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Genomes and Genes | Anne E KwitekSummaryAffiliation: Medical College of Wisconsin Country: USA Publications
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Publications
BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced ratAnne E Kwitek
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Physiol Genomics 25:303-13. 2006..These data provide a baseline for physiological comparison of traits related to cardiovascular, lung, blood, and renal function in the sequenced BN rats relative to the major strains of rats studied in biomedical research...
High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequenceAnne E Kwitek
Human and Molecular Genetics Center and Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Genome Res 14:750-7. 2004..This new integrated RH map contains approximately 10 RH-mapped elements per Mb on the genome assembly, enabling the RH maps to serve as a scaffold for a variety of data visualization tools...- Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal diseaseDavid L Mattson
Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Am J Physiol Renal Physiol 295:F837-42. 2008..Furthermore, this consomic rat panel provides a stable genetic platform that can facilitate further gene mapping by either linkage studies or the breeding of congenic and subcongenic rats... - Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH ratsDavid L Mattson
Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Am J Physiol Renal Physiol 293:F1905-14. 2007..The present data indicate that genes that can modify l-NAME-induced hypertension and proteinuria are on chromosomes 1, 15, 16, 18, and 20... 
Molecular networks in Dahl salt-sensitive hypertension based on transcriptome analysis of a panel of consomic ratsMingyu Liang
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Physiol Genomics 34:54-64. 2008....- Consomic strategies to localize genomic regions related to vascular reactivity in the Dahl salt-sensitive ratMary Pat Kunert
University of Wisconsin Milwaukee, College of Nursing, Milwaukee, Wisconsin 53211, USA
Physiol Genomics 26:218-25. 2006..Because the BN chromosome is removed from its native background and the SS rat loses a native chromosome, it is also necessary to consider the contribution of changes in gene-to-gene interaction... - Integrative genomics: in silico coupling of rat physiology and complex traits with mouse and human dataSimon N Twigger
Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Genome Res 14:651-60. 2004..Integrating rat physiology with mouse genetics and clinical results from human by using the respective genomes provides a novel route to capitalize on comparative genomics and the strengths of model organism biology... - Tools and strategies for physiological genomics: the Rat Genome DatabaseSimon N Twigger
Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Physiol Genomics 23:246-56. 2005..We present an overview of the database with a focus on these unique computational tools and describe strategies for the use of these resources in the area of physiological genomics... - The Rat Genome Database, update 2007--easing the path from disease to data and back againSimon N Twigger
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Nucleic Acids Res 35:D658-62. 2007..We have published a number of papers that provide additional information on the ontology annotations and the tools at RGD for data mining and analysis to better enable researchers to fully utilize the database... - In silico analysis of 2085 clones from a normalized rat vestibular periphery 3' cDNA libraryJoseph P Roche
Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Audiol Neurootol 10:310-22. 2005..Physiological studies are necessary to further elucidate the roles of the identified genes and novel sequences in vestibular function... - Impact of genomics on research in the ratJozef Lazar
Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Genome Res 15:1717-28. 2005..The impact of the rat genome project has just started, but it is an exciting time with tremendous progress... - Comparative genomics for detecting human disease genesCarol Moreno
Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Adv Genet 60:655-97. 2008..In this chapter, the current state of comparative genomics and the available tools are discussed in the context of developing animal model systems that reflect the clinical picture... - Genetic linkage and association of the growth hormone secretagogue receptor (ghrelin receptor) gene in human obesityAndrea Baessler
Department of Physiology, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Diabetes 54:259-67. 2005.... - Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat strainsNancy E Schlick
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226-0509, USA
Am J Physiol Cell Physiol 291:C1183-92. 2006..Moreover, these data provide information that may be useful as new animal models, which result in novel combinations of nuclear and mitochondrial genomes, are developed... - Expression of G-protein alpha subunit genes in the vestibular periphery of Rattus norvegicus and their chromosomal mappingJoseph A Cioffi
Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Acta Otolaryngol 123:1027-34. 2003..The purpose of this study was to better define the role of these proteins by examining their expression in the rat vestibular periphery and characterizing their chromosomal location... - Evidence of a functional role for mast cells in the development of type 1 diabetes mellitus in the BioBreeding ratRhonda Geoffrey
Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics at the Medical College of Wisconsin, and Children's Research Institute of the Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA
J Immunol 177:7275-86. 2006..05) delayed T1DM onset. These findings are consistent with a growing body of evidence in human and animal models, where a role for mast cells in the initiation and progression of autoimmune disease is emerging... - Mapping the genetic determinants of hypertension, metabolic diseases, and related phenotypes in the lyon hypertensive ratMarijo Bilusic
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Hypertension 44:695-701. 2004..quot; These intermediate phenotypes may be used as closer surrogates to the mechanisms leading to hypertension and metabolic dysfunction in the LH rat... - Characterization of blood pressure and renal function in chromosome 5 congenic strains of Dahl S ratsRichard J Roman
Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Am J Physiol Renal Physiol 290:F1463-71. 2006.... - The application of microarray analysis to pediatric diseasesMartin J Hessner
The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Pediatr Clin North Am 53:579-90. 2006..This article reviews the basics of array technology and analysis, and highlights its application to pediatric diseases... - Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5Ryan D Schulteis
Blood Research Institute, Blood Center of Wisconsin, Milwaukee, USA
Blood 112:4905-14. 2008..We conclude that mouse gimap5 is necessary for the survival of peripheral T cells, NK/NKT-cell development, and the maintenance of normal liver function. These functions involve cell-intrinsic as well as cell-extrinsic mechanisms... - Radiation hybrid mapping of five muscarinic acetylcholine receptor subtype genes in Rattus norvegicusJeffrey Tseng
Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA
Hear Res 174:86-92. 2002..With the chromosomal location for each of these muscarinic subtypes known, it is now possible to develop congenic and consomic strains of rats that can be used to study the functions of each of these subtypes... - Rat genetics: attaching physiology and pharmacology to the genomeHoward J Jacob
Department of Physiology, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
Nat Rev Genet 3:33-42. 2002..Most importantly, this combined physiological and genomic information should also lead to the development of better pre-clinical models of human disease, which will aid in the development of new therapeutics... - Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the ratMieczyslaw Michalkiewicz
Department of Physiology, Human Molecular and Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
Physiol Genomics 19:228-32. 2004..It also demonstrates that transgenic rescue in the rat is a practical and definitive method for revealing the function of a novel gene... - Genetic determinants of obesity-related lipid traitsGabriele E Sonnenberg
Division of Endocrinology, Metabolism and Clinical Nutrition, Department of Medicine and Human Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI, USA
J Lipid Res 45:610-5. 2004..These newly identified loci likely harbor genetic elements that influence traits underlying lipid adversities associated with obesity... - Radiation hybrid mapping of 70 rat genes from a data set of differentially expressed genesCaroline A Wallace
Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Mamm Genome 13:194-7. 2002..The data provide new map locations for rat genes and will aid efforts to advance the rat genome map. The data may also be used to prioritize candidate QTL genes in SHR and other rat strains on the basis of their map location... - Progress and prospects in rat genetics: a community viewTimothy J Aitman
Medical Research Council Clinical Sciences Centre and Imperial College London, Du Cane Road, London W12 0NN, UK
Nat Genet 40:516-22. 2008..Finally, we present a set of principles that justify continuing and strengthening genetic studies in the rat model, and further development of genomic infrastructure for rat research... - Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related geneArmand J MacMurray
Robert H Williams Laboratory, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
Genome Res 12:1029-39. 2002..The lymphopenia mutation may thus be useful not only to elucidate Type 1 diabetes, but also in the function of the Ian gene family as a whole... - Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 ratDaniel H Moralejo
Robert H Williams Laboratory, Department of Medicine, University of Washington, Seattle, WA 98195, USA
J Autoimmun 21:315-24. 2003..The congenic F344.lyp rat should prove useful to dissect the mechanisms by which the Ian5 frameshift mutation affects T cell selection, differentiation and maturation without organ-specific autoimmunity... - Introgression of F344 rat genomic DNA on BB rat chromosome 4 generates diabetes-resistant lymphopenic BB ratsJessica M Fuller
University of Washington, Department of Medicine, 1959 NE Pacific St, Box 357710, Seattle, WA 98195, USA
Diabetes 55:3351-7. 2006..Spontaneous diabetes in the BB rat may therefore be controlled, in part, by a diabetogenic factor(s), perhaps unrelated to the Gimap5 mutation on rat chromosome 4... - Genome sequence of the Brown Norway rat yields insights into mammalian evolutionRichard A Gibbs
Human Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, MS BCM226, One Baylor Plaza, Houston, Texas 77030, USA <http://www.hgsc.bcm.tmc.edu
Nature 428:493-521. 2004.... - Physiogenomic resources for rat models of heart, lung and blood disordersRenae L Malek
TREX, The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
Nat Genet 38:234-9. 2006..We performed a variety of data-mining manipulations on the profiles and used complementary physiological data from the PhysGen resource to demonstrate how TREX can be used by the cardiovascular community for hypothesis generation... - Assessing unmodified 70-mer oligonucleotide probe performance on glass-slide microarraysHong-Ying Wang
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
Genome Biol 4:R5. 2003..CONCLUSIONS: Microarrays of UV cross-linked unmodified oligonucleotides provided sensitive and specific measurements for most of the genes studied... - Association of the Ghrelin receptor gene region with left ventricular hypertrophy in the general population: results of the MONICA/KORA Augsburg Echocardiographic SubstudyAndrea Baessler
Clinic for Internal Medicine II, University of Regensburg, Regensburg, Germany
Hypertension 47:920-7. 2006..These data suggest that common variants in the GHSR region are associated with parameters of LVM and geometry independent of blood pressure and body mass in the general population and, thus, may be involved in the pathogenesis of LVH...