Wai Meng Kwok

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Differential modulation of the cardiac adenosine triphosphate-sensitive potassium channel by isoflurane and halothane
    Wai Meng Kwok
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 97:50-6. 2002
  2. ncbi request reprint Preconditioning of the myocardium by volatile anesthetics
    Wai Meng Kwok
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Curr Med Chem Cardiovasc Hematol Agents 2:249-55. 2004
  3. ncbi request reprint Protein kinase C-epsilon primes the cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel to modulation by isoflurane
    Kei Aizawa
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Anesthesiology 101:381-9. 2004
  4. ncbi request reprint Isoflurane sensitizes the cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel to pinacidil
    Susanne Gassmayr
    Department of Anesthesiology double dagger Assistant Professor, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 98:114-20. 2003
  5. ncbi request reprint The effects of isoflurane on the cardiac slowly activating delayed-rectifier potassium channel in Guinea pig ventricular myocytes
    Akihiro Suzuki
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Anesth Analg 96:1308-15, table of contents. 2003
  6. ncbi request reprint The interaction of isoflurane and protein kinase C-activators on sarcolemmal KATP channels
    Lawrence A Turner
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Anesth Analg 100:1680-6. 2005
  7. ncbi request reprint Gabapentin decreases membrane calcium currents in injured as well as in control mammalian primary afferent neurons
    Constantine Sarantopoulos
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Reg Anesth Pain Med 27:47-57. 2002
  8. pmc Protection against cardiac injury by small Ca(2+)-sensitive K(+) channels identified in guinea pig cardiac inner mitochondrial membrane
    David F Stowe
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA
    Biochim Biophys Acta 1828:427-42. 2013
  9. pmc Ca²⁺-dependent regulation of Ca²⁺ currents in rat primary afferent neurons: role of CaMKII and the effect of injury
    Qingbo Tang
    Medical College of Wisconsin, Department of Anesthesiology, Milwaukee, Wisconsin 53226, USA
    J Neurosci 32:11737-49. 2012
  10. ncbi request reprint ATP-sensitive potassium channels in rat primary afferent neurons: the effect of neuropathic injury and gabapentin
    Constantine Sarantopoulos
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neurosci Lett 343:185-9. 2003

Research Grants

  1. VOLATILE ANESTHETIC ACTION ON CARDIAC K CHANNELS
    Wai Meng Kwok; Fiscal Year: 2005
  2. VOLATILE ANESTHETIC ACTION ON CARDIAC K CHANNELS
    Wai Meng Kwok; Fiscal Year: 2006
  3. VOLATILE ANESTHETIC ACTION ON CARDIAC K CHANNELS
    Wai Meng Kwok; Fiscal Year: 2007

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Differential modulation of the cardiac adenosine triphosphate-sensitive potassium channel by isoflurane and halothane
    Wai Meng Kwok
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 97:50-6. 2002
    ..The goal of this study was to investigate the ability of volatile anesthetics halothane and isoflurane to modulate the cardiac sarcolemmal K(ATP) channel...
  2. ncbi request reprint Preconditioning of the myocardium by volatile anesthetics
    Wai Meng Kwok
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Curr Med Chem Cardiovasc Hematol Agents 2:249-55. 2004
    ..This review highlights the major recent findings on the cardioprotective effects of volatile anesthetics...
  3. ncbi request reprint Protein kinase C-epsilon primes the cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel to modulation by isoflurane
    Kei Aizawa
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Anesthesiology 101:381-9. 2004
    ....
  4. ncbi request reprint Isoflurane sensitizes the cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel to pinacidil
    Susanne Gassmayr
    Department of Anesthesiology double dagger Assistant Professor, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 98:114-20. 2003
    ..The authors tested the hypothesis that isoflurane sensitizes sarcK ATP channels to a potassium channel opener, pinacidil, adenosine- and phospholipid-mediated pathways...
  5. ncbi request reprint The effects of isoflurane on the cardiac slowly activating delayed-rectifier potassium channel in Guinea pig ventricular myocytes
    Akihiro Suzuki
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Anesth Analg 96:1308-15, table of contents. 2003
    ..Because most of the ion channel studies on anesthetic effects are conducted at room temperature, the temperature-dependent effect on IKs confirms the importance of anesthetic experiments conducted at physiological temperature...
  6. ncbi request reprint The interaction of isoflurane and protein kinase C-activators on sarcolemmal KATP channels
    Lawrence A Turner
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Anesth Analg 100:1680-6. 2005
    ....
  7. ncbi request reprint Gabapentin decreases membrane calcium currents in injured as well as in control mammalian primary afferent neurons
    Constantine Sarantopoulos
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Reg Anesth Pain Med 27:47-57. 2002
    ....
  8. pmc Protection against cardiac injury by small Ca(2+)-sensitive K(+) channels identified in guinea pig cardiac inner mitochondrial membrane
    David F Stowe
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA
    Biochim Biophys Acta 1828:427-42. 2013
    ..This study shows that 1) SK(Ca) channels are located and functional in IMM, 2) mSK(Ca) channel opening by DCEB leads to protection that is O(2)(-) dependent, and 3) protection by DCEB is evident beginning during ischemia...
  9. pmc Ca²⁺-dependent regulation of Ca²⁺ currents in rat primary afferent neurons: role of CaMKII and the effect of injury
    Qingbo Tang
    Medical College of Wisconsin, Department of Anesthesiology, Milwaukee, Wisconsin 53226, USA
    J Neurosci 32:11737-49. 2012
    ..These findings indicate that I(Ca) in sensory neurons is subject to both CDI and CDF, and that hyperexcitability following injury-induced loss of CDF may result from diminished CaMKII activity...
  10. ncbi request reprint ATP-sensitive potassium channels in rat primary afferent neurons: the effect of neuropathic injury and gabapentin
    Constantine Sarantopoulos
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neurosci Lett 343:185-9. 2003
    ..We conclude that normal primary afferent neurons express K(ATP) channels that conduct current which is eliminated by peripheral nerve injury. Gabapentin does not affect this current significantly...
  11. pmc Opposing effects of spinal nerve ligation on calcium-activated potassium currents in axotomized and adjacent mammalian primary afferent neurons
    Constantine D Sarantopoulos
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Brain Res 1132:84-99. 2007
    ..In an additional set of experiments we found that small-sized control DRG neurons also expressed iberiotoxin-sensitive currents, which are reduced in both axotomized (L5) and adjacent (L4) neurons...
  12. pmc Painful peripheral nerve injury decreases calcium current in axotomized sensory neurons
    J Bruce McCallum
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, 53226, USA
    Anesthesiology 105:160-8. 2006
    ..The authors hypothesized that I(Ca) loss is a result of neuronal injury, so they compared axotomized L5 dorsal root ganglion neurons to spared L4 neurons, as well as neurons from rats undergoing skin incision alone...
  13. ncbi request reprint Isoflurane activates rat mitochondrial ATP-sensitive K+ channels reconstituted in lipid bilayers
    Yuri Nakae
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 284:H1865-71. 2003
    ..8 mM (P < 0.05, n = 5 approximately 8). We conclude that direct activation of the mitoK(ATP) channel by isoflurane is likely to contribute to volatile anesthetic-induced myocardial preconditioning...
  14. ncbi request reprint Biphasic effects of isoflurane on the cardiac action potential: an ionic basis for anesthetic-induced changes in cardiac electrophysiology
    Akihiro Suzuki
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Anesthesiology 97:1209-17. 2002
    ..The results were correlated to modulation of the L-type calcium (I(Ca,L)), the delayed-rectifier potassium (I(Kdr)), and the inward-rectifier potassium (I(Kir)) currents...
  15. ncbi request reprint Isoflurane-induced facilitation of the cardiac sarcolemmal K(ATP) channel
    Kazuhiro Fujimoto
    Department of Anesthesiology, Medical College Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 97:57-65. 2002
    ..However, evidence for a direct effect of volatile anesthetic on the K(ATP) channel is limited. In this study, the effects of isoflurane on the cardiac sarcolemmal K(ATP) channel were investigated...
  16. ncbi request reprint Loss of T-type calcium current in sensory neurons of rats with neuropathic pain
    J Bruce McCallum
    Department of Anesthesiology, Medical College of Wisconsin, Wisconsi 53226, USA
    Anesthesiology 98:209-16. 2003
    ..However, the physiologic function of these channels is unknown. Their possible role in rebound burst firing makes them a candidate for increased excitability after neuropathic injury...
  17. ncbi request reprint Protein tyrosine kinase-dependent modulation of isoflurane effects on cardiac sarcolemmal K(ATP) channel
    Anna Stadnicka
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Anesthesiology 97:1198-208. 2002
    ....
  18. ncbi request reprint Characterization of human cardiac mitochondrial ATP-sensitive potassium channel and its regulation by phorbol ester in vitro
    Ming Tao Jiang
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 290:H1770-6. 2006
    ..This local PKC control mechanism may represent an alternative pathway to that proposed previously for cytosolic PKC during ischemic/pharmacological preconditioning...
  19. pmc Store-operated Ca2+ entry in sensory neurons: functional role and the effect of painful nerve injury
    Geza Gemes
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Neurosci 31:3536-49. 2011
    ....
  20. pmc Suppressed Ca2+/CaM/CaMKII-dependent K(ATP) channel activity in primary afferent neurons mediates hyperalgesia after axotomy
    Takashi Kawano
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Proc Natl Acad Sci U S A 106:8725-30. 2009
    ..Unitary current conductance and sensitivity of K(ATP) channels to cytosolic ATP and ligands were preserved even after painful nerve injury, thus providing opportunities for selective therapeutic targeting against neuropathic pain...
  21. ncbi request reprint Isoflurane activates human cardiac mitochondrial adenosine triphosphate-sensitive K+ channels reconstituted in lipid bilayers
    Ming T Jiang
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Anesth Analg 105:926-32, table of contents. 2007
    ..In this study, we examined the direct effect of isoflurane and ROS on human cardiac mitoK(ATP) channels reconstituted into the lipid bilayers...
  22. ncbi request reprint Contribution of reactive oxygen species to isoflurane-induced sensitization of cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel to pinacidil
    Jianzhong An
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
    Anesthesiology 100:575-80. 2004
    ..Because reactive oxygen species seem to be mediators in anesthetic preconditioning, the authors investigated whether they contribute to the mechanism of the sensitization effect by isoflurane...
  23. pmc Tyrosine nitration of voltage-dependent anion channels in cardiac ischemia-reperfusion: reduction by peroxynitrite scavenging
    Meiying Yang
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Biochim Biophys Acta 1817:2049-59. 2012
    ..These results identify tyr-N of VDAC and show that reducing ONOO(-) during cardiac IR injury can attenuate tyr-N of VDAC and improve cardiac function...
  24. pmc Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel
    Qunli Cheng
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    FEBS Lett 585:328-34. 2011
    ..These biphasic effects on the cardiac VDAC and the mitochondrial PT pore reveal a tandem impact of NO() on the two mitochondrial entities...
  25. ncbi request reprint Beta-escin diminishes voltage-gated calcium current rundown in perforated patch-clamp recordings from rat primary afferent neurons
    Constantine Sarantopoulos
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Neurosci Methods 139:61-8. 2004
    ..Limited rundown may be due to better preservation of cytosolic ATP content...
  26. pmc The A3 adenosine receptor agonist CP-532,903 [N6-(2,5-dichlorobenzyl)-3'-aminoadenosine-5'-N-methylcarboxamide] protects against myocardial ischemia/reperfusion injury via the sarcolemmal ATP-sensitive potassium channel
    Tina C Wan
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Pharmacol Exp Ther 324:234-43. 2008
    ..We conclude that CP-532,903 is a highly selective agonist of the mouse A(3)AR that protects against ischemia/reperfusion injury by activating sarcolemmal K(ATP) channels...
  27. pmc Mitochondrial matrix K+ flux independent of large-conductance Ca2+-activated K+ channel opening
    Mohammed Aldakkak
    M4280, 8701 Watertown Plank Rd, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Cell Physiol 298:C530-41. 2010
    ....
  28. ncbi request reprint Sigma-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons
    Bin Pan
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin B P, Y G, W M K, Q H, H e W and Department of Anesthesiology, Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin Q H
    J Pharmacol Exp Ther 350:290-300. 2014
    ..Together, the findings suggest that activation of σR1 decreases ICa in sensory neurons and may play a pivotal role in pain generation. ..
  29. pmc Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels
    Sreedhar Bodiga
    Pulmonary and Critical Care Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Mol Cell Cardiol 46:978-88. 2009
    ....
  30. pmc Nitric oxide activates ATP-sensitive potassium channels in mammalian sensory neurons: action by direct S-nitrosylation
    Takashi Kawano
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Mol Pain 5:12. 2009
    ..NO-dependent mechanisms modulate both KATP channels and participate in the pathophysiology and pharmacology of neuropathic pain. Therefore, we investigated NO modulation of KATP channels in control and axotomized DRG neurons...
  31. doi request reprint Survival of neurally induced mesenchymal cells may determine degree of motor recovery in injured spinal cord rats
    Arshak R Alexanian
    Neuroscience Research Labs, Deptpartment of Neurosurgery, Medical College of Wisconsin, VAMC, Milwaukee, WI 53295, USA
    Restor Neurol Neurosci 28:761-7. 2010
    ..The aim of this study was to determine whether transplanted NI-MSCs survive, differentiate, and integrate in injured spinal cord (ISC) rats and promote functional recovery...
  32. pmc Partial restoration of the long QT syndrome associated KCNQ1 A341V mutant by the KCNE1 β-subunit
    Ikuomi Mikuni
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Biochim Biophys Acta 1810:1285-93. 2011
    ..We investigated the biophysical characteristics of A341V in a cardiac environment by utilizing a cardiac cell line, and in particular the impact of the KCNE1 β-subunit...

Research Grants4

  1. VOLATILE ANESTHETIC ACTION ON CARDIAC K CHANNELS
    Wai Meng Kwok; Fiscal Year: 2005
    ..This novel approach to anesthetic interaction with ion channels will have functional significance in the diseased myocardium where up- and downregulation of channel subunits are known to occur. ..
  2. VOLATILE ANESTHETIC ACTION ON CARDIAC K CHANNELS
    Wai Meng Kwok; Fiscal Year: 2006
    ..This novel approach to anesthetic interaction with ion channels will have functional significance in the diseased myocardium where up- and downregulation of channel subunits are known to occur. ..
  3. VOLATILE ANESTHETIC ACTION ON CARDIAC K CHANNELS
    Wai Meng Kwok; Fiscal Year: 2007
    ..This novel approach to anesthetic interaction with ion channels will have functional significance in the diseased myocardium where up- and downregulation of channel subunits are known to occur. ..