Jeffrey R Lee

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. ncbi Gastrointestinal autonomic nerve tumor: immunohistochemical and molecular identity with gastrointestinal stromal tumor
    J R Lee
    Veterans Affairs Medical Center, Department of Pathology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30904, USA
    Am J Surg Pathol 25:979-87. 2001
  2. ncbi Gastrointestinal stromal tumor of the posterior mediastinum
    Jeffrey R Lee
    Veterans Affairs Medical Center, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, USA
    Eur J Cardiothorac Surg 22:1014-6. 2002
  3. ncbi Differential protein analysis of spasomolytic polypeptide expressing metaplasia using laser capture microdissection and two-dimensional difference gel electrophoresis
    Jeffrey R Lee
    Department of Pathology and Laboratory Medicine, Veterans Affairs Medical Center, Augusta, Georgia, 30904, USA
    Appl Immunohistochem Mol Morphol 11:188-93. 2003
  4. ncbi Pattern of recruitment of immunoregulatory antigen-presenting cells in malignant melanoma
    Jeffrey R Lee
    Institute of Molecular Medicine and Genetics, Augusta Veterans Affairs Medical Center, Department of Pathology, Medical College of Georgia, Augusta, Georgia, USA
    Lab Invest 83:1457-66. 2003
  5. pmc Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes
    David H Munn
    Department of Pediatrics, Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Clin Invest 114:280-90. 2004
  6. pmc Association of the actin-binding protein transgelin with lymph node metastasis in human colorectal cancer
    Ying Lin
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Neoplasia 11:864-73. 2009
  7. doi Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis
    Nagendra Singh
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA Cancer Research Center, Georgia Regents University, Augusta, GA 30912, USA Electronic address
    Immunity 40:128-39. 2014
  8. pmc 2D-DIGE proteomic characterization of head and neck squamous cell carcinoma
    Mark A Merkley
    Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Otolaryngol Head Neck Surg 141:626-32. 2009
  9. doi Calretinin immunostaining as an adjunct in the diagnosis of Hirschsprung disease
    Susan K Holland
    Department of Pathology, Medical College of Georgia, Augusta, USA
    Ann Diagn Pathol 15:323-8. 2011
  10. pmc Human papillomavirus-active head and neck cancer and ethnic health disparities
    Paul M Weinberger
    Department of Otolaryngology, Medical College of Georgia, Augusta, Georgia, USA
    Laryngoscope 120:1531-7. 2010

Collaborators

Detail Information

Publications39

  1. ncbi Gastrointestinal autonomic nerve tumor: immunohistochemical and molecular identity with gastrointestinal stromal tumor
    J R Lee
    Veterans Affairs Medical Center, Department of Pathology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30904, USA
    Am J Surg Pathol 25:979-87. 2001
    ..The clinicopathologic, histologic, immunohistologic, and molecular features of GANT are similar to GIST, indicating that GANT merely represents a phenotypic variant of GIST...
  2. ncbi Gastrointestinal stromal tumor of the posterior mediastinum
    Jeffrey R Lee
    Veterans Affairs Medical Center, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, USA
    Eur J Cardiothorac Surg 22:1014-6. 2002
    ..Accurate diagnosis of gastrointestinal stromal tumor is imperative, as specific medical therapy is now available for potential control of recurrent or metastatic disease...
  3. ncbi Differential protein analysis of spasomolytic polypeptide expressing metaplasia using laser capture microdissection and two-dimensional difference gel electrophoresis
    Jeffrey R Lee
    Department of Pathology and Laboratory Medicine, Veterans Affairs Medical Center, Augusta, Georgia, 30904, USA
    Appl Immunohistochem Mol Morphol 11:188-93. 2003
    ..Identification of novel SPEM-related proteins would allow the development of new immunohistochemical antibodies to further study this important metaplasia...
  4. ncbi Pattern of recruitment of immunoregulatory antigen-presenting cells in malignant melanoma
    Jeffrey R Lee
    Institute of Molecular Medicine and Genetics, Augusta Veterans Affairs Medical Center, Department of Pathology, Medical College of Georgia, Augusta, Georgia, USA
    Lab Invest 83:1457-66. 2003
    ....
  5. pmc Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes
    David H Munn
    Department of Pediatrics, Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Clin Invest 114:280-90. 2004
    ..We hypothesize that IDO-mediated suppression by pDCs in TDLNs creates a local microenvironment that is potently suppressive of host antitumor T cell responses...
  6. pmc Association of the actin-binding protein transgelin with lymph node metastasis in human colorectal cancer
    Ying Lin
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Neoplasia 11:864-73. 2009
    ..Transgelin localizes to the nucleus of CRC cells, and its sequence and properties suggest that it may participate in regulation of the transcriptional program associated with the epithelial-to-mesenchymal transition...
  7. doi Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis
    Nagendra Singh
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA Cancer Research Center, Georgia Regents University, Augusta, GA 30912, USA Electronic address
    Immunity 40:128-39. 2014
    ..Niacin, a pharmacological Gpr109a agonist, suppressed colitis and colon cancer in a Gpr109a-dependent manner. Thus, Gpr10a has an essential role in mediating the beneficial effects of gut microbiota and dietary fiber in colon...
  8. pmc 2D-DIGE proteomic characterization of head and neck squamous cell carcinoma
    Mark A Merkley
    Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Otolaryngol Head Neck Surg 141:626-32. 2009
    ..Identify proteins that are differentially expressed between head and neck squamous cell cancer (HNSCC) and patient-matched normal adjacent tissue, and validate findings in a separate patient cohort...
  9. doi Calretinin immunostaining as an adjunct in the diagnosis of Hirschsprung disease
    Susan K Holland
    Department of Pathology, Medical College of Georgia, Augusta, USA
    Ann Diagn Pathol 15:323-8. 2011
    ..0001). We also found calretinin immunostaining to be a useful adjunctive modality in the diagnosis of Hirschsprung disease...
  10. pmc Human papillomavirus-active head and neck cancer and ethnic health disparities
    Paul M Weinberger
    Department of Otolaryngology, Medical College of Georgia, Augusta, Georgia, USA
    Laryngoscope 120:1531-7. 2010
    ..We hypothesized that prevalence of this HPV-active disease class would be lower in black HNSCC patients compared to white patients...
  11. pmc Use of combination proteomic analysis to demonstrate molecular similarity of head and neck squamous cell carcinoma arising from different subsites
    Paul M Weinberger
    Department of Otolaryngology, Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Arch Otolaryngol Head Neck Surg 135:694-703. 2009
    ..To evaluate head and neck squamous cell carcinomas (HNSCCs) for differences in protein expression between oral cavity, oropharynx, larynx, and hypopharynx subsites...
  12. ncbi Saturation labeling with cysteine-reactive cyanine fluorescent dyes provides increased sensitivity for protein expression profiling of laser-microdissected clinical specimens
    Olga Greengauz-Roberts
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, 30904, USA
    Proteomics 5:1746-57. 2005
    ..The identification of a number of proteins that are potentially relevant to tumor progression suggests that the method holds promise for biomarker discovery...
  13. pmc The current state of proteomics in GI oncology
    Ying Lin
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Dig Dis Sci 54:431-57. 2009
    ....
  14. pmc Constitutively CD40-activated B cells regulate CD8 T cell inflammatory response by IL-10 induction
    Pandelakis A Koni
    Department of Medicine, Georgia Regents University, Augusta, GA 30912, USA
    J Immunol 190:3189-96. 2013
    ..Thus, B cells expressing CD40L can be a therapeutic goal to regulate inflammatory CD8 T cell response by IL-10 induction...
  15. ncbi Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase
    David H Munn
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Science 297:1867-70. 2002
    ..IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans...
  16. pmc Engineering DNA nanoparticles as immunomodulatory reagents that activate regulatory T cells
    Lei Huang
    Immunotherapy Center, Georgia Health Sciences University, Augusta, GA 30912, USA
    J Immunol 188:4913-20. 2012
    ..Thus, DNPs lacking TLR9 ligands may be safe and effective reagents to protect healthy tissues from immune-mediated destruction in clinical hyperimmune syndromes...
  17. ncbi Four cases of patients with gastrointestinal granular cell tumors
    Douglas L Lowe
    Department of Internal Medicine, Section of Gastroenterology Hepatology, Medical College of Georgia 1120 15th Street, BBR2538, Augusta, GA 30912 3120, USA
    South Med J 100:298-300. 2007
    ..Although most GCTs are benign and can be followed endoscopically without resection, the malignant potential warrants evaluation with endoscopic ultrasound for possible endoscopic or surgical resection...
  18. ncbi Rab11a immunohistochemical analysis does not distinguish indefinite, low-, and high-grade dysplasia in Barrett esophagus
    Marie E Robert
    Department of Pathology, Yale University, New Haven, CT 06520, USA
    Am J Clin Pathol 124:519-27. 2005
    ..Rab11a immunoreactivity did not enhance the diagnostic assessment of dysplasia in Barrett esophagus. The previously reported positive correlation of p53 immunoreactivity with the presence of dysplasia in Barrett esophagus was confirmed...
  19. ncbi Johanson-Blizzard syndrome: autopsy findings with special emphasis on hypopituitarism and review of the literature
    William H Hoffman
    Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA, and Department of Pathology, St Michael s Hospital, Toronto, ON, Canada
    Pediatr Dev Pathol 10:55-60. 2007
    ..The microlobules were separated by loose fibrous tissue, and there was extensive periductal fibrosis. The spectrum of the pathognomic feature of congenital pancreatic exocrine insufficiency in JBS is discussed...
  20. pmc Immunohistochemical expression of PAX5 and TdT by Merkel cell carcinoma and pulmonary small cell carcinoma: a potential diagnostic pitfall but useful discriminatory marker
    Ravindra Kolhe
    Department of Pathology, Georgia Health Sciences University Augusta, GA, USA
    Int J Clin Exp Pathol 6:142-7. 2013
    ..The aim of our study was to evaluate and compare the expression of PAX5 and Terminal deoxynucleotidyl transferase (TdT), in Merkel cell carcinoma and pulmonary small cell carcinoma...
  21. doi Utilization of peripherin and S-100 immunohistochemistry in the diagnosis of Hirschsprung disease
    Susan K Holland
    Department of Pathology, Medical College of Georgia, Augusta, GA, USA
    Mod Pathol 23:1173-9. 2010
    ..Diff Quick staining was found to be very useful. In this study, our protocol proved to be very sensitive, specific, and efficient for the diagnosis of Hirschsprung disease...
  22. doi Primary leiomyosarcomas of the gastrointestinal tract in the post-gastrointestinal stromal tumor era
    Gitika Aggarwal
    Department of Pathology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA, USA
    Ann Diagn Pathol 16:532-40. 2012
    ..Owing to different treatment options, it is necessary to accurately differentiate these from GIST, using a combination of histologic appearance, presence of smooth muscle antigens, and absence of specific GIST immunomarkers...
  23. ncbi Liquid-based pap smears as a source of RNA for gene expression analysis
    Ellen F Hildebrandt
    Institute of Molecular Medicine and Genetics, The Department of Pathology, Medical College of Georgia, Augusta, GA, U S A
    Appl Immunohistochem Mol Morphol 11:345-51. 2003
    ....
  24. ncbi Appendiceal mass in a middle-aged woman. Endometrioid endometrial carcinoma metastatic to the appendix
    Jeremy S Miller
    Department of Pathology, Medical College of Georgia, Augusta, GA, USA
    Arch Pathol Lab Med 130:407-8. 2006
  25. ncbi Malignant myoepithelial tumor of soft tissue: a report of two cases of the lower extremity and a review of the literature
    Jeffrey R Lee
    Department of Pathology, Medical College of Georgia, Augusta, GA 30912, USA
    Ann Diagn Pathol 11:190-8. 2007
    ..Of these, 30% had locally recurrent disease and 32% developed metastatic disease. Treatment benefit from chemotherapy and radiation therapy is unclear...
  26. pmc Connexin 43 signaling enhances the generation of Foxp3+ regulatory T cells
    Michal Kuczma
    Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 187:248-57. 2011
    ..We propose that a possible mechanism of Cx43 activity is by regulating Foxp3 expression in T(R) lineage cells...
  27. ncbi Enrichment of regulatory CD4(+)CD25(+) T cells by inhibition of phospholipase D signaling
    Nagendra Singh
    Immunotherapy Center, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, 1120 15th Street, Augusta, Georgia 30912, USA
    Nat Methods 3:629-36. 2006
    ..Consequently, cells expanded in vitro for one week by antigen receptor stimulation with PLD signal inhibition were markedly enriched for regulatory T cells...
  28. pmc Dysplastic hepatocytes develop nuclear inclusions in a mouse model of viral hepatitis
    Priyanka Thakur
    Section of Gastroenterology Hepatology, Department of Medicine, Medical College of Georgia, Georgia Regents University, Augusta, Georgia, United States of America
    PLoS ONE 9:e99872. 2014
    ..Our results suggest that the presence of nuclear inclusions in hepatocytes correlates with oxidative stress and cellular proliferation in a model of antigen mediated hepatitis. ..
  29. pmc NF-κB directly regulates Fas transcription to modulate Fas-mediated apoptosis and tumor suppression
    Feiyan Liu
    Department of Biochemistry and Molecular Biology, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    J Biol Chem 287:25530-40. 2012
    ..Our observations suggest that canonical NF-κB is a Fas transcription activator and alternate NF-κB is a Fas transcription repressor, and Fas functions as a suppressor of spontaneous sarcoma and colon carcinoma...
  30. ncbi Liposarcoma in a colonic polyp: case report and review of the literature
    Rassa Shahidzadeh
    Section of Gastroenterology and Hepatology, Medical College of Georgia, 1120 15th Street, BBR2538, Augusta, Georgia 30912 3120, USA
    Dig Dis Sci 52:3377-80. 2007
  31. doi Protective effects of the carotenoid zeaxanthin in experimental nonalcoholic steatohepatitis
    Sherman M Chamberlain
    Section of Gastroenterology, Department of Medicine, Medical College of Georgia, BBR 2538, Augusta, GA 30912, USA
    Dig Dis Sci 54:1460-4. 2009
    ..The obtained results show that zeaxanthin significantly prevented NASH progression by decreasing oxidative stress and liver fibrosis, thus suggesting a potential therapeutic application for this carotenoid in the management of NASH...
  32. pmc Primary mucinous adenocarcinoma in a defunctionalized urinary bladder: a case report
    Mary Taneous
    Section of Pathology, Augusta Veterans Affairs Medical Center, 1 Freedom Way, Augusta, GA 30904, USA
    J Med Case Reports 3:9306. 2009
    ..Transitional cell and squamous cell carcinomas are the most common but there are three reported cases of mucinous adenocarcinoma...
  33. ncbi Association of nuclear, cytoplasmic expression of galectin-3 with beta-catenin/Wnt-pathway activation in thyroid carcinoma
    Paul M Weinberger
    Department of Otolaryngology, Medical College of Georgia, Augusta, GA 30912, USA
    Arch Otolaryngol Head Neck Surg 133:503-10. 2007
    ..To characterize the localization of galectin-3 in benign and malignant thyroid neoplasms and to correlate this with alterations in beta-catenin and cyclin D1 expression...
  34. ncbi Spasmolytic polypeptide-expressing metaplasia (SPEM) associated with gastric cancer in Iceland
    Anna Margrét Halldórsdóttir
    Department of Pathology, University Hospital of Iceland, Reykjavik
    Dig Dis Sci 48:431-41. 2003
    ..In addition, early gastric cancers demonstrated a high incidence of SP expression. These results suggest that SPEM merits consideration as an important pre-neoplastic gastric lesion...
  35. ncbi Alterations in gastric mucosal lineages induced by acute oxyntic atrophy in wild-type and gastrin-deficient mice
    Sachiyo Nomura
    Nashville VA Medical Center, Department of Surgery, Epithelial Biology Program, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Gastrointest Liver Physiol 288:G362-75. 2005
    ..The results indicate that foveolar hyperplasia requires the influence of gastrin, whereas SPEM develops in response to oxyntic atrophy independent of gastrin, likely through transdifferentiation of chief cells...
  36. ncbi Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis-infected mice
    Sachiyo Nomura
    Nashville VA Medical Center and the Department of Surgery, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Tennessee, USA
    Gastroenterology 127:582-94. 2004
    ..To examine the relationship of SPEM to the neoplastic process in the H. felis -infected C57BL/6 mouse, we have now studied the association of SPEM-related transcripts with preneoplasia...
  37. ncbi Loss of heterozygosity on chromosome 22q in gastrointestinal stromal tumors (GISTs): a study on 50 cases
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Lab Invest 85:237-47. 2005
    ..An isolated LOH at D22S425 was equally found in both benign and malignant tumors. These observations may suggest that LOHs on chromosome 22q in GISTs play a role in early stages of tumor formation as well as in late tumor progression...
  38. ncbi Association of spasmolytic polypeptide-expressing metaplasia with carcinogen administration and oxyntic atrophy in rats
    Hirokazu Yamaguchi
    Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Lab Invest 82:1045-52. 2002
    ..These findings support our hypothesis that SPEM develops from a second progenitor cell population, reflecting either the unmasking of a cryptic zone or transdifferentiation of chief cells...
  39. ncbi Identification of spasmolytic polypeptide expressing metaplasia (SPEM) in remnant gastric cancer and surveillance postgastrectomy biopsies
    Hirokazu Yamaguchi
    Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Japan
    Dig Dis Sci 47:573-8. 2002
    ..These findings implicate SPEM as a potential precursor lesion of gastric adenocarcinoma...