GIRIJA KONDURI

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. pmc Antenatal betamethasone improves postnatal transition in late preterm lambs with persistent pulmonary hypertension of the newborn
    Girija G Konduri
    Department of Pediatrics, Children s Research Institute and Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Pediatr Res 73:621-9. 2013
  2. pmc Decreases in manganese superoxide dismutase expression and activity contribute to oxidative stress in persistent pulmonary hypertension of the newborn
    Adeleye J Afolayan
    Department of Pediatrics, Cardiovascular Research Center and Children s Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Physiol Lung Cell Mol Physiol 303:L870-9. 2012
  3. pmc Impaired voltage gated potassium channel responses in a fetal lamb model of persistent pulmonary hypertension of the newborn
    Girija G Konduri
    Department of Pediatrics, Medical College of Wisconsin and Zablocki VA Medical Center, Milwaukee, Wisconsin 53226, USA
    Pediatr Res 66:289-94. 2009
  4. pmc Advances in the diagnosis and management of persistent pulmonary hypertension of the newborn
    G Ganesh Konduri
    Department of Pediatrics, Division of Neonatology, Children s Research Institute and Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Pediatr Clin North Am 56:579-600, Table of Contents. 2009
  5. pmc Early inhaled nitric oxide therapy for term and near-term newborn infants with hypoxic respiratory failure: neurodevelopmental follow-up
    G Ganesh Konduri
    Medical College of WI, Dept of Pediatrics and the Children s Research Institute, Milwaukee, WI 53201 1997, USA
    J Pediatr 150:235-40, 240.e1. 2007
  6. ncbi request reprint Oxidant stress from uncoupled nitric oxide synthase impairs vasodilation in fetal lambs with persistent pulmonary hypertension
    Girija G Konduri
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53201 1997, USA
    Am J Physiol Heart Circ Physiol 292:H1812-20. 2007
  7. ncbi request reprint New approaches for persistent pulmonary hypertension of newborn
    G Ganesh Konduri
    Division of Neonatology, Medical College of Wisconsin and Children s Research Institute of Children s Hospital of Wisconsin, MS 213 A, Milwaukee, WI 53226, USA
    Clin Perinatol 31:591-611. 2004
  8. ncbi request reprint A randomized trial of early versus standard inhaled nitric oxide therapy in term and near-term newborn infants with hypoxic respiratory failure
    G Ganesh Konduri
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Pediatrics 113:559-64. 2004
  9. ncbi request reprint P2Y purine receptor responses and expression in the pulmonary circulation of juvenile rabbits
    Girija G Konduri
    Department of Pediatrics, Medical College of Wisconsin, CHW OB 213 A, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 287:H157-64. 2004
  10. ncbi request reprint Decreased association of HSP90 impairs endothelial nitric oxide synthase in fetal lambs with persistent pulmonary hypertension
    Girija G Konduri
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 285:H204-11. 2003

Research Grants

Detail Information

Publications15

  1. pmc Antenatal betamethasone improves postnatal transition in late preterm lambs with persistent pulmonary hypertension of the newborn
    Girija G Konduri
    Department of Pediatrics, Children s Research Institute and Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Pediatr Res 73:621-9. 2013
    ..Betamethasone decreases the oxidative stress and improves antioxidant balance in PPHN. We investigated whether antenatal betamethasone improves pulmonary vasodilation and postnatal oxygenation in late preterm lambs with PPHN...
  2. pmc Decreases in manganese superoxide dismutase expression and activity contribute to oxidative stress in persistent pulmonary hypertension of the newborn
    Adeleye J Afolayan
    Department of Pediatrics, Cardiovascular Research Center and Children s Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Physiol Lung Cell Mol Physiol 303:L870-9. 2012
    ..Our observations suggest that decreased MnSOD expression and activity contribute to the endothelial dysfunction observed in PPHN...
  3. pmc Impaired voltage gated potassium channel responses in a fetal lamb model of persistent pulmonary hypertension of the newborn
    Girija G Konduri
    Department of Pediatrics, Medical College of Wisconsin and Zablocki VA Medical Center, Milwaukee, Wisconsin 53226, USA
    Pediatr Res 66:289-94. 2009
    ..Oxidative stress impairs Kv channel function in PPHN. Superoxide scavengers may improve pulmonary vasodilation in PPHN in part by restoring Kv channel function...
  4. pmc Advances in the diagnosis and management of persistent pulmonary hypertension of the newborn
    G Ganesh Konduri
    Department of Pediatrics, Division of Neonatology, Children s Research Institute and Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Pediatr Clin North Am 56:579-600, Table of Contents. 2009
    ..This review focuses on the diagnosis, recent advances in management, and recommendations for the long-term follow-up of infants who have PPHN...
  5. pmc Early inhaled nitric oxide therapy for term and near-term newborn infants with hypoxic respiratory failure: neurodevelopmental follow-up
    G Ganesh Konduri
    Medical College of WI, Dept of Pediatrics and the Children s Research Institute, Milwaukee, WI 53201 1997, USA
    J Pediatr 150:235-40, 240.e1. 2007
    ..To report the neurodevelopmental outcome of infants enrolled in a randomized multicenter trial of early inhaled nitric oxide (iNO) in term and near-term neonates with hypoxic respiratory failure and pulmonary hypertension...
  6. ncbi request reprint Oxidant stress from uncoupled nitric oxide synthase impairs vasodilation in fetal lambs with persistent pulmonary hypertension
    Girija G Konduri
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53201 1997, USA
    Am J Physiol Heart Circ Physiol 292:H1812-20. 2007
    ..HSP90 immunoprecipitated from PPHN pulmonary arteries had increased nitrotyrosine signal. Oxidant stress from uncoupled eNOS contributes to impaired pulmonary vasodilation in PPHN induced by ductal ligation in fetal lambs...
  7. ncbi request reprint New approaches for persistent pulmonary hypertension of newborn
    G Ganesh Konduri
    Division of Neonatology, Medical College of Wisconsin and Children s Research Institute of Children s Hospital of Wisconsin, MS 213 A, Milwaukee, WI 53226, USA
    Clin Perinatol 31:591-611. 2004
    ..Further research is needed to understand the basis for the biologic susceptibility of some infants to environmental insults such as intra-uterine stressor exposure to NSAIDs in utero...
  8. ncbi request reprint A randomized trial of early versus standard inhaled nitric oxide therapy in term and near-term newborn infants with hypoxic respiratory failure
    G Ganesh Konduri
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Pediatrics 113:559-64. 2004
    ..We conducted a randomized, double masked, multicenter trial to determine whether administration of iNO earlier in respiratory failure results in additional reduction in the incidence of these outcomes...
  9. ncbi request reprint P2Y purine receptor responses and expression in the pulmonary circulation of juvenile rabbits
    Girija G Konduri
    Department of Pediatrics, Medical College of Wisconsin, CHW OB 213 A, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 287:H157-64. 2004
    ..ATP appears to cause NO-mediated vasodilation predominantly through P2Y2 receptors on endothelium...
  10. ncbi request reprint Decreased association of HSP90 impairs endothelial nitric oxide synthase in fetal lambs with persistent pulmonary hypertension
    Girija G Konduri
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 285:H204-11. 2003
    ..Decreased HSP90-eNOS interactions may contribute to the impaired NO release and vasodilation observed in the ductal ligation model of PPHN...
  11. ncbi request reprint Inhaled nitric oxide for premature infants with severe respiratory failure
    Krisa P Van Meurs
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, Calif 94304, USA
    N Engl J Med 353:13-22. 2005
    ..We conducted a multicenter, randomized, blinded, controlled trial to determine whether inhaled nitric oxide reduced the rate of death or bronchopulmonary dysplasia in such infants...
  12. doi request reprint Inhaled nitric oxide for preterm neonates
    Nandini Arul
    Division of Neonatology, Medical College of Wisconsin, Milwaukee, WI, USA
    Clin Perinatol 36:43-61. 2009
    ..This article focuses on the potential toxicities, persistent controversies, and unanswered questions regarding the use of this treatment modality in this patient population at high risk for adverse outcomes...
  13. pmc Perinatal systemic inflammatory response syndrome and retinopathy of prematurity
    Beena G Sood
    Department of Pediatrics, Wayne State University, Detroit, Michigan 48201, USA
    Pediatr Res 67:394-400. 2010
    ..We conclude that perinatal inflammation may be involved in the pathogenesis of ROP...
  14. pmc eNOS function is developmentally regulated: uncoupling of eNOS occurs postnatally
    Eugenia Mata-Greenwood
    Dept of Pediatrics, Northwestern Univ, Ward 12 191, 303 E Chicago Ave, Chicago, IL 60611 008, USA
    Am J Physiol Lung Cell Mol Physiol 290:L232-41. 2006
    ..We speculate this may be related to cellular production and/or maintenance of BH4 levels...
  15. ncbi request reprint Tetrahydrobiopterin in pulmonary hypertension: pulmonary hypertension in guanosine triphosphate-cyclohydrolase-deficient mice
    Kirkwood A Pritchard
    Circulation 111:2022-4. 2005

Research Grants6

  1. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    GIRIJA KONDURI; Fiscal Year: 2000
    ..The proposed experiments will provide new information on mechanisms of O2 induced pulmonary vasodilation, a critical step for survival of newborn. ..
  2. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    GIRIJA KONDURI; Fiscal Year: 2006
    ..These studies will provide new information on mechanisms of impaired adaptation in PPHN. ..
  3. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2010
    ..The proposed studies will investigate the mechanisms and potential new therapies for this disease. ..