.... - Differential protein analysis of spasomolytic polypeptide expressing metaplasia using laser capture microdissection and two-dimensional difference gel electrophoresisJeffrey R Lee
Department of Pathology and Laboratory Medicine, Veterans Affairs Medical Center, Augusta, Georgia, 30904, USA
Appl Immunohistochem Mol Morphol 11:188-93. 2003..Identification of novel SPEM-related proteins would allow the development of new immunohistochemical antibodies to further study this important metaplasia... 
Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodesDavid H Munn
Department of Pediatrics, Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
J Clin Invest 114:280-90. 2004..We hypothesize that IDO-mediated suppression by pDCs in TDLNs creates a local microenvironment that is potently suppressive of host antitumor T cell responses...- Association of the actin-binding protein transgelin with lymph node metastasis in human colorectal cancerYing Lin
Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
Neoplasia 11:864-73. 2009..Transgelin localizes to the nucleus of CRC cells, and its sequence and properties suggest that it may participate in regulation of the transcriptional program associated with the epithelial-to-mesenchymal transition... - 2D-DIGE proteomic characterization of head and neck squamous cell carcinomaMark A Merkley
Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
Otolaryngol Head Neck Surg 141:626-32. 2009..Identify proteins that are differentially expressed between head and neck squamous cell cancer (HNSCC) and patient-matched normal adjacent tissue, and validate findings in a separate patient cohort... 
Calretinin immunostaining as an adjunct in the diagnosis of Hirschsprung diseaseSusan K Holland
Department of Pathology, Medical College of Georgia, Augusta, USA
Ann Diagn Pathol 15:323-8. 2011..0001). We also found calretinin immunostaining to be a useful adjunctive modality in the diagnosis of Hirschsprung disease...- Human papillomavirus-active head and neck cancer and ethnic health disparitiesPaul M Weinberger
Department of Otolaryngology, Medical College of Georgia, Augusta, Georgia, USA
Laryngoscope 120:1531-7. 2010..We hypothesized that prevalence of this HPV-active disease class would be lower in black HNSCC patients compared to white patients... - Use of combination proteomic analysis to demonstrate molecular similarity of head and neck squamous cell carcinoma arising from different subsitesPaul M Weinberger
Department of Otolaryngology, Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
Arch Otolaryngol Head Neck Surg 135:694-703. 2009..To evaluate head and neck squamous cell carcinomas (HNSCCs) for differences in protein expression between oral cavity, oropharynx, larynx, and hypopharynx subsites... - Saturation labeling with cysteine-reactive cyanine fluorescent dyes provides increased sensitivity for protein expression profiling of laser-microdissected clinical specimensOlga Greengauz-Roberts
Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, 30904, USA
Proteomics 5:1746-57. 2005..The identification of a number of proteins that are potentially relevant to tumor progression suggests that the method holds promise for biomarker discovery... - The current state of proteomics in GI oncologyYing Lin
Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
Dig Dis Sci 54:431-57. 2009.... - Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenaseDavid H Munn
Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
Science 297:1867-70. 2002..IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans... - Engineering DNA nanoparticles as immunomodulatory reagents that activate regulatory T cellsLei Huang
Immunotherapy Center, Georgia Health Sciences University, Augusta, GA 30912, USA
J Immunol 188:4913-20. 2012..Thus, DNPs lacking TLR9 ligands may be safe and effective reagents to protect healthy tissues from immune-mediated destruction in clinical hyperimmune syndromes... - Rab11a immunohistochemical analysis does not distinguish indefinite, low-, and high-grade dysplasia in Barrett esophagusMarie E Robert
Department of Pathology, Yale University, New Haven, CT 06520, USA
Am J Clin Pathol 124:519-27. 2005..Rab11a immunoreactivity did not enhance the diagnostic assessment of dysplasia in Barrett esophagus. The previously reported positive correlation of p53 immunoreactivity with the presence of dysplasia in Barrett esophagus was confirmed... - Four cases of patients with gastrointestinal granular cell tumorsDouglas L Lowe
Department of Internal Medicine, Section of Gastroenterology Hepatology, Medical College of Georgia 1120 15th Street, BBR2538, Augusta, GA 30912 3120, USA
South Med J 100:298-300. 2007..Although most GCTs are benign and can be followed endoscopically without resection, the malignant potential warrants evaluation with endoscopic ultrasound for possible endoscopic or surgical resection... - Johanson-Blizzard syndrome: autopsy findings with special emphasis on hypopituitarism and review of the literatureWilliam H Hoffman
Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA, and Department of Pathology, St Michael s Hospital, Toronto, ON, Canada
Pediatr Dev Pathol 10:55-60. 2007..The microlobules were separated by loose fibrous tissue, and there was extensive periductal fibrosis. The spectrum of the pathognomic feature of congenital pancreatic exocrine insufficiency in JBS is discussed... - Utilization of peripherin and S-100 immunohistochemistry in the diagnosis of Hirschsprung diseaseSusan K Holland
Department of Pathology, Medical College of Georgia, Augusta, GA, USA
Mod Pathol 23:1173-9. 2010..Diff Quick staining was found to be very useful. In this study, our protocol proved to be very sensitive, specific, and efficient for the diagnosis of Hirschsprung disease... - Primary leiomyosarcomas of the gastrointestinal tract in the post-gastrointestinal stromal tumor eraGitika Aggarwal
Department of Pathology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA Electronic address
Ann Diagn Pathol 16:532-40. 2012..Owing to different treatment options, it is necessary to accurately differentiate these from GIST, using a combination of histologic appearance, presence of smooth muscle antigens, and absence of specific GIST immunomarkers... - Connexin 43 signaling enhances the generation of Foxp3+ regulatory T cellsMichal Kuczma
Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, GA 30912, USA
J Immunol 187:248-57. 2011..We propose that a possible mechanism of Cx43 activity is by regulating Foxp3 expression in T(R) lineage cells... - Liquid-based pap smears as a source of RNA for gene expression analysisEllen F Hildebrandt
Institute of Molecular Medicine and Genetics, The Department of Pathology, Medical College of Georgia, Augusta, GA, U.S.A
Appl Immunohistochem Mol Morphol 11:345-51. 2003.... - Enrichment of regulatory CD4(+)CD25(+) T cells by inhibition of phospholipase D signalingNagendra Singh
Immunotherapy Center, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, 1120 15th Street, Augusta, Georgia 30912, USA
Nat Methods 3:629-36. 2006..Consequently, cells expanded in vitro for one week by antigen receptor stimulation with PLD signal inhibition were markedly enriched for regulatory T cells... - Appendiceal mass in a middle-aged woman. Endometrioid endometrial carcinoma metastatic to the appendixJeremy S Miller
Department of Pathology, Medical College of Georgia, Augusta, GA, USA
Arch Pathol Lab Med 130:407-8. 2006 - Malignant myoepithelial tumor of soft tissue: a report of two cases of the lower extremity and a review of the literatureJeffrey R Lee
Department of Pathology, Medical College of Georgia, Augusta, GA 30912, USA
Ann Diagn Pathol 11:190-8. 2007..Of these, 30% had locally recurrent disease and 32% developed metastatic disease. Treatment benefit from chemotherapy and radiation therapy is unclear... - NF-κB directly regulates Fas transcription to modulate Fas-mediated apoptosis and tumor suppressionFeiyan Liu
Department of Biochemistry and Molecular Biology, Georgia Health Sciences University, Augusta, Georgia 30912, USA
J Biol Chem 287:25530-40. 2012..Our observations suggest that canonical NF-κB is a Fas transcription activator and alternate NF-κB is a Fas transcription repressor, and Fas functions as a suppressor of spontaneous sarcoma and colon carcinoma... - Association of nuclear, cytoplasmic expression of galectin-3 with beta-catenin/Wnt-pathway activation in thyroid carcinomaPaul M Weinberger
Department of Otolaryngology, Medical College of Georgia, Augusta, GA 30912, USA
Arch Otolaryngol Head Neck Surg 133:503-10. 2007..To characterize the localization of galectin-3 in benign and malignant thyroid neoplasms and to correlate this with alterations in beta-catenin and cyclin D1 expression... - Protective effects of the carotenoid zeaxanthin in experimental nonalcoholic steatohepatitisSherman M Chamberlain
Section of Gastroenterology, Department of Medicine, Medical College of Georgia, BBR 2538, Augusta, GA 30912, USA
Dig Dis Sci 54:1460-4. 2009..The obtained results show that zeaxanthin significantly prevented NASH progression by decreasing oxidative stress and liver fibrosis, thus suggesting a potential therapeutic application for this carotenoid in the management of NASH... - Primary mucinous adenocarcinoma in a defunctionalized urinary bladder: a case reportMary Taneous
Section of Pathology, Augusta Veterans Affairs Medical Center, 1 Freedom Way, Augusta, GA 30904, USA
J Med Case Reports 3:9306. 2009..Transitional cell and squamous cell carcinomas are the most common but there are three reported cases of mucinous adenocarcinoma... - Liposarcoma in a colonic polyp: case report and review of the literatureRassa Shahidzadeh
Section of Gastroenterology and Hepatology, Medical College of Georgia, 1120 15th Street, BBR2538, Augusta, Georgia 30912-3120, USA
Dig Dis Sci 52:3377-80. 2007 - Spasmolytic polypeptide-expressing metaplasia (SPEM) associated with gastric cancer in IcelandAnna Margrét Halldórsdóttir
Department of Pathology, University Hospital of Iceland, Reykjavik
Dig Dis Sci 48:431-41. 2003..In addition, early gastric cancers demonstrated a high incidence of SP expression. These results suggest that SPEM merits consideration as an important pre-neoplastic gastric lesion... - Alterations in gastric mucosal lineages induced by acute oxyntic atrophy in wild-type and gastrin-deficient miceSachiyo Nomura
Nashville VA Medical Center, Department of Surgery, Epithelial Biology Program, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Am J Physiol Gastrointest Liver Physiol 288:G362-75. 2005..The results indicate that foveolar hyperplasia requires the influence of gastrin, whereas SPEM develops in response to oxyntic atrophy independent of gastrin, likely through transdifferentiation of chief cells... - Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis-infected miceSachiyo Nomura
Nashville VA Medical Center and the Department of Surgery, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Tennessee, USA
Gastroenterology 127:582-94. 2004..To examine the relationship of SPEM to the neoplastic process in the H. felis -infected C57BL/6 mouse, we have now studied the association of SPEM-related transcripts with preneoplasia... - Association of spasmolytic polypeptide-expressing metaplasia with carcinogen administration and oxyntic atrophy in ratsHirokazu Yamaguchi
Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Lab Invest 82:1045-52. 2002..These findings support our hypothesis that SPEM develops from a second progenitor cell population, reflecting either the unmasking of a cryptic zone or transdifferentiation of chief cells... - Identification of spasmolytic polypeptide expressing metaplasia (SPEM) in remnant gastric cancer and surveillance postgastrectomy biopsiesHirokazu Yamaguchi
Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Japan
Dig Dis Sci 47:573-8. 2002..These findings implicate SPEM as a potential precursor lesion of gastric adenocarcinoma... - Loss of heterozygosity on chromosome 22q in gastrointestinal stromal tumors (GISTs): a study on 50 casesJerzy Lasota
Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
Lab Invest 85:237-47. 2005..An isolated LOH at D22S425 was equally found in both benign and malignant tumors. These observations may suggest that LOHs on chromosome 22q in GISTs play a role in early stages of tumor formation as well as in late tumor progression...