STEVEN KUBALAK

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. pmc Elevated transforming growth factor beta2 enhances apoptosis and contributes to abnormal outflow tract and aortic sac development in retinoic X receptor alpha knockout embryos
    Steven W Kubalak
    Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Development 129:733-46. 2002
  2. pmc Regulation of Ncx1 expression. Identification of regulatory elements mediating cardiac-specific expression and up-regulation
    Lin Xu
    Gazes Cardiac Research Institute, Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 281:34430-40. 2006
  3. pmc Stem cells and the formation of the myocardium in the vertebrate embryo
    Leonard M Eisenberg
    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Anat Rec A Discov Mol Cell Evol Biol 276:2-12. 2004
  4. pmc Retinoids regulate TGFbeta signaling at the level of Smad2 phosphorylation and nuclear accumulation
    Loretta L Hoover
    Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, 173 Ashley Avenue Suite 601BSB Charleston, SC 29425, USA
    Biochim Biophys Acta 1783:2279-86. 2008
  5. pmc The expanding role for retinoid signaling in heart development
    Loretta L Hoover
    Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, Charleston, SC, USA
    ScientificWorldJournal 8:194-211. 2008
  6. pmc Regulation of Ncx1 gene expression in the normal and hypertrophic heart
    Donald R Menick
    Division of Cardiology, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, 114 Doughty St, Charleston, SC 29425, USA
    Ann N Y Acad Sci 1099:195-203. 2007
  7. ncbi request reprint Spatiotemporal pattern of commitment to slowed proliferation in the embryonic mouse heart indicates progressive differentiation of the cardiac conduction system
    David Sedmera
    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Anat Rec A Discov Mol Cell Evol Biol 274:773-7. 2003
  8. pmc Knockout of the neural and heart expressed gene HF-1b results in apical deficits of ventricular structure and activation
    Kenneth W Hewett
    Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, United States
    Cardiovasc Res 67:548-60. 2005
  9. ncbi request reprint Isl1 expression at the venous pole identifies a novel role for the second heart field in cardiac development
    Brian S Snarr
    Department of Cell Biology and Anatomy, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Circ Res 101:971-4. 2007
  10. pmc Analysis of the proepicardium-epicardium transition during the malformation of the RXRalpha-/- epicardium
    Shantae J Jenkins
    Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Dev Dyn 233:1091-101. 2005

Research Grants

Collaborators

Detail Information

Publications12

  1. pmc Elevated transforming growth factor beta2 enhances apoptosis and contributes to abnormal outflow tract and aortic sac development in retinoic X receptor alpha knockout embryos
    Steven W Kubalak
    Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Development 129:733-46. 2002
    ....
  2. pmc Regulation of Ncx1 expression. Identification of regulatory elements mediating cardiac-specific expression and up-regulation
    Lin Xu
    Gazes Cardiac Research Institute, Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 281:34430-40. 2006
    ..This work is the first in vivo study that demonstrates which cis elements are important for Ncx1 regulation...
  3. pmc Stem cells and the formation of the myocardium in the vertebrate embryo
    Leonard M Eisenberg
    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Anat Rec A Discov Mol Cell Evol Biol 276:2-12. 2004
    ..Accordingly, this review will examine the initial events of cardiac developmental biology for insights into the identity and characteristics of the stem cells that can be used to generate myocardial tissue for therapeutic purposes...
  4. pmc Retinoids regulate TGFbeta signaling at the level of Smad2 phosphorylation and nuclear accumulation
    Loretta L Hoover
    Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, 173 Ashley Avenue Suite 601BSB Charleston, SC 29425, USA
    Biochim Biophys Acta 1783:2279-86. 2008
    ..These data show retinoid signaling influences the TGFbeta pathway in an acute and direct manner that has been unappreciated until now...
  5. pmc The expanding role for retinoid signaling in heart development
    Loretta L Hoover
    Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, Charleston, SC, USA
    ScientificWorldJournal 8:194-211. 2008
    ..It is our hope that this review of the role of retinoid signaling during formation, remodeling, and maturation of the developing heart will serve as a tool for future discoveries...
  6. pmc Regulation of Ncx1 gene expression in the normal and hypertrophic heart
    Donald R Menick
    Division of Cardiology, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, 114 Doughty St, Charleston, SC 29425, USA
    Ann N Y Acad Sci 1099:195-203. 2007
    ....
  7. ncbi request reprint Spatiotemporal pattern of commitment to slowed proliferation in the embryonic mouse heart indicates progressive differentiation of the cardiac conduction system
    David Sedmera
    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Anat Rec A Discov Mol Cell Evol Biol 274:773-7. 2003
    ..5-13.5. These patterns of slowed proliferation correlate well with those in other species, and can serve as a useful marker for the forming conduction system...
  8. pmc Knockout of the neural and heart expressed gene HF-1b results in apical deficits of ventricular structure and activation
    Kenneth W Hewett
    Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, United States
    Cardiovasc Res 67:548-60. 2005
    ..This abnormality in myocardial Cx40 led us to address whether 4-week-old HF-1b knockout postnates display other disruptions to ventricular structure and function...
  9. ncbi request reprint Isl1 expression at the venous pole identifies a novel role for the second heart field in cardiac development
    Brian S Snarr
    Department of Cell Biology and Anatomy, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Circ Res 101:971-4. 2007
    ..We further demonstrate that abnormal development of the SHF-derived DMP is associated with the pathogenesis of atrioventricular septal defects. These results identify a novel role for the SHF...
  10. pmc Analysis of the proepicardium-epicardium transition during the malformation of the RXRalpha-/- epicardium
    Shantae J Jenkins
    Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Dev Dyn 233:1091-101. 2005
    ..We propose that these events contribute to a developmental delay in the formation of the epicardium, which leads to an abnormal epicardium and ultimately contributes to the cardiac malformations seen in the RXRalpha-/-...
  11. pmc Holding their own: the noncanonical roles of Smad proteins
    Loretta L Hoover
    Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, Charleston, SC 29425, USA
    Sci Signal 1:pe48. 2008
    ..Investigating these interactions will likely yield more evidence that Smads serve important and diverse purposes beyond their original reported function as signal transducers in the TGF-beta pathway...
  12. pmc Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation
    Esther Merki
    Institute of Molecular Medicine, University of California, San Diego, CA 92093, USA
    Proc Natl Acad Sci U S A 102:18455-60. 2005
    ....

Research Grants8

  1. CARDIOVASCULAR REMODELING MEDIATED BY RXRa RECEPTORS
    STEVEN KUBALAK; Fiscal Year: 2003
    ..III) To test the hypothesis that disruption of RXRalpha expression during cardiogenesis results in cardiac defects that are TGFbeta2 dependent. ..
  2. Signaling Mechanisms Regulating Cardiac Remodeling
    STEVEN KUBALAK; Fiscal Year: 2009
    ..2) To determine how retinoic acid signaling regulates TGFbeta2-induced apoptosis and remodeling in the outflow tract. 3) To determine if RXRalpha directly interacts with Smad signaling in the outflow tract. ..