Subra Kugathasan

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Comparative phenotypic and CARD15 mutational analysis among African American, Hispanic, and White children with Crohn's disease
    Subra Kugathasan
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Inflamm Bowel Dis 11:631-8. 2005
  2. ncbi request reprint Inflammatory bowel disease--environmental modification and genetic determinants
    Subra Kugathasan
    Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Pediatr Clin North Am 53:727-49. 2006
  3. ncbi request reprint CARD15 gene mutations and risk for early surgery in pediatric-onset Crohn's disease
    Subra Kugathasan
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226, USA
    Clin Gastroenterol Hepatol 2:1003-9. 2004
  4. ncbi request reprint Severe colitis in children
    Subra Kugathasan
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Pediatr Gastroenterol Nutr 41:375-85. 2005
  5. ncbi request reprint Body mass index in children with newly diagnosed inflammatory bowel disease: observations from two multicenter North American inception cohorts
    Subra Kugathasan
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Pediatr 151:523-7. 2007
  6. ncbi request reprint Epidemiologic and clinical characteristics of children with newly diagnosed inflammatory bowel disease in Wisconsin: a statewide population-based study
    Subra Kugathasan
    Division of Pediatric Gastroenterology and Nutrition, The Department of Epidemiology and Biostatistics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Pediatr 143:525-31. 2003
  7. ncbi request reprint Dermatologic manifestations of Crohn disease in children: response to infliximab
    Subra Kugathasan
    Division of Pediatric Gastroenterology and Nutrition, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Pediatr Gastroenterol Nutr 37:150-4. 2003
  8. ncbi request reprint Pancreatitis as a presenting manifestation of pediatric Crohn's disease: a report of three cases
    Subra Kugathasan
    Division of Gastroenterology and Nutrition, Department of Pediatrics, Medical College of Wisconsin, The Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Pediatr Gastroenterol Nutr 35:96-8. 2002
  9. ncbi request reprint Intercenter variation in initial management of children with Crohn's disease
    Michael D Kappelman
    Center for Inflammatory Bowel Disease, Division of Gastroenterology and Nutrition, Children s Hospital Boston, Massachusetts 02115, USA
    Inflamm Bowel Dis 13:890-5. 2007
  10. ncbi request reprint DLG5 R30Q variant is a female-specific protective factor in pediatric onset Crohn's disease
    Vincent Biank
    Department of Pediatrics, Medical College Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Gastroenterol 102:391-8. 2007

Research Grants

Detail Information

Publications49

  1. ncbi request reprint Comparative phenotypic and CARD15 mutational analysis among African American, Hispanic, and White children with Crohn's disease
    Subra Kugathasan
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Inflamm Bowel Dis 11:631-8. 2005
    ..The first identified CD susceptibility gene, CARD15, seems to be present in up to 40% of white children with CD. However, the frequency of this gene among patients with CD of other racial/ethnic groups in the United States is not known...
  2. ncbi request reprint Inflammatory bowel disease--environmental modification and genetic determinants
    Subra Kugathasan
    Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Pediatr Clin North Am 53:727-49. 2006
    ..Technical advances of the HapMap project and the promise of whole genome association scans have given hopes for clarifying gene-environmental interactions in IBD that ultimately lead to a clearer understanding of the pathogenesis...
  3. ncbi request reprint CARD15 gene mutations and risk for early surgery in pediatric-onset Crohn's disease
    Subra Kugathasan
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226, USA
    Clin Gastroenterol Hepatol 2:1003-9. 2004
    ..We investigated the effect of CARD15 mutations on disease manifestation, disease progression, and the risk for early surgery in childhood-onset CD...
  4. ncbi request reprint Severe colitis in children
    Subra Kugathasan
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Pediatr Gastroenterol Nutr 41:375-85. 2005
  5. ncbi request reprint Body mass index in children with newly diagnosed inflammatory bowel disease: observations from two multicenter North American inception cohorts
    Subra Kugathasan
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Pediatr 151:523-7. 2007
    ..To conduct a systematic review of children with newly diagnosed inflammatory bowel disease (IBD) from 2 prospective inception cohorts to examine body mass index (BMI) status at presentation...
  6. ncbi request reprint Epidemiologic and clinical characteristics of children with newly diagnosed inflammatory bowel disease in Wisconsin: a statewide population-based study
    Subra Kugathasan
    Division of Pediatric Gastroenterology and Nutrition, The Department of Epidemiology and Biostatistics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Pediatr 143:525-31. 2003
    ..To define epidemiologic and clinical characteristics of newly diagnosed pediatric inflammatory bowel disease (IBD) in a large population-based model...
  7. ncbi request reprint Dermatologic manifestations of Crohn disease in children: response to infliximab
    Subra Kugathasan
    Division of Pediatric Gastroenterology and Nutrition, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Pediatr Gastroenterol Nutr 37:150-4. 2003
    ..No adverse reactions occurred. Infliximab should be considered for treating the extraintestinal dermatologic manifestations of Crohn disease in children...
  8. ncbi request reprint Pancreatitis as a presenting manifestation of pediatric Crohn's disease: a report of three cases
    Subra Kugathasan
    Division of Gastroenterology and Nutrition, Department of Pediatrics, Medical College of Wisconsin, The Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Pediatr Gastroenterol Nutr 35:96-8. 2002
  9. ncbi request reprint Intercenter variation in initial management of children with Crohn's disease
    Michael D Kappelman
    Center for Inflammatory Bowel Disease, Division of Gastroenterology and Nutrition, Children s Hospital Boston, Massachusetts 02115, USA
    Inflamm Bowel Dis 13:890-5. 2007
    ..We undertook this study to determine the extent of intercenter variation in the initial management of children newly diagnosed with Crohn's disease...
  10. ncbi request reprint DLG5 R30Q variant is a female-specific protective factor in pediatric onset Crohn's disease
    Vincent Biank
    Department of Pediatrics, Medical College Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Gastroenterol 102:391-8. 2007
    ..Pediatric onset CD features a significantly lower incidence for female children compared with male children. We, therefore, studied the influence of gender on R30Q susceptibility in an exclusively pediatric onset IBD cohort...
  11. ncbi request reprint Contribution of OCTN variants within the IBD5 locus to pediatric onset Crohn's disease
    Umesh Babusukumar
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Gastroenterol 101:1354-61. 2006
    ..We performed a comprehensive analysis of OCTN variants in an independent, exclusively pediatric onset CD cohort and examined the genotype/phenotype correlations...
  12. pmc Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease
    Subra Kugathasan
    Department of Pediatrics, Children s Research Institute and Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Nat Genet 40:1211-5. 2008
    ..30 x 10(-8) and 6.95 x 10(-8), respectively; odds ratio (OR) = 0.74 for both) and 21q22 (rs2836878[A]; P = 6.01 x 10(-8); OR = 0.73), located close to the TNFRSF6B and PSMG1 genes, respectively...
  13. pmc Increased immune reactivity predicts aggressive complicating Crohn's disease in children
    Marla C Dubinsky
    Department of Pediatrics, IBD Center, Cedars Sinai Medical Center, Los Angeles, California, USA
    Clin Gastroenterol Hepatol 6:1105-11. 2008
    ..The aims of this study were to determine whether immune responses and/or CARD15 variants are associated with complicated disease phenotypes and predict disease progression...
  14. ncbi request reprint Pediatric inflammatory bowel disease: clinical and molecular genetics
    Vincent Biank
    Department of Pediatrics, Children s Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Inflamm Bowel Dis 13:1430-8. 2007
    ..Finally, the future directions of genetic investigations in pediatric IBD are discussed...
  15. pmc Common NOD2 risk variants in African Americans with Crohn's disease are due exclusively to recent Caucasian admixture
    Oloruntosin Adeyanju
    Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Inflamm Bowel Dis 18:2357-9. 2012
    ..Since genotype-based tools are becoming increasingly available for CD, it is important that we validate the risk variants in different populations, such as admixed AAs...
  16. pmc IL-10R polymorphisms are associated with very-early-onset ulcerative colitis
    Christopher J Moran
    Division of Pediatric Gastroenterology, Department of Pediatrics, MassGeneral Hospital for Children, Boston, Massachusetts, USA
    Inflamm Bowel Dis 19:115-23. 2013
    ..Our objective was to determine if IL-10R polymorphisms were associated with early-onset IBD (EO-IBD) and very-early-onset IBD (VEO-IBD)...
  17. doi request reprint Fecal calprotectin is useful in predicting disease relapse in pediatric inflammatory bowel disease
    Dorota Walkiewicz
    Department of Pediatrics, Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Inflamm Bowel Dis 14:669-73. 2008
    ..The aim was to compare FC levels in IBD and healthy controls, to correlate FC levels with clinical disease activity, and to assess whether FC levels can be used to predict clinical relapse in children with IBD...
  18. ncbi request reprint Molecular stratification of Crohn's disease by chemokine receptors: fractalkine receptor polymorphisms define a fibrostenosing ileal subgroup
    David G Binion
    Division of Gastroenterology and Hepatology, Froedtert Memorial Lutheran Hospital, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Gastroenterol 101:107-9. 2006
    ....
  19. doi request reprint Markers that differentiate early from late IBD
    Clifton Huang
    Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Emory University School of Medicine and Children s Healthcare of Atlanta, Atlanta, GA 30322, USA
    Dig Dis 30:380-2. 2012
    ....
  20. ncbi request reprint Progress in basic inflammatory bowel disease research
    Subra Kugathasan
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Semin Pediatr Surg 16:146-53. 2007
    ....
  21. ncbi request reprint Pancreatitis in children
    Steven L Werlin
    Department of Pediatrics, The Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee 53226, USA
    J Pediatr Gastroenterol Nutr 37:591-5. 2003
    ..To determine the incidence, etiology and outcome of pancreatitis at a regional children's hospital...
  22. doi request reprint Brief report: development of the inflammatory bowel disease family responsibility questionnaire
    Rachel Neff Greenley
    Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Pediatr Psychol 35:183-7. 2010
    ..To present psychometric data on youth and parent versions of the Inflammatory Bowel Disease-Family Responsibility Questionnaire (IBD-FRQ), a measure of family involvement in IBD management...
  23. ncbi request reprint Functional genomics and its implications for molecular medicine
    Ulrich Broeckel
    Department of Medicine, Medical College of Wisconsin, and Department of Pediatrics, Children s Hospital of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Pediatr Clin North Am 53:807-16, vii. 2006
    ..Ultimately how the unique genetic signature of an individual influences the risk and prognosis of disease will be the basis for individualized medicine in the years to come...
  24. ncbi request reprint Asymptomatic inflammatory bowel disease presenting with mucocutaneous findings
    Sheila S Galbraith
    Department of Dermatology and Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Pediatrics 116:e439-44. 2005
    ....
  25. doi request reprint Pediatric inflammatory bowel disease: highlighting pediatric differences in IBD
    Cary G Sauer
    Department of Pediatrics, Emory University School of Medicine, Emory Children s Center, 2015 Uppergate Drive, Atlanta, GA 30322, USA
    Gastroenterol Clin North Am 38:611-28. 2009
    ..Evidence-based treatment algorithms, with special focus on pediatric studies and care for children, are also highlighted...
  26. pmc Association of Crohn's disease, thiopurines, and primary epstein-barr virus infection with hemophagocytic lymphohistiocytosis
    Vincent F Biank
    Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, The Medical College of Wisconsin, The Children s Hospital of Wisconsin, Milwaukee, WI, USA
    J Pediatr 159:808-12. 2011
    ....
  27. doi request reprint Incidence, clinical characteristics, and natural history of pediatric IBD in Wisconsin: a population-based epidemiological study
    Tonya Adamiak
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Inflamm Bowel Dis 19:1218-23. 2013
    ....
  28. doi request reprint Genetic determinants of pediatric inflammatory bowel disease: is age of onset genetically determined?
    Rebecca Scherr
    Department of Pediatrics, Emory University School of Medicine and Children s Health Care of Atlanta, Atlanta, GA 30322, USA
    Dig Dis 27:236-9. 2009
    ..A future joint analysis of genome-wide association data of early- and late-onset cohorts will likely reveal more IBD risk variants since the power to detect small effects of genes increases...
  29. ncbi request reprint Infliximab retreatment in adults and children with Crohn's disease: risk factors for the development of delayed severe systemic reaction
    Subra Kugathasan
    Department of Medicine, Digestive Disease Center, Children s Hospital of Wisconsin, Milwaukee, USA
    Am J Gastroenterol 97:1408-14. 2002
    ....
  30. ncbi request reprint Inflammatory bowel disease
    Daryl Fish
    Division of Pediatric Gastroenterology and Nutrition, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Adolesc Med Clin 15:67-90, ix. 2004
    ....
  31. doi request reprint Barriers to adherence among adolescents with inflammatory bowel disease
    Rachel Neff Greenley
    Medical College of Wisconsin, Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Milwaukee, Wisconsin 53226, USA
    Inflamm Bowel Dis 16:36-41. 2010
    ..A final goal was to examine relationships between the frequencies of barriers and levels of nonadherence...
  32. ncbi request reprint Corticosteroid therapy in the age of infliximab: acute and 1-year outcomes in newly diagnosed children with Crohn's disease
    James Markowitz
    North Shore Long Island Jewish Health System, New Hyde Park, New York, USA
    Clin Gastroenterol Hepatol 4:1124-9. 2006
    ..We also aimed to determine whether there are clinical or laboratory characteristics associated with corticosteroid therapy outcomes...
  33. doi request reprint Searching for new clues in inflammatory bowel disease: tell tales from pediatric IBD natural history studies
    Subra Kugathasan
    Gastroenterology 135:1038-41. 2008
  34. ncbi request reprint Analysis of keratin polypeptides 8 and 19 variants in inflammatory bowel disease
    Guo Zhong Tao
    Department of Medicine, Palo Alto Veterans Affairs Medical Center and Stanford University Digestive Disease Center, Palo Alto, California 94304, USA
    Clin Gastroenterol Hepatol 5:857-64. 2007
    ..We asked whether mutations in KRT8 or KRT19, the major intestinal keratins, are associated with UC/CD...
  35. ncbi request reprint The natural history of corticosteroid therapy for ulcerative colitis in children
    Jeffrey Hyams
    Connecticut Children s Medical Center, Hartford, Connecticut, USA
    Clin Gastroenterol Hepatol 4:1118-23. 2006
    ..The aim of this study was to determine the clinical outcome after corticosteroid therapy in children who are newly diagnosed with ulcerative colitis (UC)...
  36. ncbi request reprint Evidence of transmission ratio distortion of DLG5 R30Q variant in general and implication of an association with Crohn disease in men
    Frauke Friedrichs
    Leibniz Institute for Arteriosclerosis Research, Domagkstr 3, 48149, Muenster, Germany
    Hum Genet 119:305-11. 2006
    ....
  37. ncbi request reprint Health-related quality of life in the first year after a diagnosis of pediatric inflammatory bowel disease
    Anthony R Otley
    FRCPC, Division of Gastroenterology and Nutrition, IWK Health Centre, Halifax, Nova Scotia, Canada
    Inflamm Bowel Dis 12:684-91. 2006
    ..The aim of this study was to describe HRQOL and influential factors in newly diagnosed pediatric patients with Crohn's disease and ulcerative colitis during the first 12 months after diagnosis...
  38. doi request reprint Effect of early immunomodulator use in moderate to severe pediatric Crohn disease
    Jaya Punati
    Nationwide Children s Hospital, Ohio State University, Columbus, Ohio 43210, USA
    Inflamm Bowel Dis 14:949-54. 2008
    ..We describe IM use in newly diagnosed pediatric CD, comparing outcomes of "early" versus "late" initiation of therapy...
  39. ncbi request reprint Laboratory values for children with newly diagnosed inflammatory bowel disease
    David R Mack
    Department of Pediatrics, Children s Hospital of Eastern Ontario, 401 Smyth Rd, Ottawa, Ontario, Canada K1H 8L1
    Pediatrics 119:1113-9. 2007
    ..The goal was to determine how often common laboratory tests yield normal results at the time of diagnosis for children with inflammatory bowel disease...
  40. ncbi request reprint Differentiating ulcerative colitis from Crohn disease in children and young adults: report of a working group of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Crohn's and Colitis Foundation of America
    Athos Bousvaros
    J Pediatr Gastroenterol Nutr 44:653-74. 2007
    ....
  41. ncbi request reprint Induction and maintenance infliximab therapy for the treatment of moderate-to-severe Crohn's disease in children
    Jeffrey Hyams
    Connecticut Children s Medical Center, Hartford, Conneticut 06106, USA
    Gastroenterology 132:863-73; quiz 1165-6. 2007
    ..The REACH study evaluated the safety and efficacy of infliximab in children with moderately to severely active Crohn's disease...
  42. ncbi request reprint Pediatric onset Crohn's colitis is characterized by genotype-dependent age-related susceptibility
    Arie Levine
    Pediatric Gastroenterology Unit, Wolfson Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Inflamm Bowel Dis 13:1509-15. 2007
    ..Differences in disease site by age may suggest a different genotype, or different host responses such as decreased ileal susceptibility or increased susceptibility of the colon...
  43. doi request reprint CARD15 and IL23R influences Crohn's disease susceptibility but not disease phenotype in a Brazilian population
    Márcia Luiza Baptista
    Department of Internal Medicine, Federal University of Parana, Curitiba, PR
    Inflamm Bowel Dis 14:674-9. 2008
    ..We investigated the contribution of CARD15, IL23R, and ATG16L1 with CD risk in a heterogeneous Brazilian population...
  44. ncbi request reprint Natalizumab therapy for moderate to severe Crohn disease in adolescents
    Jeffrey S Hyams
    Division of Digestive Diseases and Nutrition, Connecticut Children s Medical Center, Hartford, CT 06106, USA
    J Pediatr Gastroenterol Nutr 44:185-91. 2007
    ..This study evaluated the safety, tolerability, and efficacy of natalizumab, a humanized monoclonal immunoglobulin-G4 antibody to [alpha]4 integrin, in adolescent patients with moderately to severely active Crohn disease (CD)...
  45. ncbi request reprint Guidelines for immunizations in patients with inflammatory bowel disease
    Bruce E Sands
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Inflamm Bowel Dis 10:677-92. 2004
    ..We conclude that for most patients with IBD, recommendations for immunization do not deviate from recommended schedules for the general population...
  46. ncbi request reprint Methotrexate following unsuccessful thiopurine therapy in pediatric Crohn's disease
    Dan Turner
    Division of Gastroenterology, Hepatology, and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    Am J Gastroenterol 102:2804-12; quiz 2803, 2813. 2007
    ..We report outcomes with methotrexate treatment in pediatric patients previously refractory to or intolerant of thiopurines...
  47. ncbi request reprint Evaluation of the pediatric crohn disease activity index: a prospective multicenter experience
    Jeffrey Hyams
    Connecticut Children s Medical Center, Hartford, Connecticut, USA
    J Pediatr Gastroenterol Nutr 41:416-21. 2005
    ....
  48. ncbi request reprint A randomized, double-blind trial of Lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn's disease
    Athos Bousvaros
    Division of Pediatric Gastroenterology, Children s Hospital, Boston, Massachusetts 02115, USA
    Inflamm Bowel Dis 11:833-9. 2005
    ..18). The LGG was well tolerated, with a side effect profile comparable with placebo. This study suggests that LGG does not prolong time to relapse in children with CD when given as an adjunct to standard therapy...
  49. ncbi request reprint Challenges in pediatric inflammatory bowel disease
    Athos Bousvaros
    Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Inflamm Bowel Dis 12:885-913. 2006
    ..At the conclusion of the meeting, investigators discussed the formation of a multicenter collaborative network to advance clinical and basic research in the field...

Research Grants5

  1. MUCOSAL T-CELLS IN EARLY&LATE PEDIATRIC CROHN'S DISEASE
    Subra Kugathasan; Fiscal Year: 2005
    ..abstract_text> ..