Theodore A Kotchen

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Identification of hypertension-related QTLs in African American sib pairs
    Theodore A Kotchen
    Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA
    Hypertension 40:634-9. 2002
  2. ncbi request reprint NIH peer review of grant applications for clinical research
    Theodore A Kotchen
    Center for Scientific Review, National Institutes of Health, Bethesda, MD, USA
    JAMA 291:836-43. 2004
  3. ncbi request reprint Outcomes of National Institutes of Health peer review of clinical grant applications
    Theodore A Kotchen
    Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA
    J Investig Med 54:13-9. 2006
  4. doi request reprint Obesity-related hypertension: epidemiology, pathophysiology, and clinical management
    Theodore A Kotchen
    Department of Medicine, Medical College of Wisconsin, Milwaukee, USA
    Am J Hypertens 23:1170-8. 2010
  5. doi request reprint Altered relationship of blood pressure to adiposity in hypertension
    Theodore A Kotchen
    Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Hypertens 21:284-9. 2008
  6. doi request reprint Aldosterone and alterations of hypertension-related vascular function in African Americans
    Theodore A Kotchen
    Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Hypertens 22:319-24. 2009
  7. pmc Cardiovascular correlates of insulin resistance in normotensive and hypertensive African Americans
    Srividya Kidambi
    Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Metabolism 60:835-42. 2011
  8. doi request reprint Hypertension, insulin resistance, and aldosterone: sex-specific relationships
    Srividya Kidambi
    Medical College of Wisconsin, Milwaukee, WI, USA
    J Clin Hypertens (Greenwich) 11:130-7. 2009
  9. ncbi request reprint Hyperaldosteronism and hypertension: ethnic differences
    Clarence E Grim
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 45:766-72. 2005
  10. pmc Non-replication study of a genome-wide association study for hypertension and blood pressure in African Americans
    Srividya Kidambi
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    BMC Med Genet 13:27. 2012

Research Grants

  1. GENES OF HYPERTENSION IN AFRICAN AMERICANS
    Theodore Kotchen; Fiscal Year: 2006
  2. INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDS
    Theodore Kotchen; Fiscal Year: 2006

Detail Information

Publications36

  1. ncbi request reprint Identification of hypertension-related QTLs in African American sib pairs
    Theodore A Kotchen
    Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA
    Hypertension 40:634-9. 2002
    ..Focusing on hypertension-related phenotypes is a promising approach for identifying the genetic determinants of hypertension...
  2. ncbi request reprint NIH peer review of grant applications for clinical research
    Theodore A Kotchen
    Center for Scientific Review, National Institutes of Health, Bethesda, MD, USA
    JAMA 291:836-43. 2004
    ..Nevertheless, a perception exists among clinical investigators that the NIH peer review process may discriminate against clinical research...
  3. ncbi request reprint Outcomes of National Institutes of Health peer review of clinical grant applications
    Theodore A Kotchen
    Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA
    J Investig Med 54:13-9. 2006
    ..The present analysis was undertaken to determine if factors related to the review process might contribute to this difference...
  4. doi request reprint Obesity-related hypertension: epidemiology, pathophysiology, and clinical management
    Theodore A Kotchen
    Department of Medicine, Medical College of Wisconsin, Milwaukee, USA
    Am J Hypertens 23:1170-8. 2010
    ....
  5. doi request reprint Altered relationship of blood pressure to adiposity in hypertension
    Theodore A Kotchen
    Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Hypertens 21:284-9. 2008
    ..We evaluated the relationship of adiposity to blood pressure in normotensive and untreated hypertensive African Americans-an ethnic group with a high prevalence of hypertension and obesity...
  6. doi request reprint Aldosterone and alterations of hypertension-related vascular function in African Americans
    Theodore A Kotchen
    Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Hypertens 22:319-24. 2009
    ..This study evaluates the hypothesis that hypertension and hypertension-related alterations of peripheral vascular and renal vascular function are associated with aldosterone...
  7. pmc Cardiovascular correlates of insulin resistance in normotensive and hypertensive African Americans
    Srividya Kidambi
    Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Metabolism 60:835-42. 2011
    ..These observations suggest that an exclusive focus on effects of IR on DM or BP may ignore independent pathophysiologic contributions of IR to cardiovascular disease...
  8. doi request reprint Hypertension, insulin resistance, and aldosterone: sex-specific relationships
    Srividya Kidambi
    Medical College of Wisconsin, Milwaukee, WI, USA
    J Clin Hypertens (Greenwich) 11:130-7. 2009
    ..The association of IR with both hypertension and PA in men, but not in women, may contribute to the high prevalence of cardiovascular disease in African American men...
  9. ncbi request reprint Hyperaldosteronism and hypertension: ethnic differences
    Clarence E Grim
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 45:766-72. 2005
    ..These observations are consistent with the hypothesis that aldosterone-induced volume expansion is an important contributor to hypertension, especially in blacks...
  10. pmc Non-replication study of a genome-wide association study for hypertension and blood pressure in African Americans
    Srividya Kidambi
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    BMC Med Genet 13:27. 2012
    ..We attempted to replicate these findings in an independent sample of 2474 unrelated African Americans in the Milwaukee metropolitan area; 53% were women and 47% were hypertensives...
  11. doi request reprint Aldosterone contributes to blood pressure variance and to likelihood of hypertension in normal-weight and overweight African Americans
    Srividya Kidambi
    Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Hypertens 22:1303-8. 2009
    ..We have previously reported that both plasma aldosterone (PA) and body mass index (BMI) are higher in hypertensive than in normotensive AAs. This study evaluates the relative contributions of adiposity and PA to hypertension in AAs...
  12. ncbi request reprint Association of adrenal steroids with hypertension and the metabolic syndrome in blacks
    Srividya Kidambi
    Medical College of Wisconsin, Milwaukee, USA
    Hypertension 49:704-11. 2007
    ..In addition, we speculate that relatively high aldosterone and low PRA in these hypertensive individuals may reflect a mild variant of primary aldosteronism...
  13. ncbi request reprint Gender-specific correlates of leptin with hypertension-related phenotypes in African Americans
    Areeg H El-Gharbawy
    Department of Medicine, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Am J Hypertens 15:989-93. 2002
    ..01). Thus, in these obese hypertensive African American women, there is no direct or independent association of leptin with BP. However, leptin may contribute to hypertension in these women by increasing renal tubular sodium reabsorption...
  14. doi request reprint Treatment of hypertension in obese patients
    Srividya Kidambi
    Division of Endocrinology, Metabolism and Clinical Nutrition, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Am J Cardiovasc Drugs 13:163-75. 2013
    ..A number of novel drug and invasive therapies are in development and hold significant potential for the effective management of obesity-related hypertension...
  15. doi request reprint Temporomandibular disorders and associated clinical comorbidities
    Raymond G Hoffmann
    Medical College of Wisconsin, Milwaukee, WI, USA
    Clin J Pain 27:268-74. 2011
    ..Temporomandibular joint and muscle disorders (TMJD) are ill-defined, painful debilitating disorders. This study was undertaken to identify the spectrum of clinical manifestations based on self-report from affected patients...
  16. ncbi request reprint Hypertension: trends in prevalence, incidence, and control
    Ihab Hajjar
    Department of Medicine, Harvard Medical School and Hebrew Senior Life, 1200 Centre St, Boston, Massachusetts 02131, USA
    Annu Rev Public Health 27:465-90. 2006
    ..Only about one third of all hypertensives are controlled in the United States. Programs that improve hypertension control rates and prevent hypertension are urgently needed...
  17. doi request reprint Characteristics of inner-city African-Americans with uncontrolled hypertension
    Gerard Coly
    Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    J Am Soc Hypertens 2:366-71. 2008
    ..Strategies to improve hypertension control should be directed to patients and to health care providers...
  18. ncbi request reprint Cocaine use in inner city african american research volunteers
    Benjamin W Weston
    From the Department of Medicine, Medical College of Wisconsin, Watertown Plank Road, Milwaukee, WI
    J Addict Med 3:83-8. 2009
    ..To determine the prevalence of cocaine use and associated risk factors in African Americans volunteering as research subjects for a hypertension study...
  19. pmc Why are peer review outcomes less favorable for clinical science than for basic science grant applications?
    Michael R Martin
    Center for Scientific Review, National Institutes of Health, Bethesda, MD, USA
    Am J Med 121:637-41. 2008
  20. ncbi request reprint Trends in prevalence, awareness, treatment, and control of hypertension in the United States, 1988-2000
    Ihab Hajjar
    Division of Geriatrics, Department of Medicine, Palmetto Health Richland, University of South Carolina, Columbia, USA
    JAMA 290:199-206. 2003
    ..Prior analyses of National Health and Nutrition Examination Survey (NHANES) data through 1991 have suggested that hypertension prevalence is declining, but more recent self-reported rates of hypertension suggest that the rate is increasing...
  21. pmc Epigenomics of hypertension
    Mingyu Liang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI Electronic address
    Semin Nephrol 33:392-9. 2013
    ....
  22. ncbi request reprint Impact of female hormones on blood pressure: review of potential mechanisms and clinical studies
    Jane Morley Kotchen
    Division of Epidemiology, Health Policy Institute, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Curr Hypertens Rep 5:505-12. 2003
    ..These observations suggest that the excess rates of cardiovascular disease are not caused by increased blood pressure...
  23. ncbi request reprint Obesity-related hypertension?: weighing the evidence
    Theodore A Kotchen
    Hypertension 52:801-2. 2008
  24. ncbi request reprint Genome-wide scan for linkage to obesity-associated hypertension in French Canadians
    Zdenka Pausova
    Brain and Body Centre, University of Nottingham, United Kingdom
    Hypertension 46:1280-5. 2005
    ..These results suggest that investigating clinically defined subtypes of hypertension, such as obesity-associated hypertension, may facilitate the search for genes of this complex disorder...
  25. doi request reprint Systematic, genome-wide, sex-specific linkage of cardiovascular traits in French Canadians
    Ondrej Seda
    Centre de Recherche, Centre hospitalier de l Université de Montréal Technopôle Angus, Montreal, Quebec, Canada
    Hypertension 51:1156-62. 2008
    ..Many of these would have been missed in a traditional, sex-adjusted setting...
  26. ncbi request reprint A genealogical study of essential hypertension with and without obesity in French Canadians
    Zdenka Pausova
    University of Montreal Health Centre, Canada
    Obes Res 10:463-70. 2002
    ....
  27. ncbi request reprint Hypertension control: trends, approaches, and goals
    Theodore A Kotchen
    Hypertension 49:19-20. 2007
  28. ncbi request reprint Clinical trials report. Risks and benefits of hormone replacement therapy
    Theodore A Kotchen
    Curr Hypertens Rep 5:483-4. 2003
  29. ncbi request reprint Primary prevention of hypertension: clinical and public health advisory from The National High Blood Pressure Education Program
    Paul K Whelton
    Department of Epidemiology and Medicine, Tulane University Health Sciences Center, Tulane University, New Orleans, LA, USA
    JAMA 288:1882-8. 2002
    ....
  30. ncbi request reprint Dietary calcium lowers the age-related rise in blood pressure in the United States: the NHANES III survey
    Ihab M Hajjar
    Division of Geriatrics, Department of Internal Medicine, Palmetto Health Alliance University of South Carolina, Columbia, SC 29206, USA
    J Clin Hypertens (Greenwich) 5:122-6. 2003
    ..001). If the calcium intake of the general population were to increase to above 1200 mg, the incidence of isolated systolic hypertension in the elderly might be decreased...
  31. ncbi request reprint Calcium channel blockers (felodipine) and pediatric essential hypertension
    Theodore A Kotchen
    Curr Hypertens Rep 5:484-5. 2003
  32. ncbi request reprint Contributions of sodium and chloride to NaCl-induced hypertension
    Theodore A Kotchen
    Hypertension 45:849-50. 2005
  33. pmc Effect of calcium and vitamin D supplementation on blood pressure: the Women's Health Initiative Randomized Trial
    Karen L Margolis
    HealthPartners Research Foundation, Box 1524, Mailstop 21111R, Minneapolis, Minnesota 55440 1524, USA
    Hypertension 52:847-55. 2008
    ..01 (95% CI: 0.96 to 1.06.) In postmenopausal women, calcium plus vitamin D3 supplementation did not reduce either blood pressure or the risk of developing hypertension over 7 years of follow-up...
  34. ncbi request reprint From clinical trials to clinical practice: why the gap?
    Theodore A Kotchen
    Hypertension 48:196-7. 2006
  35. ncbi request reprint Why the slow diffusion of treatment guidelines into clinical practice?
    Theodore A Kotchen
    Arch Intern Med 167:2394-5. 2007
  36. ncbi request reprint Mechanisms of hypertension
    Theodore A Kotchen
    N Engl J Med 357:827-9; author reply 827-9. 2007

Research Grants5

  1. GENES OF HYPERTENSION IN AFRICAN AMERICANS
    Theodore Kotchen; Fiscal Year: 2006
    ..abstract_text> ..
  2. INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDS
    Theodore Kotchen; Fiscal Year: 2006
    ..The chairpersons of the working groups will serve as an Advisory Committee during the planning process and will meet monthly. ..